Antibody data
- Antibody Data
- Antigen structure
- References [27]
- Comments [0]
- Validations [0]
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- Product number
- 24756-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- VHL antibody
- Antibody type
- Polyclonal
- Description
- VHL antibody (Cat. #24756-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Highly potent and selective degrader targeting ERα to improve the treatment outcomes of breast cancer.
C-Arg9-APCR3-VHL promotes β-catenin degradation via the VHL-mediated ubiquitin-proteasome system in APC-mutant colorectal cancer.
PROTAR Vaccine 2.0 generates influenza vaccines by degrading multiple viral proteins.
Cytoplasmic TRIM24 promotes colorectal cancer cell proliferation by activating Wnt/β-catenin signaling.
RPL6 Interacts with HMGCS1 to Stabilize HIF-1α by Promoting Cholesterol Production in Hepatocellular Carcinoma.
VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway.
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.
Targeted Degradation of HCV Polymerase by GalNAc-Conjugated ApTACs for Pan-Genotypic Antiviral Therapy with High Resistance Barriers.
VH032 suppresses glioma proliferation by inhibiting the VHL/HIF-1α/VEGF pathway.
Comprehensive analysis of angiogenesis and stemness-related genes in chemotherapy and immunotherapy of bladder cancer.
UBE2S promotes glycolysis in hepatocellular carcinoma by enhancing E3 enzyme-independent polyubiquitination of VHL.
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
Tumor-associated macrophages/C-X-C motif chemokine ligand 1 promotes breast cancer autophagy-mediated chemoresistance via IGF1R/STAT3/HMGB1 signaling.
Design of Murine Double Minute 2 Proteolysis Targeting Chimera Degraders with a Built-In Tumor-Targeting Ability.
TET3-overexpressing macrophages promote endometriosis.
MITF regulates the subcellular location of HIF1α through SUMOylation to promote the invasion and metastasis of daughter cells derived from polyploid giant cancer cells.
Identification of TAP1 as a T-cell related therapeutic target in gastric cancer by mediating oxalipliatin-related synergistic enhancement of immunotherapy.
DNMT3A loss drives a HIF-1-dependent synthetic lethality to HDAC6 inhibition in non-small cell lung cancer.
FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation.
Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle.
MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma.
A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress.
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
A positive feedback loop between miR-574-3p and HIF-1α in promoting angiogenesis under hypoxia.
Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression.
Hypoxia-Induced LncRNA-MIR210HG Promotes Cancer Progression By Inhibiting HIF-1α Degradation in Ovarian Cancer.
Septin4 promotes cardiomyocytes apoptosis by enhancing the VHL-mediated degradation of HIF-1α.
Bao X, Yin X, Xu J, Zhu Z, Lu W, Cai Y, Dai R, Zheng Z, Xu W, Mei S, Xu S, Li J, Li N, Zhu H, Wang J, Liu J
European journal of medicinal chemistry 2026 Jan 5;301:118199
European journal of medicinal chemistry 2026 Jan 5;301:118199
C-Arg9-APCR3-VHL promotes β-catenin degradation via the VHL-mediated ubiquitin-proteasome system in APC-mutant colorectal cancer.
Luo P, Shi W, Tian L, Li Y, Cheng X, Yang J, Li Y, Dong J
International journal of biological macromolecules 2025 Sep;322(Pt 1):146678
International journal of biological macromolecules 2025 Sep;322(Pt 1):146678
PROTAR Vaccine 2.0 generates influenza vaccines by degrading multiple viral proteins.
Zhang C, Hou J, Li Z, Shen Q, Bai H, Chen L, Shen J, Wang P, Su Y, Li J, Zhang Q, Liu C, Xi X, Qi F, Chen Y, Xie X, Ye AY, Liu X, Plebani R, Church G, Si L
Nature chemical biology 2025 Sep;21(9):1330-1340
Nature chemical biology 2025 Sep;21(9):1330-1340
Cytoplasmic TRIM24 promotes colorectal cancer cell proliferation by activating Wnt/β-catenin signaling.
