RACGAP1

This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]

Description

Rac GTPase activating protein 1

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue, testis)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (49976923 - 50033136)

Ensembl ID

ENSG00000161800  (ver. 103.38)

Orthologs

Mouse Racgap1: ENSMUSG00000023015

UniProt

Q9H0H5

neXtProt

NX_Q9H0H5

Human splice variants
Mouse splice variants

Protein structure