Antibody data
- Antibody Data
- Antigen structure
- References [73]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
Submit
Validation data
Reference
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- Product number
- 18304-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18304-1-AP, RRID:AB_2201959
- Product name
- Thrombospondin 1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Thrombospondin 1 antibody (Cat. #18304-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Stem cell therapy targets THBS1 to reverse endometrial fibrosis.
Clu(+) transitional alveolar epithelial cells promote lung injury repair and fibrosis progression.
Beneficial effects of electro-acupuncture treatment in photothrombotic ischemia model rats by remodeling neurovascular unit.
Suppression of distal-less homeobox 3 increased alveolar bone mass in mouse tooth socket by targeting thrombospondin 1.
CGRP/TSP1 Signaling Dampens Corneal Inflammation and Fibrosis by Targeting A2M During Corneal Stromal Wound Healing.
Hydrogel with cell-cell adhesion cues enhances neural regeneration.
Impaired Mitophagy-Induced Apoptosis of Gingival Fibroblasts Exacerbates Diabetic Periodontitis Via THBS-1/CD36-Dependent Macrophage Activation.
LSKL mitigates dehydroepiandrosterone-induced apoptosis and oxidative stress by THBS1/PI3K/AKT pathway in rat granulosa cells.
ADAMTS-7 Increase Contributes to Worsened Neurological Outcome in Mice on High Fat Diet.
Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis.
Discovery and confirmation of crucial genes associated with radiation-induced heart disease.
Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways.
Human induced pluripotent stem cell-derived cardiomyocytes improve recovery from myocardial infarction in non-human primates.
PA2G4 in CAFs promotes biochemical recurrence of prostate cancer via H3K18la.
Single-cell sequencing reveals a senescent immune landscape in bone marrow lesions inducing articular cartilage damage in osteoarthritis.
NAALAD2 mutations disrupt the fate of photoreceptor cells and retinal pigment epithelial cells during early retinal development.
Engrailed-1 inactivation leads to scarless skin wound healing through extracellular matrix remodeling.
Zedoarondiol Inhibits Neovascularization in Atherosclerotic Plaques of ApoE(-/-) Mice by Reducing Platelet Exosomes-Derived MiR-let-7a.
Potential targets for synergistic bipolar irreversible electroporation in tumor suppression through transcriptomics and proteomics analysis.
Hypoxia Activated Nitric Oxide Donor Compounds for the Prevention and Treatment of Myocardial Hypoxia-Induced Injury.
Inhibition of THBS1 axis contributes to the antitumor effect of PA-MSHA in anaplastic thyroid cancer.
Knockdown of KLF6 ameliorates myocardial infarction by regulating autophagy via transcriptional regulation of PTTG1.
THBS1 in macrophage-derived exosomes exacerbates cerebral ischemia-reperfusion injury by inducing ferroptosis in endothelial cells.
N6-methyladenosine modification of THBS1 induced by affluent WTAP promotes Graves' ophthalmopathy progression through glycolysis to affect Th17/Treg balance.
THBS1 Contributes to Chemoresistance in Ovarian Clear Cell Carcinoma via Promoting Epithelial-Mesenchymal Transition.
Thrombospondin-1 modulation by Bifidobacterium spp. mitigates lung damage in an acute lung injury mouse model.
Design and discovery of novel cyclic peptides as TSP1-CD36 interaction inhibitors for intestinal fibrosis treatment.
Identification of Shared Genes and Immune Profiling for Pathological Scar.
THBS2-producing matrix CAFs promote colorectal cancer progression and link to poor prognosis via the CD47-MAPK axis.
Activation of SIRT3 by Tanshinone IIA ameliorates renal fibrosis by suppressing the TGF-β/TSP-1 pathway and attenuating oxidative stress.
THBS1 promotes angiogenesis and accelerates ESCC malignant progression by the HIF-1/VEGF signaling pathway.
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling.
Targeting Thbs1 reduces bladder remodeling caused by partial bladder outlet obstruction via the FGFR3/p-FGFR3 pathway.
Exploration and validation of signature genes and immune associations in septic cardiomyopathy.
Identification of driving genes of recurrent miscarriage based on transcriptome sequencing and immunoinfiltration analysis.
Polystyrene microplastics exposure reduces meat quality and disturbs skeletal muscle angiogenesis via thrombospondin 1.
Integrated transcriptomic and proteomic profiling reveals the key molecular signatures of brain endothelial reperfusion injury.
hsa_circ_0007919 promotes pancreatic cancer metastasis by modulating Sp1-mediated THBS1 transcription.
