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- Product number
- 22915-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Caspase 1/p20/p10 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Caspase 1/p20/p10 antibody (Cat. #22915-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Protocatechuic aldehyde prevents ischemic injury by attenuating brain microvascular endothelial cell pyroptosis via lncRNA Xist.
H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion.
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway.
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy.
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk.
Effect and Mechanism of Mycobacterium tuberculosis Lipoprotein LpqH in NLRP3 Inflammasome Activation in Mouse Ana-1 Macrophage.
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation.
Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation.
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Tongxinluo Exerts Inhibitory Effects on Pyroptosis and Amyloid-β Peptide Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways.
Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.
SOCS2 Suppresses Inflammation and Apoptosis during NASH Progression through Limiting NF-κB Activation in Macrophages.
Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer.
GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.
Punicalin Ameliorates Cell Pyroptosis Induced by LPS/ATP Through Suppression of ROS/NLRP3 Pathway.
Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes.
PARK2 attenuates house dust mite-induced inflammatory reaction, pyroptosis and barrier dysfunction in BEAS-2B cells by ubiquitinating NLRP3.
An Integrative Pharmacology Based Analysis of Refined Liuweiwuling Against Liver Injury: A Novel Component Combination and Hepaprotective Mechanism.
CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome-Pyroptosis Pathway.
AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation.
Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.
Inflammasome-Induced Osmotic Pressure and the Mechanical Mechanisms Underlying Astrocytic Swelling and Membrane Blebbing in Pyroptosis.
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
LPS Mediates Bovine Endometrial Epithelial Cell Pyroptosis Directly Through Both NLRP3 Classical and Non-Classical Inflammasome Pathways.
Subicular Caspase-1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy.
Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.
The Role of NF-κB/NLRP3 Inflammasome Signaling Pathway in Attenuating Pyroptosis by Melatonin Upon Spinal Nerve Ligation Models.
H2S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.
MerTK inhibits the activation of the NLRP3 inflammasome after subarachnoid hemorrhage by inducing autophagy.
Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis.
Gardnerella vaginalis induces NLRP3 inflammasome-mediated pyroptosis in macrophages and THP-1 monocytes.
IL-38-mediated NLRP3/caspase-1 inhibition is a disease-modifying treatment for TMJ inflammation.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome.
Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury.
Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.
Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-κB pathway.
LncRNA HOTAIR Promotes Neuronal Damage Through Facilitating NLRP3 Mediated-Pyroptosis Activation in Parkinson's Disease via Regulation of miR-326/ELAVL1 Axis.
Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Inflammatory and immune-related factor Caspase 1 contributes to the development of oral lichen planus.
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis.
Suppression of the caspase-1/GSDMD-mediated pyroptotic signaling pathway through dexamethasone alleviates corneal alkali injuries.
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo.
Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis.
Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase-1 signaling pathway and oxidative stress in Wistar rats.
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats.
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Cordyceps acid alleviates lung cancer in nude mice.
NLRP3 inflammasome-mediated endothelial cells pyroptosis is involved in decabromodiphenyl ethane-induced vascular endothelial injury.
Airborne particulate matter (PM2.5) triggers ocular hypertension and glaucoma through pyroptosis.
Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1.
Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway.
Golgi phosphoprotein 3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome.
IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation.
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.
Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway.
MIF inhibitor ISO-1 alleviates severe acute pancreatitis-associated acute kidney injury by suppressing the NLRP3 inflammasome signaling pathway.
Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes.
N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia-reperfusion rats via the TLR4/NF-κB/NLRP3 pathway.
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.
Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis.
hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis.
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.
Toll‑like receptor 4 activates the NLRP3 inflammasome pathway and periodontal inflammaging by inhibiting Bmi‑1 expression.
Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway.
Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342-3p targeting of CASP1 in diabetic retinopathy.
Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice.
Kupffer Cell-targeting strategy for the protection of Hepatic Ischemia/Reperfusion Injury.
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth.
Protection of hUC-MSCs against neuronal complement C3a receptor-mediated NLRP3 activation in CUMS-induced mice.
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis.
Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression.
lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome.
Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.
Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
Silenced microRNA-222 suppresses inflammatory response in gestational diabetes mellitus mice by promoting CXCR4.
Huoxue Qianyang Qutan recipe attenuates cardiac fibrosis by inhibiting the NLRP3 inflammasome signalling pathway in obese hypertensive rats.
Dexmedetomidine inhibits endoplasmic reticulum stress to suppress pyroptosis of hypoxia/reoxygenation-induced intestinal epithelial cells via activating the SIRT1 expression.
Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM2.5.
Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway.
MEHP induces pyroptosis and autophagy alternation by cathepsin B activation in INS-1 cells.
DDX3X deficiency alleviates LPS-induced H9c2 cardiomyocytes pyroptosis by suppressing activation of NLRP3 inflammasome.
MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice.
ESR2 regulates PINK1-mediated mitophagy via transcriptional repression of microRNA-423 expression to promote asthma development.
Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke.
Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway.
Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice.
Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice.
Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways.
Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome‑mediated inflammation.
Resveratrol affects the expression of uric acid transporter by improving inflammation.
Microtubule associated protein 4 (MAP4) phosphorylation reduces cardiac microvascular density through NLRP3-related pyroptosis.
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Carthamin yellow improves cerebral ischemia‑reperfusion injury by attenuating inflammation and ferroptosis in rats.
Therapeutic Effect of Endothelin-Converting Enzyme Inhibitor on Chronic Kidney Disease through the Inhibition of Endoplasmic Reticulum Stress and the NLRP3 Inflammasome.
Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.
Absent in melanoma 2 suppresses gastric cancer cell proliferation and migration via inactivation of AKT signaling pathway.
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis.
Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats.
VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice.
Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R-/-) Mice via Its Anti-inflammatory and Antipyroptotic Effects.
Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia.
Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice.
Blocking the LncRNA MALAT1/miR-224-5p/NLRP3 Axis Inhibits the Hippocampal Inflammatory Response in T2DM With OSA.
Maresin 1 Attenuates Radicular Pain Through the Inhibition of NLRP3 Inflammasome-Induced Pyroptosis via NF-κB Signaling.
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux.
Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.
Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease.
Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway.
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome.
Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury.
Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats.
MiR-139 protects against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced nerve injury through targeting c-Jun to inhibit NLRP3 inflammasome activation.
Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity.
Mesenchymal stem cells-derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis.
Trimethylamine N-oxide promotes apoE-/- mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor.
A novel mechanism of protection against isoproterenol-induced cardiac inflammation via regulation of the SIRT1/NRF2 signaling pathway with a natural SIRT1 agonist.
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice.
Cyanidin-3-O-β-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SirT1/NF-κB signaling pathway.
Polysaccharides from Armillariella tabescens mycelia ameliorate insulin resistance in type 2 diabetic mice.
Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo.
Antiviral mechanism of carvacrol on HSV-2 infectivity through inhibition of RIP3-mediated programmed cell necrosis pathway and ubiquitin-proteasome system in BSC-1 cells.
Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway.
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway.
Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.
Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages.
Dose-dependent structural and immunological changes in the placenta and fetal brain in response to systemic inflammation during pregnancy.
RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.
Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury.
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome.
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
H2S alleviates renal injury and fibrosis in response to unilateral ureteral obstruction by regulating macrophage infiltration via inhibition of NLRP3 signaling.
Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME.
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Salvianolic acid B alleviates myocardial ischemic injury by promoting mitophagy and inhibiting activation of the NLRP3 inflammasome.
Latcripin-7A, derivative of Lentinula edodes C91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G1 phase in breast cancer cells.
MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma.
Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm.
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.
A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.
FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis.
Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway.
Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice.
Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells.
Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.
Methylene Blue Attenuates Diabetic Retinopathy by Inhibiting NLRP3 Inflammasome Activation in STZ-Induced Diabetic Rats.
Purple Sweet Potato Color Attenuates Kidney Damage by Blocking VEGFR2/ROS/NLRP3 Signaling in High-Fat Diet-Treated Mice.
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Eplerenone Ameliorates Cell Pyroptosis in Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction.
Porous Se@SiO2 nanospheres attenuate ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) and inflammation by antioxidative stress.
Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats.
NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.
Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation.
TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease.
Weighted Gene Co-expression Network Analysis for RNA-Sequencing Data of the Varicose Veins Transcriptome.
Sorghum Phenolics Inhibits Inflammasomes in Lipopolysaccharide (LPS)-Primed and Adenosine Triphosphate (ATP)-Activated Macrophages.
Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.
Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway.
Treatment with andrographolide sulfonate provides additional benefits to imipenem in a mouse model of Klebsiella pneumoniae pneumonia.
FNDC5 inhibits foam cell formation and monocyte adhesion in vascular smooth muscle cells via suppressing NFκB-mediated NLRP3 upregulation.
Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways.
Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation.
Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high-fat high cholesterol diet via regulating NF-κB and NLRP3 inflammasome pathway.
Iguratimod (T-614) attenuates severe acute pancreatitis by inhibiting the NLRP3 inflammasome and NF-κB pathway.
Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis.
Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli.
The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice.
OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway.
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice.
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3.
Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3.
NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.
MicroRNA-135b alleviates MPP+-mediated Parkinson's disease in in vitro model through suppressing FoxO1-induced NLRP3 inflammasome and pyroptosis.
LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF-κB/NLRP3 inflammasome pathway.
Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.
Granisetron protects polymicrobial sepsis-induced acute lung injury in mice.
Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.
LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.
Protective effects of acarbose against vascular endothelial dysfunction through inhibiting Nox4/NLRP3 inflammasome pathway in diabetic rats.
Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy.
Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.
UFL1 modulates NLRP3 inflammasome activation and protects against pyroptosis in LPS-stimulated bovine mammary epithelial cells.
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.
Chronic Kidney Disease Increases Atrial Fibrillation Inducibility: Involvement of Inflammation, Atrial Fibrosis, and Connexins.
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.
Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice.
Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway.
Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome.
Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3 inflammasome activation.
Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.
Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.
Salvianolate reduces atrial fibrillation through suppressing atrial interstitial fibrosis by inhibiting TGF-β1/Smad2/3 and TXNIP/NLRP3 inflammasome signaling pathways in post-MI rats.
2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease.
Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway.
A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells.
The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease.
Pepsin-pancreatin hydrolysis reduced the ability of lunasin-enriched material to inhibit activation of the inflammasomes in THP-1 human macrophages.
Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice.
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice.
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.
The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.
Guo Y, Yang JH, He Y, Zhou HF, Wang Y, Ding ZS, Jin B, Wan HT
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153849
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153849
H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion.
Zhang X, Li C, Chen D, He X, Zhao Y, Bao L, Wang Q, Zhou J, Xie Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Jan;71(1):141-155
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Jan;71(1):141-155
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway.
Zhang K, Chai B, Ji H, Chen L, Ma Y, Zhu L, Xu J, Wu Y, Lan Y, Li H, Feng Z, Xiao J, Zhang H, Xu K
Laboratory investigation; a journal of technical methods and pathology 2022 Jan;102(1):90-101
Laboratory investigation; a journal of technical methods and pathology 2022 Jan;102(1):90-101
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Zhou GQ, Chen G, Yang J, Qin WY, Ping J
Journal of ethnopharmacology 2022 Jan 30;283:114707
Journal of ethnopharmacology 2022 Jan 30;283:114707
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Xu LT, Wang T, Fang KL, Zhao Y, Wang XN, Ren DM, Shen T
Journal of ethnopharmacology 2022 Jan 30;283:114694
Journal of ethnopharmacology 2022 Jan 30;283:114694
The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy.
Meihe L, Shan G, Minchao K, Xiaoling W, Peng A, Xili W, Jin Z, Huimin D
Frontiers in cell and developmental biology 2021;9:707959
Frontiers in cell and developmental biology 2021;9:707959
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Liu H, Zhang Y, Song W, Sun Y, Jiang Y
Frontiers in cell and developmental biology 2021;9:681790
Frontiers in cell and developmental biology 2021;9:681790
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Zhang Q, Zhao C, Zhang L, Sun K, Yu L, Wang X, Ren L, Zhang N, Chen C, Liu J, Wang H, Tian H
Oxidative medicine and cellular longevity 2021;2021:9921839
Oxidative medicine and cellular longevity 2021;2021:9921839
P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk.
Li Z, Huang Z, Zhang H, Lu J, Tian Y, Wei Y, Yang Y, Bai L
Oxidative medicine and cellular longevity 2021;2021:8868361
Oxidative medicine and cellular longevity 2021;2021:8868361
Effect and Mechanism of Mycobacterium tuberculosis Lipoprotein LpqH in NLRP3 Inflammasome Activation in Mouse Ana-1 Macrophage.
Liu L, Zhai K, Chen Y, Chen X, Wang G, Wu L
BioMed research international 2021;2021:8239135
BioMed research international 2021;2021:8239135
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Xu Y, Hu X, Li F, Zhang H, Lou J, Wang X, Wang H, Yin L, Ni W, Kong J, Wang X, Li Y, Zhou K, Xu H
Oxidative medicine and cellular longevity 2021;2021:8186877
Oxidative medicine and cellular longevity 2021;2021:8186877
Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation.
Zhu JJ, Yu BY, Huang XK, He MZ, Chen BW, Chen TT, Fang HY, Chen SQ, Fu XQ, Li PJ, Lin ZL, Zhu JH
Oxidative medicine and cellular longevity 2021;2021:6654954
Oxidative medicine and cellular longevity 2021;2021:6654954
Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation.
Ma W, Wang Z, Zhao Y, Wang Q, Zhang Y, Lei P, Lu W, Yan S, Zhou J, Li X, Yu W, Zhong Y, Chen L, Zheng T
Oxidative medicine and cellular longevity 2021;2021:6614574
Oxidative medicine and cellular longevity 2021;2021:6614574
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Zhu X, Hu X, Lou J, Li J, Xu Y, Yu G, Wu C, Ding J, Gao W, Xiao J, Zhou K, Jia C
Oxidative medicine and cellular longevity 2021;2021:6610603
Oxidative medicine and cellular longevity 2021;2021:6610603
Tongxinluo Exerts Inhibitory Effects on Pyroptosis and Amyloid-β Peptide Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Wang B, Lyu Z, Chan Y, Li Q, Zhang L, Liu K, Li Y, Yu Z
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5788602
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5788602
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Liao Z, Li S, Liu R, Feng X, Shi Y, Wang K, Li S, Zhang Y, Wu X, Yang C
Oxidative medicine and cellular longevity 2021;2021:5584447
Oxidative medicine and cellular longevity 2021;2021:5584447
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
Bai Y, Feng Y, Jiang B, Yang Y, Pei Z, Yang Q, Cui Y
BioMed research international 2021;2021:5512518
BioMed research international 2021;2021:5512518
Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Lyu Z, Chan Y, Li Q, Zhang Q, Liu K, Xiang J, Li X, Cai D, Li Y, Wang B, Yu Z
Neural plasticity 2021;2021:4504363
Neural plasticity 2021;2021:4504363
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Zhang Y, Liu W, Zhong Y, Li Q, Wu M, Yang L, Liu X, Zou L
Oxidative medicine and cellular longevity 2021;2021:1806344
Oxidative medicine and cellular longevity 2021;2021:1806344
Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways.
Zhang H, Zhao J, Lu Q, Sun B, Liu X, Yang C, Li S, Li L, Yi S, Yang Z, Xu J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1718709
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1718709
Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.
Wu C, Chen H, Zhuang R, Zhang H, Wang Y, Hu X, Xu Y, Li J, Li Y, Wang X, Xu H, Ni W, Zhou K
International journal of biological sciences 2021;17(4):1138-1152
International journal of biological sciences 2021;17(4):1138-1152
SOCS2 Suppresses Inflammation and Apoptosis during NASH Progression through Limiting NF-κB Activation in Macrophages.
Li S, Han S, Jin K, Yu T, Chen H, Zhou X, Tan Z, Zhang G
International journal of biological sciences 2021;17(15):4165-4175
International journal of biological sciences 2021;17(15):4165-4175
Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer.
Yan H, Luo B, Wu X, Guan F, Yu X, Zhao L, Ke X, Wu J, Yuan J
International journal of biological sciences 2021;17(10):2606-2621
International journal of biological sciences 2021;17(10):2606-2621
GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.
Peng W, Wu Y, Zhang G, Zhu W, Chang M, Rouzi A, Jiang W, Tong L, Wang Q, Liu J, Song Y, Li H, Li K, Zhou J
International journal of chronic obstructive pulmonary disease 2021;16:2817-2832
International journal of chronic obstructive pulmonary disease 2021;16:2817-2832
Punicalin Ameliorates Cell Pyroptosis Induced by LPS/ATP Through Suppression of ROS/NLRP3 Pathway.
Shen R, Yin P, Yao H, Chen L, Chang X, Li H, Hou X
Journal of inflammation research 2021;14:711-718
Journal of inflammation research 2021;14:711-718
Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes.
Fan W, Chen S, Wu X, Zhu J, Li J
Journal of inflammation research 2021;14:3523-3536
Journal of inflammation research 2021;14:3523-3536
PARK2 attenuates house dust mite-induced inflammatory reaction, pyroptosis and barrier dysfunction in BEAS-2B cells by ubiquitinating NLRP3.
Ge X, Cai F, Shang Y, Chi F, Xiao H, Xu J, Fu Y, Bai C
American journal of translational research 2021;13(1):326-335
American journal of translational research 2021;13(1):326-335
An Integrative Pharmacology Based Analysis of Refined Liuweiwuling Against Liver Injury: A Novel Component Combination and Hepaprotective Mechanism.
Gao Y, Shi W, Yao H, Ai Y, Li R, Wang Z, Liu T, Dai W, Xiao X, Zhao J, Niu M, Bai Z
Frontiers in pharmacology 2021;12:747010
Frontiers in pharmacology 2021;12:747010
CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome-Pyroptosis Pathway.
Jiang X, Gu Y, Huang Y, Zhou Y, Pang N, Luo J, Tang Z, Zhang Z, Yang L
Frontiers in pharmacology 2021;12:724747
Frontiers in pharmacology 2021;12:724747
AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation.
Kong L, Zhang H, Lu C, Shi K, Huang H, Zheng Y, Wang Y, Wang D, Wang H, Huang W
Frontiers in pharmacology 2021;12:724514
Frontiers in pharmacology 2021;12:724514
Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.
