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- References [20]
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- Western blot [2]
- Immunohistochemistry [2]
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- Product number
- 19961-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- IGFBP7 antibody
- Antibody type
- Polyclonal
- Description
- IGFBP7 antibody (Cat. #19961-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti-PD-1 efficacy in bladder cancer.
Airway immune profiles and therapeutic implications of IGF1 in eosinophilic granulomatosis with polyangiitis.
Single-cell RNA sequencing analysis identified GARP-expressing myeloid cells that deteriorate postinfarct myocardial remodeling.
Comparison and Analysis of the Drug-Resistance Mechanism of Osimertinib- and Almonertinib-Resistant Cell Lines.
IGFBP2 plays a key role in aerobic exercise-mediated inhibition of ferroptosis in cardiac ischemia/reperfusion (I/R) injury.
IGFBP7 and CCT2 are novel lactylation-driven mediators of endothelial-to-mesenchymal transition in idiopathic pulmonary fibrosis.
Enteric GABAergic neuron-derived γ-aminobutyric acid initiates expression of Igfbp7 to sustain ILC3 homeostasis.
IGFBP7 inhibition relieves LPS induced nucleus pulposus cell injury by regulating the ERK1/2 pathway.
Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease.
Renal tubular epithelial IGFBP7 interacts with PKM2 to drive renal lipid accumulation and fibrosis.
IGFBP7 regulates cell proliferation and migration through JAK/STAT pathway in gastric cancer and is regulated by DNA and RNA methylation.
IGFBP7 promotes gastric cancer by facilitating epithelial-mesenchymal transition of gastric cells.
Exosomal Serum Biomarkers as Predictors for Laryngeal Carcinoma.
FERMT2 upregulation in CAFs enhances EMT of OSCC and M2 macrophage polarization.
The Circ_35953 induced by the NF-κB mediated the septic AKI via targeting miR-7219-5p/HOOK3 and IGFBP7 axis.
METTL3-mediated m(6)A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis.
IGFBP7-AS1 is a p53-responsive long noncoding RNA downregulated by Epstein-Barr virus that contributes to viral tumorigenesis.
MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract.
IGFBP7 contributes to epithelial-mesenchymal transition of HPAEpiC cells in response to radiation.
Mechanisms Underlying Increased TIMP2 and IGFBP7 Urinary Excretion in Experimental AKI.
Zhang C, Cao S, Zeng G, Dong Y, Li H, Ma X, Zhang X, Li Z, Huang Y
Scientific reports 2026 Mar 15;16(1)
Scientific reports 2026 Mar 15;16(1)
Airway immune profiles and therapeutic implications of IGF1 in eosinophilic granulomatosis with polyangiitis.
Dong C, Lu B, Zhong C, Ou C, Yang X, Wang L, Zuo X, Xue L, Lu C, Wang S, Wen J, Ma J, Deng Z, Liu Y, Ma L, Liu M, Lew AM, Mukherjee M, Nair P, Zhong N, Chen R, Chen Z, Zhang Y, Zhang Q
Nature communications 2026 Jan 7;17(1):1346
Nature communications 2026 Jan 7;17(1):1346
Single-cell RNA sequencing analysis identified GARP-expressing myeloid cells that deteriorate postinfarct myocardial remodeling.
Tomimatsu M, Obana M, Tanaka S, Kajiura R, Nagano R, Matsumoto K, Yokota K, Kominami S, Ito T, Suzuki S, Motooka D, Liu YC, Seno S, Okuzaki D, Nagatomo I, Maeda M, Fukada SI, Okada Y, Fujio Y
American journal of physiology. Heart and circulatory physiology 2026 Jan 1;330(1):H12-H30
American journal of physiology. Heart and circulatory physiology 2026 Jan 1;330(1):H12-H30
Comparison and Analysis of the Drug-Resistance Mechanism of Osimertinib- and Almonertinib-Resistant Cell Lines.
Zheng C, Ren Y, Wang K, Chen X, Tao J, Zhang C, Liu Z, Sun L, Zhai L
Analytical cellular pathology (Amsterdam) 2025;2025:5578693
Analytical cellular pathology (Amsterdam) 2025;2025:5578693
IGFBP2 plays a key role in aerobic exercise-mediated inhibition of ferroptosis in cardiac ischemia/reperfusion (I/R) injury.
Yang C, Meng X, Xia C, Sun Y, Ren Y, Wang J, Li Y, Wang X
Journal of translational medicine 2025 Oct 13;23(1):1080
Journal of translational medicine 2025 Oct 13;23(1):1080
IGFBP7 and CCT2 are novel lactylation-driven mediators of endothelial-to-mesenchymal transition in idiopathic pulmonary fibrosis.
Wenhao L, Ling H, Wanqing F, Wanrong W, Chao C, Ran W
Functional & integrative genomics 2025 Nov 20;25(1):250
Functional & integrative genomics 2025 Nov 20;25(1):250
Enteric GABAergic neuron-derived γ-aminobutyric acid initiates expression of Igfbp7 to sustain ILC3 homeostasis.
