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- Antibody Data
- Antigen structure
- References [20]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 51045-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#51045-1-AP, RRID:AB_2187322
- Product name
- SIK1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SIK1 antibody (Cat. #51045-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Salt-inducible kinase 1 is a key gene in suppressing EVD68-induced asthma by modulating antiviral immunity.
Investigating the therapeutic potential of naringin in MK-801-induced schizophrenia model: focus on cognitive impairment and miR-25-3p-regulated pathways.
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.
YKL-06-061 exerts antitumor effect through G1/S phase arrest by downregulating c-Myc and inhibition of metastasis via SIK1 upregulation in pancreatic cancer.
Demethylase FTO-mediated m6A modification of SIK1 modulates placental cytotrophoblast syncytialization in type 2 diabetes mellitus.
Discovery of the Natural Bibenzyl Compound Erianin in Dendrobium Inhibiting the Growth and EMT of Gastric Cancer through Downregulating the LKB1-SIK2/3-PARD3 Pathway.
ETNPPL modulates hyperinsulinemia-induced insulin resistance through the SIK1/ROS-mediated inactivation of the PI3K/AKT signaling pathway in hepatocytes.
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Salt-inducible kinase 1 deficiency promotes vascular remodeling in pulmonary arterial hypertension via enhancement of yes-associated protein-mediated proliferation.
Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network.
Identification of novel targets in adipose tissue involved in non-alcoholic fatty liver disease progression.
HG-9-91-01 Attenuates Murine Experimental Colitis by Promoting Interleukin-10 Production in Colonic Macrophages Through the SIK/CRTC3 Pathway.
Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
High-salt diet downregulates TREM2 expression and blunts efferocytosis of macrophages after acute ischemic stroke.
SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.
Zhenqing recipe attenuates non-alcoholic fatty liver disease by regulating the SIK1/CRTC2 signaling in experimental diabetic rats.
SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.
Attenuated LKB1-SIK1 signaling promotes epithelial-mesenchymal transition and radioresistance of non-small cell lung cancer cells.
GINS complex protein Sld5 recruits SIK1 to activate MCM helicase during DNA replication.
Role of salt-induced kinase 1 in androgen neuroprotection against cerebral ischemia.
Liu J, Wang Y, Zou L, Han X, Lv M, Deng X, Liao J, Zang G, Xu L, Gu T, Lu N, Zhang G
Genes & diseases 2026 May;13(3):101845
Genes & diseases 2026 May;13(3):101845
Investigating the therapeutic potential of naringin in MK-801-induced schizophrenia model: focus on cognitive impairment and miR-25-3p-regulated pathways.
Pu Y, Xu Y, Zhuo Z, Xiao H, Xu X
The International journal of neuroscience 2026 Jan;136(1):109-122
The International journal of neuroscience 2026 Jan;136(1):109-122
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.
Fu Y, Hou J, Yang Q, Lin Y, Rui N, Wang J, Wu H, Yu B
Journal of nanobiotechnology 2025 Jul 5;23(1):486
Journal of nanobiotechnology 2025 Jul 5;23(1):486
YKL-06-061 exerts antitumor effect through G1/S phase arrest by downregulating c-Myc and inhibition of metastasis via SIK1 upregulation in pancreatic cancer.
Zeng CY, Wang WD, Shang Y, Xi SH, Li LP, Chen SZ
Anti-cancer drugs 2025 Feb 1;36(2):114-125
Anti-cancer drugs 2025 Feb 1;36(2):114-125
Demethylase FTO-mediated m6A modification of SIK1 modulates placental cytotrophoblast syncytialization in type 2 diabetes mellitus.
Ning J, Yan J, Wang S, Cui Z, Xue Y, Juan J, Yang H
iScience 2024 Jun 21;27(6):109900
iScience 2024 Jun 21;27(6):109900
Discovery of the Natural Bibenzyl Compound Erianin in Dendrobium Inhibiting the Growth and EMT of Gastric Cancer through Downregulating the LKB1-SIK2/3-PARD3 Pathway.
Wei X, Liu Q, Liu L, Wang D, Liu J, Zhu Q, Xu Z, Chen Q, Xu W
International journal of molecular sciences 2024 Jul 21;25(14)
International journal of molecular sciences 2024 Jul 21;25(14)
ETNPPL modulates hyperinsulinemia-induced insulin resistance through the SIK1/ROS-mediated inactivation of the PI3K/AKT signaling pathway in hepatocytes.
