BS5592

antibody from Bioworld Technology, Inc

Targeting: TNFAIP3 A20, OTUD7C

Immunocytochemistry

Antibody data

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Validation data

Product number: BS5592 - Provider product page
Provider: Bioworld Technology, Inc
Product name: TNFAIP3 polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 365-410 of Human TNFAIP3.
Description: A20, also referred to as TNF-Ï«-induced protein 3 (TNFAIP3), is cytokine-inducible protein that functions to inhibit apoptosis and activate NF-°ÙB. It was first identified as a TNF-Ï« inducible primary response gene in human umbilical vein endothelial cells, and encodes a 790-amino acid protein containing seven Cys2/Cys2-zinc finger motifs. Constitutive expression of A20 is observed in lymphoid tissues, but it is transiently expressed in a variety of cell types in response to inflammatory signals such as TNF-Ï«, IL-1, phorbol esters, and LPS. Expression of A20 can confer resistance to apoptosis and NF-°ÙB activation triggered by these signals, probably through interference with TRAF (TNF receptor associated factor) family members, and interaction with the NF-°ÙB inhibiting protein ABIN.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

TNFAIP3 protein structure - BS5592 shown in red.