NB110-57130
antibody from Novus Biologicals
Targeting: TERF2
TRBF2, TRF2
Antibody data
- Antibody Data
- Antigen structure
- References [69]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [3]
- Flow cytometry [1]
- Chromatin Immunoprecipitation [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- NB110-57130 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB110-57130, RRID:AB_844199
- Product name
- Rabbit Polyclonal TRF-2 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres.
Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection.
Telomerase promotes formation of a telomere protective complex in cancer cells.
Condensin II subunit NCAPH2 associates with shelterin protein TRF1 and is required for telomere stability.
Telomere repeat-binding factor 2 binds extensively to extra-telomeric G-quadruplexes and regulates the epigenetic status of several gene promoters.
TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity.
ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells.
FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis.
TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1.
SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing.
Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.
Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends.
The C-Terminal Extension Unique to the Long Isoform of the Shelterin Component TIN2 Enhances Its Interaction with TRF2 in a Phosphorylation- and Dyskeratosis Congenita Cluster-Dependent Fashion.
SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage.
CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length.
The Use of 3D Telomere FISH for the Characterization of the Nuclear Architecture in EBV-Positive Hodgkin's Lymphoma.
Distinct TERB1 Domains Regulate Different Protein Interactions in Meiotic Telomere Movement.
Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.
Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation.
TZAP: A telomere-associated protein involved in telomere length control.
E-type cyclins modulate telomere integrity in mammalian male meiosis.
Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma.
A role for Separase in telomere protection.
The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence.
Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis.
MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.
Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells.
BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function.
RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells.
TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends.
Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.
c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA.
The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis.
T-oligo as an anticancer agent in colorectal cancer.
Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma.
Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas.
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.
PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells.
Metastases suppressor NME2 associates with telomere ends and telomerase and reduces telomerase activity within cells.
A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.
Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.
Five dysfunctional telomeres predict onset of senescence in human cells.
Cohesin SMC1beta protects telomeres in meiocytes.
Telomere protection by mammalian Pot1 requires interaction with Tpp1.
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase.
MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres.
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end.
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint.
Homologous recombination generates T-loop-sized deletions at human telomeres.
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex.
Significant role for p16INK4a in p53-independent telomere-directed senescence.
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
DNA damage foci at dysfunctional telomeres.
DNA damage foci at dysfunctional telomeres.
POT1 as a terminal transducer of TRF1 telomere length control.
Rap1 affects the length and heterogeneity of human telomeres.
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.
Different telomere damage signaling pathways in human and mouse cells.
Different telomere damage signaling pathways in human and mouse cells.
Tankyrase promotes telomere elongation in human cells.
Tankyrase promotes telomere elongation in human cells.
Control of human telomere length by TRF1 and TRF2.
Control of human telomere length by TRF1 and TRF2.
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.
Porreca RM, Herrera-Moyano E, Skourti E, Law PP, Gonzalez Franco R, Montoya A, Faull P, Kramer H, Vannier JB
eLife 2020 Jan 14;9
eLife 2020 Jan 14;9
Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection.
Masamsetti VP, Low RRJ, Mak KS, O'Connor A, Riffkin CD, Lamm N, Crabbe L, Karlseder J, Huang DCS, Hayashi MT, Cesare AJ
Nature communications 2019 Sep 17;10(1):4224
Nature communications 2019 Sep 17;10(1):4224
Telomerase promotes formation of a telomere protective complex in cancer cells.
Perera ON, Sobinoff AP, Teber ET, Harman A, Maritz MF, Yang SF, Pickett HA, Cesare AJ, Arthur JW, MacKenzie KL, Bryan TM
Science advances 2019 Oct;5(10):eaav4409
Science advances 2019 Oct;5(10):eaav4409
Condensin II subunit NCAPH2 associates with shelterin protein TRF1 and is required for telomere stability.
Wallace HA, Rana V, Nguyen HQ, Bosco G
Journal of cellular physiology 2019 Nov;234(11):20755-20768
Journal of cellular physiology 2019 Nov;234(11):20755-20768
Telomere repeat-binding factor 2 binds extensively to extra-telomeric G-quadruplexes and regulates the epigenetic status of several gene promoters.
Mukherjee AK, Sharma S, Bagri S, Kutum R, Kumar P, Hussain A, Singh P, Saha D, Kar A, Dash D, Chowdhury S
The Journal of biological chemistry 2019 Nov 22;294(47):17709-17722
The Journal of biological chemistry 2019 Nov 22;294(47):17709-17722
TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity.
