CBFA2T2

gene product
MTGR1, ZMYND3
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
277 antibodies from 30 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Proteintech Group
1 antibody
LifeSpan BioSciences, Inc.
50 antibodies
Novus Biologicals
9 antibodies
Abnova Corporation
8 antibodies
Invitrogen Antibodies
10 antibodies
antibodies-online
101 antibodies
Biorbyt
8 antibodies
Bioworld Technology, Inc
1 antibody
NovoPro Bioscience Inc.
1 antibody
OriGene
10 antibodies
GeneTex
4 antibodies
Aviva Systems Biology
6 antibodies
Atlas Antibodies
2 antibodies
Abgent
2 antibodies
Signalway Antibody LLC
1 antibody
Bethyl Laboratories
1 antibody
St John's Laboratory
1 antibody
Acris Antibodies GmbH
5 antibodies
RabMAbs
1 antibody
MyBioSource
6 antibodies
Creative Biolabs
8 antibodies
Creative Diagnostics
3 antibodies
Affinity Biosciences
1 antibody
Boster Biological Technology
1 antibody
RayBiotech, Inc.
1 antibody
United States Biological
14 antibodies
Sigma-Aldrich
4 antibodies
Exalpha Biologicals, Inc.
1 antibody
GenWay
1 antibody