MA5-13395
antibody from Invitrogen Antibodies
Targeting: THBS1
THBS, THBS-1, TSP, TSP-1, TSP1
Antibody data
- Antibody Data
- Antigen structure
- References [120]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
- Other assay [8]
Submit
Validation data
Reference
Comment
Report error
- Product number
- MA5-13395 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Thrombospondin 1 Monoclonal Antibody (A6.1), Biotin
- Antibody type
- Monoclonal
- Antigen
- Purifed from natural sources
- Description
- MA5-13395 targets Thrombospondin in FACS, IF, IHC (P), IM, IP, and WB applications and shows reactivity with Bovine, Canine, Equine, Human, mouse, Ovine, Porcine, and Rat samples. The MA5-13395 immunogen is reduced and alkylated purified human TSP (fully denatured) from the supernatant of thrombin-activated platelets.
- Reactivity
- Human, Mouse, Rat, Bovine, Canine, Porcine
- Host
- Mouse
- Conjugate
- Biotin
- Isotype
- IgG
- Antibody clone number
- A6.1
- Vial size
- 500 µL
- Concentration
- 0.2 mg/mL
- Storage
- 4° C
Submitted references Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy.
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta.
Regulation of T-lymphocyte motility, adhesion and de-adhesion by a cell surface mechanism directed by low density lipoprotein receptor-related protein 1 and endogenous thrombospondin-1.
Long-term gene therapy with thrombospondin 2 inhibits TGF-β activation, inflammation and angiogenesis in chronic allograft nephropathy.
Inflammatory cytokine-specific alterations in retinal endothelial cell function.
Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress.
A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation.
Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis.
The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity.
A histone deacetylase inhibitory prodrug - butyroyloxymethyl diethyl phosphate - protects the heart and cardiomyocytes against ischemia injury.
BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment.
Localization of thrombospondin-1 and myofibroblasts during corneal wound repair.
Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells.
Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer.
Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries.
Effect of Qingre Quyu Granule (清热祛瘀颗粒) on stabilizing plaques in the brachiocephalic artery of apolipoprotein E deficient mice.
The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors.
Opposing effects of bim and bcl-2 on lung endothelial cell migration.
Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin alpha1beta1 in astrocytes.
Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors.
Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis.
The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.
PECAM-1 regulates proangiogenic properties of endothelial cells through modulation of cell-cell and cell-matrix interactions.
Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation.
VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment.
Impaired function of circulating CD34(+) CD45(-) cells in patients with proliferative diabetic retinopathy.
Angiotensin II sustains brain inflammation in mice via TGF-beta.
Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.
Differential expression of pancreatitis-associated protein and thrombospondins in arterial versus venous tissues.
Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells.
Estrogen regulation of thrombospondin-1 in human breast cancer cells.
Vascular endothelial growth factor inhibition by dRK6 causes endothelial apoptosis, fibrosis, and inflammation in the heart via the Akt/eNOS axis in db/db mice.
Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation.
Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release.
Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation.
Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1.
Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc.
Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma.
Capillary sprout endothelial cells exhibit a CD36 low phenotype: regulation by shear stress and vascular endothelial growth factor-induced mechanism for attenuating anti-proliferative thrombospondin-1 signaling.
Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain.
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.
Treatment of liver ischemia-reperfusion injury by limiting thrombospondin-1/CD47 signaling.
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2.
Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets.
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.
Meteorin regulates angiogenesis at the gliovascular interface.
Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose.
High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs.
Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1.
Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts.
Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1.
Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1.
Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations.
Differential regulation of thrombospondin-1 expression and antiangiogenesis of ECV304 cells by trichostatin A and helixor A.
Thrombospondin-1 expression and localization in the developing ovine lung.
Bcl-2 expression modulates cell adhesion and migration promoting branching of ureteric bud cells.
Increasing survival of ischemic tissue by targeting CD47.
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation.
PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis.
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).
PPARalpha deficiency in inflammatory cells suppresses tumor growth.
Glycosylation mediates up-regulation of a potent antiangiogenic and proatherogenic protein, thrombospondin-1, by glucose in vascular smooth muscle cells.
The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats.
Isolation and characterization of corneal endothelial cells from wild type and thrombospondin-1 deficient mice.
Gene expression changes evoked in a venous segment exposed to arterial flow.
Expression of thrombospondin 1 (TSP 1) in patients with uterine smooth muscle tumors: an immunohistochemical study.
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.
HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy.
Versican-thrombospondin-1 binding in vitro and colocalization in microfibrils induced by inflammation on vascular smooth muscle cells.
Enhanced proangiogenic signaling in thrombospondin-1-deficient retinal endothelial cells.
Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats.
Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization.
Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes.
Thrombospondins, metallo proteases and thrombospondin receptors messenger RNA and protein expression in different tumour sublines of the Dunning prostate cancer model.
Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis.
1,25-dihydroxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression.
Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition.
Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling.
Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch.
Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch.
Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction.
Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.
Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.
Kinetics of biglycan, decorin and thrombospondin-1 in mercuric chloride-induced renal tubulointerstitial fibrosis.
Isolation and characterization of murine retinal astrocytes.
Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor.
Impairment of thrombospondin-1 expression during epithelial wound healing in corneas of vitamin A-deficient mice.
Impairment of thrombospondin-1 expression during epithelial wound healing in corneas of vitamin A-deficient mice.
Increased expression of protein C-mannosylation in the aortic vessels of diabetic Zucker rats.
Role of thrombospondin-1 in the autologous phase of an accelerated model of anti-glomerular basement membrane glomerulonephritis.
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro.
Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol.
Thrombospondin-1 accelerates wound healing of corneal epithelia.
Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice.
Significance of CD 105 expression for tumour angiogenesis and prognosis in endometrial carcinomas.
Significance of CD 105 expression for tumour angiogenesis and prognosis in endometrial carcinomas.
Isolation and characterization of murine retinal endothelial cells.
Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis.
Connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells by both GJIC-dependent and -independent mechanisms.
Connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells by both GJIC-dependent and -independent mechanisms.
Regulation of multiple tumor microenvironment markers by overexpression of single or paired combinations of ErbB receptors.
Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat.
Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cells.
Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cells.
Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling.
Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice.
Characteristics of long-term survivors of untreated lung cancer.
Characteristics of long-term survivors of untreated lung cancer.
Investigation of the role of nitric oxide synthase 2 in pregnancy using mutant mice.
Investigation of the role of nitric oxide synthase 2 in pregnancy using mutant mice.
In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin.
Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma.
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
T lymphocyte expression of thrombospondin-1 and adhesion to extracellular matrix components.
Thrombospondin-1-mediated metastasis suppression by the primary tumor in human melanoma xenografts.
Association of thrombospondin-1 and cardiac allograft vasculopathy in human cardiac allografts.
Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?
Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?
Vanhoutte D, Schips TG, Vo A, Grimes KM, Baldwin TA, Brody MJ, Accornero F, Sargent MA, Molkentin JD
Nature communications 2021 Jun 24;12(1):3928
Nature communications 2021 Jun 24;12(1):3928
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta.
Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T
eLife 2020 Feb 24;9
eLife 2020 Feb 24;9
Regulation of T-lymphocyte motility, adhesion and de-adhesion by a cell surface mechanism directed by low density lipoprotein receptor-related protein 1 and endogenous thrombospondin-1.
Talme T, Bergdahl E, Sundqvist KG
Immunology 2014 Jun;142(2):176-92
Immunology 2014 Jun;142(2):176-92
Long-term gene therapy with thrombospondin 2 inhibits TGF-β activation, inflammation and angiogenesis in chronic allograft nephropathy.
Daniel C, Vogelbacher R, Stief A, Grigo C, Hugo C
PloS one 2013;8(12):e83846
PloS one 2013;8(12):e83846
Inflammatory cytokine-specific alterations in retinal endothelial cell function.
Palenski TL, Sorenson CM, Sheibani N
Microvascular research 2013 Sep;89:57-69
Microvascular research 2013 Sep;89:57-69
Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress.
Zhao Y, Wang S, Sorenson CM, Teixeira L, Dubielzig RR, Peters DM, Conway SJ, Jefcoate CR, Sheibani N
Molecular and cellular biology 2013 Nov;33(21):4225-40
Molecular and cellular biology 2013 Nov;33(21):4225-40
A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation.
Bergström SE, Bergdahl E, Sundqvist KG
Immunology 2013 Dec;140(4):441-55
Immunology 2013 Dec;140(4):441-55
Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis.
Martin-Manso G, Navarathna DH, Galli S, Soto-Pantoja DR, Kuznetsova SA, Tsokos M, Roberts DD
PloS one 2012;7(11):e48775
PloS one 2012;7(11):e48775
The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity.
Tarasenko N, Kessler-Icekson G, Boer P, Inbal A, Schlesinger H, Phillips DR, Cutts SM, Nudelman A, Rephaeli A
Investigational new drugs 2012 Feb;30(1):130-43
Investigational new drugs 2012 Feb;30(1):130-43
A histone deacetylase inhibitory prodrug - butyroyloxymethyl diethyl phosphate - protects the heart and cardiomyocytes against ischemia injury.
Kessler-Icekson G, Hochhauser E, Sinai T, Kremer A, Dick J, Tarasenko N, Nudelman V, Schlesinger H, Abraham S, Nudelman A, Rephaeli A
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012 Apr 11;45(5):592-9
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012 Apr 11;45(5):592-9
BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment.
Sheibani N, Morrison ME, Gurel Z, Park S, Sorenson CM
American journal of physiology. Renal physiology 2012 Apr 1;302(7):F809-19
American journal of physiology. Renal physiology 2012 Apr 1;302(7):F809-19
Localization of thrombospondin-1 and myofibroblasts during corneal wound repair.
Matsuba M, Hutcheon AE, Zieske JD
Experimental eye research 2011 Oct;93(4):534-40
Experimental eye research 2011 Oct;93(4):534-40
Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells.
El Btaouri H, Morjani H, Greffe Y, Charpentier E, Martiny L
Biochimica et biophysica acta 2011 May;1813(5):695-703
Biochimica et biophysica acta 2011 May;1813(5):695-703
Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer.
Guerrero D, Guarch R, Ojer A, Casas JM, Méndez-Meca C, Esteller M, Barba-Ramos E, Garcia-Bragado F, Puras A
International journal of cancer 2011 Jun 15;128(12):2853-64
International journal of cancer 2011 Jun 15;128(12):2853-64
Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries.
Hohberg M, Knöchel J, Hoffmann CJ, Chlench S, Wunderlich W, Alter A, Maroski J, Vorderwülbecke BJ, Da Silva-Azevedo L, Knudsen R, Lehmann R, Fiedorowicz K, Bongrazio M, Nitsche B, Hoepfner M, Styp-Rekowska B, Pries AR, Zakrzewicz A
Journal of cellular physiology 2011 Feb;226(2):350-61
Journal of cellular physiology 2011 Feb;226(2):350-61
Effect of Qingre Quyu Granule (清热祛瘀颗粒) on stabilizing plaques in the brachiocephalic artery of apolipoprotein E deficient mice.
Wang Y, Cheng WL, Ke YN, Cai Z, Chen L, Xi Y, Wang P, Guo J, Li H, Huang CX
Chinese journal of integrative medicine 2010 Oct;16(5):442-7
Chinese journal of integrative medicine 2010 Oct;16(5):442-7
The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors.
Dews M, Fox JL, Hultine S, Sundaram P, Wang W, Liu YY, Furth E, Enders GH, El-Deiry W, Schelter JM, Cleary MA, Thomas-Tikhonenko A
Cancer research 2010 Oct 15;70(20):8233-46
Cancer research 2010 Oct 15;70(20):8233-46
Opposing effects of bim and bcl-2 on lung endothelial cell migration.