Pike AM, Strong MA, Ouyang JPT, Greider CW
Molecular and cellular biology 2019 Nov 1;39(21)
Molecular and cellular biology 2019 Nov 1;39(21)
ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells.
Wu Y, Li X, Yu J, Björkholm M, Xu D
Cell death & disease 2019 Jan 28;10(2):76
Cell death & disease 2019 Jan 28;10(2):76
FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis.
Hua R, Wei H, Liu C, Zhang Y, Liu S, Guo Y, Cui Y, Zhang X, Guo X, Li W, Liu M
Nucleic acids research 2019 Dec 16;47(22):11755-11770
Nucleic acids research 2019 Dec 16;47(22):11755-11770
TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1.
Episkopou H, Diman A, Claude E, Viceconte N, Decottignies A
Molecular cell 2019 Aug 8;75(3):469-482.e6
Molecular cell 2019 Aug 8;75(3):469-482.e6
SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing.
Kroustallaki P, Lirussi L, Carracedo S, You P, Esbensen QY, Götz A, Jobert L, Alsøe L, Sætrom P, Gagos S, Nilsen H
Cell reports 2019 Aug 13;28(7):1690-1702.e10
Cell reports 2019 Aug 13;28(7):1690-1702.e10
Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.
Chow TT, Shi X, Wei JH, Guan J, Stadler G, Huang B, Blackburn EH
Nature communications 2018 Sep 4;9(1):3583
Nature communications 2018 Sep 4;9(1):3583
Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends.
Mukherjee AK, Sharma S, Sengupta S, Saha D, Kumar P, Hussain T, Srivastava V, Roy SD, Shay JW, Chowdhury S
PLoS genetics 2018 Nov;14(11):e1007782
PLoS genetics 2018 Nov;14(11):e1007782
The C-Terminal Extension Unique to the Long Isoform of the Shelterin Component TIN2 Enhances Its Interaction with TRF2 in a Phosphorylation- and Dyskeratosis Congenita Cluster-Dependent Fashion.
Nelson ND, Dodson LM, Escudero L, Sukumar AT, Williams CL, Mihalek I, Baldan A, Baird DM, Bertuch AA
Molecular and cellular biology 2018 Jun 15;38(12)
Molecular and cellular biology 2018 Jun 15;38(12)
SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage.
Biswas U, Stevense M, Jessberger R
Current biology : CB 2018 Jan 22;28(2):249-261.e4
Current biology : CB 2018 Jan 22;28(2):249-261.e4
CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length.
Gu P, Jia S, Takasugi T, Smith E, Nandakumar J, Hendrickson E, Chang S
Aging cell 2018 Aug;17(4):e12783
Aging cell 2018 Aug;17(4):e12783
The Use of 3D Telomere FISH for the Characterization of the Nuclear Architecture in EBV-Positive Hodgkin's Lymphoma.
Knecht H, Mai S
Methods in molecular biology (Clifton, N.J.) 2017;1532:93-104
Methods in molecular biology (Clifton, N.J.) 2017;1532:93-104
Distinct TERB1 Domains Regulate Different Protein Interactions in Meiotic Telomere Movement.
Zhang J, Tu Z, Watanabe Y, Shibuya H
Cell reports 2017 Nov 14;21(7):1715-1726
Cell reports 2017 Nov 14;21(7):1715-1726
Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.
Ilic A, Lu S, Bhatia V, Begum F, Klonisch T, Agarwal P, Xu W, Davie JR
Epigenetics & chromatin 2017 Nov 10;10(1):54
Epigenetics & chromatin 2017 Nov 10;10(1):54
Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation.
Tu Z, Bayazit MB, Liu H, Zhang J, Busayavalasa K, Risal S, Shao J, Satyanarayana A, Coppola V, Tessarollo L, Singh M, Zheng C, Han C, Chen Z, Kaldis P, Gustafsson JÅ, Liu K
Proceedings of the National Academy of Sciences of the United States of America 2017 Jan 17;114(3):592-597
Proceedings of the National Academy of Sciences of the United States of America 2017 Jan 17;114(3):592-597
TZAP: A telomere-associated protein involved in telomere length control.
Li JS, Miralles Fusté J, Simavorian T, Bartocci C, Tsai J, Karlseder J, Lazzerini Denchi E
Science (New York, N.Y.) 2017 Feb 10;355(6325):638-641
Science (New York, N.Y.) 2017 Feb 10;355(6325):638-641
E-type cyclins modulate telomere integrity in mammalian male meiosis.