Transplantation of Human Amniotic Mesenchymal Stem Cells Up-Regulates Angiogenic Factor Expression to Attenuate Diabetic Kidney Disease in Rats.
FN1 mRNA 3'-UTR supersedes traditional fibronectin 1 in facilitating the invasion and metastasis of gastric cancer through the FN1 3'-UTR-let-7i-5p-THBS1 axis.
Transcriptomic characterization revealed that METTL7A inhibits melanoma progression via the p53 signaling pathway and immunomodulatory pathway.
Exosomes derived from menstrual blood stromal cells ameliorated premature ovarian insufficiency and granulosa cell apoptosis by regulating SMAD3/AKT/MDM2/P53 pathway via delivery of thrombospondin-1.
Investigation of a UPR-Related Gene Signature Identifies the Pro-Fibrotic Effects of Thrombospondin-1 by Activating CD47/ROS/Endoplasmic Reticulum Stress Pathway in Lung Fibroblasts.
Gastric cancer derived exosomal THBS1 enhanced Vγ9Vδ2 T-cell function through activating RIG-I-like receptor signaling pathway in a N6-methyladenosine methylation dependent manner.
Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage.
MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis.
CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis.
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
Single-cell RNA sequencing analysis of the temporomandibular joint condyle in 3 and 4-month-old human embryos.
PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.
Yth m(6)A RNA-Binding Protein 1 Regulates Osteogenesis of MC3T3-E1 Cells under Hypoxia via Translational Control of Thrombospondin-1.
High Concentrations of Nucleotides Prevent Capillary Regression during Hindlimb Unloading by Inhibiting Oxidative Stress and Enhancing Mitochondrial Metabolism of Soleus Muscles in Rats.
Discovery of Efficient Hypoxia-Targeted NO Donor Compounds to Alleviate Hypoxia Cardiac Disease.
Lactic acidosis induces metabolic and phenotypic reprogramming in cholangiocarcinoma cells via the upregulation of thrombospondin-1.
HBx Mediated Increase of DDX17 Contributes to HBV-Related Hepatocellular Carcinoma Tumorigenesis.
Identification of metastasis-associated exoDEPs in colorectal cancer using label-free proteomics.
Circ_0047339 promotes the activation of fibroblasts and affects the development of urethral stricture by targeting the miR-4691-5p/TSP-1 axis.
miR-19a-3p Promotes Tumor-Relevant Behaviors in Bladder Urothelial Carcinoma via Targeting THBS1.
MiR-18a-5p acts as a novel serum biomarker for venous malformation and promotes angiogenesis by regulating the thrombospondin-1/P53 signaling axis.
tRNA-Derived Fragment tRF-17-79MP9PP Attenuates Cell Invasion and Migration via THBS1/TGF-β1/Smad3 Axis in Breast Cancer.
Cross-talk between synovial fibroblasts and chondrocytes in condylar hyperplasia: an in vitro pilot study.
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation.
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets.
High Level of Staufen1 Expression Confers Longer Recurrence Free Survival to Non-Small Cell Lung Cancer Patients by Promoting THBS1 mRNA Degradation.
The protective effect of HOXA5 on carotid atherosclerosis occurs by modulating the vascular smooth muscle cell phenotype.
Serum Exosomal Proteins F9 and TSP-1 as Potential Diagnostic Biomarkers for Newly Diagnosed Epilepsy.
Discovery of small extracellular vesicle proteins from human serum for liver cirrhosis and liver cancer.
Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.
Thrombospondin-1 Production Regulates the Inflammatory Cytokine Secretion in THP-1 Cells Through NF-κB Signaling Pathway.
Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction.
IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway.
Upregulation of proangiogenic factors expression in the synovium of temporomandibular joint condylar hyperplasia.
Novel circulating peptide biomarkers for esophageal squamous cell carcinoma revealed by a magnetic bead-based MALDI-TOFMS assay.
Yu X, Shi L, Qu M, Zhang Y, Zhang Y, Xu X, Liu L, Wang H, Wang H
Frontiers in cell and developmental biology 2026;14:1766915
Frontiers in cell and developmental biology 2026;14:1766915
Clu(+) transitional alveolar epithelial cells promote lung injury repair and fibrosis progression.
