Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60732 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- CAPN3 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human CAPN3
- Description
- Calpain, an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, plays a role in cytoskeletal reorganization and muscle protein degradation . Calpain is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits, designated calpain 1, calpain 2 and calpain 3 . Calpain 3 (calpain p94) is a muscle-preferred calcium activated neutral protease that localizes to the nucleus. The gene encoding human calpain 3 maps to chromosome 15q15.1-q21.1. Mutations involving the calpain 3 gene are associated with limb-girdle muscle dystrophy type 2A, a form of autosomal recessive and progressive neuromuscular disorder. Calpastatin regulates calpain by inhibiting both the proteolytic activity of calpain and its binding to membranes . Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing .
- Reactivity
- Human, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of CAPN3 pAb at 1:500 dilutionLane1:MCF-7 whole cell lysateLane2:PC12 whole cell lysate