BS60732

antibody from Bioworld Technology, Inc
Targeting: CAPN3 CANP3, LGMD2, LGMD2A, nCL-1, p94
Provider product page for BS60732

Antibody data

Product number
BS60732 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CAPN3 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human CAPN3
Description
Calpain, an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, plays a role in cytoskeletal reorganization and muscle protein degradation . Calpain is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits, designated calpain 1, calpain 2 and calpain 3 . Calpain 3 (calpain p94) is a muscle-preferred calcium activated neutral protease that localizes to the nucleus. The gene encoding human calpain 3 maps to chromosome 15q15.1-q21.1. Mutations involving the calpain 3 gene are associated with limb-girdle muscle dystrophy type 2A, a form of autosomal recessive and progressive neuromuscular disorder. Calpastatin regulates calpain by inhibiting both the proteolytic activity of calpain and its binding to membranes . Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing .
Reactivity
Human, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CAPN3 protein structure - BS60732 shown in red.