Wang Y, Guo J, Wang Y, Liu Q, Cui Y, Ning Z, Chen Y, Liu Y, Luo Z, Gao H, Jin T, Wang X, Guo E, Zhang Y, Bian Y, Pan T, Wang S, Li X, Liang H, Gu Y
British journal of pharmacology 2026 Jun;183(12):3252-3271
British journal of pharmacology 2026 Jun;183(12):3252-3271
Beneficial effects of electro-acupuncture treatment in photothrombotic ischemia model rats by remodeling neurovascular unit.
Li Z, Xiao Y, Zhou S, Lam M, Ding Y, Lin R, Yang M, Liang S, Tao J
Brain research bulletin 2026 Jun 1;239:111858
Brain research bulletin 2026 Jun 1;239:111858
Suppression of distal-less homeobox 3 increased alveolar bone mass in mouse tooth socket by targeting thrombospondin 1.
Diao C, Li F, Sun K, Yu M, Liu H, Feng H, Liu Y, Han D
Journal of dental sciences 2026 Jan;21(1):115-124
Journal of dental sciences 2026 Jan;21(1):115-124
CGRP/TSP1 Signaling Dampens Corneal Inflammation and Fibrosis by Targeting A2M During Corneal Stromal Wound Healing.
Ge H, Zhang Y, Guo Q, Li Y, Yang L, Zang X, Xie J, Wang Y, Li Y, Qi X, Wang Y, Zhou Q, Wang X
Investigative ophthalmology & visual science 2026 Jan 5;67(1):10
Investigative ophthalmology & visual science 2026 Jan 5;67(1):10
Hydrogel with cell-cell adhesion cues enhances neural regeneration.
Tang X, Zhang S, Liu M, Liang Y, Fan Y, Sun X, He C, Yang X, Zhu R, Jin X, Zhuang Q, Ge Y, Ling J, Yang Y
Nature communications 2026 Jan 19;17(1)
Nature communications 2026 Jan 19;17(1)
Impaired Mitophagy-Induced Apoptosis of Gingival Fibroblasts Exacerbates Diabetic Periodontitis Via THBS-1/CD36-Dependent Macrophage Activation.
Yuan R, Meng L, Zhang M, Liu H, Guo J, Li M
Inflammation 2026 Jan 14;49(1):45
Inflammation 2026 Jan 14;49(1):45
LSKL mitigates dehydroepiandrosterone-induced apoptosis and oxidative stress by THBS1/PI3K/AKT pathway in rat granulosa cells.
Zhang L, Wang C, Liu Y, Wang X, Li S, Zhang H, Zhang X, Wang Y, Zhang Y, Liu L, Liu M
Life sciences 2026 Feb 1;386:124156
Life sciences 2026 Feb 1;386:124156
ADAMTS-7 Increase Contributes to Worsened Neurological Outcome in Mice on High Fat Diet.
Xu Y, Li J, Zuo Z
CNS neuroscience & therapeutics 2026 Apr;32(4):e70877
CNS neuroscience & therapeutics 2026 Apr;32(4):e70877
Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis.
Li BB, Zhang JT, Jiang YY, Li X, Wang DN, Zang JM, Liu ZL, Hu FX, Zhu X, Shen CC, Zhang W, Xu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 19;156:158220
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 19;156:158220
Discovery and confirmation of crucial genes associated with radiation-induced heart disease.
Liu C, Shi J, Xing L, Yao B, Liu J, Wang Y, Fan J
International journal of medical sciences 2025;22(6):1278-1291
International journal of medical sciences 2025;22(6):1278-1291
Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways.
Tang Q, Dong J, Zhang F, Zhao D, Yang Q, Wen J, Sun Y, Wei J, Liu Z
Frontiers in pharmacology 2025;16:1489210
Frontiers in pharmacology 2025;16:1489210
Human induced pluripotent stem cell-derived cardiomyocytes improve recovery from myocardial infarction in non-human primates.
Guan X, Zhang P, Wang Q, Zhang Y, Zhang Y, Zhang H, Zhang H, Jiang W, Wu Y, Wang X, Wang D, Wang J, Gao L
Stem cell research & therapy 2025 Oct 27;16(1):581
Stem cell research & therapy 2025 Oct 27;16(1):581
PA2G4 in CAFs promotes biochemical recurrence of prostate cancer via H3K18la.
Ji S, Xi Z, Li T, Jia G, Zhang Y, Zheng C, Wang W, Ni W, Zhang Y, Zhou Z, Wu W, Jiang Q
Cell & bioscience 2025 Nov 4;15(1):152
Cell & bioscience 2025 Nov 4;15(1):152
Single-cell sequencing reveals a senescent immune landscape in bone marrow lesions inducing articular cartilage damage in osteoarthritis.
