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Western blot
Immunocytochemistry
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Immunocytochemistry [1]
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- Product number
- ALX-804-408-C100 - Provider product page
- Provider
- Enzo Life Sciences
- Proper citation
- Enzo Life Sciences Cat#ALX-804-408-C100, RRID:AB_2052079
- Product name
- Noxa monoclonal antibody (114C307.1)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full length protein
- Description
- Protein G-affinity purified.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 114C307.1
- Vial size
- 100 μg
- Storage
- -20°C
- Handling
- Avoid freeze/thaw cycles.
Submitted references MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies.
MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors.
Broad degradation of proapoptotic proteins with the conserved Bcl-2 homology domain 3 during infection with Chlamydia trachomatis.
BOK and NOXA are essential mediators of p53-dependent apoptosis.
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation.
p53 has a direct apoptogenic role at the mitochondria.
Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage.
Choudhary GS, Al-Harbi S, Mazumder S, Hill BT, Smith MR, Bodo J, Hsi ED, Almasan A
Cell death & disease 2015 Jan 15;6:e1593
Cell death & disease 2015 Jan 15;6:e1593
MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors.
Knorr KL, Schneider PA, Meng XW, Dai H, Smith BD, Hess AD, Karp JE, Kaufmann SH
Cell death and differentiation 2015 Dec;22(12):2133-42
Cell death and differentiation 2015 Dec;22(12):2133-42
Broad degradation of proapoptotic proteins with the conserved Bcl-2 homology domain 3 during infection with Chlamydia trachomatis.
Ying S, Seiffert BM, Häcker G, Fischer SF
Infection and immunity 2005 Mar;73(3):1399-403
Infection and immunity 2005 Mar;73(3):1399-403
BOK and NOXA are essential mediators of p53-dependent apoptosis.
Yakovlev AG, Di Giovanni S, Wang G, Liu W, Stoica B, Faden AI
The Journal of biological chemistry 2004 Jul 2;279(27):28367-74
The Journal of biological chemistry 2004 Jul 2;279(27):28367-74
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation.
Erster S, Mihara M, Kim RH, Petrenko O, Moll UM
Molecular and cellular biology 2004 Aug;24(15):6728-41
Molecular and cellular biology 2004 Aug;24(15):6728-41
p53 has a direct apoptogenic role at the mitochondria.
Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM
Molecular cell 2003 Mar;11(3):577-90
Molecular cell 2003 Mar;11(3):577-90
Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage.
Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosová I, Kulans LA, Fu X, Weinberg JS, Heinecke JW, Roth KA, Weintraub SJ
Cell 2002 Oct 4;111(1):51-62
Cell 2002 Oct 4;111(1):51-62
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Supportive validation
- Submitted by
- Enzo Life Sciences (provider)
- Main image
- Experimental details
- Western blot detection of Noxa in RL-7 cell (a follicular lymphoma) lysate. A protein band of approximate molecular weight of ~11kDa was detected using ALX-804-408 at 2µg/ml dilution.