Feng B, Zhao X, Zhao W, Jiang H, Ren Z, Chen Y, Yuan Y, Du Z
Frontiers in pharmacology 2021;12:719822
Frontiers in pharmacology 2021;12:719822
Inflammasome-Induced Osmotic Pressure and the Mechanical Mechanisms Underlying Astrocytic Swelling and Membrane Blebbing in Pyroptosis.
Zheng Z, Wang T, Chen J, Qiu H, Zhang C, Liu W, Qin S, Tian J, Guo J
Frontiers in immunology 2021;12:688674
Frontiers in immunology 2021;12:688674
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Liu X, Xu Y, Cheng S, Zhou X, Zhou F, He P, Hu F, Zhang L, Chen Y, Jia Y
Frontiers in pharmacology 2021;12:687394
Frontiers in pharmacology 2021;12:687394
LPS Mediates Bovine Endometrial Epithelial Cell Pyroptosis Directly Through Both NLRP3 Classical and Non-Classical Inflammasome Pathways.
Ma X, Li Y, Shen W, Oladejo AO, Yang J, Jiang W, Imam BH, Wu X, Ding X, Yang Y, Wang S, Yan Z
Frontiers in immunology 2021;12:676088
Frontiers in immunology 2021;12:676088
Subicular Caspase-1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy.
Xu C, Zhang S, Gong Y, Nao J, Shen Y, Tan B, Xu S, Cui S, Ruan Y, Wang S, Wang Y, Chen Z
Annals of neurology 2021 Sep;90(3):377-390
Annals of neurology 2021 Sep;90(3):377-390
Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Liao Z, Liu H, Ma L, Lei J, Tong B, Li G, Ke W, Wang K, Feng X, Hua W, Li S, Yang C
ACS nano 2021 Sep 28;15(9):14709-14724
ACS nano 2021 Sep 28;15(9):14709-14724
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.
Chen S, Li Y, Chu B, Yuan L, Liu N, Zhu Y, Wang J
Microorganisms 2021 Sep 17;9(9)
Microorganisms 2021 Sep 17;9(9)
The Role of NF-κB/NLRP3 Inflammasome Signaling Pathway in Attenuating Pyroptosis by Melatonin Upon Spinal Nerve Ligation Models.
Wang YH, Gao X, Tang YR, Yu Y, Sun MJ, Chen FQ, Li Y
Neurochemical research 2021 Sep 13;
Neurochemical research 2021 Sep 13;
H2S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.
Cui J, Xu G, Bian F
International journal of cardiology 2021 Sep 1;338:215-225
International journal of cardiology 2021 Sep 1;338:215-225
MerTK inhibits the activation of the NLRP3 inflammasome after subarachnoid hemorrhage by inducing autophagy.
Du Y, Lu Z, Yang D, Wang D, Jiang L, Shen Y, Du Q, Yu W
Brain research 2021 Sep 1;1766:147525
Brain research 2021 Sep 1;1766:147525
Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
Xu M, Ye Z, Zhao X, Guo H, Gong X, Huang R
Cellular signalling 2021 Oct;86:110084
Cellular signalling 2021 Oct;86:110084
Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis.
Hou CC, Ma HF, Ye JF, Luo D, Bao HF, Guan JL
Clinical rheumatology 2021 Oct;40(10):4143-4155
Clinical rheumatology 2021 Oct;40(10):4143-4155
Gardnerella vaginalis induces NLRP3 inflammasome-mediated pyroptosis in macrophages and THP-1 monocytes.
Xiang N, Yin T, Chen T
Experimental and therapeutic medicine 2021 Oct;22(4):1174
Experimental and therapeutic medicine 2021 Oct;22(4):1174
IL-38-mediated NLRP3/caspase-1 inhibition is a disease-modifying treatment for TMJ inflammation.
Luo P, Zhao T, He H
Annals of the New York Academy of Sciences 2021 Oct 20;
Annals of the New York Academy of Sciences 2021 Oct 20;
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome.
Song L, Yao S, Zheng D, Xuan Y, Li W
International urology and nephrology 2021 Oct 15;
International urology and nephrology 2021 Oct 15;
Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury.
Chen Y, Gong K, Guo L, Zhang B, Chen S, Li Z, Quanhua X, Liu W, Wang Z
Cell death discovery 2021 Oct 12;7(1):290
Cell death discovery 2021 Oct 12;7(1):290
Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.
Zhu M, Wang Y, Zhu L, Du S, Wang Z, Zhang Y, Guo Y, Tu Y, Song E
Inflammation 2021 Oct 1;
Inflammation 2021 Oct 1;
Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-κB pathway.
Wei YY, Fan YM, Ga Y, Zhang YN, Han JC, Hao ZH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov;92:153743
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov;92:153743
LncRNA HOTAIR Promotes Neuronal Damage Through Facilitating NLRP3 Mediated-Pyroptosis Activation in Parkinson's Disease via Regulation of miR-326/ELAVL1 Axis.
Zhang Q, Huang XM, Liao JX, Dong YK, Zhu JL, He CC, Huang J, Tang YW, Wu D, Tian JY
Cellular and molecular neurobiology 2021 Nov;41(8):1773-1786
Cellular and molecular neurobiology 2021 Nov;41(8):1773-1786
Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.
Zhai J, Gao H, Wang S, Zhang S, Qu X, Zhang Y, Tao L, Sun J, Song Y, Fu L
Journal of biochemical and molecular toxicology 2021 Nov;35(11):e22896
Journal of biochemical and molecular toxicology 2021 Nov;35(11):e22896
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Hao W, Hao C, Wu C, Xu Y, Wu S, Lu X, Yang J, Jin C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Inflammatory and immune-related factor Caspase 1 contributes to the development of oral lichen planus.
Zeng X, Luo X, Mao X, Wen D, Zhang H, Wang J
Archives of oral biology 2021 Nov;131:105244
Archives of oral biology 2021 Nov;131:105244
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Wang L, Wang X, Kong L, Wang S, Huang K, Wu J, Wang C, Sun H, Liu K, Meng Q
International immunopharmacology 2021 Nov;100:108159
International immunopharmacology 2021 Nov;100:108159
Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis.
Huang J, An Q, Ju BM, Zhang J, Fan P, He L, Wang L
International immunopharmacology 2021 Nov;100:108131
International immunopharmacology 2021 Nov;100:108131
Suppression of the caspase-1/GSDMD-mediated pyroptotic signaling pathway through dexamethasone alleviates corneal alkali injuries.
Tan Y, Zhang M, Pan Y, Feng H, Xie L
Experimental eye research 2021 Nov 23;214:108858
Experimental eye research 2021 Nov 23;214:108858
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Ge S, Yang W, Chen H, Yuan Q, Liu S, Zhao Y, Zhang J
International journal of molecular sciences 2021 Nov 17;22(22)
International journal of molecular sciences 2021 Nov 17;22(22)
Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo.
Liu Y, Shang L, Zhou J, Pan G, Zhou F, Yang S
Inflammation 2021 Nov 17;
Inflammation 2021 Nov 17;
Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis.
Li Z, Huang Z, Zhang H, Lu J, Tian Y, Piao S, Lin Z, Bai L
Cell death discovery 2021 Nov 10;7(1):346
Cell death discovery 2021 Nov 10;7(1):346
Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
Zhuang J, Zhou X, Liu T, Zhang S, Yuan F, Zhang L, Yang Z, Chen Y
Die Pharmazie 2021 Nov 1;76(11):551-558
Die Pharmazie 2021 Nov 1;76(11):551-558
The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase-1 signaling pathway and oxidative stress in Wistar rats.
Wei J, Wang X, Liu Q, Zhou N, Zhu S, Li Z, Li X, Yao J, Zhang L
Environmental toxicology 2021 May;36(5):935-944
Environmental toxicology 2021 May;36(5):935-944
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Li J, Chen H, Lou J, Bao G, Wu C, Lou Z, Wang X, Ding J, Li Z, Xiao J, Xu H, Gao W, Zhou K
Journal of cellular physiology 2021 May;236(5):3641-3659
Journal of cellular physiology 2021 May;236(5):3641-3659
The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.
Yue XF, Shen CX, Wang JW, Dai LY, Fang Q, Long L, Zhi Y, Li XR, Wang YW, Shen GF, Liu ZJ, Shi CM, Li WB
Asian journal of andrology 2021 May-Jun;23(3):249-258
Asian journal of andrology 2021 May-Jun;23(3):249-258
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
Han M, Li S, Li L
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75
Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats.
Nie C, Ding X, A R, Zheng M, Li Z, Pan S, Yang W
Life sciences 2021 May 1;272:119248
Life sciences 2021 May 1;272:119248
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Wei Z, Fei Y, Wang Q, Hou J, Cai X, Yang Y, Chen T, Xu Q, Wang Y, Li YG
Free radical biology & medicine 2021 May 1;167:243-257
Free radical biology & medicine 2021 May 1;167:243-257
Cordyceps acid alleviates lung cancer in nude mice.
Wang J, Chen H, Li W, Shan L
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
NLRP3 inflammasome-mediated endothelial cells pyroptosis is involved in decabromodiphenyl ethane-induced vascular endothelial injury.
Zheng D, Shi Z, Yang M, Liang B, Zhou X, Jing L, Sun Z
Chemosphere 2021 Mar;267:128867
Chemosphere 2021 Mar;267:128867
Airborne particulate matter (PM2.5) triggers ocular hypertension and glaucoma through pyroptosis.