Lou P, Lu X, Li M, Yao Y, Shao X, Shou D, Fan X, Tong P, Zhang Y
Bone research 2025 Nov 21;13(1):94
Bone research 2025 Nov 21;13(1):94
NAALAD2 mutations disrupt the fate of photoreceptor cells and retinal pigment epithelial cells during early retinal development.
Qian Y, Gao J, Zhang Z, Chen Y, Su J, Niu X, Zheng K, Bao Y, Qin Y, Zheng J, Yang Y, Wu Q, Mo K, Wei Y, Duan S
Pharmacological research 2025 May;215:107724
Pharmacological research 2025 May;215:107724
Engrailed-1 inactivation leads to scarless skin wound healing through extracellular matrix remodeling.
Hao A, Dong X, Gou Y, Li A, Li J, Xiang H, Rahaman S, Zhu Y, Zhang H, You W, Shen G, Luo C, Mei O, Wu X, Shi LL, Reid RR, He TC, Fan J
Genes & diseases 2025 May;12(3):101484
Genes & diseases 2025 May;12(3):101484
Zedoarondiol Inhibits Neovascularization in Atherosclerotic Plaques of ApoE(-/-) Mice by Reducing Platelet Exosomes-Derived MiR-let-7a.
Xie BL, Song BC, Liu MW, Wen W, Yan YX, Gao MJ, Jiang LL, Jin ZD, Yang L, Liu JG, Shi DZ, Zhao FH
Chinese journal of integrative medicine 2025 Mar;31(3):228-239
Chinese journal of integrative medicine 2025 Mar;31(3):228-239
Potential targets for synergistic bipolar irreversible electroporation in tumor suppression through transcriptomics and proteomics analysis.
Wang Y, Liu X, Liu R, Qian K, Zhu T, Liu H, Zhou Q, Dong S, Liu H, Yao C
Gene 2025 Jun 10;952:149420
Gene 2025 Jun 10;952:149420
Hypoxia Activated Nitric Oxide Donor Compounds for the Prevention and Treatment of Myocardial Hypoxia-Induced Injury.
Yang W, Zhou W, Gou S
Journal of medicinal chemistry 2025 Jan 9;68(1):491-505
Journal of medicinal chemistry 2025 Jan 9;68(1):491-505
Inhibition of THBS1 axis contributes to the antitumor effect of PA-MSHA in anaplastic thyroid cancer.
Li Z, He T, Xing Z, Zhu J, Wu W, Su A
Experimental cell research 2025 Jan 15;444(2):114373
Experimental cell research 2025 Jan 15;444(2):114373
Knockdown of KLF6 ameliorates myocardial infarction by regulating autophagy via transcriptional regulation of PTTG1.
Chen Y, Zhao Q, Wu T, Sun F, Fu W
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C115-C127
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C115-C127
THBS1 in macrophage-derived exosomes exacerbates cerebral ischemia-reperfusion injury by inducing ferroptosis in endothelial cells.
Liu C, Sui H, Li Z, Sun Z, Li C, Chen G, Ma Z, Cao H, Xi H
Journal of neuroinflammation 2025 Feb 24;22(1):48
Journal of neuroinflammation 2025 Feb 24;22(1):48
N6-methyladenosine modification of THBS1 induced by affluent WTAP promotes Graves' ophthalmopathy progression through glycolysis to affect Th17/Treg balance.
Li LN, Wu JM, Zheng ZJ, Li SX, Cai MY, Zou MC
Autoimmunity 2025 Dec;58(1):2433628
Autoimmunity 2025 Dec;58(1):2433628
THBS1 Contributes to Chemoresistance in Ovarian Clear Cell Carcinoma via Promoting Epithelial-Mesenchymal Transition.
Ye D, Liu Y, Cheng A, Xu D, Huo C, Zhao X, Pang SW, Huang C, Wang L, Lin S, Lu H
The journal of gene medicine 2025 Dec;27(12):e70058
The journal of gene medicine 2025 Dec;27(12):e70058
Thrombospondin-1 modulation by Bifidobacterium spp. mitigates lung damage in an acute lung injury mouse model.
