Ab113231

antibody from Aladdin Scientific Corporation

Targeting: LCN2 24p3, NGAL

Western blot (Data presented on provider website)

Antibody Data

Product number

Ab113231

Provider

Aladdin Scientific Corporation

Product name

Lipocalin-2/NGAL Mouse mAb

Antibody type

Monoclonal

Description

Mouse anti Human Lipocalin-2 / NGAL Antibody, Monoclonal (J13), could be used for WB and so on. Application: WB: 0.5-2µg/mL Protein Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

AA 21-198


Antibody clone number

J13

Vial size

100μl,10μl,1ml,20μl,50μl

Concentration

Lot by Lot

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Upon delivery aliquot. Avoid freeze/thaw cycle.