Chen X, Liu P, Zhang W, Li X, Wang C, Han F, Liu W, Huang Y, Li M, Li Y, Sun X, Fan X, Li W, Xiong Y, Qian L
Journal of cellular physiology 2023 May;238(5):1046-1062
Journal of cellular physiology 2023 May;238(5):1046-1062
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Song D, Zhang A, Hu X, Zeng M, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Salt-inducible kinase 1 deficiency promotes vascular remodeling in pulmonary arterial hypertension via enhancement of yes-associated protein-mediated proliferation.
Pu J, Wang F, Ye P, Jiang X, Zhou W, Gu Y, Chen S
Heliyon 2022 Oct;8(10):e11016
Heliyon 2022 Oct;8(10):e11016
Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network.
Jin Y, Wang H
Journal of ovarian research 2022 Jan 4;15(1):3
Journal of ovarian research 2022 Jan 4;15(1):3
Identification of novel targets in adipose tissue involved in non-alcoholic fatty liver disease progression.
Lopez-Yus M, Lorente-Cebrian S, Del Moral-Bergos R, Hörndler C, Garcia-Sobreviela MP, Casamayor C, Sanz-Paris A, Bernal-Monterde V, Arbones-Mainar JM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22429
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22429
HG-9-91-01 Attenuates Murine Experimental Colitis by Promoting Interleukin-10 Production in Colonic Macrophages Through the SIK/CRTC3 Pathway.
Fu Y, Ma G, Zhang Y, Wang W, Shi T, Zhu J, Zhang J, Huang Z, Chen J
Inflammatory bowel diseases 2021 Oct 20;27(11):1821-1831
Inflammatory bowel diseases 2021 Oct 20;27(11):1821-1831
Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
Hu J, Qiao J, Yu Q, Liu B, Zhen J, Liu Y, Ma Q, Li Y, Wang Q, Wang C, Lv Z
Journal of translational medicine 2021 Feb 15;19(1):69
Journal of translational medicine 2021 Feb 15;19(1):69
High-salt diet downregulates TREM2 expression and blunts efferocytosis of macrophages after acute ischemic stroke.
Hu M, Lin Y, Men X, Wang S, Sun X, Zhu Q, Lu D, Liu S, Zhang B, Cai W, Lu Z
Journal of neuroinflammation 2021 Apr 12;18(1):90
Journal of neuroinflammation 2021 Apr 12;18(1):90
SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.
Wang C, Song D, Fu J, Wen X
Frontiers in endocrinology 2020;11:580
Frontiers in endocrinology 2020;11:580
Zhenqing recipe attenuates non-alcoholic fatty liver disease by regulating the SIK1/CRTC2 signaling in experimental diabetic rats.
Song D, Yin L, Wang C, Wen X
BMC complementary medicine and therapies 2020 Jan 31;20(1):27
BMC complementary medicine and therapies 2020 Jan 31;20(1):27
SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.
Lombardi MS, Gilliéron C, Dietrich D, Gabay C
Journal of leukocyte biology 2016 May;99(5):711-21
Journal of leukocyte biology 2016 May;99(5):711-21
Attenuated LKB1-SIK1 signaling promotes epithelial-mesenchymal transition and radioresistance of non-small cell lung cancer cells.
Yao YH, Cui Y, Qiu XN, Zhang LZ, Zhang W, Li H, Yu JM
Chinese journal of cancer 2016 Jun 7;35:50
Chinese journal of cancer 2016 Jun 7;35:50
GINS complex protein Sld5 recruits SIK1 to activate MCM helicase during DNA replication.
Joshi K, Shah VJ, Maddika S
Cellular signalling 2016 Dec;28(12):1852-1862
Cellular signalling 2016 Dec;28(12):1852-1862
Role of salt-induced kinase 1 in androgen neuroprotection against cerebral ischemia.
Cheng J, Uchida M, Zhang W, Grafe MR, Herson PS, Hurn PD
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011 Jan;31(1):339-50
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011 Jan;31(1):339-50
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 51045-1-AP(SIK1 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using Sik1 antibody 51045-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 51045-1-AP(SIK1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 51045-1-AP(SIK1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
