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Protein structure
SPRY2
Sprouty RTK signaling antagonist 2hSPRY2
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Novus Biologicals |  H00010253-M01 |
3 references | Monoclonal |
WB
EL
ICC
IHC
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| Abnova Corporation | H00010253-M01 |
3 references | Monoclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN564439 |
3 references | Monoclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | PA5-98172 |
1 references | Polyclonal |
WB
EL
ICC
IHC
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| Proteintech Group | 11383-1-AP |
Polyclonal |
WB
EL
ICC
IHC
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