TAB-509CL

antibody from Creative Biolabs

Targeting: MADCAM1 MACAM1

Immunohistochemistry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

TAB-509CL

Provider

Creative Biolabs

Product name

Anti-Human MADCAM1 Recombinant Antibody (PF-00547659)

Antibody type

Monoclonal

Description

Recombinant Humanized monoclonal antibody expressed in CHO binding to Human MADCAM1. PF-00547659 is an anti-human MAdCAM monoclonal antibody which has potential utility in the treatment of inflammatory conditions by blocking tissue homing of activated ¦Á4¦Â7+ leukocytes. The characterization of a rodent cross-reacting antibody as a surrogate for PF-00547659 in the search for potential pharmacological biomarkers and the determination of efficacious doses was effective in addressing the restricted orthologous cross-reactivity of PF-00547659 and the challenges this poses with respect to efficacy and safety testing.

Reactivity

Human

Storage

Store at 4¡ãC short term (1-2 weeks). Aliquot and store at -20¡ãC long term. Avoid repeated freeze/thaw cycles.