Grutzmacher C, Park S, Elmergreen TL, Tang Y, Scheef EA, Sheibani N, Sorenson CM
American journal of physiology. Lung cellular and molecular physiology 2010 Nov;299(5):L607-20
American journal of physiology. Lung cellular and molecular physiology 2010 Nov;299(5):L607-20
Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin alpha1beta1 in astrocytes.
Yonezawa T, Hattori S, Inagaki J, Kurosaki M, Takigawa T, Hirohata S, Miyoshi T, Ninomiya Y
Glia 2010 May;58(7):755-67
Glia 2010 May;58(7):755-67
Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors.
Olsson A, Björk A, Vallon-Christersson J, Isaacs JT, Leanderson T
Molecular cancer 2010 May 17;9:107
Molecular cancer 2010 May 17;9:107
Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis.
Zaslavsky A, Baek KH, Lynch RC, Short S, Grillo J, Folkman J, Italiano JE Jr, Ryeom S
Blood 2010 Jun 3;115(22):4605-13
Blood 2010 Jun 3;115(22):4605-13
The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.
Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D
The Journal of biological chemistry 2010 Feb 26;285(9):6770-80
The Journal of biological chemistry 2010 Feb 26;285(9):6770-80
PECAM-1 regulates proangiogenic properties of endothelial cells through modulation of cell-cell and cell-matrix interactions.
Park S, DiMaio TA, Scheef EA, Sorenson CM, Sheibani N
American journal of physiology. Cell physiology 2010 Dec;299(6):C1468-84
American journal of physiology. Cell physiology 2010 Dec;299(6):C1468-84
Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation.
Ikeda H, Miyatake M, Koshikawa N, Ochiai K, Yamada K, Kiss A, Donlin MJ, Panneton WM, Churchill JD, Green M, Siddiqui AM, Leinweber AL, Crews NR, Ezerskiy LA, Rendell VR, Belcheva MM, Coscia CJ
The Journal of biological chemistry 2010 Dec 3;285(49):38415-27
The Journal of biological chemistry 2010 Dec 3;285(49):38415-27
VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment.
Patten SG, Adamcic U, Lacombe K, Minhas K, Skowronski K, Coomber BL
BMC cancer 2010 Dec 15;10:683
BMC cancer 2010 Dec 15;10:683
Impaired function of circulating CD34(+) CD45(-) cells in patients with proliferative diabetic retinopathy.
Tan K, Lessieur E, Cutler A, Nerone P, Vasanji A, Asosingh K, Erzurum S, Anand-Apte B
Experimental eye research 2010 Aug;91(2):229-37
Experimental eye research 2010 Aug;91(2):229-37
Angiotensin II sustains brain inflammation in mice via TGF-beta.
Lanz TV, Ding Z, Ho PP, Luo J, Agrawal AN, Srinagesh H, Axtell R, Zhang H, Platten M, Wyss-Coray T, Steinman L
The Journal of clinical investigation 2010 Aug;120(8):2782-94
The Journal of clinical investigation 2010 Aug;120(8):2782-94
Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.
Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP, Jain MK
Science translational medicine 2010 Apr 7;2(26):26ra26
Science translational medicine 2010 Apr 7;2(26):26ra26
Differential expression of pancreatitis-associated protein and thrombospondins in arterial versus venous tissues.
Szasz T, Eddy S, Paulauskis J, Burnett R, Ellekilde M, Iovanna JL, Watts SW
Journal of vascular research 2009;46(6):551-60
Journal of vascular research 2009;46(6):551-60
Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells.
Hyder SM, Liang Y, Wu J, Welbern V
Endocrine-related cancer 2009 Sep;16(3):809-17
Endocrine-related cancer 2009 Sep;16(3):809-17
Estrogen regulation of thrombospondin-1 in human breast cancer cells.
Hyder SM, Liang Y, Wu J
International journal of cancer 2009 Sep 1;125(5):1045-53
International journal of cancer 2009 Sep 1;125(5):1045-53
Vascular endothelial growth factor inhibition by dRK6 causes endothelial apoptosis, fibrosis, and inflammation in the heart via the Akt/eNOS axis in db/db mice.
Park CW, Kim HW, Lim JH, Yoo KD, Chung S, Shin SJ, Chung HW, Lee SJ, Chae CB, Kim YS, Chang YS
Diabetes 2009 Nov;58(11):2666-76
Diabetes 2009 Nov;58(11):2666-76
Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation.
Daniel C, Wagner A, Hohenstein B, Hugo C
American journal of physiology. Renal physiology 2009 Nov;297(5):F1299-309
American journal of physiology. Renal physiology 2009 Nov;297(5):F1299-309
Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release.
Rex S, Beaulieu LM, Perlman DH, Vitseva O, Blair PS, McComb ME, Costello CE, Freedman JE
Thrombosis and haemostasis 2009 Jul;102(1):97-110
Thrombosis and haemostasis 2009 Jul;102(1):97-110
Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation.
Isenberg JS, Shiva S, Gladwin M
Nitric oxide : biology and chemistry 2009 Aug;21(1):52-62
Nitric oxide : biology and chemistry 2009 Aug;21(1):52-62
Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1.
Scheef EA, Sorenson CM, Sheibani N
American journal of physiology. Cell physiology 2009 Apr;296(4):C724-34
American journal of physiology. Cell physiology 2009 Apr;296(4):C724-34
Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc.
Gruber HE, Bornstein P, Sage EH, Ingram JA, Zinchenko N, Norton HJ, Hanley EN Jr
Arthritis research & therapy 2008;10(4):R96
Arthritis research & therapy 2008;10(4):R96
Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma.
Guerrero D, Guarch R, Ojer A, Casas JM, Ropero S, Mancha A, Pesce C, Lloveras B, Garcia-Bragado F, Puras A
BJU international 2008 Sep;102(6):747-55
BJU international 2008 Sep;102(6):747-55
Capillary sprout endothelial cells exhibit a CD36 low phenotype: regulation by shear stress and vascular endothelial growth factor-induced mechanism for attenuating anti-proliferative thrombospondin-1 signaling.