Li L, Xing C, Zhou J, Niu L, Luo B, Song M, Niu J, Ruan Y, Sun X, Lei Y
Particle and fibre toxicology 2021 Mar 4;18(1):10
Particle and fibre toxicology 2021 Mar 4;18(1):10
Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1.
Zeng J, Tao J, Xia L, Zeng Z, Chen J, Wang Z, Meng J, Liu L
Biochemistry and cell biology = Biochimie et biologie cellulaire 2021 Jun;99(3):339-347
Biochemistry and cell biology = Biochimie et biologie cellulaire 2021 Jun;99(3):339-347
Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway.
Huang X, Shen H, Liu Y, Qiu S, Guo Y
International immunopharmacology 2021 Jun;95:107505
International immunopharmacology 2021 Jun;95:107505
Golgi phosphoprotein 3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome.
Zhu Z, Zhu Q, Cai D, Chen L, Xie W, Bai Y, Luo K
Oncology reports 2021 Jun;45(6)
Oncology reports 2021 Jun;45(6)
IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.
Wang J, Yuan X, Ding N
Experimental and therapeutic medicine 2021 Jun;21(6):593
Experimental and therapeutic medicine 2021 Jun;21(6):593
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Lam HYP, Liang TR, Peng SY
PLoS neglected tropical diseases 2021 Jun;15(6):e0009554
PLoS neglected tropical diseases 2021 Jun;15(6):e0009554
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
Li D, Liu M, Li Z, Zheng G, Chen A, Zhao L, Yang P, Wei L, Chen Y, Ruan XZ
Aging and disease 2021 Jun;12(3):747-763
Aging and disease 2021 Jun;12(3):747-763
Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation.
Ge C, Cheng Y, Fan Y, He Y
Clinical science (London, England : 1979) 2021 Jun 11;135(11):1409-1426
Clinical science (London, England : 1979) 2021 Jun 11;135(11):1409-1426
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.
Li J, Qin X, Shi J, Wang X, Li T, Xu M, Chen X, Zhao Y, Han J, Piao Y, Zhang W, Qu P, Wang L, Xiang R, Shi Y
eLife 2021 Jun 11;10
eLife 2021 Jun 11;10
Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway.
Xu X, Huang X, Zhang L, Huang X, Qin Z, Hua F
BMC nephrology 2021 Jun 10;22(1):218
BMC nephrology 2021 Jun 10;22(1):218
MIF inhibitor ISO-1 alleviates severe acute pancreatitis-associated acute kidney injury by suppressing the NLRP3 inflammasome signaling pathway.
Liu Y, Liu Y, Wang Q, Song Y, Chen S, Cheng B, Zhang Y, Cui Z, Wu Z, Zhu C
International immunopharmacology 2021 Jul;96:107555
International immunopharmacology 2021 Jul;96:107555
Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes.
Liu X, Zhang M, Liu H, Zhu R, He H, Zhou Y, Zhang Y, Li C, Liang D, Zeng Q, Huang G
Experimental neurology 2021 Jul;341:113700
Experimental neurology 2021 Jul;341:113700
N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia-reperfusion rats via the TLR4/NF-κB/NLRP3 pathway.
Liu J, Zhang N, Zhang M, Yin H, Zhang X, Wang X, Wang X, Zhao Y
Experimental eye research 2021 Jul;208:108595
Experimental eye research 2021 Jul;208:108595
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.
Tang W, Yang Y, Yang L, Tang M, Chen Y, Li C
Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470
Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470
Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis.
Liu Y, Li YP, Xiao LM, Chen LK, Zheng SY, Zeng EM, Xu CH
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):837-850
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):837-850
hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis.
Cai X, Zhang ZY, Yuan JT, Ocansey DKW, Tu Q, Zhang X, Qian H, Xu WR, Qiu W, Mao F
Stem cell research & therapy 2021 Jul 22;12(1):416
Stem cell research & therapy 2021 Jul 22;12(1):416
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.
Malireddi RKS, Karki R, Sundaram B, Kancharana B, Lee S, Samir P, Kanneganti TD
ImmunoHorizons 2021 Jul 21;5(7):568-580
ImmunoHorizons 2021 Jul 21;5(7):568-580
Toll‑like receptor 4 activates the NLRP3 inflammasome pathway and periodontal inflammaging by inhibiting Bmi‑1 expression.
Qin ZY, Gu X, Chen YL, Liu JB, Hou CX, Lin SY, Hao NN, Liang Y, Chen W, Meng HY
International journal of molecular medicine 2021 Jan;47(1):137-150
International journal of molecular medicine 2021 Jan;47(1):137-150
Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway.
Xu S, Chen H, Ni H, Dai Q
Atherosclerosis 2021 Jan;317:1-9
Atherosclerosis 2021 Jan;317:1-9
Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342-3p targeting of CASP1 in diabetic retinopathy.
Yu X, Ma X, Lin W, Xu Q, Zhou H, Kuang H
Experimental eye research 2021 Jan;202:108300
Experimental eye research 2021 Jan;202:108300
Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice.
Yu Y, Chen D, Zhao Y, Zhu J, Dong X
International journal of immunopathology and pharmacology 2021 Jan-Dec;35:20587384211036819
International journal of immunopathology and pharmacology 2021 Jan-Dec;35:20587384211036819
Kupffer Cell-targeting strategy for the protection of Hepatic Ischemia/Reperfusion Injury.
Dai Q, Jiang W, Liu H, Qing X, Wang G, Huang F, Yang Z, Wang C, Gu E, Zhao H, Zhang J, Liu X
Nanotechnology 2021 Jan 20;
Nanotechnology 2021 Jan 20;
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Guo Z, Qiu C, Mecca C, Zhang Y, Bian J, Wang Y, Wu X, Wang T, Su W, Li X, Zhang W, Chen B, Xiang H
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth.
Fu F, Bao R, Yao S, Zhou C, Luo H, Zhang Z, Zhang H, Li Y, Yan S, Yu H, Du W, Yang Y, Jin H, Tong P, Sun ZT, Yue M, Chen D, Wu C, Ruan H
Scientific reports 2021 Jan 12;11(1):772
Scientific reports 2021 Jan 12;11(1):772
Protection of hUC-MSCs against neuronal complement C3a receptor-mediated NLRP3 activation in CUMS-induced mice.
Li J, Tian S, Wang H, Wang Y, Du C, Fang J, Wang X, Wang Y, Gong Z, Yan B, Wang M
Neuroscience letters 2021 Jan 10;741:135485
Neuroscience letters 2021 Jan 10;741:135485
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis.
Wang X, Liu K, Gong H, Li D, Chu W, Zhao D, Wang X, Xu D
Toxicology and applied pharmacology 2021 Jan 1;410:115363
Toxicology and applied pharmacology 2021 Jan 1;410:115363
Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression.
Li W, Ali T, He K, Liu Z, Shah FA, Ren Q, Liu Y, Jiang A, Li S
Brain, behavior, and immunity 2021 Feb;92:10-24
Brain, behavior, and immunity 2021 Feb;92:10-24
lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome.
Dai W, Wang M, Wang P, Wen J, Wang J, Cha S, Xiao X, He Y, Shu R, Bai D
International journal of molecular medicine 2021 Feb;47(2):607-620
International journal of molecular medicine 2021 Feb;47(2):607-620
Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.
Chen LJ, Zhi X, Zhang KK, Wang LB, Li JH, Liu JL, Xu LL, Yoshida JS, Xie XL, Wang Q
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111946
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111946
Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
Hu J, Qiao J, Yu Q, Liu B, Zhen J, Liu Y, Ma Q, Li Y, Wang Q, Wang C, Lv Z
Journal of translational medicine 2021 Feb 15;19(1):69
Journal of translational medicine 2021 Feb 15;19(1):69
Silenced microRNA-222 suppresses inflammatory response in gestational diabetes mellitus mice by promoting CXCR4.
Zhang H, Luan S, Xiao X, Lin L, Zhao X, Liu X
Life sciences 2021 Feb 1;266:118850
Life sciences 2021 Feb 1;266:118850
Huoxue Qianyang Qutan recipe attenuates cardiac fibrosis by inhibiting the NLRP3 inflammasome signalling pathway in obese hypertensive rats.
Lu B, Xie J, Fu D, Chen X, Zhao M, Gui M, Yao L, Zhou X, Li J
Pharmaceutical biology 2021 Dec;59(1):1045-1057
Pharmaceutical biology 2021 Dec;59(1):1045-1057
Dexmedetomidine inhibits endoplasmic reticulum stress to suppress pyroptosis of hypoxia/reoxygenation-induced intestinal epithelial cells via activating the SIRT1 expression.
Liu X, Leng Y, Lv X, Lv J, Zhang M, Shi Y
Journal of bioenergetics and biomembranes 2021 Dec;53(6):655-664
Journal of bioenergetics and biomembranes 2021 Dec;53(6):655-664
Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM2.5.
Zhang X, Qi W, Shi Y, Li X, Yin J, Huo C, Zhang R, Zhao W, Ye J, Zhou L, Ye L
Toxicology 2021 Dec;464:152993
Toxicology 2021 Dec;464:152993
Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway.
Jiang W, Geng H, Lv X, Ma J, Liu F, Lin P, Yan C
Cardiovascular drugs and therapy 2021 Dec;35(6):1129-1145
Cardiovascular drugs and therapy 2021 Dec;35(6):1129-1145
MEHP induces pyroptosis and autophagy alternation by cathepsin B activation in INS-1 cells.
