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Cell line expression
Protein structure
APAF1
Apoptotic peptidase activating factor 1APAF-1, CED4
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  21710-1-AP |
43 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | 21710-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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| Novus Biologicals | NBP1-77000 |
2 references | Polyclonal |
WB
EL
ICC
IHC
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| LSBio | LS-C285 |
Polyclonal |
WB
EL
IHC
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| antibodies-online | ABIN400811 |
4 references | Monoclonal |
WB
EL
ICC
IHC
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