66594-1-Ig

antibody from Proteintech Group

Targeting: MADCAM1 MACAM1

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66594-1-Ig

Provider

Proteintech Group

Product name

MAdCAM1 antibody

Antibody type

Monoclonal

Description

MAdCAM1 antibody (Cat. #66594-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, IHC, ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2A12E8

Vial size

20ul, 150ul

References

Submitted references

Therapeutic targets established in adult ulcerative colitis exhibit correlations with disease severity and pathological relevance in pediatric pouchitis.

Otake S, Khorolgarav E, Yokobori T, Gombodorj N, Ogushi K, Suzuki N, Okami H, Zadeh SMM, Shiraishi T, Ozawa N, Dorjkhorloo G, Okada T, Sano A, Sakai M, Suzuki M, Kuwano H, Shirabe K, Saeki H
Scientific reports 2026 Feb 17;16(1)

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Association of Vascular Cell Adhesion Molecule-1 Expression in Colonic Mucosa With Mucosal Inflammation and Subsequent Relapse in Patients With Ulcerative Colitis.

Takagi T, Uchiyama K, Asaeda K, Murakami E, Inoue K, Mizushima K, Hirai Y, Naito Y, Itoh Y
Journal of gastroenterology and hepatology 2025 Jul;40(7):1719-1727

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Colonic Tissue Expression of MAdCAM-1 Is Not Predictive of Vedolizumab Responsiveness in Inflammatory Bowel Disease.

Reddy N, Klein JA, Thomas N, Micic D, Deng Z, Rubin DT, Cohen RD, Dalal S, Christensen B, Haider HI, Valuckaite V, Meckel KR, Bissonnette M, Weber CR, Pekow J
Clinical and translational science 2025 Dec;18(12):e70422

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Tumor-associated high endothelial venules are associated with enhanced lymphocyte infiltration and favorable prognosis in resected hepatocellular carcinoma.

Aoyama S, Noda T, Akita H, Mukai Y, Sasaki K, Hasegawa S, Yamada D, Tomimaru Y, Asaoka T, Takahashi H, Kobayashi S, Shimizu J, Ueyama A, Saito T, Kido K, Morii E, Wada H, Doki Y, Eguchi H
Cancer immunology, immunotherapy : CII 2025 Dec 19;75(1):20

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MAdCAM-1 targeting strategy can prevent colitic cancer carcinogenesis and progression via suppression of immune cell infiltration and inflammatory signals.

Ozawa N, Yokobori T, Osone K, Bilguun EO, Okami H, Shimoda Y, Shiraishi T, Okada T, Sano A, Sakai M, Sohda M, Miyazaki T, Ide M, Ogawa H, Yao T, Oyama T, Shirabe K, Saeki H
International journal of cancer 2024 Jan 15;154(2):359-371

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Mucosal Addressin Cell Adhesion Molecule 1 Expression Reflects Mucosal Inflammation and Subsequent Relapse in Patients with Ulcerative Colitis.

Uchiyama K, Takagi T, Mizushima K, Hirai Y, Asaeda K, Sugaya T, Kajiwara-Kubota M, Kashiwagi S, Minagawa Y, Hotta Y, Tanaka M, Inoue K, Katada K, Kamada K, Ishikawa T, Yasuda H, Konishi H, Kishimoto M, Naito Y, Itoh Y
Journal of Crohn's & colitis 2023 May 3;17(5):786-794