Jiang L, Qiu T, Yao X, Chen H, Yao K, Sun X, Yang G, Jiang L, Zhang C, Wang N, Zhang H, Liu X
Environmental science and pollution research international 2021 Dec;28(47):66628-66642
Environmental science and pollution research international 2021 Dec;28(47):66628-66642
DDX3X deficiency alleviates LPS-induced H9c2 cardiomyocytes pyroptosis by suppressing activation of NLRP3 inflammasome.
Feng D, Guo L, Liu J, Song Y, Ma X, Hu H, Liu J, Hao E
Experimental and therapeutic medicine 2021 Dec;22(6):1389
Experimental and therapeutic medicine 2021 Dec;22(6):1389
MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice.
Wu X, Zhang Y, Zhang Y, Xia L, Yang Y, Wang P, Xu Y, Ren Z, Liu H
Brain research bulletin 2021 Dec;177:31-38
Brain research bulletin 2021 Dec;177:31-38
ESR2 regulates PINK1-mediated mitophagy via transcriptional repression of microRNA-423 expression to promote asthma development.
Kong X, Chen R, Zhang L, Wu M, Wu J, Wei Y, Dai W, Jiang Y
Pharmacological research 2021 Dec;174:105956
Pharmacological research 2021 Dec;174:105956
Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke.
Li F, Xu D, Hou K, Gou X, Lv N, Fang W, Li Y
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2021 Dec;16(4):835-853
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2021 Dec;16(4):835-853
Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway.
Ruan Y, Ling J, Ye F, Cheng N, Wu F, Tang Z, Cheng X, Liu H
International immunopharmacology 2021 Dec;101(Pt B):108364
International immunopharmacology 2021 Dec;101(Pt B):108364
Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice.
Li A, Wu X, Yang J, Li J, Guo H, Zhang Y, Jiang H, Huo T
Journal of ethnopharmacology 2021 Dec 5;281:114584
Journal of ethnopharmacology 2021 Dec 5;281:114584
Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice.
Cao LL, Guan PP, Zhang SQ, Yang Y, Huang XS, Wang P
Journal of neuroinflammation 2021 Dec 3;18(1):281
Journal of neuroinflammation 2021 Dec 3;18(1):281
Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways.
Wang X, Chen S, Zhao L, Shi X
International immunopharmacology 2021 Aug;97:107506
International immunopharmacology 2021 Aug;97:107506
Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome‑mediated inflammation.
Feng H, Zhu X, Tang Y, Fu S, Kong B, Liu X
International journal of molecular medicine 2021 Aug;48(2)
International journal of molecular medicine 2021 Aug;48(2)
Resveratrol affects the expression of uric acid transporter by improving inflammation.
Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, Wang X, Song G
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Microtubule associated protein 4 (MAP4) phosphorylation reduces cardiac microvascular density through NLRP3-related pyroptosis.
Feng YH, Li LF, Zhang Q, Zhang JH, Huang Y, Lv YL, Jia JZ, Zhang D, Hu JY, Huang YS
Cell death discovery 2021 Aug 12;7(1):213
Cell death discovery 2021 Aug 12;7(1):213
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Zeng J, Tao J, Xi L, Wang Z, Liu L
International journal of molecular medicine 2021 Apr;47(4)
International journal of molecular medicine 2021 Apr;47(4)
Carthamin yellow improves cerebral ischemia‑reperfusion injury by attenuating inflammation and ferroptosis in rats.
Guo H, Zhu L, Tang P, Chen D, Li Y, Li J, Bao C
International journal of molecular medicine 2021 Apr;47(4)
International journal of molecular medicine 2021 Apr;47(4)
Therapeutic Effect of Endothelin-Converting Enzyme Inhibitor on Chronic Kidney Disease through the Inhibition of Endoplasmic Reticulum Stress and the NLRP3 Inflammasome.
Hsu YH, Zheng CM, Chou CL, Chen YJ, Lee YH, Lin YF, Chiu HW
Biomedicines 2021 Apr 7;9(4)
Biomedicines 2021 Apr 7;9(4)
Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.
Dai J, Chen Q, Huang W, Shi K, Zhang Y, Li T, Mou T, Huang Z, Wu Z
Acta biochimica et biophysica Sinica 2021 Apr 15;53(5):601-611
Acta biochimica et biophysica Sinica 2021 Apr 15;53(5):601-611
Absent in melanoma 2 suppresses gastric cancer cell proliferation and migration via inactivation of AKT signaling pathway.
Wang D, Zou J, Dai J, Cheng Z
Scientific reports 2021 Apr 15;11(1):8235
Scientific reports 2021 Apr 15;11(1):8235
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis.
Zheng T, Wang Q, Bian F, Zhao Y, Ma W, Zhang Y, Lu W, Lei P, Zhang L, Hao X, Chen L
Toxicology and applied pharmacology 2021 Apr 1;416:115468
Toxicology and applied pharmacology 2021 Apr 1;416:115468
Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats.
Hou J, Lei Z, Cui L, Hou Y, Yang L, An R, Wang Q, Li S, Zhang H, Zhang L
Ecotoxicology and environmental safety 2021 Apr 1;212:112012
Ecotoxicology and environmental safety 2021 Apr 1;212:112012
VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice.
Sun Z, Nyanzu M, Yang S, Zhu X, Wang K, Ru J, Yu E, Zhang H, Wang Z, Shen J, Zhuge Q, Huang L
Oxidative medicine and cellular longevity 2020;2020:7879629
Oxidative medicine and cellular longevity 2020;2020:7879629
Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R-/-) Mice via Its Anti-inflammatory and Antipyroptotic Effects.
Pei ZW, Guo Y, Zhu HL, Dong M, Zhang Q, Wang F
BioMed research international 2020;2020:4878704
BioMed research international 2020;2020:4878704
Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia.
He XM, Zhou YZ, Sheng S, Li JJ, Wang GQ, Zhang F
Oxidative medicine and cellular longevity 2020;2020:2963540
Oxidative medicine and cellular longevity 2020;2020:2963540
Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice.
Guo LP, Liu SX, Yang Q, Liu HY, Xu LL, Hao YH, Zhang XQ
BioMed research international 2020;2020:1594726
BioMed research international 2020;2020:1594726
Blocking the LncRNA MALAT1/miR-224-5p/NLRP3 Axis Inhibits the Hippocampal Inflammatory Response in T2DM With OSA.
Du P, Wang J, Han Y, Feng J
Frontiers in cellular neuroscience 2020;14:97
Frontiers in cellular neuroscience 2020;14:97
Maresin 1 Attenuates Radicular Pain Through the Inhibition of NLRP3 Inflammasome-Induced Pyroptosis via NF-κB Signaling.
Wang YH, Li Y, Wang JN, Zhao QX, Jin J, Wen S, Wang SC, Sun T
Frontiers in neuroscience 2020;14:831
Frontiers in neuroscience 2020;14:831
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Gao Z, Sui J, Fan R, Qu W, Dong X, Sun D
Drug design, development and therapy 2020;14:1971-1982
Drug design, development and therapy 2020;14:1971-1982
Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux.
Zeng Q, Zhou Y, Liang D, He H, Liu X, Zhu R, Zhang M, Luo X, Wang Y, Huang G
Frontiers in cellular neuroscience 2020;14:182
Frontiers in cellular neuroscience 2020;14:182
Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.
Wu X, Mao X, Huang Y, Zhu Q, Guan J, Wu L
International journal of clinical and experimental pathology 2020;13(6):1408-1414
International journal of clinical and experimental pathology 2020;13(6):1408-1414
Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease.
Zhang J, Pei L, Zang D, Xue Y, Wang X, Chen Y, Li J, Yu J, Gao Q, Di W, Cui C, Su W, Wang X
Frontiers in aging neuroscience 2020;12:512097
Frontiers in aging neuroscience 2020;12:512097
Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway.
Luo W, Han Y, Meng P, Yang Q, Zhao H, Ling J, Wang Y
Cancer management and research 2020;12:13003-13014
Cancer management and research 2020;12:13003-13014
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
Li N, Zhao T, Cao Y, Zhang H, Peng L, Wang Y, Zhou X, Wang Q, Li J, Yan M, Dong X, Zhao H, Li P
Frontiers in pharmacology 2020;11:623489
Frontiers in pharmacology 2020;11:623489
Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome.
Wei C, Guo S, Liu W, Jin F, Wei B, Fan H, Su H, Liu J, Zhang N, Fang D, Li G, Shu S, Li X, He X, Zhang X, Duan C
Frontiers in pharmacology 2020;11:610734
Frontiers in pharmacology 2020;11:610734
Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury.
Jin H, Zhao Z, Lan Q, Zhou H, Mai Z, Wang Y, Ding X, Zhang W, Pi J, Evans CE, Liu X
Frontiers in pharmacology 2020;11:592238
Frontiers in pharmacology 2020;11:592238
Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats.
Jiang M, Wang W, Zhang J, Wang C, Bi Y, Li P, Yang S, Li J, Xu YT, Wang T
Frontiers in pharmacology 2020;11:546
Frontiers in pharmacology 2020;11:546
MiR-139 protects against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced nerve injury through targeting c-Jun to inhibit NLRP3 inflammasome activation.
