MMP1

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Description

Matrix metallopeptidase 1

Tissue specificity

Tissue enhanced (gallbladder, stomach , urinary bladder)

Subcell location

Vesicles

Predicted location

Secreted to extracellular matrix

Protein family

Cancer-related genes
Candidate cardiovascular disease genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (102789401 - 102798160)

Ensembl ID

ENSG00000196611  (ver. 103.38)

Orthologs

-

UniProt

P03956

neXtProt

NX_P03956

Human splice variants

Protein structure