BS7696

antibody from Bioworld Technology, Inc
Targeting: CAPN3 CANP3, LGMD2, LGMD2A, nCL-1, p94
Provider product page for BS7696
Western blot
Immunohistochemistry

Antibody data

Product number
BS7696 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CAPN3 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human CAPN3.
Description
Calpain, an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, plays a role in cytoskeletal reorganization and muscle protein degradation. Calpain is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits, designated calpain 1, calpain 2 and calpain 3. Calpain 3 (calpain p94) is a muscle-preferred calcium activated neutral protease that localizes to the nucleus. Mutations involving the calpain 3 gene are associated with limb-girdle muscle dystrophy type 2A, a form of autosomal recessive and progressive neuromuscular diso4. Calpastatin regulates calpain by inhibiting both the proteolytic activity of calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CAPN3 protein structure - BS7696 shown in red.