26991-1-AP

antibody from Proteintech Group

Targeting: LCN2 24p3, NGAL

Provider product page for 26991-1-AP

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Immunohistochemistry

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Antigen structure
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Product number: 26991-1-AP - Provider product page
Provider: Proteintech Group
Product name: LCN2 antibody
Antibody type: Polyclonal
Description: LCN2 antibody (Cat. #26991-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

LCN2 protein structure - 26991-1-AP shown in red.

Submitted references Cinnamaldehyde attenuates LPS-induced acute kidney injury by inhibiting ferroptosis via the Gsk3β/Nrf2/Gpx4 pathway.

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The CDO1-ACSM3 Axis Mediates Renal Tubule Lipid Deposition and Injury by Causing Mitochondrial Dysfunction in Lupus Nephritis.

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Cells 2026 Mar 4;15(5)

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Yang L, Wang S, Ma Y, Duan L, You J, Li B, Yang Y, Li D
Scientific reports 2026 Mar 28;16(1)

Cytoskeletal remodeling promotes tunneling nanotube formation and drives cardiac resident cell mitochondrial transfer in sepsis.

Song R, Huang C, Ma Y, Zhang Z, Liu Y, Chen B, Zhang X, Hao S, Huang H, Ashrafizadeh M, Conde J, Duan C
Science advances 2026 Mar 13;12(11):eadz3266

Dexmedetomidine alleviates sepsis-associated acute kidney injury by inhibiting renal tubular ferroptosis via JNK/MAPK-LCN2 pathway.

Liu B, Ao S, Luo L, Qiao L, Kuang T, Xiao H, Zhou J, Yin S, Liang H, Li F, Dai W, Zhu J
European journal of medical research 2026 Jan 26;31(1):315

Nephropathy II Decoction Attenuates Renal Fibrosis via Regulating TLR4 and Gut Microbiota Along the Gut-Kidney Axis.

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Biological & pharmaceutical bulletin 2025;48(5):577-594

Single-Cell RNA-Seq Uncovers Cellular Heterogeneity from Deep Fascia in Necrotizing Fasciitis Patients.

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Electroacupuncture alleviates behaviors associated with posttraumatic stress disorder by modulating lipocalin-2-mediated neuroinflammation and neuronal activity in the prefrontal cortex.

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Journal of integrative medicine 2025 Sep;23(5):537-547

Yishen Qufeng formula mediates ferroptosis to improve renal fibrosis in unilateral ureteral obstruction rats.

Gao J, Wei Y, Zhang W, Yu Y, Ge H, Tian F, Zhou E
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The BPIFA2 - LRP5 axis orchestrates mitochondrial dysfunction to mediate kidney injury in lupus nephritis.

Liu Y, Tian Y, Wang H, Li N, Zhuo R, Cui H, Miao X, Liu J, Liu Q, Zhang W, Guo H, Xing L, Yang L, Feng X, Liu S
International immunopharmacology 2025 Sep 23;162:115114

Pathogenicity and Transcriptomic Profiling Revealed Activation of Apoptosis and Pyroptosis in Brain of Mice Infected with the Beta Variant of SARS-CoV-2.

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Zhu XX, Meng XY, Zhang AY, Zhao CY, Wei YT, Wen YY, Su JB, Fu X, Chen G, Xu AJ, Wang MY, Ji LM, Bao N, Bao ZY, Li N, Lu QB, Sun HJ
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CircFGFR2 induces astrocyte pyroptosis to promote ischemic stroke.

Pang N, Liu Y, Yu S, Li Y, Shi K
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Tumor-derived lactate fuels the STAT3-LCN2 pathway to promote bladder cancer malignancy and chemoresistance.

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Verbascoside (VB) Inhibits Ischemic Stroke Progression via Suppression of Cell Damage and Ferroptosis By Targeting LCN2/ALOX5/SLC7A11/GPX4 Expression.

Zhang C, You J, Zhou X, Feng J, Li Q, Zhou H
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Integrated multi-omics profiling identifies Cmpk1 as a monocyte-specific therapeutic target for renal ischemia-reperfusion injury.

Zhang H, Zhang G, Wang B, Xiong F, Ji X, Wang C
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DEF6 regulates renal ischemia reperfusion injury through suppressing the WWP2 mediated ubiquitination of PARP1.

Hu H, Liu Y, Han S, Guo J, Zhou J, Qiu T
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Platelet glycoprotein VI promotes folic acid-induced acute kidney injury through interaction with tubular epithelial cell-derived galectin-3.

Guo YW, Luo Q, Lu M, Zeng XB, Zhang YM, Lin YL, Guo XR, Ma R, Ming ZY
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Exploring Core Genes Involved in Ischemic Stroke and the Therapeutic Potential of Hyperbaric Oxygen: Insights from Transcriptomic Analysis.

Bao Y, Guo X, Wang J, Kang J, Ma R, Cheng X, Ma Y, Niu Y, Zhang W, Li X
Neuromolecular medicine 2025 Jul 26;27(1):54

Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.