Anderson CR, Hastings NE, Blackman BR, Price RJ
The American journal of pathology 2008 Oct;173(4):1220-8
The American journal of pathology 2008 Oct;173(4):1220-8
Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain.
Gayen Betal S, Setty BN
Translational research : the journal of laboratory and clinical medicine 2008 Oct;152(4):165-77
Translational research : the journal of laboratory and clinical medicine 2008 Oct;152(4):165-77
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.
Mazan-Mamczarz K, Hagner PR, Corl S, Srikantan S, Wood WH, Becker KG, Gorospe M, Keene JD, Levenson AS, Gartenhaus RB
Oncogene 2008 Oct 16;27(47):6151-63
Oncogene 2008 Oct 16;27(47):6151-63
Treatment of liver ischemia-reperfusion injury by limiting thrombospondin-1/CD47 signaling.
Isenberg JS, Maxhimer JB, Powers P, Tsokos M, Frazier WA, Roberts DD
Surgery 2008 Nov;144(5):752-61
Surgery 2008 Nov;144(5):752-61
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Ide M, Ishii H, Mukae H, Iwata A, Sakamoto N, Kadota J, Kohno S
Respiratory medicine 2008 Nov;102(11):1625-30
Respiratory medicine 2008 Nov;102(11):1625-30
Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2.
Kondo S, Tang Y, Scheef EA, Sheibani N, Sorenson CM
American journal of physiology. Cell physiology 2008 Jun;294(6):C1521-30
American journal of physiology. Cell physiology 2008 Jun;294(6):C1521-30
Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets.
Olerud J, Johansson M, Lawler J, Welsh N, Carlsson PO
Diabetes 2008 Jul;57(7):1870-7
Diabetes 2008 Jul;57(7):1870-7
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.
Rojas A, Meherem S, Kim YH, Washington MK, Willis JE, Markowitz SD, Grady WM
International journal of cancer 2008 Jul 1;123(1):14-21
International journal of cancer 2008 Jul 1;123(1):14-21
Meteorin regulates angiogenesis at the gliovascular interface.
Park JA, Lee HS, Ko KJ, Park SY, Kim JH, Choe G, Kweon HS, Song HS, Ahn JC, Yu YS, Kim KW
Glia 2008 Feb;56(3):247-58
Glia 2008 Feb;56(3):247-58
Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose.
Bhattacharyya S, Marinic TE, Krukovets I, Hoppe G, Stenina OI
The Journal of biological chemistry 2008 Feb 29;283(9):5699-707
The Journal of biological chemistry 2008 Feb 29;283(9):5699-707
High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs.
Huang Q, Sheibani N
American journal of physiology. Cell physiology 2008 Dec;295(6):C1647-57
American journal of physiology. Cell physiology 2008 Dec;295(6):C1647-57
Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1.
Johnson AM, O'Connell MJ, Miyamoto H, Huang J, Yao JL, Messing EM, Reeder JE
BMC urology 2008 Apr 23;8:7
BMC urology 2008 Apr 23;8:7
Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts.
Pohlers D, Beyer A, Koczan D, Wilhelm T, Thiesen HJ, Kinne RW
Arthritis research & therapy 2007;9(3):R59
Arthritis research & therapy 2007;9(3):R59
Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1.
Derks RA, Jankowska-Gan E, Xu Q, Burlingham WJ
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3443-51
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3443-51
Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1.
Derks RA, Jankowska-Gan E, Xu Q, Burlingham WJ
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3443-51
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3443-51
Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations.
Annis DS, Gunderson KA, Mosher DF
The Journal of biological chemistry 2007 Sep 14;282(37):27067-27075
The Journal of biological chemistry 2007 Sep 14;282(37):27067-27075
Differential regulation of thrombospondin-1 expression and antiangiogenesis of ECV304 cells by trichostatin A and helixor A.
Hong S, Chang SY, Yeom DH, Kang JH, Hong KJ
Anti-cancer drugs 2007 Oct;18(9):1005-14
Anti-cancer drugs 2007 Oct;18(9):1005-14
Thrombospondin-1 expression and localization in the developing ovine lung.
Sozo F, Hooper SB, Wallace MJ
The Journal of physiology 2007 Oct 15;584(Pt 2):625-35
The Journal of physiology 2007 Oct 15;584(Pt 2):625-35
Bcl-2 expression modulates cell adhesion and migration promoting branching of ureteric bud cells.
Sheibani N, Scheef EA, Dimaio TA, Wang Y, Kondo S, Sorenson CM
Journal of cellular physiology 2007 Mar;210(3):616-25
Journal of cellular physiology 2007 Mar;210(3):616-25
Increasing survival of ischemic tissue by targeting CD47.
Isenberg JS, Romeo MJ, Abu-Asab M, Tsokos M, Oldenborg A, Pappan L, Wink DA, Frazier WA, Roberts DD
Circulation research 2007 Mar 16;100(5):712-20
Circulation research 2007 Mar 16;100(5):712-20
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation.
Isenberg JS, Hyodo F, Matsumoto K, Romeo MJ, Abu-Asab M, Tsokos M, Kuppusamy P, Wink DA, Krishna MC, Roberts DD
Blood 2007 Mar 1;109(5):1945-52
Blood 2007 Mar 1;109(5):1945-52
PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis.
Kondo S, Scheef EA, Sheibani N, Sorenson CM
American journal of physiology. Cell physiology 2007 Jun;292(6):C2070-83
American journal of physiology. Cell physiology 2007 Jun;292(6):C2070-83
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).
Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C, Chiao JH, Reilly JF, Ricker JL, Richon VM, Frankel SR
Blood 2007 Jan 1;109(1):31-9
Blood 2007 Jan 1;109(1):31-9
PPARalpha deficiency in inflammatory cells suppresses tumor growth.
