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- Product number
- 22915-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Caspase 1/p20/p10 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Caspase 1/p20/p10 antibody (Cat. #22915-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A new mechanism regulating microglial NLRP3 inflammasome: FMR1 mediates NLRP3 mRNA stability.
Enterotoxigenic Escherichia coli-induced intestinal epithelial necroptosis drives lamina propria immune cell pyroptosis and mucosal injury in piglets.
SLC31A1 knockdown mitigates post-MI heart failure via regulation of copper metabolism.
Identifying pyroptosis-related lncRNAs to predict prognosis and immune regulation in hepatocellular carcinoma.
Cell membrane-encased thylakoid as white light triggered PDT therapy for facile and targeted choroidal melanoma treatment.
Targeting methionine-induced pyroptosis enhances anti-tumor immunity.
Canine adenovirus type 1 induces PANoptosis in canine splenocytes via AIM2 inflammasome activation.
Maresin 1 activates autophagy through SIRT1/PPAR-γ signaling to mitigate high glucose-induced pyroptosis in human retinal pigment epithelial cells.
The "Tianyu" Formulation Alleviates Rheumatoid Arthritis by Modulating the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway.
Trishizukaol A alleviates chronic kidney disease by restraining P2X7/PSME3-driven 20S proteasome hyperactivation.
CGRP regulates macrophage polarization through JAK-STAT pathway to improve Hashimoto's thyroiditis.
Betaine improves hyperoxic lung injury through downregulating pulmonary macrophage pyroptosis in newborn mice.
The sphingolipid metabolite sphingosine protects against hypertension by targeting metabolic-inflammatory crosstalk via the NLRP3 inflammasome.
Chromatin remodeling factor CHRAC1 regulates doxorubicin-induced cardiotoxicity via IRF9/GSDMD/CASP-1.
Caspase-3/GSDME-Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early-Onset Preeclampsia.
Spared cognitive and social function following perinatal ablation of ATRX despite transient microglia dysregulation.
USP16 drives psoriasis progression by deubiquitinating and stabilizing NLRP3 in keratinocytes.
SELENOF Mitigates Bovine Mastitis by Preserving Mitochondrial Homeostasis and Suppressing NLRP3-Mediated Pyroptosis.
FXR overexpression promotes liver regeneration through inducing FGF2 activation in APAP-induced acute liver injury.
Didymin alleviates neuropathic pain by targeting RKIP-mediated NF-κB/NLRP3 crosstalk to inhibit pyroptosis and neuroinflammation.
Hydrogen sulfide ameliorates oxalate crystal-related renal injury via inhibiting the activation of NOD-like receptor thermal protein domain associated protein 3 inflammasome in mice.
Taurine attenuates Listeria monocytogenes-induced inflammation and pyroptosis in mouse model by regulating MAPK and NLRP3/caspase-1/GSDMD pathways.
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression.
Hungatella hathewayi: A Tumor-Derived Bacterium Enriched in Colorectal Cancer Tissues and a Potential Diagnostic Biomarker.
Microglial NLRP3-dependent pyroptosis promotes cognitive dysfunction of diabetic encephalopathy by inhibiting adult hippocampal neurogenesis through the release of IL-1β.
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregulating Nrf2 to inhibit TGF-β1/Smad3 and NLRP3/ASC/Caspase-1 pathways.
3D-MSCs apoptotic bodies-integrated conductive hydrogel mitigates spinal cord injury via immunoregulation and alleviating neuronal pyroptosis.
Dual-targeting nuclear and mitochondrial DNA damage drives immunogenic activation via PANoptosis for synergistic magneto-thermodynamic-chemotherapy.
Modified Ganlu Xiaodu decoction attenuates airway barrier injury in Mycoplasma pneumoniae pneumonia by inhibiting ZBP1-mediated PANoptosis.
SSD: Targeting inflammasome and oxidative stress as a therapeutic strategy in inflammatory diseases.
Cathepsin B regulated via TFEB and lysosomal membrane permeabilization in adipose tissue macrophages aggravates obesity-related severe acute pancreatitis.