Liu N, He J, Yang Y, Wang Y, Zhang L, Xiao Z, Xiong Z, Zhong S, Xu Y, Gu Y, Wang J, Lan Y, Du Y, Zhu P, Zhang Z, Fan X, Liu B, Fan Z
Nature immunology 2025 Mar;26(3):404-415
Nature immunology 2025 Mar;26(3):404-415
IGFBP7 inhibition relieves LPS induced nucleus pulposus cell injury by regulating the ERK1/2 pathway.
Gao J, Gao C, Wang X, Wu M
Cytotechnology 2025 Jun;77(3):116
Cytotechnology 2025 Jun;77(3):116
Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease.
Yu JT, Hu XW, Wang JN, Yang Q, Li XY, Shan RR, Pu T, Hou R, Shen XY, Wang YQ, Zhang F, Yu XW, Wang J, Li FH, Wen JG, Fan Y, Jin J, Jiang YY, Meng XM
Nature communications 2025 Dec 1;17(1):30
Nature communications 2025 Dec 1;17(1):30
Renal tubular epithelial IGFBP7 interacts with PKM2 to drive renal lipid accumulation and fibrosis.
Yu JT, Xie SS, Shen XY, Li Z, Hu XW, Zhang Y, Dong ZH, Wang JN, Li XY, Dong YH, Li C, Ji ML, Suo XG, Yang C, Jin J, Wang W, Wen JG, Liu MM, Li L, Yang Q, Meng XM
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Aug 6;33(8):3757-3777
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Aug 6;33(8):3757-3777
IGFBP7 regulates cell proliferation and migration through JAK/STAT pathway in gastric cancer and is regulated by DNA and RNA methylation.
Mo W, Deng L, Cheng Y, Ge S, Wang J
Journal of cellular and molecular medicine 2024 Oct;28(19):e70080
Journal of cellular and molecular medicine 2024 Oct;28(19):e70080
IGFBP7 promotes gastric cancer by facilitating epithelial-mesenchymal transition of gastric cells.
Wang J, Wang X, Liu Z, Li S, Yin W
Heliyon 2024 May 30;10(10):e30986
Heliyon 2024 May 30;10(10):e30986
Exosomal Serum Biomarkers as Predictors for Laryngeal Carcinoma.
Schuster J, Wendler O, Pesold VV, Koch M, Sievert M, Balk M, Rupp R, Mueller SK
Cancers 2024 May 27;16(11)
Cancers 2024 May 27;16(11)
FERMT2 upregulation in CAFs enhances EMT of OSCC and M2 macrophage polarization.
Ma X, Zhao D, Liu S, Zuo J, Wang W, Wang F, Li Y, Ding Z, Wang J, Wang X
Oral diseases 2024 Apr;30(3):991-1003
Oral diseases 2024 Apr;30(3):991-1003
The Circ_35953 induced by the NF-κB mediated the septic AKI via targeting miR-7219-5p/HOOK3 and IGFBP7 axis.
Feng Y, Liu B, Chen J, Li H, Zhang D
Journal of cellular and molecular medicine 2023 May;27(9):1261-1276
Journal of cellular and molecular medicine 2023 May;27(9):1261-1276
METTL3-mediated m(6)A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis.
Tang Y, Hong F, Ding S, Yang J, Zhang M, Ma Y, Zheng Q, Yang D, Jin Y, Ma C
Cell reports 2023 Jun 27;42(6):112589
Cell reports 2023 Jun 27;42(6):112589
IGFBP7-AS1 is a p53-responsive long noncoding RNA downregulated by Epstein-Barr virus that contributes to viral tumorigenesis.
Dang W, Cao P, Yan Q, Yang L, Wang Y, Yang J, Xin S, Zhang J, Li J, Long S, Zhang W, Zhang S, Lu J
Cancer letters 2021 Dec 28;523:135-147
Cancer letters 2021 Dec 28;523:135-147
MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract.
Aryal S, Anand D, Hernandez FG, Weatherbee BAT, Huang H, Reddy AP, Wilmarth PA, David LL, Lachke SA
Human genetics 2020 Feb;139(2):151-184
Human genetics 2020 Feb;139(2):151-184
IGFBP7 contributes to epithelial-mesenchymal transition of HPAEpiC cells in response to radiation.
Zhong Y, Lin Z, Lin X, Lu J, Wang N, Huang S, Wang Y, Zhu Y, Shen Y, Jiang J, Lin S
Journal of cellular biochemistry 2019 Aug;120(8):12500-12507
Journal of cellular biochemistry 2019 Aug;120(8):12500-12507
Mechanisms Underlying Increased TIMP2 and IGFBP7 Urinary Excretion in Experimental AKI.
Johnson ACM, Zager RA
Journal of the American Society of Nephrology : JASN 2018 Aug;29(8):2157-2167
Journal of the American Society of Nephrology : JASN 2018 Aug;29(8):2157-2167
No comments: Submit comment
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse colon tissue were subjected to SDS PAGE followed by western blot with 19961-1-AP( IGFBP7 Antibody) at dilution of 1:300
- Validation comment
- WB
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 19961-1-AP( IGFBP7 Antibody) at dilution of 1:700
- Validation comment
- WB
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human liver tissue slide using 19961-1-AP( IGFBP7 Antibody) at dilution of 1:50 (under 40x lens)
- Validation comment
- IHC
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 19961-1-AP( IGFBP7 Antibody) at dilution of 1:50 (under 40x lens)
- Validation comment
- IHC