Kaipainen A, Kieran MW, Huang S, Butterfield C, Bielenberg D, Mostoslavsky G, Mulligan R, Folkman J, Panigrahy D
PloS one 2007 Feb 28;2(2):e260
PloS one 2007 Feb 28;2(2):e260
Glycosylation mediates up-regulation of a potent antiangiogenic and proatherogenic protein, thrombospondin-1, by glucose in vascular smooth muscle cells.
Raman P, Krukovets I, Marinic TE, Bornstein P, Stenina OI
The Journal of biological chemistry 2007 Feb 23;282(8):5704-14
The Journal of biological chemistry 2007 Feb 23;282(8):5704-14
The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats.
de Nigris F, Balestrieri ML, Williams-Ignarro S, D'Armiento FP, Fiorito C, Ignarro LJ, Napoli C
Nitric oxide : biology and chemistry 2007 Aug;17(1):50-4
Nitric oxide : biology and chemistry 2007 Aug;17(1):50-4
Isolation and characterization of corneal endothelial cells from wild type and thrombospondin-1 deficient mice.
Scheef EA, Huang Q, Wang S, Sorenson CM, Sheibani N
Molecular vision 2007 Aug 27;13:1483-95
Molecular vision 2007 Aug 27;13:1483-95
Gene expression changes evoked in a venous segment exposed to arterial flow.
Abeles D, Kwei S, Stavrakis G, Zhang Y, Wang ET, García-Cardeña G
Journal of vascular surgery 2006 Oct;44(4):863-70
Journal of vascular surgery 2006 Oct;44(4):863-70
Expression of thrombospondin 1 (TSP 1) in patients with uterine smooth muscle tumors: an immunohistochemical study.
Bodner-Adler B, Nather A, Bodner K, Czerwenka K, Kimberger O, Leodolter S, Mayerhofer K
Gynecologic oncology 2006 Oct;103(1):186-9
Gynecologic oncology 2006 Oct;103(1):186-9
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.
Giuriato S, Ryeom S, Fan AC, Bachireddy P, Lynch RC, Rioth MJ, van Riggelen J, Kopelman AM, Passegué E, Tang F, Folkman J, Felsher DW
Proceedings of the National Academy of Sciences of the United States of America 2006 Oct 31;103(44):16266-71
Proceedings of the National Academy of Sciences of the United States of America 2006 Oct 31;103(44):16266-71
HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy.
Wen XF, Yang G, Mao W, Thornton A, Liu J, Bast RC Jr, Le XF
Oncogene 2006 Nov 2;25(52):6986-96
Oncogene 2006 Nov 2;25(52):6986-96
Versican-thrombospondin-1 binding in vitro and colocalization in microfibrils induced by inflammation on vascular smooth muscle cells.
Kuznetsova SA, Issa P, Perruccio EM, Zeng B, Sipes JM, Ward Y, Seyfried NT, Fielder HL, Day AJ, Wight TN, Roberts DD
Journal of cell science 2006 Nov 1;119(Pt 21):4499-509
Journal of cell science 2006 Nov 1;119(Pt 21):4499-509
Enhanced proangiogenic signaling in thrombospondin-1-deficient retinal endothelial cells.
Wang Y, Wang S, Sheibani N
Microvascular research 2006 May;71(3):143-51
Microvascular research 2006 May;71(3):143-51
Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats.
Johansson M, Mattsson G, Andersson A, Jansson L, Carlsson PO
Endocrinology 2006 May;147(5):2315-24
Endocrinology 2006 May;147(5):2315-24
Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization.
Kopp HG, Hooper AT, Broekman MJ, Avecilla ST, Petit I, Luo M, Milde T, Ramos CA, Zhang F, Kopp T, Bornstein P, Jin DK, Marcus AJ, Rafii S
The Journal of clinical investigation 2006 Dec;116(12):3277-91
The Journal of clinical investigation 2006 Dec;116(12):3277-91
Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes.
Shoji T, Koyama H, Morioka T, Tanaka S, Kizu A, Motoyama K, Mori K, Fukumoto S, Shioi A, Shimogaito N, Takeuchi M, Yamamoto Y, Yonekura H, Yamamoto H, Nishizawa Y
Diabetes 2006 Aug;55(8):2245-55
Diabetes 2006 Aug;55(8):2245-55
Thrombospondins, metallo proteases and thrombospondin receptors messenger RNA and protein expression in different tumour sublines of the Dunning prostate cancer model.
Vallbo C, Damber JE
Acta oncologica (Stockholm, Sweden) 2005;44(3):293-8
Acta oncologica (Stockholm, Sweden) 2005;44(3):293-8
Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis.
Sutton CD, O'Byrne K, Goddard JC, Marshall LJ, Jones L, Garcea G, Dennison AR, Poston G, Lloyd DM, Berry DP
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Sep 15;11(18):6567-73
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Sep 15;11(18):6567-73
1,25-dihydroxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression.
Li Y, Spataro BC, Yang J, Dai C, Liu Y
Kidney international 2005 Oct;68(4):1500-10
Kidney international 2005 Oct;68(4):1500-10
Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition.
Bouvet C, Gilbert LA, Girardot D, deBlois D, Moreau P
Hypertension (Dallas, Tex. : 1979) 2005 Mar;45(3):432-7
Hypertension (Dallas, Tex. : 1979) 2005 Mar;45(3):432-7
Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling.
Olson LE, Zhang J, Taylor H, Rose DW, Rosenfeld MG
Proceedings of the National Academy of Sciences of the United States of America 2005 Mar 8;102(10):3708-13
Proceedings of the National Academy of Sciences of the United States of America 2005 Mar 8;102(10):3708-13
Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch.
Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N, Nishimura SL
The American journal of pathology 2005 Jun;166(6):1883-94
The American journal of pathology 2005 Jun;166(6):1883-94
Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch.
Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N, Nishimura SL
The American journal of pathology 2005 Jun;166(6):1883-94
The American journal of pathology 2005 Jun;166(6):1883-94
Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction.
