STIM2

This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]

Description

stromal interaction molecule 2

Protein family

Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

4:p15.2 (26857678 - 27025381)

Ensembl ID

ENSG00000109689  (ver. 84.38)

Orthologs

Mouse Stim2: ENSMUSG00000039156

UniProt

Q9P246

neXtProt

NX_Q9P246

Human splice variants
Mouse splice variants