14291-1-AP

antibody from Proteintech Group

Targeting: REN

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

14291-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#14291-1-AP, RRID:AB_10695894

Product name

Renin antibody

Antibody type

Polyclonal

Description

Renin antibody (Cat. #14291-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Abnormal epigenetic memory of mesenchymal stem and progenitor cells caused by fetal malnutrition induces hypertension and renal injury in adulthood.

Shimizu S, Fukuda N, Chen L, Matsumoto T, Kaneda A, Endo M, Nishiyama A, Morioka I
Hypertension research : official journal of the Japanese Society of Hypertension 2024 Sep;47(9):2405-2415

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Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis.

Zhou L, Chen S, Wei Y, Sun Y, Yang Y, Lin B, Li Y, Wang C
European journal of pharmacology 2024 Mar 15;967:176365

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Neuropilin-1 regulates renin synthesis in juxtaglomerular cells.

Shen Y, Lotenberg K, Zaworski J, Broeker KA, Vasseur F, Louedec L, Placier S, Frère P, Verpont MC, Galichon P, Buob D, Hadchouel J, Terzi F, Chatziantoniou C, Calmont A
The Journal of physiology 2024 Apr;602(8):1815-1833

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Exogenous H(2)S Attenuates Hypertension by Regulating Renin Exocytosis under Hyperglycaemic and Hyperlipidaemic Conditions.

Liu N, Li M, Liu S, Kang J, Chen L, Huang J, Wang Y, Chen H, Zhang W
International journal of molecular sciences 2023 Jan 14;24(2)

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Lysine malonylation of DgnsLIPID TRANSFER PROTEIN1 at the K81 site improves cold resistance in chrysanthemum.

Liao X, Zhang X, Li X, Tian Y, Yang Q, Wang Y, Tang S, Luo X, Zhang F, Zhang L, Jiang B, Liu Q
Plant physiology 2023 Aug 3;192(4):3152-3169

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Novel intrauterine growth retardation model: effects of maternal subtotal nephrectomy on neonates.

Ogawa S, Yana T, Kondo T, Okada T
The Journal of veterinary medical science 2022 Sep 12;84(9):1261-1264

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Essential role of Wtip in mouse development and maintenance of the glomerular filtration barrier.

Madhavan SM, Konieczkowski M, Bruggeman LA, DeWalt M, Nguyen JK, O'Toole JF, Sedor JR
American journal of physiology. Renal physiology 2022 Sep 1;323(3):F272-F287

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Silencing of Central (Pro)renin Receptor Ameliorates Salt-Induced Renal Injury in Chronic Kidney Disease.

Li J, Liang M, Zeng T, Qiu M, Zhang M, Jiang S, Tan L, Li A
Antioxidants & redox signaling 2021 Jul 10;35(2):93-112

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Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System.

Siljee S, Buchanan O, Brasch HD, Bockett N, Patel J, Paterson E, Purdie GL, Davis PF, Itinteang T, Tan ST
Cells 2021 Jan 27;10(2)

---

Expression of Components of the Renin-Angiotensin System by Cancer Stem Cells in Renal Clear Cell Carcinoma.

Siljee S, Milne B, Brasch HD, Bockett N, Patel J, Davis PF, Kennedy-Smith A, Itinteang T, Tan ST
Biomolecules 2021 Apr 7;11(4)

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Cancer Stem Cells in Head and Neck Metastatic Malignant Melanoma Express Components of the Renin-Angiotensin System.

Siljee S, Pilkington T, Brasch HD, Bockett N, Patel J, Paterson E, Davis PF, Tan ST
Life (Basel, Switzerland) 2020 Nov 2;10(11)

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Role of complement 3 in renin generation during the differentiation of mesenchymal stem cells to smooth muscle cells.