Manterola M, Sicinski P, Wolgemuth DJ
Chromosoma 2016 Jun;125(2):253-64
Chromosoma 2016 Jun;125(2):253-64
Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma.
Benhamou Y, Picco V, Raybaud H, Sudaka A, Chamorey E, Brolih S, Monteverde M, Merlano M, Lo Nigro C, Ambrosetti D, Pagès G
Oncotarget 2016 Jul 12;7(28):44236-44251
Oncotarget 2016 Jul 12;7(28):44236-44251
A role for Separase in telomere protection.
Cipressa F, Morciano P, Bosso G, Mannini L, Galati A, Raffa GD, Cacchione S, Musio A, Cenci G
Nature communications 2016 Jan 18;7:10405
Nature communications 2016 Jan 18;7:10405
The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence.
Burla R, Carcuro M, Torre ML, Fratini F, Crescenzi M, D'Apice MR, Spitalieri P, Raffa GD, Astrologo L, Lattanzi G, Cundari E, Raimondo D, Biroccio A, Gatti M, Saggio I
Open biology 2016 Aug;6(8)
Open biology 2016 Aug;6(8)
Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis.
Sishc BJ, Nelson CB, McKenna MJ, Battaglia CL, Herndon A, Idate R, Liber HL, Bailey SM
Frontiers in oncology 2015;5:257
Frontiers in oncology 2015;5:257
MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.
Shibuya H, Hernández-Hernández A, Morimoto A, Negishi L, Höög C, Watanabe Y
Cell 2015 Nov 19;163(5):1252-1266
Cell 2015 Nov 19;163(5):1252-1266
Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells.
Ci X, Li B, Ma X, Kong F, Zheng C, Björkholm M, Jia J, Xu D
Oncotarget 2015 Nov 10;6(35):38079-92
Oncotarget 2015 Nov 10;6(35):38079-92
BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
Badie S, Carlos AR, Folio C, Okamoto K, Bouwman P, Jonkers J, Tarsounas M
The EMBO journal 2015 Feb 3;34(3):410-24
The EMBO journal 2015 Feb 3;34(3):410-24
Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function.
Stimpson KM, Sullivan LL, Kuo ME, Sullivan BA
PloS one 2014;9(3):e92432
PloS one 2014;9(3):e92432
RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells.
Arora R, Lee Y, Wischnewski H, Brun CM, Schwarz T, Azzalin CM
Nature communications 2014 Oct 21;5:5220
Nature communications 2014 Oct 21;5:5220
TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends.
Wood AM, Rendtlew Danielsen JM, Lucas CA, Rice EL, Scalzo D, Shimi T, Goldman RD, Smith ED, Le Beau MM, Kosak ST
Nature communications 2014 Nov 17;5:5467
Nature communications 2014 Nov 17;5:5467
Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.
Robin JD, Ludlow AT, Batten K, Magdinier F, Stadler G, Wagner KR, Shay JW, Wright WE
Genes & development 2014 Nov 15;28(22):2464-76
Genes & development 2014 Nov 15;28(22):2464-76
c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA.
Islam MA, Thomas SD, Murty VV, Sedoris KJ, Miller DM
The Journal of biological chemistry 2014 Mar 21;289(12):8521-31
The Journal of biological chemistry 2014 Mar 21;289(12):8521-31
The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis.
Shibuya H, Ishiguro K, Watanabe Y
Nature cell biology 2014 Feb;16(2):145-56
Nature cell biology 2014 Feb;16(2):145-56
T-oligo as an anticancer agent in colorectal cancer.
Wojdyla L, Stone AL, Sethakorn N, Uppada SB, Devito JT, Bissonnette M, Puri N
Biochemical and biophysical research communications 2014 Apr 4;446(2):596-601
Biochemical and biophysical research communications 2014 Apr 4;446(2):596-601
Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma.
Pitman RT, Wojdyla L, Puri N
Oncotarget 2013 May;4(5):761-71
Oncotarget 2013 May;4(5):761-71
Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas.
Castro-Vega LJ, Jouravleva K, Liu WY, Martinez C, Gestraud P, Hupé P, Servant N, Albaud B, Gentien D, Gad S, Richard S, Bacchetti S, Londoño-Vallejo A
Carcinogenesis 2013 May;34(5):1173-80
Carcinogenesis 2013 May;34(5):1173-80
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.
Kappei D, Butter F, Benda C, Scheibe M, Draškovič I, Stevense M, Novo CL, Basquin C, Araki M, Araki K, Krastev DB, Kittler R, Jessberger R, Londoño-Vallejo JA, Mann M, Buchholz F
The EMBO journal 2013 Jun 12;32(12):1681-701
The EMBO journal 2013 Jun 12;32(12):1681-701
PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells.
