MMP25

gene product
MMP20, MMPL1, MT6-MMP
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
285 antibodies from 26 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
34 antibodies
R&D Systems
17 antibodies
antibodies-online
97 antibodies
LifeSpan BioSciences, Inc.
39 antibodies
Affinity Biosciences
1 antibody
Biorbyt
17 antibodies
GeneTex
7 antibodies
OriGene
3 antibodies
Abnova Corporation
2 antibodies
Bioworld Technology, Inc
1 antibody
NovoPro Bioscience Inc.
3 antibodies
St John's Laboratory
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Invitrogen Antibodies
3 antibodies
GenWay
7 antibodies
Aviva Systems Biology
2 antibodies
Abgent
2 antibodies
Acris Antibodies GmbH
2 antibodies
Creative Diagnostics
4 antibodies
Abiocode, Inc.
1 antibody
Boster Biological Technology
1 antibody
United States Biological
24 antibodies
MyBioSource
4 antibodies
Creative Biolabs
5 antibodies
Sigma-Aldrich
5 antibodies
ProSci
1 antibody