Flutamide exacerbates hepatic insulin resistance in type 2 diabetic mice through overproduction of ROS and activation of NLRP3 signaling.
A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition.
Transferrin receptor serves a role in promoting PANoptosis in thyroid cancer.
PAI-1 promotes thromboangiitis obliterans progression through NF-κB-NLRP3 pathway activation via HIF-1α-dependent signaling.
Elucidating the mechanism of traditional Chinese medicine formula (Yifei-sanjie Pill) in alleviating the chemobrain based on network pharmacology and experimental verification.
Caspase 1-deficient humans survive into late adulthood despite dramatically lower canonical inflammasome activity.
Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis.
Yujie recipe attenuates bleomycin-induced pulmonary fibrosis via suppressing NF-κB/NLRP3 signaling in a Nrf2-dependent manner.
Free Fatty Acids and Endotoxins Synergically Induce Pyroptosis in Bovine Hepatocytes.
Nicotinamide adenine dinucleotide inhibits the production of reactive oxygen species and myocardial cell pyroptosis caused by hypoxia/re-oxygenation injury.
Recombinant SARS-Cov-2 spike protein S1 subunit upregulates P2 × 7-NLRP3 leading to macrophage pyroptosis promoting acute lung injury.
Acupuncture as a modulator of microglial polarization and pyroptosis in depression: evidence from a chronic unpredictable mild stress rat model.
Size-dependent pyroptosis induction by calcium oxalate monohydrate crystals in HK-2 cells.
Thonningianin A derived from Penthorum chinense Pursh alleviates cerebral ischemia/reperfusion-mediated apoptosis and pyroptosis through the activation of PINK1/Parkin-dependent mitophagy.
Ecliptasaponin A alleviates inflammation and fibrosis in experimental MASH mice via targeting the NLRP3 inflammasome and YAP signaling pathway.
NLRP3/GSDMD-dependent neutrophil extracellular traps exacerbate microglia-mediated neuroinflammation following traumatic brain injury.
STING knockdown blocks disease progression and inflammation in mice with alcoholic liver disease by relieving pyroptosis via suppressing NLRP3.
Apelin-13 alleviated ischemia reperfusion injury via KLF2/NF-κB signaling pathway after kidney transplantation.
Knockdown of Lcn2 alleviates pyroptosis in a neonatal rat model of necrotizing enterocolitis through IL-17A signaling pathway suppression.
PTPN22 as a therapeutic target in intervertebral disc degeneration: Modulating mitophagy and pyroptosis through the PI3K/AKT/mTOR axis.
Therapeutic Potential of Curcumin in Diabetic Cardiomyopathy: Modulation of Pyroptosis Pathways.
Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Loaded with Emodin Alleviate Intestinal Injury in Acute Pancreatitis.
NLK facilitates Caspase-8 activation to drive macrophage PANoptosis in sepsis.
CUEDC2 improves pyroptosis and kidney damage in diabetic kidney disease by inhibiting NLRP3 inflammasome activation.
Cathepsin B overexpression and lysosomal leakage in inflammatory microglia promote neuroinflammation in olfactory dysfunction by triggering mitochondrial dysfunction and pyroptosis.
Citrate-coated Prussian blue nanozyme hitchhikes neutrophils to ameliorate calcium oxalate crystal-induced kidney injury via inhibiting pyroptosis and NETosis.
Healthy young human plasma-derived exosomes enhance neural stem cell therapy by suppressing pyroptosis via TXNIP/NLRP3 after intracerebral hemorrhage.
Targeting macrophage glycogen metabolism attenuates ulcerative colitis by suppressing IL-1β production through UDPG-P2Y(14) signaling.
Study on the mechanism of Sangbaipi Decoction in treating acute lung injury via the inflammasome NLRP3 signaling pathway.
Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway.
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome.
The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation.
TRPA1 promotes overactive bladder progression by activating the NLRP3 inflammasome and driving pyroptosis.
Integrated stress response promotes acute liver failure by activating SETD7 and enhancing NLRP3 methylation.