Chang FT, McGhie JD, Chan FL, Tang MC, Anderson MA, Mann JR, Andy Choo KH, Wong LH
Nucleic acids research 2013 Apr;41(8):4447-58
Nucleic acids research 2013 Apr;41(8):4447-58
Metastases suppressor NME2 associates with telomere ends and telomerase and reduces telomerase activity within cells.
Kar A, Saha D, Purohit G, Singh A, Kumar P, Yadav VK, Kumar P, Thakur RK, Chowdhury S
Nucleic acids research 2012 Mar;40(6):2554-65
Nucleic acids research 2012 Mar;40(6):2554-65
A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.
Morimoto A, Shibuya H, Zhu X, Kim J, Ishiguro K, Han M, Watanabe Y
The Journal of cell biology 2012 Jul 23;198(2):165-72
The Journal of cell biology 2012 Jul 23;198(2):165-72
Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.
Conomos D, Stutz MD, Hills M, Neumann AA, Bryan TM, Reddel RR, Pickett HA
The Journal of cell biology 2012 Dec 10;199(6):893-906
The Journal of cell biology 2012 Dec 10;199(6):893-906
Five dysfunctional telomeres predict onset of senescence in human cells.
Kaul Z, Cesare AJ, Huschtscha LI, Neumann AA, Reddel RR
EMBO reports 2011 Dec 23;13(1):52-9
EMBO reports 2011 Dec 23;13(1):52-9
Cohesin SMC1beta protects telomeres in meiocytes.
Adelfalk C, Janschek J, Revenkova E, Blei C, Liebe B, Göb E, Alsheimer M, Benavente R, de Boer E, Novak I, Höög C, Scherthan H, Jessberger R
The Journal of cell biology 2009 Oct 19;187(2):185-99
The Journal of cell biology 2009 Oct 19;187(2):185-99
Telomere protection by mammalian Pot1 requires interaction with Tpp1.
Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD
Nature structural & molecular biology 2007 Aug;14(8):754-61
Nature structural & molecular biology 2007 Aug;14(8):754-61
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
Hockemeyer D, Daniels JP, Takai H, de Lange T
Cell 2006 Jul 14;126(1):63-77
Cell 2006 Jul 14;126(1):63-77
Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase.
van Overbeek M, de Lange T
Current biology : CB 2006 Jul 11;16(13):1295-302
Current biology : CB 2006 Jul 11;16(13):1295-302
MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres.
Dimitrova N, de Lange T
Genes & development 2006 Dec 1;20(23):3238-43
Genes & development 2006 Dec 1;20(23):3238-43
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.
Celli GB, de Lange T
Nature cell biology 2005 Jul;7(7):712-8
Nature cell biology 2005 Jul;7(7):712-8
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end.
Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T
The EMBO journal 2005 Jul 20;24(14):2667-78
The EMBO journal 2005 Jul 20;24(14):2667-78
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint.
Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T
Genes & development 2004 Sep 1;18(17):2108-19
Genes & development 2004 Sep 1;18(17):2108-19
Homologous recombination generates T-loop-sized deletions at human telomeres.
Wang RC, Smogorzewska A, de Lange T
Cell 2004 Oct 29;119(3):355-68
Cell 2004 Oct 29;119(3):355-68
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T
The Journal of biological chemistry 2004 Nov 5;279(45):47264-71
The Journal of biological chemistry 2004 Nov 5;279(45):47264-71
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex.
Ye JZ, de Lange T
Nature genetics 2004 Jun;36(6):618-23
Nature genetics 2004 Jun;36(6):618-23
Significant role for p16INK4a in p53-independent telomere-directed senescence.
Jacobs JJ, de Lange T
Current biology : CB 2004 Dec 29;14(24):2302-8
Current biology : CB 2004 Dec 29;14(24):2302-8
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
Karlseder J, Hoke K, Mirzoeva OK, Bakkenist C, Kastan MB, Petrini JH, de Lange T
PLoS biology 2004 Aug;2(8):E240
PLoS biology 2004 Aug;2(8):E240
DNA damage foci at dysfunctional telomeres.
Takai H, Smogorzewska A, de Lange T
Current biology : CB 2003 Sep 2;13(17):1549-56
Current biology : CB 2003 Sep 2;13(17):1549-56
DNA damage foci at dysfunctional telomeres.