Li SS, Forslöw A, Sundqvist KG
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 15;174(2):654-61
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 15;174(2):654-61
Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.
Jo WS, Mizukami Y, Duerr EM, Zukerberg LR, Chung DC
Cancer biology & therapy 2005 Dec;4(12):1361-6
Cancer biology & therapy 2005 Dec;4(12):1361-6
Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.
Jo WS, Mizukami Y, Duerr EM, Zukerberg LR, Chung DC
Cancer biology & therapy 2005 Dec;4(12):1361-6
Cancer biology & therapy 2005 Dec;4(12):1361-6
Kinetics of biglycan, decorin and thrombospondin-1 in mercuric chloride-induced renal tubulointerstitial fibrosis.
Suzuki K, Wang R, Kubota H, Shibuya H, Saegusa J, Sato T
Experimental and molecular pathology 2005 Aug;79(1):68-73
Experimental and molecular pathology 2005 Aug;79(1):68-73
Isolation and characterization of murine retinal astrocytes.
Scheef E, Wang S, Sorenson CM, Sheibani N
Molecular vision 2005 Aug 22;11:613-24
Molecular vision 2005 Aug 22;11:613-24
Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor.
Isenberg JS, Calzada MJ, Zhou L, Guo N, Lawler J, Wang XQ, Frazier WA, Roberts DD
Matrix biology : journal of the International Society for Matrix Biology 2005 Apr;24(2):110-23
Matrix biology : journal of the International Society for Matrix Biology 2005 Apr;24(2):110-23
Impairment of thrombospondin-1 expression during epithelial wound healing in corneas of vitamin A-deficient mice.
Uno K, Kuroki M, Hayashi H, Uchida H, Kuroki M, Oshima K
Histology and histopathology 2005 Apr;20(2):493-9
Histology and histopathology 2005 Apr;20(2):493-9
Impairment of thrombospondin-1 expression during epithelial wound healing in corneas of vitamin A-deficient mice.
Uno K, Kuroki M, Hayashi H, Uchida H, Kuroki M, Oshima K
Histology and histopathology 2005 Apr;20(2):493-9
Histology and histopathology 2005 Apr;20(2):493-9
Increased expression of protein C-mannosylation in the aortic vessels of diabetic Zucker rats.
Ihara Y, Manabe S, Kanda M, Kawano H, Nakayama T, Sekine I, Kondo T, Ito Y
Glycobiology 2005 Apr;15(4):383-92
Glycobiology 2005 Apr;15(4):383-92
Role of thrombospondin-1 in the autologous phase of an accelerated model of anti-glomerular basement membrane glomerulonephritis.
Hochegger K, Knight S, Hugo C, Mayer G, Lawler J, Mayadas TN, Rosenkranz AR
Nephron. Experimental nephrology 2004;96(2):e31-8
Nephron. Experimental nephrology 2004;96(2):e31-8
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro.
Flügel-Koch C, Ohlmann A, Fuchshofer R, Welge-Lüssen U, Tamm ER
Experimental eye research 2004 Nov;79(5):649-63
Experimental eye research 2004 Nov;79(5):649-63
Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol.
Sengupta K, Banerjee S, Saxena NK, Banerjee SK
Molecular cancer research : MCR 2004 Mar;2(3):150-8
Molecular cancer research : MCR 2004 Mar;2(3):150-8
Thrombospondin-1 accelerates wound healing of corneal epithelia.
Uno K, Hayashi H, Kuroki M, Uchida H, Yamauchi Y, Kuroki M, Oshima K
Biochemical and biophysical research communications 2004 Mar 19;315(4):928-34
Biochemical and biophysical research communications 2004 Mar 19;315(4):928-34
Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice.
Ziehr J, Sheibani N, Sorenson CM
American journal of physiology. Renal physiology 2004 Dec;287(6):F1154-63
American journal of physiology. Renal physiology 2004 Dec;287(6):F1154-63
Significance of CD 105 expression for tumour angiogenesis and prognosis in endometrial carcinomas.
Salvesen HB, Gulluoglu MG, Stefansson I, Akslen LA
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003 Nov;111(11):1011-8
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003 Nov;111(11):1011-8
Significance of CD 105 expression for tumour angiogenesis and prognosis in endometrial carcinomas.
Salvesen HB, Gulluoglu MG, Stefansson I, Akslen LA
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003 Nov;111(11):1011-8
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003 Nov;111(11):1011-8
Isolation and characterization of murine retinal endothelial cells.
Su X, Sorenson CM, Sheibani N
Molecular vision 2003 May 1;9:171-8
Molecular vision 2003 May 1;9:171-8
Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis.
Watnick RS, Cheng YN, Rangarajan A, Ince TA, Weinberg RA
Cancer cell 2003 Mar;3(3):219-31
Cancer cell 2003 Mar;3(3):219-31
Connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells by both GJIC-dependent and -independent mechanisms.
Qin H, Shao Q, Thomas T, Kalra J, Alaoui-Jamali MA, Laird DW
Cell communication & adhesion 2003 Jul-Dec;10(4-6):387-93
Cell communication & adhesion 2003 Jul-Dec;10(4-6):387-93
Connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells by both GJIC-dependent and -independent mechanisms.
Qin H, Shao Q, Thomas T, Kalra J, Alaoui-Jamali MA, Laird DW
Cell communication & adhesion 2003 Jul-Dec;10(4-6):387-93
Cell communication & adhesion 2003 Jul-Dec;10(4-6):387-93
Regulation of multiple tumor microenvironment markers by overexpression of single or paired combinations of ErbB receptors.
Alaoui-Jamali MA, Song DJ, Benlimame N, Yen L, Deng X, Hernandez-Perez M, Wang T
Cancer research 2003 Jul 1;63(13):3764-74
Cancer research 2003 Jul 1;63(13):3764-74
Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat.
Stenina OI, Krukovets I, Wang K, Zhou Z, Forudi F, Penn MS, Topol EJ, Plow EF
Circulation 2003 Jul 1;107(25):3209-15
Circulation 2003 Jul 1;107(25):3209-15
Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cells.