Wang Y, Yao Y, Liu Z, Long S, Yi F, Fang Q, Wu D, Zhu Q, Zai H, Xiao S, Wan F, Fu K
Nature communications 2025 Sep 29;16(1):8598
Nature communications 2025 Sep 29;16(1):8598
RPL6 Interacts with HMGCS1 to Stabilize HIF-1α by Promoting Cholesterol Production in Hepatocellular Carcinoma.
Yang M, Cheng S, Gu H, Zhong S, Zhang D, He X, Chen W, Deng H, Ren J, Chen P, Tan M, Zhang H, Li F, Zhang Z, Hu Y, Chen J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e01373
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e01373
VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway.
Sun H, Yang C, Yin X, Chen S, Huang Y, Kuang H, Luo W
Scientific reports 2025 Mar 4;15(1):7563
Scientific reports 2025 Mar 4;15(1):7563
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.
Zhai X, Yang R, Chu Q, Guo Z, Hou P, Li X, Bai C, Lu Z, Qiao L, Fu Y, Niu J, Li B
Nature cell biology 2025 Jan;27(1):141-153
Nature cell biology 2025 Jan;27(1):141-153
Targeted Degradation of HCV Polymerase by GalNAc-Conjugated ApTACs for Pan-Genotypic Antiviral Therapy with High Resistance Barriers.
Pan W, Wu S, Zhou H, Xia Y, Li Q, Ge R, Wu J, Han H, Chen S, Li Y, Li J, Chen M, Liu M, Zhou J, Xie S
Journal of medicinal chemistry 2025 Jan 23;68(2):1473-1482
Journal of medicinal chemistry 2025 Jan 23;68(2):1473-1482
VH032 suppresses glioma proliferation by inhibiting the VHL/HIF-1α/VEGF pathway.
Zhang Y, Zhu XY, Gu JR, Wang P, Wen YJ, Hou SZ, Yang JY, Gu JH
Biochemistry and biophysics reports 2025 Dec;44:102254
Biochemistry and biophysics reports 2025 Dec;44:102254
Comprehensive analysis of angiogenesis and stemness-related genes in chemotherapy and immunotherapy of bladder cancer.
Yin ZX, Qiu Y, Xu C, Pei C
Biomolecules & biomedicine 2025 Apr 18;25(10):2209-2228
Biomolecules & biomedicine 2025 Apr 18;25(10):2209-2228
UBE2S promotes glycolysis in hepatocellular carcinoma by enhancing E3 enzyme-independent polyubiquitination of VHL.
Zhang R, Li C, Zhang S, Kong L, Liu Z, Guo Y, Sun Y, Zhang C, Yong Y, Lv J, Lu M, Liu M, Wu D, Zhang T, Yang H, Wei D, Chen Z, Bian H
Clinical and molecular hepatology 2024 Oct;30(4):771-792
Clinical and molecular hepatology 2024 Oct;30(4):771-792
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
Yan P, Yang K, Xu M, Zhu M, Duan Y, Li W, Liu L, Liang C, Li Z, Pan X, Wang L, Yu G
Journal of molecular cell biology 2024 Oct 21;16(5)
Journal of molecular cell biology 2024 Oct 21;16(5)
Tumor-associated macrophages/C-X-C motif chemokine ligand 1 promotes breast cancer autophagy-mediated chemoresistance via IGF1R/STAT3/HMGB1 signaling.
Yang B, Li G, Wang S, Zheng Y, Zhang J, Pan B, Wang N, Wang Z
Cell death & disease 2024 Oct 11;15(10):743
Cell death & disease 2024 Oct 11;15(10):743
Design of Murine Double Minute 2 Proteolysis Targeting Chimera Degraders with a Built-In Tumor-Targeting Ability.
Wang Z, Yue S, Chen X, Li J, Zhu P, Chen H, Qiu F, Xie D, Liang Y, Li D, Lu A, Liang C
Journal of medicinal chemistry 2024 Nov 14;67(21):18865-18882
Journal of medicinal chemistry 2024 Nov 14;67(21):18865-18882
TET3-overexpressing macrophages promote endometriosis.
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael GG, Li D, Taylor HS, Huang Y
The Journal of clinical investigation 2024 Nov 1;134(21)
The Journal of clinical investigation 2024 Nov 1;134(21)
MITF regulates the subcellular location of HIF1α through SUMOylation to promote the invasion and metastasis of daughter cells derived from polyploid giant cancer cells.