Kim Y, Ki MS, Shin MH, Choi JS, Park MS, Kim Y, Oh CM, Lee SH
Microbiological research 2025 Aug;297:128173
Microbiological research 2025 Aug;297:128173
Design and discovery of novel cyclic peptides as TSP1-CD36 interaction inhibitors for intestinal fibrosis treatment.
Zhang W, Qi L, Cheng W, Wang X, Hong Y, Dong R, Yuan W, Zhang D
Bioorganic chemistry 2025 Aug;163:108667
Bioorganic chemistry 2025 Aug;163:108667
Identification of Shared Genes and Immune Profiling for Pathological Scar.
Dou S, Deng Y, Wang D, Liu W
Journal of burn care & research : official publication of the American Burn Association 2025 Aug 30;46(4):870-885
Journal of burn care & research : official publication of the American Burn Association 2025 Aug 30;46(4):870-885
THBS2-producing matrix CAFs promote colorectal cancer progression and link to poor prognosis via the CD47-MAPK axis.
Liu Z, Ba Y, Shan D, Zhou X, Zuo A, Zhang Y, Xu H, Liu S, Liu B, Zhao Y, Weng S, Wang R, Deng J, Luo P, Cheng Q, Hu X, Yang S, Wang F, Han X
Cell reports 2025 Apr 22;44(4):115555
Cell reports 2025 Apr 22;44(4):115555
Activation of SIRT3 by Tanshinone IIA ameliorates renal fibrosis by suppressing the TGF-β/TSP-1 pathway and attenuating oxidative stress.
Fan Y, Kang S, Shao T, Xu L, Chen J
Cellular signalling 2024 Oct;122:111348
Cellular signalling 2024 Oct;122:111348
THBS1 promotes angiogenesis and accelerates ESCC malignant progression by the HIF-1/VEGF signaling pathway.
Zhou X, Xia Q, Chen M, Zhang X, Huang M, Zheng X, Wang S, Wu B, Du Z
Cell biology international 2024 Mar;48(3):311-324
Cell biology international 2024 Mar;48(3):311-324
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling.
Wei ZX, Cai XX, Fei YD, Wang Q, Hu XL, Li C, Hou JW, Yang YL, Wang YP, Li YG
Translational research : the journal of laboratory and clinical medicine 2024 Jul;269:64-75
Translational research : the journal of laboratory and clinical medicine 2024 Jul;269:64-75
Targeting Thbs1 reduces bladder remodeling caused by partial bladder outlet obstruction via the FGFR3/p-FGFR3 pathway.
Long J, Yang Y, Yang J, Chen L, Wang S, Zhou X, Su Y, Liu C
Neurourology and urodynamics 2024 Feb;43(2):516-526
Neurourology and urodynamics 2024 Feb;43(2):516-526
Exploration and validation of signature genes and immune associations in septic cardiomyopathy.
Zhao Z, Wang X, Tan F, Liu H, Chen W, Wang J, Deng S, Du J
Clinical and experimental hypertension (New York, N.Y. : 1993) 2024 Dec 31;46(1):2302570
Clinical and experimental hypertension (New York, N.Y. : 1993) 2024 Dec 31;46(1):2302570
Identification of driving genes of recurrent miscarriage based on transcriptome sequencing and immunoinfiltration analysis.
Yang Y, Zhao A, Wang T, Tang Q, Qi S, Shi X, Wang F, Gao Y
International immunopharmacology 2024 Dec 25;143(Pt 1):113095
International immunopharmacology 2024 Dec 25;143(Pt 1):113095
Polystyrene microplastics exposure reduces meat quality and disturbs skeletal muscle angiogenesis via thrombospondin 1.
Yang Y, Liu H, Zou D, Ji F, Lv R, Wu H, Zhou H, Ren A, Xu T, Hou G, Hu C
Food research international (Ottawa, Ont.) 2024 Aug;190:114581
Food research international (Ottawa, Ont.) 2024 Aug;190:114581
Integrated transcriptomic and proteomic profiling reveals the key molecular signatures of brain endothelial reperfusion injury.
Ji Y, Chen Y, Tan X, Huang X, Gao Q, Ma Y, Yang S, Yin M, Yu M, Fang C, Wang Y, Shi Z, Chang J
CNS neuroscience & therapeutics 2024 Apr;30(4):e14483
CNS neuroscience & therapeutics 2024 Apr;30(4):e14483
hsa_circ_0007919 promotes pancreatic cancer metastasis by modulating Sp1-mediated THBS1 transcription.