Wang QS, Luo XY, Fu H, Luo Q, Wang MQ, Zou DY
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Sep;29(9):105037
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Sep;29(9):105037
Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity.
Li S, Shi M, Wan Y, Wang Y, Zhu M, Wang B, Zhan Y, Ran B, Wu C
Ecotoxicology and environmental safety 2020 Sep 15;201:110801
Ecotoxicology and environmental safety 2020 Sep 15;201:110801
Mesenchymal stem cells-derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis.
Zhang J, Zhang J, Zhang Y, Liu W, Ni W, Huang X, Yuan J, Zhao B, Xiao H, Xue F
Journal of cellular and molecular medicine 2020 Oct;24(20):11742-11754
Journal of cellular and molecular medicine 2020 Oct;24(20):11742-11754
Trimethylamine N-oxide promotes apoE-/- mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Wu P, Chen J, Chen J, Tao J, Wu S, Xu G, Wang Z, Wei D, Yin W
Journal of cellular physiology 2020 Oct;235(10):6582-6591
Journal of cellular physiology 2020 Oct;235(10):6582-6591
The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.
Wang G, Zuo T, Li R
Drug development research 2020 Nov;81(7):859-866
Drug development research 2020 Nov;81(7):859-866
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
Xu Y, Fang H, Xu Q, Xu C, Yang L, Huang C
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3054-3065
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3054-3065
MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor.
Tao J, Xia LZ, Liang L, Chen Y, Wei D, Meng J, Wu S, Wang Z
Placenta 2020 Nov;101:176-184
Placenta 2020 Nov;101:176-184
A novel mechanism of protection against isoproterenol-induced cardiac inflammation via regulation of the SIRT1/NRF2 signaling pathway with a natural SIRT1 agonist.
Nie Q, Zhang J, He B, Wang F, Sun M, Wang C, Sun W, Guo J, Wen J, Liu P
European journal of pharmacology 2020 Nov 5;886:173398
European journal of pharmacology 2020 Nov 5;886:173398
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice.
Wang D, Weng Y, Zhang Y, Wang R, Wang T, Zhou J, Shen S, Wang H, Wang Y
The Science of the total environment 2020 Nov 25;745:141049
The Science of the total environment 2020 Nov 25;745:141049
Cyanidin-3-O-β-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SirT1/NF-κB signaling pathway.
Zhou Y, Wang S, Wan T, Huang Y, Pang N, Jiang X, Gu Y, Zhang Z, Luo J, Yang L
Free radical biology & medicine 2020 Nov 20;160:334-341
Free radical biology & medicine 2020 Nov 20;160:334-341
Polysaccharides from Armillariella tabescens mycelia ameliorate insulin resistance in type 2 diabetic mice.
Yang R, Li Y, Cai J, Ji J, Wang Y, Zhang W, Pan W, Chen Y
Food & function 2020 Nov 18;11(11):9675-9685
Food & function 2020 Nov 18;11(11):9675-9685
Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo.
Tan S, Gao J, Li Q, Guo T, Dong X, Bai X, Yang J, Hao S, He F
Scientific reports 2020 Nov 17;10(1):20013
Scientific reports 2020 Nov 17;10(1):20013
Antiviral mechanism of carvacrol on HSV-2 infectivity through inhibition of RIP3-mediated programmed cell necrosis pathway and ubiquitin-proteasome system in BSC-1 cells.
Wang L, Wang D, Wu X, Xu R, Li Y
BMC infectious diseases 2020 Nov 11;20(1):832
BMC infectious diseases 2020 Nov 11;20(1):832
Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway.
Jia Y, Cui R, Wang C, Feng Y, Li Z, Tong Y, Qu K, Liu C, Zhang J
Redox biology 2020 May;32:101534
Redox biology 2020 May;32:101534
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
Zhu Y, Zhu C, Yang H, Deng J, Fan D
Pharmacological research 2020 May;155:104746
Pharmacological research 2020 May;155:104746
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H
Cellular & molecular immunology 2020 Mar;17(3):283-299
Cellular & molecular immunology 2020 Mar;17(3):283-299
Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway.
Yang K, Zhan L, Lu T, Zhou C, Chen X, Dong Y, Lv G, Chen S
Cytokine 2020 Mar 26;130:155058
Cytokine 2020 Mar 26;130:155058
Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.
Luo X, Li Y, Yang P, Chen Y, Wei L, Yu T, Xia J, Ruan XZ, Zhao L, Chen Y
EBioMedicine 2020 Jun;56:102797
EBioMedicine 2020 Jun;56:102797
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.
Kai J, Yang X, Wang Z, Wang F, Jia Y, Wang S, Tan S, Chen A, Shao J, Zhang F, Zhang Z, Zheng S
Free radical biology & medicine 2020 Jun;153:89-102
Free radical biology & medicine 2020 Jun;153:89-102
Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages.
Zhang C, Zhao C, Chen X, Tao R, Wang S, Meng G, Liu X, Shao C, Su X
Cell death & disease 2020 Jun 18;11(6):470
Cell death & disease 2020 Jun 18;11(6):470
Dose-dependent structural and immunological changes in the placenta and fetal brain in response to systemic inflammation during pregnancy.
Chudnovets A, Lei J, Na Q, Dong J, Narasimhan H, Klein SL, Burd I
American journal of reproductive immunology (New York, N.Y. : 1989) 2020 Jul;84(1):e13248
American journal of reproductive immunology (New York, N.Y. : 1989) 2020 Jul;84(1):e13248
RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.
Liu N, Wang Y, Zeng L, Yin S, Hu Y, Li S, Fu Y, Zhang X, Xie C, Shu L, Li Y, Sun H, Yang M, Sun J, Yang X
Journal of agricultural and food chemistry 2020 Jul 8;68(27):7143-7151
Journal of agricultural and food chemistry 2020 Jul 8;68(27):7143-7151
Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
Lam HYP, Liang TR, Jiang SJ, Peng SY
Biomolecules 2020 Jul 5;10(7)
Biomolecules 2020 Jul 5;10(7)
NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury.
Chang Y, Zhu J, Wang D, Li H, He Y, Liu K, Wang X, Peng Y, Pan S, Huang K
Journal of neuroinflammation 2020 Jul 23;17(1):219
Journal of neuroinflammation 2020 Jul 23;17(1):219
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Xie C, Ge M, Jin J, Xu H, Mao L, Geng S, Wu J, Zhu J, Li X, Zhong C
Journal of hazardous materials 2020 Jul 15;394:122549
Journal of hazardous materials 2020 Jul 15;394:122549
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Pang H, Wang N, Chai J, Wang X, Zhang Y, Bi Z, Wu W, He G
European journal of medicinal chemistry 2020 Jul 1;197:112314
European journal of medicinal chemistry 2020 Jul 1;197:112314
α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome.
Wang X, Chi J, Huang D, Ding L, Zhao X, Jiang L, Yu Y, Gao F
Experimental and therapeutic medicine 2020 Feb;19(2):931-938
Experimental and therapeutic medicine 2020 Feb;19(2):931-938
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
Zhou Y, Fu X, Guan Y, Gong M, He K, Huang B
Biochemical pharmacology 2020 Feb;172:113752
Biochemical pharmacology 2020 Feb;172:113752
H2S alleviates renal injury and fibrosis in response to unilateral ureteral obstruction by regulating macrophage infiltration via inhibition of NLRP3 signaling.
Zhou Y, Zhu X, Wang X, Peng Y, Du J, Yin H, Yang H, Ni X, Zhang W
Experimental cell research 2020 Feb 1;387(1):111779
Experimental cell research 2020 Feb 1;387(1):111779
Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME.
Zheng X, Zhong T, Ma Y, Wan X, Qin A, Yao B, Zou H, Song Y, Yin D
Life sciences 2020 Feb 1;242:117186
Life sciences 2020 Feb 1;242:117186
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Lang L, Xu B, Yuan J, Li S, Lian S, Chen Y, Guo J, Yang H
International immunopharmacology 2020 Dec;89(Pt B):106908
International immunopharmacology 2020 Dec;89(Pt B):106908
Salvianolic acid B alleviates myocardial ischemic injury by promoting mitophagy and inhibiting activation of the NLRP3 inflammasome.
Hu Y, Wang X, Li Q, Pan Y, Xu L
Molecular medicine reports 2020 Dec;22(6):5199-5208
Molecular medicine reports 2020 Dec;22(6):5199-5208
Latcripin-7A, derivative of Lentinula edodes C91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G1 phase in breast cancer cells.
Din SRU, Zhong M, Nisar MA, Saleem MZ, Hussain A, Khinsar KH, Alam S, Ayub G, Kanwal S, Li X, Zhang W, Wang X, Ning A, Cao J, Huang M
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma.
Tang Q, Li W, Zheng X, Ren L, Liu J, Li S, Wang J, Du G
Signal transduction and targeted therapy 2020 Dec 2;5(1):279
Signal transduction and targeted therapy 2020 Dec 2;5(1):279
Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm.
Zhang X, Li F, Wang W, Ji L, Sun B, Xiao X, Wang X, Chen Y, Liu B, Ye W, Tian C, Wang H, Zheng Y
Biochemical and biophysical research communications 2020 Dec 17;533(4):1012-1020
Biochemical and biophysical research communications 2020 Dec 17;533(4):1012-1020
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.
