130-10066-100

antibody from RayBiotech, Inc.

Targeting: BIRC3 API2, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

130-10066-100

Provider

RayBiotech, Inc.

Product name

Rabbit Anti-Human TNi

Antibody type

Polyclonal

Antigen

Recombinant protein derived from human TnI.

Description

Troponin I, one of 3 subunits that form the troponin complex of the thin filaments of striated muscle, is the inhibitory component of troponin. Troponin, in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits: the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI) . Unlike other contractile proteins, the cardiac isoform of troponin I (TnIc) is expressed only in cardiac muscle and therefore offers a model for cardiac-specific expression. It is also subject to developmental regulation with increased expression occurring at the time of birth. TnIc, a sensitive and specific marker of myocardial cell injury, is useful in diagnosing and assessing prognosis in acute coronary syndromes. Studies report that TnIc is elevated in severe heart failure and may predict adverse outcomes. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum by ammonium sulphate precipitation followed by Protein A/G affinity chromatography.

Reactivity

Human

Host

Rabbit

Antigen sequence

This antibody was produced from a r
abbit immunized with the immunogen.
The IgG fraction was purified from
rabbit serum by ammonium sulphate
precipitation followed by Protein A
/G affinity chromatography.


Isotype

IgG

Vial size

100 µg

Handling

Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile 1x PBS to a final concentration of 1 mg/ml.