PCSK6

gene product
PACE4, SPC4
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]
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246 antibodies from 29 providers.

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AntibodyRefsTypeAVIWBELICCIPIHCFC
Novus Biologicals
7 antibodies
antibodies-online
66 antibodies
Enzo Life Sciences
1 antibody
Atlas Antibodies
1 antibody
Abgent
9 antibodies
Antibodies.com
1 antibody
LifeSpan BioSciences, Inc.
35 antibodies
Biorbyt
10 antibodies
Invitrogen Antibodies
7 antibodies
Acris Antibodies GmbH
5 antibodies
NSJ Bioreagents
3 antibodies
Everest Biotech
2 antibodies
OriGene
9 antibodies
Aviva Systems Biology
6 antibodies
Abnova Corporation
5 antibodies
GeneTex
3 antibodies
Arigo
1 antibody
ProSci
5 antibodies
St John's Laboratory
2 antibodies
Creative Diagnostics
3 antibodies
MyBioSource
6 antibodies
Creative Biolabs
2 antibodies
Boster Biological Technology
1 antibody
RayBiotech, Inc.
6 antibodies
Sigma-Aldrich
5 antibodies
RabMAbs
1 antibody
United States Biological
42 antibodies
Exalpha Biologicals, Inc.
1 antibody
GenWay
1 antibody