Liu L, Ma Y, Jian Z, Liao B, Li Y, Lin L, Wang M, Chen J, Wei J, Yang M, Liu Y, Yuan Y, Wen J, Xiang L, Qi S, Jin X, Wang K
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The SIRT6/BAP1/xCT signaling axis mediates ferroptosis in cisplatin-induced AKI.

Yang S, Chen L, Din S, Ye Z, Zhou X, Cheng F, Li W
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Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells.

Nie B, Zhang D, Liu X, Lei C, Li Z, Zhang N, Zhang S, Wei Y, Zhang J
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Transcriptomics study of hippocampus in mice exposed to heat stress.

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Targeting intrinsically disordered nuclear protein 1 (NUPR1) with single-domain antibodies alleviates triple-negative breast cancer (TNBC) progression in vivo.

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EGFRvIII-driven microenvironmental fibroblast activation and transformation accelerate oral cancer progression via lipocalin-2/STAT3 axis.

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Proprotein convertase subtilisin/kexin type 9 contributes to cisplatin-induced acute kidney injury by interacting with cyclase-associated protein 1 to promote megalin lysosomal degradation.

Wang Z, Yu X, Ma H, Yao S, Li Z, Zhang R, Liang H, Jiao J
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Biliary Metaplasia and Macrophage Activation Define the Cellular Landscape of Cardiogenic Liver Disease.

Park AC, Fu CF, Parvathaneni A, Yang BQ, Chan MM, Byrnes K, Schilling JD
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The role of the C5a-C5aR pathway in iron metabolism and gastric cancer progression.

Ni Q, Yang H, Rao H, Zhang L, Xiong M, Han X, Deng B, Wang L, Chen J, Shi Y
Frontiers in immunology 2024;15:1522181

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Li X, Dong X, Zhang L, Zhang S, Huang W, Wang C, Huo Z, Li X, Zhang X, Jia X, Chen G, Kuang B
Frontiers in pharmacology 2024;15:1285797

Lipocalin-2-mediated intestinal epithelial cells pyroptosis via NF-κB/NLRP3/GSDMD signaling axis adversely affects inflammation in colitis.

Yang Y, Li S, Liu K, Zhang Y, Zhu F, Ben T, Chen Z, Zhi F
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167279

Suppression of ferroptosis through the SLC7A11/glutathione/glutathione peroxidase 4 axis contributes to the therapeutic action of the Tangshenning formula on diabetic renal tubular injury.

Shan XM, Chen CW, Zou DW, Gao YB, Ba YY, He JX, Zhu ZY, Liang JJ
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Gut microbiome and metabolites mediate the benefits of caloric restriction in mice after acute kidney injury.

Zhu XX, Fu X, Meng XY, Su JB, Zheng GL, Xu AJ, Chen G, Zhang Y, Liu Y, Hou XH, Qiu HB, Sun QY, Hu JY, Lv ZL, Wang Y, Jiang HB, Bao N, Han ZJ, Lu QB, Sun HJ
Redox biology 2024 Nov;77:103373

S100A9 promotes renal calcium oxalate stone formation via activating the TLR4-p38/MAPK-LCN2 signaling pathway.

Wang Q, Chen X, Huang K, Deng G, Tian Y, Jiang K
International journal of biological macromolecules 2024 Nov;281(Pt 1):136178

VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy.

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Qiao J, Tan Y, Liu H, Yang B, Zhang Q, Liu Q, Sun W, Li Z, Wang Q, Feng W, Yang S, Cui L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2307216

Inhibiting LCN2 can suppress the development of NSCLC by promoting ferroptosis.

Pan Z, Li B, Lu P, Rong G, Wang X
Gene 2024 Feb 5;894:148026

mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms.

Ali Y, Gomez-Sanchez CE, Plonczynski M, Naray-Fejes-Toth A, Fejes-Toth G, Gomez-Sanchez EP
Endocrinology 2024 Feb 20;165(4)

Identification of SLC40A1, LCN2, CREB5, and SLC7A11 as ferroptosis-related biomarkers in alopecia areata through machine learning.

Xu W, Wei D, Song X
Scientific reports 2024 Feb 15;14(1):3800

Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial-mesenchymal transition.

Zhao J, Wang X, Wu Y, Zhao C
Renal failure 2024 Dec;46(1):2316259

C-176 inhibits macrophage polarization towards M1-subtype and ameliorates LPS induced acute kidney injury.

Leng X, Li Q, Chen W, Feng H, Li L, Yu L, Huang P, Ma P, Xie F
European journal of pharmacology 2024 Dec 5;984:177028

BMAL1 alleviates sepsis-induced AKI by inhibiting ferroptosis.

Yang S, Ye Z, Chen W, Wang P, Zhao S, Zhou X, Li W, Cheng F
International immunopharmacology 2024 Dec 5;142(Pt B):113159

Identifying novel aging-related diagnostic and prognostic models and aging-targeted drugs for sepsis patients.