Chen L, Fukuda N, Shimizu S, Kobayashi H, Tanaka S, Nakamura Y, Matsumoto T, Abe M
American journal of physiology. Cell physiology 2020 May 1;318(5):C981-C990

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Increased Complement 3 With Suppression of miR-145 Induces the Synthetic Phenotype in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats.

Chen L, Fukuda N, Otsuki T, Tanaka S, Nakamura Y, Kobayashi H, Matsumoto T, Abe M
Journal of the American Heart Association 2019 May 21;8(10):e012327

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Neonatal nephron loss during active nephrogenesis - detrimental impact with long-term renal consequences.

Menendez-Castro C, Nitz D, Cordasic N, Jordan J, Bäuerle T, Fahlbusch FB, Rascher W, Hilgers KF, Hartner A
Scientific reports 2018 Mar 14;8(1):4542

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Novel inhibitors of the cellular renin-angiotensin system components, poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis.

Wang M, Chen DQ, Chen L, Cao G, Zhao H, Liu D, Vaziri ND, Guo Y, Zhao YY
British journal of pharmacology 2018 Jul;175(13):2689-2708

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Novel RAS Inhibitors Poricoic Acid ZG and Poricoic Acid ZH Attenuate Renal Fibrosis via a Wnt/β-Catenin Pathway and Targeted Phosphorylation of smad3 Signaling.

Wang M, Chen DQ, Chen L, Liu D, Zhao H, Zhang ZH, Vaziri ND, Guo Y, Zhao YY, Cao G
Journal of agricultural and food chemistry 2018 Feb 28;66(8):1828-1842

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Involvement of complement 3 in the salt-sensitive hypertension by activation of renal renin-angiotensin system in spontaneously hypertensive rats.

Negishi E, Fukuda N, Otsuki T, Katakawa M, Komatsu K, Chen L, Tanaka S, Kobayashi H, Hatanaka Y, Ueno T, Endo M, Mashimo T, Nishiyama A, Abe M
American journal of physiology. Renal physiology 2018 Dec 1;315(6):F1747-F1758

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Urotensin II Exerts Pressor Effects By Stimulating Renin And Aldosterone Synthase Gene Expression.

Caroccia B, Menegolo M, Seccia TM, Petrelli L, Antonello M, Limena A, Porzionato A, De Caro R, Poglitsch M, Rossi GP
Scientific reports 2017 Oct 24;7(1):13876

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Pericytic tumors of the kidney-a clinicopathologic analysis of 17 cases.

Sirohi D, Smith SC, Epstein JI, Balzer BL, Simko JP, Balitzer D, Benhamida J, Kryvenko ON, Gupta NS, Paluru S, da Cunha IW, Leal DN, Williamson SR, de Peralta-Venturina M, Amin MB
Human pathology 2017 Jun;64:106-117

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Dysregulation of Aldosterone Secretion in Mast Cell-Deficient Mice.

Boyer HG, Wils J, Renouf S, Arabo A, Duparc C, Boutelet I, Lefebvre H, Louiset E
Hypertension (Dallas, Tex. : 1979) 2017 Dec;70(6):1256-1263

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Role of RAS/Wnt/β-catenin axis activation in the pathogenesis of podocyte injury and tubulo-interstitial nephropathy.

Chen L, Chen DQ, Wang M, Liu D, Chen H, Dou F, Vaziri ND, Zhao YY
Chemico-biological interactions 2017 Aug 1;273:56-72

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Juxtaglomerular cell tumor that was preoperatively diagnosed using selective renal venous sampling.

Osawa S, Hosokawa Y, Soda T, Yasuda T, Kaneto H, Kitamura T, Kozawa J, Otsuki M, Imagawa A, Okumi M, Miyagawa Y, Nonomura N, Shimomura I
Internal medicine (Tokyo, Japan) 2013;52(17):1937-42

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse heart tissue were subjected to SDS PAGE followed by western blot with 14291-1-AP(REN antibody) at dilution of 1:300

Sample type

tissue

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using REN antibody 14291-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

Sample type

cell line