18977-1-AP

antibody from Proteintech Group

Targeting: IRF8 ICSBP, ICSBP1, IRF-8

Provider product page for 18977-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [19]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 18977-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#18977-1-AP, RRID:AB_10596482
Product name: IRF8 antibody
Antibody type: Polyclonal
Description: IRF8 antibody (Cat. #18977-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IRF8 protein structure - 18977-1-AP shown in red.

Submitted references Association of interferon regulatory factor 8 dysregulation with dry eye in Sjögren's syndrome.

Wang J, Chu GH, Wang ZH, Cai XY, Shi SY, Qing QP, Zhang Q
International journal of ophthalmology 2025;18(8):1456-1463

TRIM63/IRF-8 axis promotes tumor progression and immunosuppression of melanoma with BRAF mutation.

Yi F, Liu S, Ma Y, Li Y, Chen B, Yu B
Cell death & disease 2025 Nov 28;16(1):869

Modulation of the tumor immune microenvironment by Interferon Regulatory Factor 8 enhances immunotherapy in lung adenocarcinoma.

Huo W, Chen M, Chang C, Yu J, Chen D, Wang R
Scientific reports 2025 Mar 20;15(1):9565

An Experimental Animal Study: Electroacupuncture Facilitates Antiviral Immunity Against Hepatitis B Virus Through the IFN-γ/JAK/STAT Axis.

Yang Y, Ge F, Luo C, Liao C, Deng J, Yang Y, Chen Y, Guo X, Bai Z, Xiao X, Tang C
Journal of inflammation research 2024;17:6547-6562

Daphnetin Ameliorates Neuropathic Pain via Regulation of Microglial Responses and Glycerophospholipid Metabolism in the Spinal Cord.

Liang W, Zhang T, Zhang M, Gao J, Huang R, Huang X, Chen J, Cheng L, Zhang L, Huang Z, Tan Q, Jia Z, Zhang S
Pharmaceuticals (Basel, Switzerland) 2024 Jun 16;17(6)

Knockdown of IRF8 alleviates neuroinflammation through regulating microglial activation in Parkinson's disease.

Ma L, Mi N, Wang Z, Bao R, Fang J, Ren Y, Xu X, Zhang H, Tang Y
Journal of chemical neuroanatomy 2024 Jul;138:102424

Blockade of OX40/OX40L signaling using anti-OX40L alleviates murine lupus nephritis.

Zhao J, Li L, Feng X, Yin H, Fan X, Gao C, Zhao M, Lu Q
European journal of immunology 2024 Aug;54(8):e2350915

TIGIT-Fc fusion protein alleviates murine lupus nephritis through the regulation of SPI-B-PAX5-XBP1 axis-mediated B-cell differentiation.

Zhao J, Li L, Feng X, Gao C, Gao L, Zhan Y, Wang Z, Zhao M, Yin H, Lu Q
Journal of autoimmunity 2023 Sep;139:103087

Deacetylation of IRF8 inhibits iNOS expression and inflammation via SIRT1 in macrophages.

Jia Y, Shen K, Yang Y, Cai W, Wang K, Zhang Y, Zhao M, Luo L, Su L, Guan H, Hu D
Immunobiology 2022 Nov;227(6):152300

Resveratrol alleviates aluminum-induced intestinal barrier dysfunction in mice.

Hao W, Zhu X, Liu Z, Song Y, Wu S, Lu X, Yang J, Jin C
Environmental toxicology 2022 Jun;37(6):1373-1381

Berberine inhibits IFN-γ signaling pathway in DSS-induced ulcerative colitis.

Yang T, Ma X, Wang R, Liu H, Wei S, Jing M, Li H, Zhao Y
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 2022 Jun;30(6):764-778

Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.

Yang T, Wang R, Liu H, Wang L, Li J, Wu S, Chen X, Yang X, Zhao Y
Life sciences 2021 Feb 1;266:118903

Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl(4)/2-AAF.

Xu Y, Xu W, Liu W, Chen G, Jiang S, Chen J, Jian X, Zhang H, Liu P, Mu Y
Pharmaceutical biology 2021 Dec;59(1):1150-1160

Cross-talk of pyroptosis and tumor immune landscape in lung adenocarcinoma.

Wang X, Lin W, Liu T, Xu Z, Wang Z, Cao Z, Feng X, Gao Y, He J
Translational lung cancer research 2021 Dec;10(12):4423-4444

Mechanism of berberine in treating Helicobacter pylori induced chronic atrophic gastritis through IRF8-IFN-γ signaling axis suppressing.

Yang T, Wang R, Zhang J, Bao C, Zhang J, Li R, Chen X, Wu S, Wen J, Wei S, Li H, Cai H, Yang X, Zhao Y
Life sciences 2020 May 1;248:117456

The unique regulation of implant surface nanostructure on macrophages M1 polarization.

He Y, Luo J, Zhang Y, Li Z, Chen F, Song W, Zhang Y
Materials science & engineering. C, Materials for biological applications 2020 Jan;106:110221

Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling.

Sheng W, Shi X, Lin Y, Tang J, Jia C, Cao R, Sun J, Wang G, Zhou L, Dong M
Journal of experimental & clinical cancer research : CR 2020 Jan 17;39(1):16

The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice.

Minamizaki T, Nakao Y, Irie Y, Ahmed F, Itoh S, Sarmin N, Yoshioka H, Nobukiyo A, Fujimoto C, Niida S, Sotomaru Y, Tanimoto K, Kozai K, Sugiyama T, Bonnelye E, Takei Y, Yoshiko Y
Communications biology 2020 Jan 16;3(1):30

IRF8 is the target of SIRT1 for the inflammation response in macrophages.

Jia Y, Han S, Li J, Wang H, Liu J, Li N, Yang X, Shi J, Han J, Li Y, Bai X, Su L, Hu D
Innate immunity 2017 Feb;23(2):188-195

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse spleen tissue were subjected to SDS PAGE followed by western blot with 18977-1-AP(IRF8 antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The IRF8 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human IRF8. This antibody recognizes human, mouse antigen. The IRF8 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 18977-1-AP.pdf

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