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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [89]
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- Validations
- Western blot [1]
- Other assay [2]
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- Product number
- MA5-11330 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Thrombospondin 1 Antibody Cocktail
- Antibody type
- Monoclonal
- Antigen
- Purifed from natural sources
- Description
- MA5-11330 targets Thrombospondin in WB applications and shows reactivity with Human samples.
- Antibody clone number
- D4.6, A6.1, MBC 200.1
- Concentration
- 0.2 mg/mL
Submitted references Thrombospondin-1 Silencing Improves Lymphocyte Infiltration in Tumors and Response to Anti-PD-1 in Triple-Negative Breast Cancer.
Neutrophil-Mediated Proteolysis of Thrombospondin-1 Promotes Platelet Adhesion and String Formation.
Identification of Reprogrammed Myeloid Cell Transcriptomes in NSCLC.
Trivalent chromium inhibits TSP-1 expression, proliferation, and O-GlcNAc signaling in vascular smooth muscle cells in response to high glucose in vitro.
Spontaneous reversion of the angiogenic phenotype to a nonangiogenic and dormant state in human tumors.
Regulation of T-lymphocyte motility, adhesion and de-adhesion by a cell surface mechanism directed by low density lipoprotein receptor-related protein 1 and endogenous thrombospondin-1.
Acute and chronic mu opioids differentially regulate thrombospondins 1 and 2 isoforms in astrocytes.
Long-term gene therapy with thrombospondin 2 inhibits TGF-β activation, inflammation and angiogenesis in chronic allograft nephropathy.
Inflammatory cytokine-specific alterations in retinal endothelial cell function.
Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress.
HGF regulates the activation of TGF-β1 in rat hepatocytes and hepatic stellate cells.
A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation.
Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis.
Autocrine stimulation of clear-cell renal carcinoma cell migration in hypoxia via HIF-independent suppression of thrombospondin-1.
BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment.
Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries.
p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers.
The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors.
Opposing effects of bim and bcl-2 on lung endothelial cell migration.
Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors.
Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis.
Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation.
Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.
Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells.
Estrogen regulation of thrombospondin-1 in human breast cancer cells.
Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation.
Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1.
Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain.
Calcium indirectly regulates immunochemical reactivity and functional activities of the N-domain of thrombospondin-1.
Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways.
Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2.
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.
Meteorin regulates angiogenesis at the gliovascular interface.
High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs.
Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1.
Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1.
Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1.
Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations.
Differential regulation of thrombospondin-1 expression and antiangiogenesis of ECV304 cells by trichostatin A and helixor A.
Thrombospondin-1 expression and localization in the developing ovine lung.
Bcl-2 expression modulates cell adhesion and migration promoting branching of ureteric bud cells.
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation.
PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis.
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).
PPARalpha deficiency in inflammatory cells suppresses tumor growth.
The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats.
Isolation and characterization of corneal endothelial cells from wild type and thrombospondin-1 deficient mice.
Proteomic analysis of amniotic membrane prepared for human transplantation: characterization of proteins and clinical implications.
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Expression of thrombospondin 1 (TSP 1) in patients with uterine smooth muscle tumors: an immunohistochemical study.
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.
Twist1 dimer selection regulates cranial suture patterning and fusion.
Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling.
Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes.
Thrombospondin-1 is induced in rat myocardial infarction and its induction is accelerated by ischemia/reperfusion.
Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition.
Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling.
Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch.
Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch.
Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction.
Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.
Isolation and characterization of murine retinal astrocytes.
Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor.
Increased expression of protein C-mannosylation in the aortic vessels of diabetic Zucker rats.
Mechanism of CD47-induced alpha4beta1 integrin activation and adhesion in sickle reticulocytes.
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro.
Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol.
Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice.
Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism.
Isolation and characterization of murine retinal endothelial cells.
Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis.
Regulation of multiple tumor microenvironment markers by overexpression of single or paired combinations of ErbB receptors.
Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cells.
Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cells.
Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling.
Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling.
Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice.
Characteristics of long-term survivors of untreated lung cancer.
Characteristics of long-term survivors of untreated lung cancer.
Polarized trafficking of thyrocyte proteins in MDCK cells.
Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma.
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
T lymphocyte expression of thrombospondin-1 and adhesion to extracellular matrix components.
Thrombospondin-1-mediated metastasis suppression by the primary tumor in human melanoma xenografts.