Takai H, Smogorzewska A, de Lange T
Current biology : CB 2003 Sep 2;13(17):1549-56
Current biology : CB 2003 Sep 2;13(17):1549-56
POT1 as a terminal transducer of TRF1 telomere length control.
Loayza D, De Lange T
Nature 2003 Jun 26;423(6943):1013-8
Nature 2003 Jun 26;423(6943):1013-8
Rap1 affects the length and heterogeneity of human telomeres.
Li B, de Lange T
Molecular biology of the cell 2003 Dec;14(12):5060-8
Molecular biology of the cell 2003 Dec;14(12):5060-8
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.
Zhu XD, Niedernhofer L, Kuster B, Mann M, Hoeijmakers JH, de Lange T
Molecular cell 2003 Dec;12(6):1489-98
Molecular cell 2003 Dec;12(6):1489-98
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.
Zhu XD, Niedernhofer L, Kuster B, Mann M, Hoeijmakers JH, de Lange T
Molecular cell 2003 Dec;12(6):1489-98
Molecular cell 2003 Dec;12(6):1489-98
Different telomere damage signaling pathways in human and mouse cells.
Smogorzewska A, de Lange T
The EMBO journal 2002 Aug 15;21(16):4338-48
The EMBO journal 2002 Aug 15;21(16):4338-48
Different telomere damage signaling pathways in human and mouse cells.
Smogorzewska A, de Lange T
The EMBO journal 2002 Aug 15;21(16):4338-48
The EMBO journal 2002 Aug 15;21(16):4338-48
Tankyrase promotes telomere elongation in human cells.
Smith S, de Lange T
Current biology : CB 2000 Oct 19;10(20):1299-302
Current biology : CB 2000 Oct 19;10(20):1299-302
Tankyrase promotes telomere elongation in human cells.
Smith S, de Lange T
Current biology : CB 2000 Oct 19;10(20):1299-302
Current biology : CB 2000 Oct 19;10(20):1299-302
Control of human telomere length by TRF1 and TRF2.
Smogorzewska A, van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, de Lange T
Molecular and cellular biology 2000 Mar;20(5):1659-68
Molecular and cellular biology 2000 Mar;20(5):1659-68
Control of human telomere length by TRF1 and TRF2.
Smogorzewska A, van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, de Lange T
Molecular and cellular biology 2000 Mar;20(5):1659-68
Molecular and cellular biology 2000 Mar;20(5):1659-68
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.
Zhu XD, Küster B, Mann M, Petrini JH, de Lange T
Nature genetics 2000 Jul;25(3):347-52
Nature genetics 2000 Jul;25(3):347-52
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Simple Western: TRF-2 Antibody [NB110-57130] - Lane view shows a specific band for TRF2 in 1.0 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: TRF-2 Antibody [NB110-57130] - Analysis of HeLa whole cell lysate (A), HeLa nuclear cell lysate (B), k562 cell lysate (C), HepG2 cell lysate (D), NIH/3T3 cell lysate (E), CHO cell lysate (F), PC12 cell lysate (G), and Cos7 cell lysate (H) using antibody at a concentration of 2 ug/ml.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: TRF-2 Antibody [NB110-57130] - Analysis in xenografted human breast cancer tissue using DAB with hematoxylin counterstain.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: TRF-2 Antibody [NB110-57130] - Analysis of FFPE human breast cancer tissue with rabbit polyclonal TRF2 antibody at a dilution of 1:200. The staining was developed with HRP-DAB detection method and the counterstaining was performed using hematoxylin. This TRF2 antibody generated an expected nuclear signal in all the cancer cells and the stromal cells. In the tested section, only a subset of myoepithelial cells showed positivity for this protein.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: TRF-2 Antibody [NB110-57130] - Analysis of FFPE human breast cancer tissue with rabbit polyclonal TRF2 antibody at 1:200 dilution. The staining was developed with HRP-DAB detection method and the counterstaining was performed using hematoxylin. This TRF2 antibody generated an expected nuclear signal in all the cancer cells and the stromal cells. In the tested section, only a subset of myoepithelial cells showed positivity for this protein.
Supportive validation
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- Novus Biologicals (provider)
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- Flow Cytometry: TRF-2 Antibody [NB110-57130] - An intracellular stain was performed on HeLa cells with TRF-2 Antibody NB110-57130AF488 (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 488.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
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- Experimental details
- Chromatin Immunoprecipitation: TRF-2 Antibody [NB110-57130] - Analysis in mouse. Titrated TRF2 antibody to determine concentration required for ChIP experiment. Image from verified customer review.