53-9176-80

antibody from Invitrogen Antibodies
Targeting: BIRC5 API4, EPR-1, survivin
Provider product page for 53-9176-80

Antibody data

Product number
53-9176-80 - Provider product page
Provider
Invitrogen Antibodies
Product name
Survivin Monoclonal Antibody (STLALYV), Alexa Fluor™ 488, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This STLALYV monoclonal antibody recognizes human survivin (also known as Birc5). Survivin is a member of the inhibitor of apoptosis (IAP) family that also includes XIAP, c-IAP1, c-IAP2, and NAIP. Survivin functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Survivin also plays a critical role in mitosis and cytokinesis where it is expressed only during G2/M and localizes to the mitotic spindle and is found at the cleavage furrow/midplate. Thus, survivin is highly expressed in tumors and in fetal tissue, but is absent in terminally-differentiated cells and non-proliferating cells. Deletion of survivin in developing thymocytes as well as in mature T cells showed that survivin is critical for cell division in lymphoid cells but not for inhibition of survival; the same is true for B lymphocytes.
Conjugate
Green dye
Antibody clone number
STLALYV
Concentration
0.5 mg/mL
BIRC5 protein structure - 53-9176-80 shown in red.