Tissue expression
Cell line expression
Protein structure
CBFA2T2
CBFA2/RUNX1 partner transcriptional co-repressor 2MTGR1, ZMYND3
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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LSBio | ![]() |
Monoclonal |
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Proteintech Group | ![]() |
1 references | Polyclonal |
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Novus Biologicals | ![]() |
Monoclonal |
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Abnova Corporation | ![]() |
Monoclonal |
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Biorbyt | ![]() |
Polyclonal |
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