Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-L744 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Rabbit Anti-Human TNFAIP3 monoclonal antibody, clone TO18-42
- Antibody type
- Monoclonal
- Description
- A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor °Ù B (NF°ÙB) gene expression. By inhibiting NF°ÙB activation, A20 plays a critical role in terminating NF°ÙB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NF°ÙB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and I°ÙB kinase (IKK) ÎÛ protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- TO18-42
- Vial size
- 100 _l
- Storage
- Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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