55408-1-AP

antibody from Proteintech Group

Targeting: HIPK2

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

55408-1-AP

Provider

Proteintech Group

Product name

HIPK2 antibody

Antibody type

Polyclonal

Description

KD/KO validated HIPK2 antibody (Cat. #55408-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Sertad1 exacerbates cardiomyocytes ferroptosis in sepsis-induced myocardial injury by inhibiting HIPK2.

Hu C, Miao J, Zhao Q, Chen L
Molecular biology reports 2026 Mar 7;53(1)

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Discovery of XRF-1021, a 2,4-disubstituted-5-fluoropyrimidine derivative as a homeodomain-interacting protein kinase 2 inhibitor for the treatment of chronic kidney disease.

Hu X, Wang S, Fu S, Zeng J, Wu Y, Gong L, Cao Y, Zhang Y, Han Y, Ouyang H, Xiong Y, He X, Cheng J, Zou S, Chen Z, Tao L, Meng J, Huang L, Yuan Q, Peng Z, Li Q
European journal of medicinal chemistry 2026 Jan 15;302(Pt 2):118353

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Fragment-based discovery, dynamics simulation and pharmacological study of 2-amino-pyrimidine derivative as HIPK2 inhibitor.

Wu Y, Hu X, Wang S, Ouyang H, Yao M, Chen Z, Li Q
Chemico-biological interactions 2025 Nov 1;421:111771

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HECW1-Mediated Ubiquitination of HIPK2 Drives Metastasis in Gastric Cancer Through the AKT Signaling Pathway.

Zhang G, Qu W, Huang X, Yi J, Gao H, He J, Xue W
Laboratory investigation; a journal of technical methods and pathology 2025 Feb;105(2):102202

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Virtual Screening, Molecular Dynamics, and Mechanism Study of Homeodomain-Interacting Protein Kinase 2 Inhibitor in Renal Fibroblasts.

Hu X, Wu Y, Ouyang H, Wu J, Yao M, Chen Z, Li Q
Pharmaceuticals (Basel, Switzerland) 2024 Oct 23;17(11)

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Polystyrene nanoplastics induce cardiotoxicity by upregulating HIPK2 and activating the P53 and TGF-β1/Smad3 pathways.

Yang JZ, Zhang KK, Hsu C, Miao L, Chen LJ, Liu JL, Li JH, Li XW, Zeng JH, Chen L, Li JH, Xie XL, Wang Q
Journal of hazardous materials 2024 Aug 5;474:134823

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Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate.

Wu YQ, Zhang CS, Xiong J, Cai DQ, Wang CZ, Wang Y, Liu YH, Wang Y, Li Y, Wu J, Wu J, Lan B, Wang X, Chen S, Cao X, Wei X, Hu HH, Guo H, Yu Y, Ghafoor A, Xie C, Wu Y, Xu Z, Zhang C, Zhu M, Huang X, Sun X, Lin SY, Piao HL, Zhou J, Lin SC
Cell research 2023 Nov;33(11):835-850

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Exosome-transmitted hsa_circ_0012634 suppresses pancreatic ductal adenocarcinoma progression through regulating miR-147b/HIPK2 axis.

Wang L, Wu X, Ruan Y, Zhang X, Zhou X
Cancer biology & therapy 2023 Dec 31;24(1):2218514

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Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling.

Zhou Q, Meng D, Li F, Zhang X, Liu L, Zhu Y, Liu S, Xu M, Deng J, Lei Z, Sluijter JPG, Xiao J
EBioMedicine 2022 Nov;85:104274

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MiR-221-3p targets HIPK2 to promote diabetic wound healing.

Yu Q, Liu L, Zhang X, Chang H, Ma S, Xie Z, Tang S, Ju X, Zhu H, Shen B, Zhang Q
Microvascular research 2022 Mar;140:104306

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HIPK2 overexpression relieves hypoxia/reoxygenation-induced apoptosis and oxidative damage of cardiomyocytes through enhancement of the Nrf2/ARE signaling pathway.

Dang X, Zhang R, Peng Z, Qin Y, Sun J, Niu Z, Pei H
Chemico-biological interactions 2020 Jan 25;316:108922

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Homeodomain-interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer.

Qin Y, Hu Q, Ji S, Xu J, Dai W, Liu W, Xu W, Sun Q, Zhang Z, Ni Q, Yu X, Zhang B, Xu X
Cell proliferation 2019 May;52(3):e12603

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Exosomal miR-1229 derived from colorectal cancer cells promotes angiogenesis by targeting HIPK2.

Hu HY, Yu CH, Zhang HH, Zhang SZ, Yu WY, Yang Y, Chen Q
International journal of biological macromolecules 2019 Jul 1;132:470-477