Antibody data

Product number
Ab129838 - Provider product page
Provider
Aladdin Scientific
Product name
Survivin Mouse mAb
Antibody type
Monoclonal
Description
Mouse anti Human Survivin Antibody, Monoclonal (C3), could be used for WB, IHC and so on. Application WB: 0.01-2 µg/mL IHC: 5-30 _g/mL Protein Function Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
AA 1-142
Antibody clone number
C3
Vial size
100_l,10_l,1ml,20_l,50_l
Concentration
Lot by Lot
Storage
Store at 4_ short term (1-2 weeks). Store at -20_ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
BIRC5 protein structure - Ab129838 shown in red.