67512-1-Ig

antibody from Proteintech Group

Targeting: ABCB11 ABC16, BSEP, PFIC-2, PFIC2, PGY4, SPGP

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

67512-1-Ig

Provider

Proteintech Group

Product name

BSEP antibody

Antibody type

Monoclonal

Description

BSEP antibody (Cat. #67512-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3C11D5

Vial size

20ul, 150ul

References

Submitted references

Ameliorative Effect of Glycyrrhizic Acid on Diosbulbin B-Induced Liver Injury and Its Mechanism.

Wang X, Shi LL, Zhang YH, Zhu HZ, Cao SS, Shi Y, Shangguan HZ, Liu JP, Xie YD
The American journal of Chinese medicine 2025;53(1):309-335

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Capsaicin ameliorates cholestasis through modulation of the FXR-SHP and FXR-FGF15 gut-liver axis in mice.

Du H, Luo Y, Zhou N, Wang T, Wang R, Wang Y, Lv C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157130

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Silymarin ameliorates diet-induced gallstone formation by regulating gut microbiota-derived GCDCA to suppress ferroptosis-ROS-NFκB signaling pathway.

Wang Q, Han C, Zheng Y, Liu X, Lv Z, Du Z, Liu T, Hao C, Meng X, Li T, Xue D
Free radical biology & medicine 2025 Nov;239:496-512

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Fisetin ameliorates atherosclerosis through activating FXR-mediated hepatic cholesterol metabolism and transintestinal cholesterol excretion.

Guo Y, Shu G, Zhang Z, Hu X, Huang H, Lu W, Zhu M, Liu B, Zhang S
Food research international (Ottawa, Ont.) 2025 Nov;219:117002

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Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by attenuating the malignancy of cancer stem cells via the gut microbiota-bile acid-FXR axis.

Zhang Y, Shen M, Baokan J, Xu L, Ni M, Jin J, Shen W, Sun D, Li L, Lai Y, Yan Q, Yu C, Tan J, Xu C, Tao L, Fan M, Cheng H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157366

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Targeted cellular depletion in an immune-liver-on-a-chip platform elucidates cell-type-specific heterogeneity in drug-induced hepatotoxicity.

Yuan S, Zhang P, Yang S, Chen J, Mu X, Wu C, Deng J
Communications biology 2025 Nov 13;8(1):1560

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Gut Microbiota and Bile Acid Metabolism in the Mechanism of Ginsenoside Re Against Nonalcoholic Fatty Liver Disease.

Zheng Y, Chen J, Zhang Y, Guan H, Deng S, Chang D, Wang Y, Lu J, Zhou X, Xie Q, Song J, Huang M
Phytotherapy research : PTR 2025 May;39(5):2339-2356

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Qingre Sanjie Formula alleviates atherosclerosis by promoting LXR-α/ABCG5/G8-mediated reverse cholesterol transport and bile acid synthesis.

Li X, Huang X, Song K, Liu J, Jin Y, Li T, Zhang L, Zhang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156691

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Geniposidic Acid Targeting FXR "S332 and H447" Mediated Conformational Change to Upregulate CYPs and miR-19a-3p to Ameliorate Drug-Induced Liver Injury.

Fan M, Xu Y, Wu B, Long J, Liu C, Liang Z, Zhang R, Liu Z, Wang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2409107

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Pirfenidone ameliorates ANIT-induced cholestatic liver injury via modulation of FXR, NF-кB/TNF-α, and Wnt/GSK-3β/β-catenin signaling pathways.

Abdulaal WH, Omar UM, Zeyadi M, El-Agamy DS, Alhakamy NA, Ibrahim SRM, Almalki NAR, Asfour HZ, Al-Rabia MW, Mohamed GA, Elshal M
Toxicology and applied pharmacology 2024 Sep;490:117038

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ROS-responsive nanoparticle delivery of obeticholic acid mitigate primary sclerosing cholangitis.

Yao Q, Wang B, Yu J, Pan Q, Yu Y, Feng X, Chen W, Yang J, Gao C, Cao H
Journal of controlled release : official journal of the Controlled Release Society 2024 Oct;374:112-126

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Neoagarotetraose Alleviates Atherosclerosis via Modulating Cholesterol and Bile Acid Metabolism in ApoE(-/-) Mice.

Li J, Yang S, Liu D, Yan Q, Guo H, Jiang Z
Nutrients 2024 May 16;16(10)

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Bacteroides fragilis alleviates necrotizing enterocolitis through restoring bile acid metabolism balance using bile salt hydrolase and inhibiting FXR-NLRP3 signaling pathway.

Chen Z, Chen H, Huang W, Guo X, Yu L, Shan J, Deng X, Liu J, Li W, Shen W, Fan H
Gut microbes 2024 Jan-Dec;16(1):2379566

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Sphincter of Oddi Dysfunction Induces Gallstone by Inhibiting the Expression of ABCB11 via PKC-α.

Zhu L, Su W, Xu X, Shao S, Qin C, Gao R, Wang X, Ma M, Gao J, Zhang Z
Applied biochemistry and biotechnology 2024 Aug;196(8):5373-5390

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Lupeol improves bile acid metabolism and metabolic dysfunction-associated steatotic liver disease in mice via FXR signaling pathway and gut-liver axis.

Qin D, Pan P, Lyu B, Chen W, Gao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116942

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Vitamin C and vitamin D(3) alleviate metabolic-associated fatty liver disease by regulating the gut microbiota and bile acid metabolism via the gut-liver axis.

Chen Q, Zhao L, Mei L, Zhao X, Han P, Liu J, Meng C, Li R, Zhong R, Wang K, Li J
Frontiers in pharmacology 2023;14:1163694