orb1823842

antibody from Biorbyt
Targeting: ABCB11 ABC16, BSEP, PFIC-2, PFIC2, PGY4, SPGP
Provider product page for orb1823842
Western blot
Immunohistochemistry

Antibody data

Product number
orb1823842 - Provider product page
Provider
Biorbyt
Product name
BSEP Antibody / Bile Salt Export Pump / ABCB11
Antibody type
Monoclonal
Description
ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of proteins that catalyze the transport of molecules across extra- and intracellular membranes through the energy of ATP hydrolysis. ABC genes comprise seven subfamilies, designated ABC1, Mdr/TAP, MRP, ALD, OABP, GCN20 and White. The secretion of bile salt molecules from blood into bile is a major driving force for bile formation. Bile salt export pump (BSEP) is a member of the Mdr/TAP subfamily of ABC transporters that mediates the transport of bile acids across the hepatocyte canalicular membrane and regulates bile acid-dependent bile secretion. BSEP contains putative phosphorylation sites for protein kinase A, protein kinase C (PKC) and Ca2+-calmodulin dependent kinase II, whose regulation may be dependent on bile salt concentration.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
BSEP/7534
Vial size
100 ug
Storage
Aliquot the BSEP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
ABCB11 protein structure - orb1823842 shown in red.