Lam HYP, Chen TT, Chen CC, Yang TH, Cheng PC, Peng SY
Parasitology international 2020 Aug;77:102119
Parasitology international 2020 Aug;77:102119
A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.
Wang YH, Li Y, Wang JN, Zhao QX, Wen S, Wang SC, Sun T
Neurochemical research 2020 Aug;45(8):1860-1869
Neurochemical research 2020 Aug;45(8):1860-1869
FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis.
Zeng Z, Zheng Q, Chen J, Tan X, Li Q, Ding L, Zhang R, Lin X
Experimental cell research 2020 Aug 15;393(2):112108
Experimental cell research 2020 Aug 15;393(2):112108
Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway.
Chen JJ, Tao J, Zhang XL, Xia LZ, Zeng JF, Zhang H, Wei DH, Lv YC, Li GH, Wang Z
DNA and cell biology 2020 Apr;39(4):661-670
DNA and cell biology 2020 Apr;39(4):661-670
Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice.
Liu Q, Guo X, Huang Z, He Q, Zhu D, Zhang S, Peng Z, Che Y, Feng X
Behavioural brain research 2020 Apr 6;383:112539
Behavioural brain research 2020 Apr 6;383:112539
Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells.
Bai Z, Liu W, He D, Wang Y, Yi W, Luo C, Shen J, Hu Z
Aging 2020 Apr 22;12(8):7534-7548
Aging 2020 Apr 22;12(8):7534-7548
Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.
Yang K, Lu T, Zhan L, Zhou C, Zhang N, Lei S, Wang Y, Yang J, Yan M, Lv G, Chen S
International journal of biological macromolecules 2020 Apr 15;149:320-330
International journal of biological macromolecules 2020 Apr 15;149:320-330
Methylene Blue Attenuates Diabetic Retinopathy by Inhibiting NLRP3 Inflammasome Activation in STZ-Induced Diabetic Rats.
Hao J, Zhang H, Yu J, Chen X, Yang L
Ocular immunology and inflammation 2019;27(5):836-843
Ocular immunology and inflammation 2019;27(5):836-843
Purple Sweet Potato Color Attenuates Kidney Damage by Blocking VEGFR2/ROS/NLRP3 Signaling in High-Fat Diet-Treated Mice.
Zheng GH, Shan Q, Mu JJ, Wang YJ, Zhang ZF, Fan SH, Hu B, Li MQ, Xie J, Chen P, Wu DM, Lu J, Zheng YL
Oxidative medicine and cellular longevity 2019;2019:5189819
Oxidative medicine and cellular longevity 2019;2019:5189819
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Leng B, Zhang Y, Liu X, Zhang Z, Liu Y, Wang H, Lu M
Mediators of inflammation 2019;2019:1082497
Mediators of inflammation 2019;2019:1082497
Eplerenone Ameliorates Cell Pyroptosis in Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction.
Ma X, Chang Y, Xiong Y, Wang Z, Wang X, Xu Q
Nephron 2019;142(3):233-242
Nephron 2019;142(3):233-242
Porous Se@SiO2 nanospheres attenuate ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) and inflammation by antioxidative stress.
Zheng Z, Deng G, Qi C, Xu Y, Liu X, Zhao Z, Zhang Z, Chu Y, Wu H, Liu J
International journal of nanomedicine 2019;14:215-229
International journal of nanomedicine 2019;14:215-229
Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats.
Zhuang K, Zuo YC, Sherchan P, Wang JK, Yan XX, Liu F
Frontiers in neuroscience 2019;13:1441
Frontiers in neuroscience 2019;13:1441
NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.
Liu SG, Wu XX, Hua T, Xin XY, Feng DL, Chi SQ, Wang XX, Wang HB
OncoTargets and therapy 2019;12:6927-6936
OncoTargets and therapy 2019;12:6927-6936
Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation.
Chen C, Wei YZ, He XM, Li DD, Wang GQ, Li JJ, Zhang F
Frontiers in immunology 2019;10:936
Frontiers in immunology 2019;10:936
TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease.
Wang Y, Zhu X, Yuan S, Wen S, Liu X, Wang C, Qu Z, Li J, Liu H, Sun L, Liu F
Frontiers in endocrinology 2019;10:603
Frontiers in endocrinology 2019;10:603
Weighted Gene Co-expression Network Analysis for RNA-Sequencing Data of the Varicose Veins Transcriptome.
Zhang J, Nie Q, Si C, Wang C, Chen Y, Sun W, Pan L, Guo J, Kong J, Cui Y, Wang F, Fan X, Ye Z, Wen J, Liu P
Frontiers in physiology 2019;10:278
Frontiers in physiology 2019;10:278
Sorghum Phenolics Inhibits Inflammasomes in Lipopolysaccharide (LPS)-Primed and Adenosine Triphosphate (ATP)-Activated Macrophages.
Dia VP, Bradwell J, Pangloli P
Plant foods for human nutrition (Dordrecht, Netherlands) 2019 Sep;74(3):307-315
Plant foods for human nutrition (Dordrecht, Netherlands) 2019 Sep;74(3):307-315
Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.
Deng G, Chen W, Wang P, Zhan T, Zheng W, Gu Z, Wang X, Ji X, Sun Y
International immunopharmacology 2019 Sep;74:105682
International immunopharmacology 2019 Sep;74:105682
Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway.
Tang YS, Zhao YH, Zhong Y, Li XZ, Pu JX, Luo YC, Zhou QL
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019 Sep;68(9):727-738
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019 Sep;68(9):727-738
Treatment with andrographolide sulfonate provides additional benefits to imipenem in a mouse model of Klebsiella pneumoniae pneumonia.
Zhang G, Jiang C, Xie N, Xu Y, Liu L, Liu N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109065
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109065
FNDC5 inhibits foam cell formation and monocyte adhesion in vascular smooth muscle cells via suppressing NFκB-mediated NLRP3 upregulation.
Zang YH, Chen D, Zhou B, Chen AD, Wang JJ, Gao XY, Chen Q, Li YH, Kang YM, Zhu GQ
Vascular pharmacology 2019 Oct;121:106579
Vascular pharmacology 2019 Oct;121:106579
Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways.
Wang Y, Lin Z, Zhang B, Jiang Z, Guo F, Yang T
International journal of molecular sciences 2019 Oct 4;20(19)
International journal of molecular sciences 2019 Oct 4;20(19)
Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation.
Jia C, Zhang J, Chen H, Zhuge Y, Chen H, Qian F, Zhou K, Niu C, Wang F, Qiu H, Wang Z, Xiao J, Rong X, Chu M
Cell death & disease 2019 Oct 14;10(10):778
Cell death & disease 2019 Oct 14;10(10):778
Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high-fat high cholesterol diet via regulating NF-κB and NLRP3 inflammasome pathway.
Huang Y, Wan T, Pang N, Zhou Y, Jiang X, Li B, Gu Y, Huang Y, Ye X, Lian H, Zhang Z, Yang L
Journal of cellular physiology 2019 Nov;234(11):21224-21234
Journal of cellular physiology 2019 Nov;234(11):21224-21234
Iguratimod (T-614) attenuates severe acute pancreatitis by inhibiting the NLRP3 inflammasome and NF-κB pathway.
Hou C, Zhu X, Shi C, Peng Y, Huang D, Li Q, Miao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109455
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109455
Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis.
Wang X, Bian Y, Zhang R, Liu X, Ni L, Ma B, Zeng R, Zhao Z, Song X, Liu C
Biochemical and biophysical research communications 2019 Nov 5;519(2):402-408
Biochemical and biophysical research communications 2019 Nov 5;519(2):402-408
Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli.
Qi H, Gao Y, Li Y, Wei J, Su X, Zhang C, Liu Y, Zhu H, Sui L, Xiong Y, Yang X, Xu Y, Zhang Y, Yang R
iScience 2019 Nov 22;21:474-489
iScience 2019 Nov 22;21:474-489
The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice.
Qu J, Yuan Z, Wang G, Wang X, Li K
International immunopharmacology 2019 May;70:147-155
International immunopharmacology 2019 May;70:147-155
OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway.
Zhaolin Z, Jiaojiao C, Peng W, Yami L, Tingting Z, Jun T, Shiyuan W, Jinyan X, Dangheng W, Zhisheng J, Zuo W
Journal of cellular physiology 2019 May;234(5):7475-7491
Journal of cellular physiology 2019 May;234(5):7475-7491
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh-Asahara N
Cells 2019 May 31;8(6)
Cells 2019 May 31;8(6)
TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice.
Wang Z, Zhou L, An D, Xu W, Wu C, Sha S, Li Y, Zhu Y, Chen A, Du Y, Chen L, Chen L
Cell death & disease 2019 May 16;10(6):386
Cell death & disease 2019 May 16;10(6):386
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA
Nature neuroscience 2019 Mar;22(3):401-412
Nature neuroscience 2019 Mar;22(3):401-412
STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3.
Li N, Zhou H, Wu H, Wu Q, Duan M, Deng W, Tang Q
Redox biology 2019 Jun;24:101215
Redox biology 2019 Jun;24:101215
Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3.
Peng J, Zhang P, Zheng H, Ren YQ, Yan H
Chinese journal of traumatology = Zhonghua chuang shang za zhi 2019 Jun;22(3):161-165
Chinese journal of traumatology = Zhonghua chuang shang za zhi 2019 Jun;22(3):161-165
NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.