Mechanism of interaction of thrombospondin with human endothelium and inhibition of sickle erythrocyte adhesion to human endothelial cells by heparin.
Mechanism of interaction of thrombospondin with human endothelium and inhibition of sickle erythrocyte adhesion to human endothelial cells by heparin.
Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?
Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?
Marcheteau E, Farge T, Pérès M, Labrousse G, Tenet J, Delmas S, Chusseau M, Duprez-Paumier R, Franchet C, Dalenc F, Imbert C, Noujarède J, Colacios C, Prats H, Cabon F, Ségui B
Cancers 2021 Aug 12;13(16)
Cancers 2021 Aug 12;13(16)
Neutrophil-Mediated Proteolysis of Thrombospondin-1 Promotes Platelet Adhesion and String Formation.
Seif K, Alidzanovic L, Tischler B, Ibrahim N, Zagrapan B, Rauscher S, Salzmann M, Hell L, Mauracher LM, Budde U, Schmid JA, Jilma B, Pabinger I, Assinger A, Starlinger P, Brostjan C
Thrombosis and haemostasis 2018 Dec;118(12):2074-2085
Thrombosis and haemostasis 2018 Dec;118(12):2074-2085
Identification of Reprogrammed Myeloid Cell Transcriptomes in NSCLC.
Durrans A, Gao D, Gupta R, Fischer KR, Choi H, El Rayes T, Ryu S, Nasar A, Spinelli CF, Andrews W, Elemento O, Nolan D, Stiles B, Rafii S, Narula N, Davuluri R, Altorki NK, Mittal V
PloS one 2015;10(6):e0129123
PloS one 2015;10(6):e0129123
Trivalent chromium inhibits TSP-1 expression, proliferation, and O-GlcNAc signaling in vascular smooth muscle cells in response to high glucose in vitro.
Ganguly R, Sahu S, Chavez RJ, Raman P
American journal of physiology. Cell physiology 2015 Jan 15;308(2):C111-22
American journal of physiology. Cell physiology 2015 Jan 15;308(2):C111-22
Spontaneous reversion of the angiogenic phenotype to a nonangiogenic and dormant state in human tumors.
Rogers MS, Novak K, Zurakowski D, Cryan LM, Blois A, Lifshits E, Bø TH, Oyan AM, Bender ER, Lampa M, Kang SY, Naxerova K, Kalland KH, Straume O, Akslen LA, Watnick RS, Folkman J, Naumov GN
Molecular cancer research : MCR 2014 May;12(5):754-64
Molecular cancer research : MCR 2014 May;12(5):754-64
Regulation of T-lymphocyte motility, adhesion and de-adhesion by a cell surface mechanism directed by low density lipoprotein receptor-related protein 1 and endogenous thrombospondin-1.
Talme T, Bergdahl E, Sundqvist KG
Immunology 2014 Jun;142(2):176-92
Immunology 2014 Jun;142(2):176-92
Acute and chronic mu opioids differentially regulate thrombospondins 1 and 2 isoforms in astrocytes.
Phamduong E, Rathore MK, Crews NR, D'Angelo AS, Leinweber AL, Kappera P, Krenning TM, Rendell VR, Belcheva MM, Coscia CJ
ACS chemical neuroscience 2014 Feb 19;5(2):106-14
ACS chemical neuroscience 2014 Feb 19;5(2):106-14
Long-term gene therapy with thrombospondin 2 inhibits TGF-β activation, inflammation and angiogenesis in chronic allograft nephropathy.
Daniel C, Vogelbacher R, Stief A, Grigo C, Hugo C
PloS one 2013;8(12):e83846
PloS one 2013;8(12):e83846
Inflammatory cytokine-specific alterations in retinal endothelial cell function.
Palenski TL, Sorenson CM, Sheibani N
Microvascular research 2013 Sep;89:57-69
Microvascular research 2013 Sep;89:57-69
Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress.
Zhao Y, Wang S, Sorenson CM, Teixeira L, Dubielzig RR, Peters DM, Conway SJ, Jefcoate CR, Sheibani N
Molecular and cellular biology 2013 Nov;33(21):4225-40
Molecular and cellular biology 2013 Nov;33(21):4225-40
HGF regulates the activation of TGF-β1 in rat hepatocytes and hepatic stellate cells.
Narmada BC, Chia SM, Tucker-Kellogg L, Yu H
Journal of cellular physiology 2013 Feb;228(2):393-401
Journal of cellular physiology 2013 Feb;228(2):393-401
A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation.