Liu X, Wu Z, Sheibani N, Brandt CR, Polansky JR, Kaufman PL
Experimental eye research 2003 Aug;77(2):181-8
Experimental eye research 2003 Aug;77(2):181-8
Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cells.
Liu X, Wu Z, Sheibani N, Brandt CR, Polansky JR, Kaufman PL
Experimental eye research 2003 Aug;77(2):181-8
Experimental eye research 2003 Aug;77(2):181-8
Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling.
Lopes N, Gregg D, Vasudevan S, Hassanain H, Goldschmidt-Clermont P, Kovacic H
Molecular and cellular biology 2003 Aug;23(15):5401-8
Molecular and cellular biology 2003 Aug;23(15):5401-8
Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice.
Flügel-Koch C, Ohlmann A, Piatigorsky J, Tamm ER
Developmental dynamics : an official publication of the American Association of Anatomists 2002 Oct;225(2):111-25
Developmental dynamics : an official publication of the American Association of Anatomists 2002 Oct;225(2):111-25
Characteristics of long-term survivors of untreated lung cancer.
Mattern J, Koomägi R, Volm M
Lung cancer (Amsterdam, Netherlands) 2002 Jun;36(3):277-82
Lung cancer (Amsterdam, Netherlands) 2002 Jun;36(3):277-82
Characteristics of long-term survivors of untreated lung cancer.
Mattern J, Koomägi R, Volm M
Lung cancer (Amsterdam, Netherlands) 2002 Jun;36(3):277-82
Lung cancer (Amsterdam, Netherlands) 2002 Jun;36(3):277-82
Investigation of the role of nitric oxide synthase 2 in pregnancy using mutant mice.
Burnett TG, Tash JS, Hunt JS
Reproduction (Cambridge, England) 2002 Jul;124(1):49-57
Reproduction (Cambridge, England) 2002 Jul;124(1):49-57
Investigation of the role of nitric oxide synthase 2 in pregnancy using mutant mice.
Burnett TG, Tash JS, Hunt JS
Reproduction (Cambridge, England) 2002 Jul;124(1):49-57
Reproduction (Cambridge, England) 2002 Jul;124(1):49-57
In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin.
Filla MS, Liu X, Nguyen TD, Polansky JR, Brandt CR, Kaufman PL, Peters DM
Investigative ophthalmology & visual science 2002 Jan;43(1):151-61
Investigative ophthalmology & visual science 2002 Jan;43(1):151-61
Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma.
Kragh M, Quistorff B, Tenan M, Van Meir EG, Kristjansen PE
Cancer research 2002 Feb 15;62(4):1191-5
Cancer research 2002 Feb 15;62(4):1191-5
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Rice AJ, Steward MA, Quinn CM
Journal of clinical pathology 2002 Dec;55(12):921-5
Journal of clinical pathology 2002 Dec;55(12):921-5
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Rice AJ, Steward MA, Quinn CM
Journal of clinical pathology 2002 Dec;55(12):921-5
Journal of clinical pathology 2002 Dec;55(12):921-5
T lymphocyte expression of thrombospondin-1 and adhesion to extracellular matrix components.
Li SS, Ivanoff A, Bergström SE, Sandström A, Christensson B, van Nerven J, Holgersson J, Hauzenberger D, Arencibia I, Sundqvist KG
European journal of immunology 2002 Apr;32(4):1069-79
European journal of immunology 2002 Apr;32(4):1069-79
Thrombospondin-1-mediated metastasis suppression by the primary tumor in human melanoma xenografts.
Rofstad EK, Graff BA
The Journal of investigative dermatology 2001 Nov;117(5):1042-9
The Journal of investigative dermatology 2001 Nov;117(5):1042-9
Association of thrombospondin-1 and cardiac allograft vasculopathy in human cardiac allografts.
Zhao XM, Hu Y, Miller GG, Mitchell RN, Libby P
Circulation 2001 Jan 30;103(4):525-31
Circulation 2001 Jan 30;103(4):525-31
Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?
Shi SR, Cote RJ, Hawes D, Thu S, Shi Y, Young LL, Taylor CR
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Apr;47(4):463-70
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Apr;47(4):463-70
Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?
Shi SR, Cote RJ, Hawes D, Thu S, Shi Y, Young LL, Taylor CR
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Apr;47(4):463-70
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Apr;47(4):463-70
No comments: Submit comment
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot of Thrombospondin using Thrombospondin Monoclonal Antibody (Product # MA5-13395) on HUVEC Cells.
- Conjugate
- Biotin
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Formalin-fixed, paraffin-embedded human placenta stained with Thrombospondin antibody using peroxidase-conjugate and AEC chromogen. Note staining of platelets in the blood vessels.
- Conjugate
- Biotin
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Conjugate
- Biotin
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Conjugate
- Biotin
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunoprecipitation of Thrombospondin using Thrombospondin Monoclonal Antibody (Product # MA5-13395) on Native Human HUVEC Cells.
