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- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Western blot [1]
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- Product number
- NB100-472 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-472, RRID:AB_2216076
- Product name
- Rabbit Polyclonal WRN Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100 ul
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C. Do not freeze.
Submitted references WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling.
Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase.
The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage.
WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.
The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest.
Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ
Nature 2019 Apr;568(7753):551-556
Nature 2019 Apr;568(7753):551-556
Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling.
Sidorova JM, Kehrli K, Mao F, Monnat R Jr
DNA repair 2013 Feb 1;12(2):128-39
DNA repair 2013 Feb 1;12(2):128-39
Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase.
Indig FE, Rybanska I, Karmakar P, Devulapalli C, Fu H, Carrier F, Bohr VA
PloS one 2012;7(6):e35229
PloS one 2012;7(6):e35229
The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage.
Liu FJ, Barchowsky A, Opresko PL
Toxicological sciences : an official journal of the Society of Toxicology 2009 Aug;110(2):307-18
Toxicological sciences : an official journal of the Society of Toxicology 2009 Aug;110(2):307-18
WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.
Li B, Jog SP, Reddy S, Comai L
Molecular and cellular biology 2008 Mar;28(6):1892-904
Molecular and cellular biology 2008 Mar;28(6):1892-904
The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest.
Sidorova JM, Li N, Folch A, Monnat RJ Jr
Cell cycle (Georgetown, Tex.) 2008 Mar 15;7(6):796-807
Cell cycle (Georgetown, Tex.) 2008 Mar 15;7(6):796-807
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: WRN Antibody [NB100-472] - Detection of human WRN on HeLa whole cell lysate using NB100-472. WRN was immunoprecipitated with NB100-472 or rabbit anti-WRN antibody NB100-471.