Bergström SE, Bergdahl E, Sundqvist KG
Immunology 2013 Dec;140(4):441-55
Immunology 2013 Dec;140(4):441-55
Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis.
Martin-Manso G, Navarathna DH, Galli S, Soto-Pantoja DR, Kuznetsova SA, Tsokos M, Roberts DD
PloS one 2012;7(11):e48775
PloS one 2012;7(11):e48775
Autocrine stimulation of clear-cell renal carcinoma cell migration in hypoxia via HIF-independent suppression of thrombospondin-1.
Bienes-Martínez R, Ordóñez A, Feijoo-Cuaresma M, Corral-Escariz M, Mateo G, Stenina O, Jiménez B, Calzada MJ
Scientific reports 2012;2:788
Scientific reports 2012;2:788
BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment.
Sheibani N, Morrison ME, Gurel Z, Park S, Sorenson CM
American journal of physiology. Renal physiology 2012 Apr 1;302(7):F809-19
American journal of physiology. Renal physiology 2012 Apr 1;302(7):F809-19
Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries.
Hohberg M, Knöchel J, Hoffmann CJ, Chlench S, Wunderlich W, Alter A, Maroski J, Vorderwülbecke BJ, Da Silva-Azevedo L, Knudsen R, Lehmann R, Fiedorowicz K, Bongrazio M, Nitsche B, Hoepfner M, Styp-Rekowska B, Pries AR, Zakrzewicz A
Journal of cellular physiology 2011 Feb;226(2):350-61
Journal of cellular physiology 2011 Feb;226(2):350-61
p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers.
Sundaram P, Hultine S, Smith LM, Dews M, Fox JL, Biyashev D, Schelter JM, Huang Q, Cleary MA, Volpert OV, Thomas-Tikhonenko A
Cancer research 2011 Dec 15;71(24):7490-501
Cancer research 2011 Dec 15;71(24):7490-501
The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors.
Dews M, Fox JL, Hultine S, Sundaram P, Wang W, Liu YY, Furth E, Enders GH, El-Deiry W, Schelter JM, Cleary MA, Thomas-Tikhonenko A
Cancer research 2010 Oct 15;70(20):8233-46
Cancer research 2010 Oct 15;70(20):8233-46
Opposing effects of bim and bcl-2 on lung endothelial cell migration.
Grutzmacher C, Park S, Elmergreen TL, Tang Y, Scheef EA, Sheibani N, Sorenson CM
American journal of physiology. Lung cellular and molecular physiology 2010 Nov;299(5):L607-20
American journal of physiology. Lung cellular and molecular physiology 2010 Nov;299(5):L607-20
Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors.
Olsson A, Björk A, Vallon-Christersson J, Isaacs JT, Leanderson T
Molecular cancer 2010 May 17;9:107
Molecular cancer 2010 May 17;9:107
Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis.
Zaslavsky A, Baek KH, Lynch RC, Short S, Grillo J, Folkman J, Italiano JE Jr, Ryeom S
Blood 2010 Jun 3;115(22):4605-13
Blood 2010 Jun 3;115(22):4605-13
Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation.
Ikeda H, Miyatake M, Koshikawa N, Ochiai K, Yamada K, Kiss A, Donlin MJ, Panneton WM, Churchill JD, Green M, Siddiqui AM, Leinweber AL, Crews NR, Ezerskiy LA, Rendell VR, Belcheva MM, Coscia CJ
The Journal of biological chemistry 2010 Dec 3;285(49):38415-27
The Journal of biological chemistry 2010 Dec 3;285(49):38415-27
Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.
Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP, Jain MK
Science translational medicine 2010 Apr 7;2(26):26ra26
Science translational medicine 2010 Apr 7;2(26):26ra26
Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells.
Hyder SM, Liang Y, Wu J, Welbern V
Endocrine-related cancer 2009 Sep;16(3):809-17
Endocrine-related cancer 2009 Sep;16(3):809-17
Estrogen regulation of thrombospondin-1 in human breast cancer cells.
Hyder SM, Liang Y, Wu J
International journal of cancer 2009 Sep 1;125(5):1045-53
International journal of cancer 2009 Sep 1;125(5):1045-53
Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation.
Isenberg JS, Shiva S, Gladwin M
Nitric oxide : biology and chemistry 2009 Aug;21(1):52-62
Nitric oxide : biology and chemistry 2009 Aug;21(1):52-62
Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1.
