LCN2

This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]

Description

Lipocalin 2

Tissue specificity

Tissue enhanced (bone marrow, gallbladder, salivary gland)

Subcell location

Endoplasmic reticulum

Predicted location

Secreted in other tissues

Protein family

Candidate cardiovascular disease genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (128149071 - 128153453)

Ensembl ID

ENSG00000148346  (ver. 103.38)

Orthologs

Mouse Lcn2: ENSMUSG00000026822

UniProt

P80188

neXtProt

NX_P80188

Human splice variants
Mouse splice variants

Protein structure