Ma X, Xu L, Gong S, Wu N, Guo J, Feng X, Zhao M, Qiu S, Sun M, Zhang C, Zhang X, Ren Z, Zhang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 15;38(7):e23591
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 15;38(7):e23591
Transplantation of Human Amniotic Mesenchymal Stem Cells Up-Regulates Angiogenic Factor Expression to Attenuate Diabetic Kidney Disease in Rats.
Ni Y, Chen Y, Jiang X, Pu T, Zhang L, Li S, Hu L, Bai B, Hu T, Yu L, Yang Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:331-343
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:331-343
FN1 mRNA 3'-UTR supersedes traditional fibronectin 1 in facilitating the invasion and metastasis of gastric cancer through the FN1 3'-UTR-let-7i-5p-THBS1 axis.
Pan S, Zhu J, Liu P, Wei Q, Zhang S, An W, Tong Y, Cheng Z, Liu F
Theranostics 2023;13(14):5130-5150
Theranostics 2023;13(14):5130-5150
Transcriptomic characterization revealed that METTL7A inhibits melanoma progression via the p53 signaling pathway and immunomodulatory pathway.
Zhang D, Zou T, Liu Q, Chen J, Xiao M, Zheng A, Zhang Z, Du F, Dai Y, Xiang S, Wu X, Li M, Chen Y, Zhao Y, Shen J, Chen G, Xiao Z
PeerJ 2023;11:e15799
PeerJ 2023;11:e15799
Exosomes derived from menstrual blood stromal cells ameliorated premature ovarian insufficiency and granulosa cell apoptosis by regulating SMAD3/AKT/MDM2/P53 pathway via delivery of thrombospondin-1.
Song A, Zhang S, Zhao X, Wu S, Qi X, Gao S, Qi J, Li P, Tan J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115319
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115319
Investigation of a UPR-Related Gene Signature Identifies the Pro-Fibrotic Effects of Thrombospondin-1 by Activating CD47/ROS/Endoplasmic Reticulum Stress Pathway in Lung Fibroblasts.
Zhan JH, Wei J, Liu L, Xu YT, Ji H, Wang CN, Liu YJ, Zhu XY
Antioxidants (Basel, Switzerland) 2023 Nov 21;12(12)
Antioxidants (Basel, Switzerland) 2023 Nov 21;12(12)
Gastric cancer derived exosomal THBS1 enhanced Vγ9Vδ2 T-cell function through activating RIG-I-like receptor signaling pathway in a N6-methyladenosine methylation dependent manner.
Li J, Feng H, Zhu J, Yang K, Zhang G, Gu Y, Shi T, Chen W
Cancer letters 2023 Nov 1;576:216410
Cancer letters 2023 Nov 1;576:216410
Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage.
Qiu X, Tao Q, Zhang L, Kuang C, Xie Y, Zhang L, Yin S, Peng J, Jiang Y
Journal of neurochemistry 2023 Mar;164(6):829-846
Journal of neurochemistry 2023 Mar;164(6):829-846
MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis.
Yang Y, Qiu R, Weng Q, Xu Z, Song J, Zhao S, Meng M, Zhang D, Kong C, Wang H, Xu M, Zhao Z, Ji J
Cancer research and treatment 2023 Jul;55(3):778-803
Cancer research and treatment 2023 Jul;55(3):778-803
CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis.
Singla B, Aithbathula RV, Pervaiz N, Kathuria I, Swanson M, Ekuban FA, Ahn W, Park F, Gyamfi M, Cherian-Shaw M, Singh UP, Kumar S
Arteriosclerosis, thrombosis, and vascular biology 2023 Jul;43(7):1234-1250
Arteriosclerosis, thrombosis, and vascular biology 2023 Jul;43(7):1234-1250
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
Zhou W, Wang C, Zhang B, Gou S
European journal of pharmacology 2023 Jul 5;950:175751
European journal of pharmacology 2023 Jul 5;950:175751
Single-cell RNA sequencing analysis of the temporomandibular joint condyle in 3 and 4-month-old human embryos.
Zhu Q, Tan M, Wang C, Chen Y, Wang C, Zhang J, Gu Y, Guo Y, Han J, Li L, Jiang R, Fan X, Xie H, Wang L, Gu Z, Liu D, Shi J, Feng X
Cell & bioscience 2023 Jul 19;13(1):130
Cell & bioscience 2023 Jul 19;13(1):130
PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.
