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- References [13]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 21192-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21192-1-AP, RRID:AB_10734322
- Product name
- STIM2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated STIM2 antibody (Cat. #21192-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Tibial cortex transverse transport regulates Orai1/STIM1-mediated NO release and improve the migration and proliferation of vessels via increasing osteopontin expression.
STIM1 mediates methamphetamine-induced neuronal autophagy and apoptosis.
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons.
Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate.
Deficiency of ER Ca(2+) sensor STIM1 in AgRP neurons confers protection against dietary obesity.
A short isoform of STIM1 confers frequency-dependent synaptic enhancement.
Resveratrol sensitizes A549 cells to irradiation damage via suppression of store-operated calcium entry with Orai1 and STIM1 downregulation.
RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
Inhibiting store-operated calcium entry attenuates white matter secondary degeneration following SCI.
Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks.
The calcium channel proteins ORAI3 and STIM1 mediate TGF-β induced Snai1 expression.
STIM1 and STIM2 differently regulate endogenous Ca(2+) entry and promote TGF-β-induced EMT in breast cancer cells.
STIM1 negatively regulates Ca²⁺ release from the sarcoplasmic reticulum in skeletal myotubes.
Kong L, Li Y, Deng Z, Chen X, Xia Y, Shen B, Ning R, Zhang L, Yin Z
Journal of orthopaedic translation 2024 Mar;45:107-119
Journal of orthopaedic translation 2024 Mar;45:107-119
STIM1 mediates methamphetamine-induced neuronal autophagy and apoptosis.
Tian Q, Zhou J, Xu Z, Wang B, Liao J, Duan K, Li X, Huang E, Xie WB
Neurotoxicology 2024 Jul;103:134-145
Neurotoxicology 2024 Jul;103:134-145
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons.
Serwach K, Nurowska E, Klukowska M, Zablocka B, Gruszczynska-Biegala J
Cellular and molecular life sciences : CMLS 2023 Nov 21;80(12):368
Cellular and molecular life sciences : CMLS 2023 Nov 21;80(12):368
Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate.
Hu A, Zhang JZ, Wang J, Li CC, Yuan M, Deng G, Lin ZC, Qiu ZP, Liu HY, Wang XW, Wei PC, He X, Zhao X, Qiu WW, Song BL
Cell research 2022 Mar;32(3):288-301
Cell research 2022 Mar;32(3):288-301
Deficiency of ER Ca(2+) sensor STIM1 in AgRP neurons confers protection against dietary obesity.
Chen Z, Pan S, Yin K, Zhang Y, Yuan X, Wang S, Yang S, Shen Q, Tang Y, Li J, Wang Y, Lu Y, Zhang G
Cell reports 2021 Oct 19;37(3):109868
Cell reports 2021 Oct 19;37(3):109868
A short isoform of STIM1 confers frequency-dependent synaptic enhancement.
Ramesh G, Jarzembowski L, Schwarz Y, Poth V, Konrad M, Knapp ML, Schwär G, Lauer AA, Grimm MOW, Alansary D, Bruns D, Niemeyer BA
Cell reports 2021 Mar 16;34(11):108844
Cell reports 2021 Mar 16;34(11):108844
Resveratrol sensitizes A549 cells to irradiation damage via suppression of store-operated calcium entry with Orai1 and STIM1 downregulation.
Lele W, Lei L, Liting Q
Experimental and therapeutic medicine 2021 Jun;21(6):587
Experimental and therapeutic medicine 2021 Jun;21(6):587
RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
Wendimu MY, Alqinyah M, Vella S, Dean P, Almutairi F, Davila-Rivera R, Rayatpisheh S, Wohlschlegel J, Moreno S, Hooks SB
Cellular signalling 2021 Jul;83:109974
Cellular signalling 2021 Jul;83:109974
Inhibiting store-operated calcium entry attenuates white matter secondary degeneration following SCI.
Orem BC, Partain SB, Stirling DP
Neurobiology of disease 2020 Mar;136:104718
Neurobiology of disease 2020 Mar;136:104718
Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks.
Stein BD, Calzolari D, Hellberg K, Hu YS, He L, Hung CM, Toyama EQ, Ross DS, Lillemeier BF, Cantley LC, Yates JR 3rd, Shaw RJ
Cell reports 2019 Dec 3;29(10):3331-3348.e7
Cell reports 2019 Dec 3;29(10):3331-3348.e7
The calcium channel proteins ORAI3 and STIM1 mediate TGF-β induced Snai1 expression.
Bhattacharya A, Kumar J, Hermanson K, Sun Y, Qureshi H, Perley D, Scheidegger A, Singh BB, Dhasarathy A
Oncotarget 2018 Jun 29;9(50):29468-29483
Oncotarget 2018 Jun 29;9(50):29468-29483
STIM1 and STIM2 differently regulate endogenous Ca(2+) entry and promote TGF-β-induced EMT in breast cancer cells.
Zhang S, Miao Y, Zheng X, Gong Y, Zhang J, Zou F, Cai C
Biochemical and biophysical research communications 2017 Jun 17;488(1):74-80
Biochemical and biophysical research communications 2017 Jun 17;488(1):74-80
STIM1 negatively regulates Ca²⁺ release from the sarcoplasmic reticulum in skeletal myotubes.
Lee KJ, Woo JS, Hwang JH, Hyun C, Cho CH, Kim DH, Lee EH
The Biochemical journal 2013 Jul 15;453(2):187-200
The Biochemical journal 2013 Jul 15;453(2):187-200
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 21192-1-AP(STIM2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 21192-1-AP(STIM2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The STIM2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human STIM2. This antibody recognizes human,mouse,rat antigen. The STIM2 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