- Conjugate
- Biotin
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig. 4 Thbs1 binds and activates a PERK-mediated ER stress response. a Representative western blots for ATF6alpha-N (50 kDa, nuclear), phospho-IRE1alpha (Ser 724; arrowhead), total IRE1alpha, phospho- and total PERK, phospho-eIF2alpha (Ser 51), total-eIF2alpha, ATF4, and DNAJC3. Phospho-PERK was analyzed using Phos-tag gels. The heart protein extracts are from the indicated mice at 4 weeks of age. Gapdh serves as a processing and loading control. b , c Western blot for Thbs1 and PERK following immunoprecipitation (IP) of PERK ( b ) or Thbs1 ( c ) from protein extracts of tTA cont. and Thbs1 DTG hearts at 6 weeks of age. IPs with corresponding IgG served as negative controls. Vinculin is an input loading control. d Schematic diagram of Thbs1 with the GST-Thbs1 fusion proteins regions shown (red bars). Below the schematic a representative western blot for PERK following GST pull-down with the different Thbs1 domains from primary neonatal rat ventricular cardiomyocyte extracts. GST protein serves as a negative control. e - i , Quantitative RT-PCR for Eif2ak3 (PERK protein; * P = 0.0317 vs tTA control), Atf4 (* P = 0.0006 vs tTA control), Atf3 (* P = 0.0058 vs tTA control), Ddit3 (Chop protein; * P < 0.0001 vs tTA control)) and Fgf21 (* P = 0.0023 vs tTA control) from mRNA isolated from hearts of tTA cont. (n = 6 biologically independent animals) and Thbs1 DTG mice (n = 5 biologically independent animals) at 6 weeks of age. Statistical analysis was performed using two-tailed Stud
- Conjugate
- Biotin
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 5--figure supplement 1. Patchy TSP1 immunoreactivity is endothelial and excluded from thoracic branch point orifices. ( A ) Whole-mount en face preparation of a mouse thoracic aorta immunostained for ITGA6, TSP1, and VEC. Scale bar is 200 uM. ( B ) Two sagittal sections ( b' and b'' ) of a mouse thoracic aorta demonstrate TSP1 expression in VEC+ arterial ECs. Sections were counterstained with DAPI to image nuclei. Scale bars are 20 uM.
- Conjugate
- Biotin
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 5. Identification of aEC1 as arterial ECs around the circumference of branch point orifices. ( A ) Barplots of scRNA-seq read counts for Nog , Itga6 , Alpl , Cldn5 , S100a4 , Thbs1 , and Vcam1 in arterial EC clusters (aEC1-6). Each bar represents a single cell, either GFP high (green) or GFP low (blue). ( B-H ) Confocal images of whole-mount en face preparations of mouse thoracic aortae centered on intercostal branch points. Immunostaining of S1PR1-GS mouse aortae for noggin (NOG) and CD31 ( B ), or integrin alpha-6 (ITGA6) and VE-Cadherin (VEC) ( C ). Immunostaining of C57BL/6J mouse aortae for CD31 and alkaline phosphatase, tissue-nonspecific isozyme (ALPL) ( D ) or claudin-5 (CLDN5), FSP1 (S100A4), and VEC ( E ). ( F ) Immunostaining of S1PR1-GS mouse aorta for ITGA6, thrombospondin 1 (TSP1), and VEC. Yellow arrows indicate TSP1+ ECs. ( G ) Immunostaining of an S1PR1-GS mouse aorta for FSP1 and TSP1. The circumference of an intercostal branch point harbors FSP1+GFP+ cells, wereas TSP1+GFP+ cells (cyan arrows) are distal from the circumference of the branch point orifice. ( H ) Immunostaining of a mouse aorta for vascular cell adhesion molecule 1 (VCAM1) and VEC. Two rows of cells exhibiting the morphology and VEC-localization of cells around branch point orifices are outlined. Images are representative of observations from 3 ( B, C, E-H ) and 2 ( D ) mice. Scale bars are 50 uM. Figure 5--figure supplement 1. Patchy TSP1 immunoreactivity is endothelial and excluded f
- Conjugate
- Biotin
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 7--figure supplement 3. Embryonic expression of ITGA6, TSP1, and aEC1-enriched and -depleted transcripts. ( A ) Aggregated E9.5 to E13.5 scRNA-seq data from Cao et al. (2019) is shown for Itga6 and Thbs1 . Red arrows indicate normalized gene expression in endothelial cells. ( B-D ) Sagittal cryosections (14 uM) of an E11.5 S1PR1-GS mouse embryo immunostained for CD31, TSP1 and ITGA6 and counterstained with DAPI, as labeled on each panel. The dorsal aorta, lung bud, and hepatic primordium are indicated in ( B ). ( C ) The boxed region of the dorsal aorta is shown at higher magnification with CD31, ITGA6, and GFP channels. Scale bars are 200 uM. ( D ) High power (40x) image of the dorsal aorta. Scale bar is 20 uM. ( E ) Expression of selected aEC1-enriched and -depleted transcripts in aggregated E9.5-E13.5 mouse embryonic endothelial cells (data from Cao et al., 2019 ).
- Conjugate
- Biotin
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 7. Spatio-temporal and molecular differences between branch point-specific arterial EC cluster aEC1 and non-branch point ECs. ( A ) Heatmap of selected transcription factors enriched and depleted in aEC1 cells (see also Figure 7--figure supplement 1A ). ( B ) Immunostaining of an S1PR1-GS mouse thoracic aorta for lymphoid enhancer-binding factor 1 (LEF1), ITGA6, and VEC. Image is representative of observations from two mice. Scale bar is 100 uM. ( C ) Immunostaining of postnatal day 6 ( P6 ) (n = 2) and 12 week (n = 3) S1PR1-GS mice thoracic aortae for ITGA6 and VEC. Arrows indicate non-branch point GFP+ EC. Scale bars are 100 uM. ( D ) Quantification of non-branch point GFP+ EC in thoracic aorta en face preparations from P6 (n = 2), P12 (n = 3), 3-4 month-old (n = 3), and 15 month old (n = 2) mice. Each dot is a field. Representative fields are shown in Figure 7--figure supplement 2 . Non-branch point GFP pixels were normalized to total VEC pixels per field. One-way ANOVA followed by Bonferroni's post hoc test, * P = 0.04; ** P = 0.04; *** P = 0.0008. ( E ) Representative images of TSP1 and VEC immunostaining of thoracic aorta en face preparations from P6, 3 month old, 15 month old mice. Scale bars are 200 uM. ( F ) Quantification of TSP1 pixels normalized to total VEC pixels per field from P6 (n = 3), 3 month old (n = 2), and 15 month old (n = 2) mice. One-way ANOVA followed by Bonferroni's post hoc test, ** P = 0.001; **** P < 0.0001. ( G ) Sagittal cryosection (14
- Conjugate
- Biotin