Peng Z, Tan X, Xie L, Li Z, Zhou S, Li Y
iScience 2023 Jan 20;26(1):105909
iScience 2023 Jan 20;26(1):105909
Yth m(6)A RNA-Binding Protein 1 Regulates Osteogenesis of MC3T3-E1 Cells under Hypoxia via Translational Control of Thrombospondin-1.
Shi D, Liu X, Li X, Li T, Liu J, Wu L
International journal of molecular sciences 2023 Jan 16;24(2)
International journal of molecular sciences 2023 Jan 16;24(2)
High Concentrations of Nucleotides Prevent Capillary Regression during Hindlimb Unloading by Inhibiting Oxidative Stress and Enhancing Mitochondrial Metabolism of Soleus Muscles in Rats.
Nakanishi R, Hashimoto N, Takuwa M, Xing J, Uemura M, Un Nisa B, Tanaka M, Hirabayashi T, Tanaka M, Fujino H
Acta histochemica et cytochemica 2023 Dec 28;56(6):95-104
Acta histochemica et cytochemica 2023 Dec 28;56(6):95-104
Discovery of Efficient Hypoxia-Targeted NO Donor Compounds to Alleviate Hypoxia Cardiac Disease.
Yang W, Zhou W, Gou S
Journal of medicinal chemistry 2023 Dec 14;66(23):15977-15989
Journal of medicinal chemistry 2023 Dec 14;66(23):15977-15989
Lactic acidosis induces metabolic and phenotypic reprogramming in cholangiocarcinoma cells via the upregulation of thrombospondin-1.
Thamrongwaranggoon U, Kuribayashi K, Araki H, Hino Y, Koga T, Seubwai W, Wongkham S, Nakao M, Hino S
Cancer science 2023 Apr;114(4):1541-1555
Cancer science 2023 Apr;114(4):1541-1555
HBx Mediated Increase of DDX17 Contributes to HBV-Related Hepatocellular Carcinoma Tumorigenesis.
Dong ML, Wen X, He X, Ren JH, Yu HB, Qin YP, Yang Z, Yang ML, Zhou CY, Zhang H, Cheng ST, Chen J
Frontiers in immunology 2022;13:871558
Frontiers in immunology 2022;13:871558
Identification of metastasis-associated exoDEPs in colorectal cancer using label-free proteomics.
Liu X, Li N, Zhang C, Wu X, Zhang S, Dong G, Liu G
Translational oncology 2022 May;19:101389
Translational oncology 2022 May;19:101389
Circ_0047339 promotes the activation of fibroblasts and affects the development of urethral stricture by targeting the miR-4691-5p/TSP-1 axis.
Ding K, Li D, Zhang R, Zuo M
Scientific reports 2022 Aug 30;12(1):14746
Scientific reports 2022 Aug 30;12(1):14746
miR-19a-3p Promotes Tumor-Relevant Behaviors in Bladder Urothelial Carcinoma via Targeting THBS1.
Xu G, Li J, Yu L
Computational and mathematical methods in medicine 2021;2021:2710231
Computational and mathematical methods in medicine 2021;2021:2710231
MiR-18a-5p acts as a novel serum biomarker for venous malformation and promotes angiogenesis by regulating the thrombospondin-1/P53 signaling axis.
Zhang L, Wang D, Wang Z, Li X, Xia W, Han Y, Su L, Fan X
American journal of translational research 2021;13(10):11271-11286
American journal of translational research 2021;13(10):11271-11286
tRNA-Derived Fragment tRF-17-79MP9PP Attenuates Cell Invasion and Migration via THBS1/TGF-β1/Smad3 Axis in Breast Cancer.
Mo D, He F, Zheng J, Chen H, Tang L, Yan F
Frontiers in oncology 2021;11:656078
Frontiers in oncology 2021;11:656078
Cross-talk between synovial fibroblasts and chondrocytes in condylar hyperplasia: an in vitro pilot study.
Guo H, Li H, Feng Y, Ke J, Fang W, Li C, Long X
Oral surgery, oral medicine, oral pathology and oral radiology 2021 May;131(5):558-564
Oral surgery, oral medicine, oral pathology and oral radiology 2021 May;131(5):558-564
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation.
Xiao Y, Cong M, Li J, He D, Wu Q, Tian P, Wang Y, Yang S, Liang C, Liang Y, Wen J, Liu Y, Luo W, Lv X, He Y, Cheng DD, Zhou T, Zhao W, Zhang P, Zhang X, Xiao Y, Qian Y, Wang H, Gao Q, Yang QC, Yang Q, Hu G
Cancer cell 2021 Mar 8;39(3):423-437.e7
Cancer cell 2021 Mar 8;39(3):423-437.e7
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets.
