Tissue expression
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Protein structure

MKNK2

MAPK interacting serine/threonine kinase 2
GPRK7, MNK2 
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]
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338 antibodies from 30 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
1 antibody
antibodies-online
80 antibodies
Biorbyt
44 antibodies
Invitrogen Antibodies
14 antibodies
Abnova Corporation
8 antibodies
Novus Biologicals
8 antibodies
NovoPro Bioscience Inc.
4 antibodies
Affinity Biosciences
3 antibodies
Abgent
2 antibodies
Aviva Systems Biology
5 antibodies
OriGene
4 antibodies
Atlas Antibodies
3 antibodies
GeneTex
3 antibodies
Cusabio Biotech Co., Ltd
1 antibody
FineTest Biotech
1 antibody
St John's Laboratory
3 antibodies
Acris Antibodies GmbH
4 antibodies
ProSci
4 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
PhosphoSolutions
2 antibodies
MilliporeSigma / Merck KGaA
6 antibodies
Creative Diagnostics
3 antibodies
Bioss
3 antibodies
Abiocode, Inc.
1 antibody
United States Biological
43 antibodies
MyBioSource
3 antibodies
Creative Biolabs
4 antibodies
Leading Biology
3 antibodies
Abbexa
5 antibodies