Scheef EA, Sorenson CM, Sheibani N
American journal of physiology. Cell physiology 2009 Apr;296(4):C724-34
American journal of physiology. Cell physiology 2009 Apr;296(4):C724-34
Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain.
Gayen Betal S, Setty BN
Translational research : the journal of laboratory and clinical medicine 2008 Oct;152(4):165-77
Translational research : the journal of laboratory and clinical medicine 2008 Oct;152(4):165-77
Calcium indirectly regulates immunochemical reactivity and functional activities of the N-domain of thrombospondin-1.
Calzada MJ, Kuznetsova SA, Sipes JM, Rodrigues RG, Cashel JA, Annis DS, Mosher DF, Roberts DD
Matrix biology : journal of the International Society for Matrix Biology 2008 May;27(4):339-51
Matrix biology : journal of the International Society for Matrix Biology 2008 May;27(4):339-51
Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways.
Moon Y, Kim JI, Yang H, Eling TE
Life sciences 2008 Mar 12;82(11-12):591-9
Life sciences 2008 Mar 12;82(11-12):591-9
Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2.
Kondo S, Tang Y, Scheef EA, Sheibani N, Sorenson CM
American journal of physiology. Cell physiology 2008 Jun;294(6):C1521-30
American journal of physiology. Cell physiology 2008 Jun;294(6):C1521-30
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.
Rojas A, Meherem S, Kim YH, Washington MK, Willis JE, Markowitz SD, Grady WM
International journal of cancer 2008 Jul 1;123(1):14-21
International journal of cancer 2008 Jul 1;123(1):14-21
Meteorin regulates angiogenesis at the gliovascular interface.
Park JA, Lee HS, Ko KJ, Park SY, Kim JH, Choe G, Kweon HS, Song HS, Ahn JC, Yu YS, Kim KW
Glia 2008 Feb;56(3):247-58
Glia 2008 Feb;56(3):247-58
High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs.
Huang Q, Sheibani N
American journal of physiology. Cell physiology 2008 Dec;295(6):C1647-57
American journal of physiology. Cell physiology 2008 Dec;295(6):C1647-57
Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1.
Johnson AM, O'Connell MJ, Miyamoto H, Huang J, Yao JL, Messing EM, Reeder JE
BMC urology 2008 Apr 23;8:7
BMC urology 2008 Apr 23;8:7
Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1.
Derks RA, Jankowska-Gan E, Xu Q, Burlingham WJ
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3443-51
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3443-51
Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1.
Derks RA, Jankowska-Gan E, Xu Q, Burlingham WJ
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3443-51
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3443-51
Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations.
Annis DS, Gunderson KA, Mosher DF
The Journal of biological chemistry 2007 Sep 14;282(37):27067-27075
The Journal of biological chemistry 2007 Sep 14;282(37):27067-27075
Differential regulation of thrombospondin-1 expression and antiangiogenesis of ECV304 cells by trichostatin A and helixor A.
Hong S, Chang SY, Yeom DH, Kang JH, Hong KJ
Anti-cancer drugs 2007 Oct;18(9):1005-14
Anti-cancer drugs 2007 Oct;18(9):1005-14
Thrombospondin-1 expression and localization in the developing ovine lung.
Sozo F, Hooper SB, Wallace MJ
The Journal of physiology 2007 Oct 15;584(Pt 2):625-35
The Journal of physiology 2007 Oct 15;584(Pt 2):625-35
Bcl-2 expression modulates cell adhesion and migration promoting branching of ureteric bud cells.
Sheibani N, Scheef EA, Dimaio TA, Wang Y, Kondo S, Sorenson CM
Journal of cellular physiology 2007 Mar;210(3):616-25
Journal of cellular physiology 2007 Mar;210(3):616-25
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation.
Isenberg JS, Hyodo F, Matsumoto K, Romeo MJ, Abu-Asab M, Tsokos M, Kuppusamy P, Wink DA, Krishna MC, Roberts DD
Blood 2007 Mar 1;109(5):1945-52
Blood 2007 Mar 1;109(5):1945-52
PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis.
Kondo S, Scheef EA, Sheibani N, Sorenson CM
American journal of physiology. Cell physiology 2007 Jun;292(6):C2070-83
American journal of physiology. Cell physiology 2007 Jun;292(6):C2070-83
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).
Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C, Chiao JH, Reilly JF, Ricker JL, Richon VM, Frankel SR
Blood 2007 Jan 1;109(1):31-9
Blood 2007 Jan 1;109(1):31-9
PPARalpha deficiency in inflammatory cells suppresses tumor growth.
Kaipainen A, Kieran MW, Huang S, Butterfield C, Bielenberg D, Mostoslavsky G, Mulligan R, Folkman J, Panigrahy D
PloS one 2007 Feb 28;2(2):e260
PloS one 2007 Feb 28;2(2):e260
The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats.
de Nigris F, Balestrieri ML, Williams-Ignarro S, D'Armiento FP, Fiorito C, Ignarro LJ, Napoli C
Nitric oxide : biology and chemistry 2007 Aug;17(1):50-4
Nitric oxide : biology and chemistry 2007 Aug;17(1):50-4
Isolation and characterization of corneal endothelial cells from wild type and thrombospondin-1 deficient mice.
Scheef EA, Huang Q, Wang S, Sorenson CM, Sheibani N
Molecular vision 2007 Aug 27;13:1483-95
Molecular vision 2007 Aug 27;13:1483-95
Proteomic analysis of amniotic membrane prepared for human transplantation: characterization of proteins and clinical implications.
Hopkinson A, McIntosh RS, Shanmuganathan V, Tighe PJ, Dua HS
Journal of proteome research 2006 Sep;5(9):2226-35
Journal of proteome research 2006 Sep;5(9):2226-35
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Dews M, Homayouni A, Yu D, Murphy D, Sevignani C, Wentzel E, Furth EE, Lee WM, Enders GH, Mendell JT, Thomas-Tikhonenko A
Nature genetics 2006 Sep;38(9):1060-5
Nature genetics 2006 Sep;38(9):1060-5
Expression of thrombospondin 1 (TSP 1) in patients with uterine smooth muscle tumors: an immunohistochemical study.
Bodner-Adler B, Nather A, Bodner K, Czerwenka K, Kimberger O, Leodolter S, Mayerhofer K
Gynecologic oncology 2006 Oct;103(1):186-9
Gynecologic oncology 2006 Oct;103(1):186-9
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.
Giuriato S, Ryeom S, Fan AC, Bachireddy P, Lynch RC, Rioth MJ, van Riggelen J, Kopelman AM, Passegué E, Tang F, Folkman J, Felsher DW
Proceedings of the National Academy of Sciences of the United States of America 2006 Oct 31;103(44):16266-71
Proceedings of the National Academy of Sciences of the United States of America 2006 Oct 31;103(44):16266-71
Twist1 dimer selection regulates cranial suture patterning and fusion.
Connerney J, Andreeva V, Leshem Y, Muentener C, Mercado MA, Spicer DB
Developmental dynamics : an official publication of the American Association of Anatomists 2006 May;235(5):1345-57
Developmental dynamics : an official publication of the American Association of Anatomists 2006 May;235(5):1345-57
Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling.
Li Z, Wang C, Jiao X, Lu Y, Fu M, Quong AA, Dye C, Yang J, Dai M, Ju X, Zhang X, Li A, Burbelo P, Stanley ER, Pestell RG
Molecular and cellular biology 2006 Jun;26(11):4240-56
Molecular and cellular biology 2006 Jun;26(11):4240-56
Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes.
Shoji T, Koyama H, Morioka T, Tanaka S, Kizu A, Motoyama K, Mori K, Fukumoto S, Shioi A, Shimogaito N, Takeuchi M, Yamamoto Y, Yonekura H, Yamamoto H, Nishizawa Y
Diabetes 2006 Aug;55(8):2245-55
Diabetes 2006 Aug;55(8):2245-55
Thrombospondin-1 is induced in rat myocardial infarction and its induction is accelerated by ischemia/reperfusion.
Sezaki S, Hirohata S, Iwabu A, Nakamura K, Toeda K, Miyoshi T, Yamawaki H, Demircan K, Kusachi S, Shiratori Y, Ninomiya Y
Experimental biology and medicine (Maywood, N.J.) 2005 Oct;230(9):621-30
Experimental biology and medicine (Maywood, N.J.) 2005 Oct;230(9):621-30
Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition.
Bouvet C, Gilbert LA, Girardot D, deBlois D, Moreau P
Hypertension (Dallas, Tex. : 1979) 2005 Mar;45(3):432-7
Hypertension (Dallas, Tex. : 1979) 2005 Mar;45(3):432-7
Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling.