Nording H, Baron L, Haberthür D, Emschermann F, Mezger M, Sauter M, Sauter R, Patzelt J, Knoepp K, Nording A, Meusel M, Meyer-Saraei R, Hlushchuk R, Sedding D, Borst O, Eitel I, Karsten CM, Feil R, Pichler B, Erdmann J, Verschoor A, Chavakis E, Chavakis T, von Hundelshausen P, Köhl J, Gawaz M, Langer HF
Nature communications 2021 Jun 7;12(1):3352
Nature communications 2021 Jun 7;12(1):3352
High Level of Staufen1 Expression Confers Longer Recurrence Free Survival to Non-Small Cell Lung Cancer Patients by Promoting THBS1 mRNA Degradation.
Bonnet-Magnaval F, Diallo LH, Brunchault V, Laugero N, Morfoisse F, David F, Roussel E, Nougue M, Zamora A, Marchaud E, Tatin F, Prats AC, Garmy-Susini B, DesGroseillers L, Lacazette E
International journal of molecular sciences 2021 Dec 25;23(1)
International journal of molecular sciences 2021 Dec 25;23(1)
The protective effect of HOXA5 on carotid atherosclerosis occurs by modulating the vascular smooth muscle cell phenotype.
Jing Y, Gao B, Han Z, Xia L, Xin S
Molecular and cellular endocrinology 2021 Aug 20;534:111366
Molecular and cellular endocrinology 2021 Aug 20;534:111366
Serum Exosomal Proteins F9 and TSP-1 as Potential Diagnostic Biomarkers for Newly Diagnosed Epilepsy.
Lin Z, Gu Y, Zhou R, Wang M, Guo Y, Chen Y, Ma J, Xiao F, Wang X, Tian X
Frontiers in neuroscience 2020;14:737
Frontiers in neuroscience 2020;14:737
Discovery of small extracellular vesicle proteins from human serum for liver cirrhosis and liver cancer.
Uzzaman A, Zhang X, Qiao Z, Zhan H, Sohail A, Wahid A, Shang Z, Guan X, Cao CX, Xiao H
Biochimie 2020 Oct;177:132-141
Biochimie 2020 Oct;177:132-141
Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.
Zhao J, Meng M, Zhang J, Li L, Zhu X, Zhang L, Wang C, Gao M
Molecular medicine reports 2019 Apr;19(4):3168-3178
Molecular medicine reports 2019 Apr;19(4):3168-3178
Thrombospondin-1 Production Regulates the Inflammatory Cytokine Secretion in THP-1 Cells Through NF-κB Signaling Pathway.
Xing T, Wang Y, Ding WJ, Li YL, Hu XD, Wang C, Ding A, Shen JL
Inflammation 2017 Oct;40(5):1606-1621
Inflammation 2017 Oct;40(5):1606-1621
Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction.
Tang J, Shen Y, Chen G, Wan Q, Wang K, Zhang J, Qin J, Liu G, Zuo S, Tao B, Yu Y, Wang J, Lazarus M, Yu Y
Nature communications 2017 Mar 3;8:14656
Nature communications 2017 Mar 3;8:14656
IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway.
Xu J, Cai H, Meng Q, Li Y, Chen G, Fang W, Long X
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2016 Sep;45(8):605-12
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2016 Sep;45(8):605-12
Upregulation of proangiogenic factors expression in the synovium of temporomandibular joint condylar hyperplasia.
Guo H, Fang W, Chen G, Xu J, Li C, Feng Y, Li Y, Long X
Oral surgery, oral medicine, oral pathology and oral radiology 2016 Apr;121(4):e65-71
Oral surgery, oral medicine, oral pathology and oral radiology 2016 Apr;121(4):e65-71
Novel circulating peptide biomarkers for esophageal squamous cell carcinoma revealed by a magnetic bead-based MALDI-TOFMS assay.
Jia K, Li W, Wang F, Qu H, Qiao Y, Zhou L, Sun Y, Ma Q, Zhao X
Oncotarget 2016 Apr 26;7(17):23569-80
Oncotarget 2016 Apr 26;7(17):23569-80
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 18304-1-AP(TSP1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The Thrombospondin-1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Thrombospondin-1. This antibody recognizes human antigen. The Thrombospondin-1 antibody has been validated for the following applications: ELISA, WB, IF analysis.