Ab113231

antibody from Aladdin Scientific
Targeting: LCN2 24p3, NGAL
Provider product page for Ab113231

Antibody data

Product number
Ab113231 - Provider product page
Provider
Aladdin Scientific
Product name
Lipocalin-2/NGAL Mouse mAb
Antibody type
Monoclonal
Description
Mouse anti Human Lipocalin-2 / NGAL Antibody, Monoclonal (J13), could be used for WB and so on. Application: WB: 0.5-2µg/mL Protein Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
AA 21-198
Antibody clone number
J13
Vial size
100_l,10_l,1ml,20_l,50_l
Concentration
Lot by Lot
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (12 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
LCN2 protein structure - Ab113231 shown in red.