Yang K, Lu Y, Gu J, Nie Y, Zhang T
Scientific reports 2024 Dec 28;14(1):31445

Perinatal asphyxia leads to acute kidney damage and increased renal susceptibility in adulthood.

Lakat T, Fekete A, Demeter K, Toth AR, Varga ZK, Patonai A, Kelemen H, Budai A, Szabo M, Szabo AJ, Kaila K, Denes A, Mikics E, Hosszu A
American journal of physiology. Renal physiology 2024 Aug 1;327(2):F314-F326

Up-regulation of LCN2 in the anterior cingulate cortex contributes to neural injury-induced chronic pain.

Song XJ, Yang CL, Chen D, Yang Y, Mao Y, Cao P, Jiang A, Wang W, Zhang Z, Tao W
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Banzhilian formula alleviates psoriasis-like lesions via the LCN2/MMP-9 axis based on transcriptome analysis.

Xing M, Yan X, Guo J, Li W, Li Z, Dong C, Guo J, Qu K, Luo Y
Frontiers in pharmacology 2023;14:1055363

Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy.

Wang Y, He X, Xue M, Sun W, He Q, Jin J
Free radical research 2023 May-Jun;57(6-12):413-429

Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling.

Huang Z, Rui X, Yi C, Chen Y, Chen R, Liang Y, Wang Y, Yao W, Xu X, Huang Z
Journal of experimental & clinical cancer research : CR 2023 Mar 11;42(1):60

Molecules of senescent glial cells differentiate Alzheimer's disease from ageing.

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Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models.

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International journal of molecular sciences 2023 Feb 13;24(4)

Fucoxanthin Inhibits Development of Sigmoid Colorectal Cancer in a PDX Model With Alterations of Growth, Adhesion, and Cell Cycle Signals.

Terasaki M, Tsuruoka K, Tanaka T, Maeda H, Shibata M, Miyashita K, Kanemitsu Y, Sekine S, Takahashi M, Yagishita S, Hamada A
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Increasing expression of STING by ERα antagonizes LCN2 downregulation during chronic endometritis.

Chu M, He S, Zhao H, Yin S, Liu Z, Zhang W, Liu X, Bao H
Journal of reproductive immunology 2023 Dec;160:104167

Mutational burden of XPNPEP3 leads to defects in mitochondrial complex I and cilia in NPHPL1.

Tong L, Rao J, Yang C, Xu J, Lu Y, Zhang Y, Cang X, Xie S, Mao J, Jiang P
iScience 2023 Aug 18;26(8):107446

IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2.

Lan Y, Yang T, Yue Q, Wang Z, Zhong X, Luo X, Zuo B, Zhang M, Zeng T, Liu B, Guo H
iScience 2023 Aug 18;26(8):107377

An Integrated Proteomics and Metabolomics Strategy for the Mechanism of Calcium Oxalate Crystal-Induced Kidney Injury.

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Frontiers in medicine 2022;9:805356

Sirtuin 1 Induces Choroidal Neovascularization and Triggers Age-Related Macular Degeneration by Promoting LCN2 through SOX9 Deacetylation.

Zhao S, Huang Z, Jiang H, Xiu J, Zhang L, Long Q, Yang Y, Yu L, Lu L, Gu H
Oxidative medicine and cellular longevity 2022;2022:1671438

Lipocalin-2 negatively regulates epithelial-mesenchymal transition through matrix metalloprotease-2 downregulation in gastric cancer.

Nishimura S, Yamamoto Y, Sugimoto A, Kushiyama S, Togano S, Kuroda K, Okuno T, Kasashima H, Ohira M, Maeda K, Yashiro M
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2022 Sep;25(5):850-861

Intermittent hilar occlusion attenuates or prevents renal ischaemia-reperfusion in mice.

Wang L, Peng C, Chen J, Li H, Jiao Q, Zhang Z, Wang L, Yuan Q, Wang B, Huang Y, Ma X
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Single-cell transcriptomic analysis highlights origin and pathological process of human endometrioid endometrial carcinoma.

Ren X, Liang J, Zhang Y, Jiang N, Xu Y, Qiu M, Wang Y, Zhao B, Chen X
Nature communications 2022 Oct 22;13(1):6300

Patulin Induces Acute Kidney Injury in Mice through Autophagy-Ferroptosis Pathway.

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miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway.

Han S, Lin F, Ruan Y, Zhao S, Yuan R, Ning J, Jiang K, Xie J, Li H, Li C, Rao T, Yu W, Xia Y, Zhou X, Cheng F
International immunopharmacology 2021 Oct;99:108022

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Ma C, Chen T, Ti Y, Yang Y, Qi Y, Zhang C, Liu L, Bu P
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Retinoic acid induced 16 deficiency exacerbates high-fat diet-induced steatohepatitis in mice.

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TET2 is involved in DNA hydroxymethylation, cell proliferation and inflammatory response in keratinocytes.

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