DMAB7232

antibody from Creative Diagnostics

Targeting: LAMB2 LAMS, NPHS5

ELISA (Recommended by provider)

Antibody Data

Product number

DMAB7232

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DMAB7232, RRID:AB_2396416

Product name

Anti-Laminin monoclonal antibody, clone 5E4C10

Antibody type

Monoclonal

Description

Laminins are major proteins in the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, adhesion as well as phenotype and survival. Laminins are trimeric proteins that contain an Ï«-chain, a ÉÇ-chain, and a ÎÛ-chain, found in five, four, and three genetic variants, respectively. The laminin molecules are named according to their chain composition. Thus, laminin-511 contains Ï«5, ÉÇ1, and ÎÛ1 chains. The laminins are a family of glycoproteins that are an integral part of the structural scaffolding in almost every tissue of an organism. They are secreted and incorporated into cell-associated extracellular matrices. Laminin is vital for the maintenance and survival of tissues. Defective laminins can cause muscles to form improperly, leading to a form of muscular dystrophy, lethal skin blistering disease (junctional epidermolysis bullosa) and defects of the kidney filter (nephrotic syndrome).

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

5E4C10

Vial size

250 _g

Storage

2°C-8°C for 1 year. Store at -20°C for long term.