Zheng M, Tian S, Zhou X, Yan M, Zhou M, Yu Y, Zhang Y, Wang X, Li N, Ren L, Zhang S
Oncology reports 2024 May;51(5)
Oncology reports 2024 May;51(5)
Identification of TAP1 as a T-cell related therapeutic target in gastric cancer by mediating oxalipliatin-related synergistic enhancement of immunotherapy.
Zhao Y, Liu Z, Deng K, Qu H, Zhang Q, Zhou P, Yang M, Yang X, Wang H, Li R, Xia J
International immunopharmacology 2024 May 10;132:111998
International immunopharmacology 2024 May 10;132:111998
DNMT3A loss drives a HIF-1-dependent synthetic lethality to HDAC6 inhibition in non-small cell lung cancer.
Zhang J, Zhao Y, Liang R, Zhou X, Wang Z, Yang C, Gao L, Zheng Y, Shao H, Su Y, Cui W, Jia L, Yang J, Wu C, Wang L
Acta pharmaceutica Sinica. B 2024 Dec;14(12):5219-5234
Acta pharmaceutica Sinica. B 2024 Dec;14(12):5219-5234
FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation.
Zhang T, Zhao C, Li Y, Wu J, Wang F, Yu J, Wang Z, Gao Y, Zhao L, Liu Y, Yan Y, Li X, Gao H, Hu Z, Cui B, Li K
Developmental cell 2024 Aug 19;59(16):2085-2100.e9
Developmental cell 2024 Aug 19;59(16):2085-2100.e9
Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle.
Guo Z, Zhang Y, Wang H, Liao L, Ma L, Zhao Y, Yang R, Li X, Niu J, Chu Q, Fu Y, Li B, Yang C
Nature communications 2024 Aug 12;15(1):6915
Nature communications 2024 Aug 12;15(1):6915
MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma.
Zhang S, Xu H, Li W, Ji J, Jin Q, Chen L, Gan Q, Tao Q, Chai Y
Pathology oncology research : POR 2023;29:1610801
Pathology oncology research : POR 2023;29:1610801
A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress.
Jiang W, Zhang M, Gao C, Yan C, Gao R, He Z, Wei X, Xiong J, Ruan Z, Yang Q, Li J, Li Q, Zhong Z, Zhang M, Yuan Q, Hu H, Wang S, Hu MM, Cai C, Wu GS, Jiang C, Zhang YL, Zhang CS, Zhang J
The EMBO journal 2023 Oct 16;42(20):e113743
The EMBO journal 2023 Oct 16;42(20):e113743
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
Mu M, Zhang Q, Li J, Zhao C, Li X, Chen Z, Sun X, Yu J
Cell death and differentiation 2023 Nov;30(11):2393-2407
Cell death and differentiation 2023 Nov;30(11):2393-2407
A positive feedback loop between miR-574-3p and HIF-1α in promoting angiogenesis under hypoxia.
Zhang R, Miao Z, Liu Y, Zhang X, Yang Q
Microvascular research 2023 Nov;150:104589
Microvascular research 2023 Nov;150:104589
Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression.
Zhou L, Luo Y, Liu Y, Zeng Y, Tong J, Li M, Hou Y, Du K, Qi Y, Pan W, Liu Y, Wang R, Tian F, Gu C, Chen K
Cancer research 2023 Dec 1;83(23):3920-3939
Cancer research 2023 Dec 1;83(23):3920-3939
Hypoxia-Induced LncRNA-MIR210HG Promotes Cancer Progression By Inhibiting HIF-1α Degradation in Ovarian Cancer.
Liu P, Huang H, Qi X, Bian C, Cheng M, Liu L, Xue L, Zhao X, Yi T, Quan Y
Frontiers in oncology 2021;11:701488
Frontiers in oncology 2021;11:701488
Septin4 promotes cardiomyocytes apoptosis by enhancing the VHL-mediated degradation of HIF-1α.
Wu S, Zhang Y, You S, Lu S, Zhang N, Sun Y
Cell death discovery 2021 Jul 6;7(1):172
Cell death discovery 2021 Jul 6;7(1):172
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