Olson LE, Zhang J, Taylor H, Rose DW, Rosenfeld MG
Proceedings of the National Academy of Sciences of the United States of America 2005 Mar 8;102(10):3708-13
Proceedings of the National Academy of Sciences of the United States of America 2005 Mar 8;102(10):3708-13
Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch.
Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N, Nishimura SL
The American journal of pathology 2005 Jun;166(6):1883-94
The American journal of pathology 2005 Jun;166(6):1883-94
Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch.
Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N, Nishimura SL
The American journal of pathology 2005 Jun;166(6):1883-94
The American journal of pathology 2005 Jun;166(6):1883-94
Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction.
Li SS, Forslöw A, Sundqvist KG
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 15;174(2):654-61
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 15;174(2):654-61
Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.
Jo WS, Mizukami Y, Duerr EM, Zukerberg LR, Chung DC
Cancer biology & therapy 2005 Dec;4(12):1361-6
Cancer biology & therapy 2005 Dec;4(12):1361-6
Isolation and characterization of murine retinal astrocytes.
Scheef E, Wang S, Sorenson CM, Sheibani N
Molecular vision 2005 Aug 22;11:613-24
Molecular vision 2005 Aug 22;11:613-24
Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor.
Isenberg JS, Calzada MJ, Zhou L, Guo N, Lawler J, Wang XQ, Frazier WA, Roberts DD
Matrix biology : journal of the International Society for Matrix Biology 2005 Apr;24(2):110-23
Matrix biology : journal of the International Society for Matrix Biology 2005 Apr;24(2):110-23
Increased expression of protein C-mannosylation in the aortic vessels of diabetic Zucker rats.
Ihara Y, Manabe S, Kanda M, Kawano H, Nakayama T, Sekine I, Kondo T, Ito Y
Glycobiology 2005 Apr;15(4):383-92
Glycobiology 2005 Apr;15(4):383-92
Mechanism of CD47-induced alpha4beta1 integrin activation and adhesion in sickle reticulocytes.
Brittain JE, Han J, Ataga KI, Orringer EP, Parise LV
The Journal of biological chemistry 2004 Oct 8;279(41):42393-402
The Journal of biological chemistry 2004 Oct 8;279(41):42393-402
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro.
Flügel-Koch C, Ohlmann A, Fuchshofer R, Welge-Lüssen U, Tamm ER
Experimental eye research 2004 Nov;79(5):649-63
Experimental eye research 2004 Nov;79(5):649-63
Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol.
Sengupta K, Banerjee S, Saxena NK, Banerjee SK
Molecular cancer research : MCR 2004 Mar;2(3):150-8
Molecular cancer research : MCR 2004 Mar;2(3):150-8
Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice.
Ziehr J, Sheibani N, Sorenson CM
American journal of physiology. Renal physiology 2004 Dec;287(6):F1154-63
American journal of physiology. Renal physiology 2004 Dec;287(6):F1154-63
Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism.
Emonard H, Bellon G, Troeberg L, Berton A, Robinet A, Henriet P, Marbaix E, Kirkegaard K, Patthy L, Eeckhout Y, Nagase H, Hornebeck W, Courtoy PJ
The Journal of biological chemistry 2004 Dec 24;279(52):54944-51
The Journal of biological chemistry 2004 Dec 24;279(52):54944-51
Isolation and characterization of murine retinal endothelial cells.
Su X, Sorenson CM, Sheibani N
Molecular vision 2003 May 1;9:171-8
Molecular vision 2003 May 1;9:171-8
Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis.
Watnick RS, Cheng YN, Rangarajan A, Ince TA, Weinberg RA
Cancer cell 2003 Mar;3(3):219-31
Cancer cell 2003 Mar;3(3):219-31
Regulation of multiple tumor microenvironment markers by overexpression of single or paired combinations of ErbB receptors.
Alaoui-Jamali MA, Song DJ, Benlimame N, Yen L, Deng X, Hernandez-Perez M, Wang T
Cancer research 2003 Jul 1;63(13):3764-74
Cancer research 2003 Jul 1;63(13):3764-74
Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cells.
Liu X, Wu Z, Sheibani N, Brandt CR, Polansky JR, Kaufman PL
Experimental eye research 2003 Aug;77(2):181-8
Experimental eye research 2003 Aug;77(2):181-8
Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cells.