Wang H, Zhong D, Chen H, Jin J, Liu Q, Li G
Life sciences 2019 Jun 15;227:101-113
Life sciences 2019 Jun 15;227:101-113
MicroRNA-135b alleviates MPP+-mediated Parkinson's disease in in vitro model through suppressing FoxO1-induced NLRP3 inflammasome and pyroptosis.
Zeng R, Luo DX, Li HP, Zhang QS, Lei SS, Chen JH
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2019 Jul;65:125-133
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2019 Jul;65:125-133
LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF-κB/NLRP3 inflammasome pathway.
Ma M, Pei Y, Wang X, Feng J, Zhang Y, Gao MQ
Cell proliferation 2019 Jan;52(1):e12525
Cell proliferation 2019 Jan;52(1):e12525
Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.
Zhang Q, Tao X, Xia S, Qu J, Song H, Liu J, Li H, Shang D
Oncology reports 2019 Jan;41(1):270-278
Oncology reports 2019 Jan;41(1):270-278
Granisetron protects polymicrobial sepsis-induced acute lung injury in mice.
Wang J, Gong S, Wang F, Niu M, Wei G, He Z, Gu T, Jiang Y, Liu A, Chen P
Biochemical and biophysical research communications 2019 Jan 22;508(4):1004-1010
Biochemical and biophysical research communications 2019 Jan 22;508(4):1004-1010
Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.
Du L, Shen K, Bai Y, Chao J, Hu G, Zhang Y, Yao H
Toxicology letters 2019 Feb;301:53-63
Toxicology letters 2019 Feb;301:53-63
LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.
Wang K, Xu T, Ruan H, Xiao H, Liu J, Song Z, Cao Q, Bao L, Liu D, Wang C, Cheng G, Liang H, Chen Z, Yang H, Chen K, Zhang X
Cell death & disease 2019 Feb 15;10(3):159
Cell death & disease 2019 Feb 15;10(3):159
Protective effects of acarbose against vascular endothelial dysfunction through inhibiting Nox4/NLRP3 inflammasome pathway in diabetic rats.
Li XX, Ling SK, Hu MY, Ma Y, Li Y, Huang PL
Free radical biology & medicine 2019 Dec;145:175-186
Free radical biology & medicine 2019 Dec;145:175-186
Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy.
Yu X, Hao M, Liu Y, Ma X, Lin W, Xu Q, Zhou H, Shao N, Kuang H
European journal of pharmacology 2019 Dec 1;864:172715
European journal of pharmacology 2019 Dec 1;864:172715
Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.
Lin Y, Wang S, Yang Z, Gao L, Zhou Z, Yu P, Wu B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Aug;116:108973
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Aug;116:108973
UFL1 modulates NLRP3 inflammasome activation and protects against pyroptosis in LPS-stimulated bovine mammary epithelial cells.
Li C, Wang X, Kuang M, Li L, Wang Y, Yang F, Wang G
Molecular immunology 2019 Aug;112:1-9
Molecular immunology 2019 Aug;112:1-9
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Liu H, Sun Y, Zhang Y, Yang G, Guo L, Zhao Y, Pei Z
Inflammation 2019 Apr;42(2):516-525
Inflammation 2019 Apr;42(2):516-525
Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.
Zhou F, Zhang Y, Chen J, Hu Y, Xu Y
Frontiers in endocrinology 2018;9:640
Frontiers in endocrinology 2018;9:640
Chronic Kidney Disease Increases Atrial Fibrillation Inducibility: Involvement of Inflammation, Atrial Fibrosis, and Connexins.
Qiu H, Ji C, Liu W, Wu Y, Lu Z, Lin Q, Xue Z, Liu X, Wu H, Jiang W, Zou C
Frontiers in physiology 2018;9:1726
Frontiers in physiology 2018;9:1726
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.
Wu Q, Zhu YH, Xu J, Liu X, Duan C, Wang MJ, Wang JF
Frontiers in microbiology 2018;9:1661
Frontiers in microbiology 2018;9:1661
Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice.
Zhong H, Liu M, Ji Y, Ma M, Chen K, Liang T, Liu C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):1885-1897
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):1885-1897
Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway.
Zheng T, Yang X, Li W, Wang Q, Chen L, Wu D, Bian F, Xing S, Jin S
Oxidative medicine and cellular longevity 2018;2018:8597897
Oxidative medicine and cellular longevity 2018;2018:8597897
Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome.
Du Y, Gu X, Meng H, Aa N, Liu S, Peng C, Ge Y, Yang Z
American journal of translational research 2018;10(12):4235-4246
American journal of translational research 2018;10(12):4235-4246
Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3 inflammasome activation.
Jiang Y, Yang W, Gui S
Immunobiology 2018 Oct;223(10):555-561
Immunobiology 2018 Oct;223(10):555-561
Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.
Bando H, Lee Y, Sakaguchi N, Pradipta A, Ma JS, Tanaka S, Cai Y, Liu J, Shen J, Nishikawa Y, Sasai M, Yamamoto M
mBio 2018 Oct 9;9(5)
mBio 2018 Oct 9;9(5)
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.
Wang S, Lin Y, Yuan X, Li F, Guo L, Wu B
Nature communications 2018 Oct 12;9(1):4246
Nature communications 2018 Oct 12;9(1):4246
Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells
Song S, Qiu D, Luo F, Wei J, Wu M, Wu H, Du C, Du Y, Ren Y, Chen N, Duan H, Shi Y
Journal of molecular endocrinology 2018 Oct 1;61(3):101-113
Journal of molecular endocrinology 2018 Oct 1;61(3):101-113
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
He W, Ye S, Zeng C, Xue S, Hu X, Zhang X, Gao S, Xiong Y, He X, Vivalda S, Li L, Wang Y, Ye Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.
Wu X, Zhang H, Qi W, Zhang Y, Li J, Li Z, Lin Y, Bai X, Liu X, Chen X, Yang H, Xu C, Zhang Y, Yang B
Cell death & disease 2018 Feb 7;9(2):171
Cell death & disease 2018 Feb 7;9(2):171
Salvianolate reduces atrial fibrillation through suppressing atrial interstitial fibrosis by inhibiting TGF-β1/Smad2/3 and TXNIP/NLRP3 inflammasome signaling pathways in post-MI rats.
Qiu H, Liu W, Lan T, Pan W, Chen X, Wu H, Xu D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Dec 1;51:255-265
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Dec 1;51:255-265
2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease.
Han M, Zhang T, Gu W, Yang X, Zhao R, Yu J
Experimental and therapeutic medicine 2018 Aug;16(2):1087-1094
Experimental and therapeutic medicine 2018 Aug;16(2):1087-1094
Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway.
Yin Y, Chen F, Wang W, Wang H, Zhang X
Molecular vision 2017;23:242-250
Molecular vision 2017;23:242-250
A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells.
Pang Y, Li C, Wang S, Ba W, Yu T, Pei G, Bi D, Liang H, Pan X, Zhu T, Gou M, Han Y, Li Q
Cell communication and signaling : CCS 2017 Oct 16;15(1):42
Cell communication and signaling : CCS 2017 Oct 16;15(1):42
The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease.
Chin LH, Hsu YJ, Hsu SC, Chen YH, Chang YL, Huang SM, Tsai CS, Lin CY
Oncotarget 2017 Dec 26;8(69):113303-113317
Oncotarget 2017 Dec 26;8(69):113303-113317
Pepsin-pancreatin hydrolysis reduced the ability of lunasin-enriched material to inhibit activation of the inflammasomes in THP-1 human macrophages.
Price SJ, Pangloli P, Dia VP
Food & function 2017 Dec 13;8(12):4449-4458
Food & function 2017 Dec 13;8(12):4449-4458
Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice.
Zhou F, Zhang Y, Chen J, Hu X, Xu Y
European journal of pharmacology 2016 Nov 15;791:735-740
European journal of pharmacology 2016 Nov 15;791:735-740
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
Ding C, Zhao Y, Shi X, Zhang N, Zu G, Li Z, Zhou J, Gao D, Lv L, Tian X, Yao J
Scientific reports 2016 Jun 27;6:28734
Scientific reports 2016 Jun 27;6:28734
Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice.
Fu X, Ju J, Lin Z, Xiao W, Li X, Zhuang B, Zhang T, Ma X, Li X, Ma C, Su W, Wang Y, Qin X, Liang S
Scientific reports 2016 Jul 22;6:30239
Scientific reports 2016 Jul 22;6:30239
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.
Wu Q, Liu MC, Yang J, Wang JF, Zhu YH
Applied and environmental microbiology 2016 Feb 15;82(4):1173-1182
Applied and environmental microbiology 2016 Feb 15;82(4):1173-1182
The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.
Wang X, Shaw DK, Hammond HL, Sutterwala FS, Rayamajhi M, Shirey KA, Perkins DJ, Bonventre JV, Velayutham TS, Evans SM, Rodino KG, VieBrock L, Scanlon KM, Carbonetti NH, Carlyon JA, Miao EA, McBride JW, Kotsyfakis M, Pedra JH
PLoS pathogens 2016 Aug;12(8):e1005803
PLoS pathogens 2016 Aug;12(8):e1005803
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The Caspase 1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Caspase 1. This antibody recognizes human, mouse, rat antigen. The Caspase 1 antibody has been validated for the following applications: ELISA, WB analysis.