Liu X, Wu Z, Sheibani N, Brandt CR, Polansky JR, Kaufman PL
Experimental eye research 2003 Aug;77(2):181-8
Experimental eye research 2003 Aug;77(2):181-8
Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling.
Lopes N, Gregg D, Vasudevan S, Hassanain H, Goldschmidt-Clermont P, Kovacic H
Molecular and cellular biology 2003 Aug;23(15):5401-8
Molecular and cellular biology 2003 Aug;23(15):5401-8
Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling.
Lopes N, Gregg D, Vasudevan S, Hassanain H, Goldschmidt-Clermont P, Kovacic H
Molecular and cellular biology 2003 Aug;23(15):5401-8
Molecular and cellular biology 2003 Aug;23(15):5401-8
Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice.
Flügel-Koch C, Ohlmann A, Piatigorsky J, Tamm ER
Developmental dynamics : an official publication of the American Association of Anatomists 2002 Oct;225(2):111-25
Developmental dynamics : an official publication of the American Association of Anatomists 2002 Oct;225(2):111-25
Characteristics of long-term survivors of untreated lung cancer.
Mattern J, Koomägi R, Volm M
Lung cancer (Amsterdam, Netherlands) 2002 Jun;36(3):277-82
Lung cancer (Amsterdam, Netherlands) 2002 Jun;36(3):277-82
Characteristics of long-term survivors of untreated lung cancer.
Mattern J, Koomägi R, Volm M
Lung cancer (Amsterdam, Netherlands) 2002 Jun;36(3):277-82
Lung cancer (Amsterdam, Netherlands) 2002 Jun;36(3):277-82
Polarized trafficking of thyrocyte proteins in MDCK cells.
Zhang X, Riedel C, Carrasco N, Arvan P
Molecular and cellular endocrinology 2002 Feb 25;188(1-2):27-36
Molecular and cellular endocrinology 2002 Feb 25;188(1-2):27-36
Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma.
Kragh M, Quistorff B, Tenan M, Van Meir EG, Kristjansen PE
Cancer research 2002 Feb 15;62(4):1191-5
Cancer research 2002 Feb 15;62(4):1191-5
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Rice AJ, Steward MA, Quinn CM
Journal of clinical pathology 2002 Dec;55(12):921-5
Journal of clinical pathology 2002 Dec;55(12):921-5
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Rice AJ, Steward MA, Quinn CM
Journal of clinical pathology 2002 Dec;55(12):921-5
Journal of clinical pathology 2002 Dec;55(12):921-5
T lymphocyte expression of thrombospondin-1 and adhesion to extracellular matrix components.
Li SS, Ivanoff A, Bergström SE, Sandström A, Christensson B, van Nerven J, Holgersson J, Hauzenberger D, Arencibia I, Sundqvist KG
European journal of immunology 2002 Apr;32(4):1069-79
European journal of immunology 2002 Apr;32(4):1069-79
Thrombospondin-1-mediated metastasis suppression by the primary tumor in human melanoma xenografts.
Rofstad EK, Graff BA
The Journal of investigative dermatology 2001 Nov;117(5):1042-9
The Journal of investigative dermatology 2001 Nov;117(5):1042-9
Mechanism of interaction of thrombospondin with human endothelium and inhibition of sickle erythrocyte adhesion to human endothelial cells by heparin.
Gupta K, Gupta P, Solovey A, Hebbel RP
Biochimica et biophysica acta 1999 Jan 6;1453(1):63-73
Biochimica et biophysica acta 1999 Jan 6;1453(1):63-73
Mechanism of interaction of thrombospondin with human endothelium and inhibition of sickle erythrocyte adhesion to human endothelial cells by heparin.
Gupta K, Gupta P, Solovey A, Hebbel RP
Biochimica et biophysica acta 1999 Jan 6;1453(1):63-73
Biochimica et biophysica acta 1999 Jan 6;1453(1):63-73
Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?
Shi SR, Cote RJ, Hawes D, Thu S, Shi Y, Young LL, Taylor CR
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Apr;47(4):463-70
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Apr;47(4):463-70
Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?
Shi SR, Cote RJ, Hawes D, Thu S, Shi Y, Young LL, Taylor CR
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Apr;47(4):463-70
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Apr;47(4):463-70
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot of Thrombospondin using Thrombospondin Monoclonal Antibody (Product # MA5-11330) on HUVEC Cells.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