Carbon-based nanomaterials induce ovarian dysfunction via NLRP3 inflammasome-mediated pyroptosis in granulosa cells.
HIFU postoperative hypoxia-activated metal-organic frameworks modulate the tumor microenvironment to augment immunotherapy.
Micro/nanoplastics induce thyroid follicular cell pyroptosis to trigger thyrotoxicity by activating NF-κB signaling.
Shh-S100A10 axis curbs neuronal PANoptosis after ischemic stroke.
Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1.
Fruit-Derived Citri Reticulatae Semen Extract Attenuates Alzheimer's Disease Neuroinflammation and Cognitive Impairment via Modulation of the PI3K/Akt/FoxO1 Pathway.
TRIM25 triggers pyroptosis through mitochondrial DNA release in intestinal ischemia-reperfusion injury.
Poly (ADP-ribose) polymerase 1-targeted photosensitizer as a dual-activator of pyroptosis and the STING pathway for enhanced cancer photoimmunotherapy.
Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway.
Characterization of NLRP3 Inflammasome-Associated Hub Genes in the Progression of Diabetic Nephropathy.
Dehydroepiandrosterone alleviates pulmonary fibrosis by modulating the TLR4/NF-κB/NLRP3 signaling cascade in macrophages.
Identification and validation of key PANoptosis-related genes via integrative machine learning and single-cell sequencing in AILI.
Resveratrol improves follicular development in PCOS rats by inhibiting the inflammatory response and pyroptosis of granulosa cells†.
KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling.
LncRNA RP11-510J16.3 exacerbates sepsis-associated encephalopathy by facilitating NLRP3-dependent pyroptosis through miR-1290 sequestering.
GM-CSF exacerbates pulmonary arterial hypertension via CCL2/CCR2-axis-mediated macrophage NLRP3 inflammasome activation.
Perfluorooctane sulfonate induces hepatotoxicity through promoting inflammation, cell death and autophagy in a rat model.
Breaking the Chains of Therapeutic Blockade: Pyroptosis-Induced Photothermal-Chemotherapy with Targeted Nanoprobes in Triple-Negative Breast Cancer.
Correlation Analysis of Pyroptosis-Related Genes CASP1, NLRP3, AIM2, and NLRP1 With Lung Adenocarcinoma.
Human Umbilical Cord Mesenchymal Stem Cells Inhibit the Progression of Osteoarthritis by Suppressing NLRP3-Mediated Synovial Inflammation in the Early Stages of the Disease.
MIF-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Spinal Neurons and Microglial Polarization Facilitate Neuropathic Pain Progression.
G Protein-Coupled Receptor 30 Attenuates Neuronal Pyroptosis Induced by Subarachnoid Hemorrhage.
Oncosis is the predominant type of cell death in rhabdomyolysis following exertional heat stroke.
Subchronic Chlorpyrifos Exposure Induces Thyroid Follicular Cell Pyroptosis to Exacerbate Thyroid Toxicity by Modulating Nrf2/Keap1/NF-κB Pathway in Male Mice.
TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway.
Gubi Decoction Ameliorates Porous Cartilage Endplate in an Intervertebral Disc Degeneration Model Mouse Through Inhibition of NF-κB Activity and Pyroptosis.
Effect of Acupotomy Modulation of NLRP3/Caspase-1/GSDMD Pathway on Chondrocyte Pyroptosis in Knee Osteoarthritis.
Systemic Lupus Erythematosus Stimulates Chondrocyte Pyroptosis to Aggravate Arthritis via Suppression of NRF-2/KEAP-1 and NF-κB Pathway.
Fingolimod Suppresses NLRP3 Inflammasome Activation and Alleviates Oxidative Stress in Traumatic Brain Injury-Induced Acute Lung Injury.
Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells.
Electroacupuncture Regulates Oxidative Stress-Mediated NLRP3/ASC/Caspase-1 Pathway to Inhibit Microglial Activation: Alleviating Neuroinflammation and Depression in IBD.
Electroacupuncture Inhibits NLRP3-Mediated Microglial Pyroptosis to Ameliorate Chronic Neuropathic Pain in Rats.
ALDH2 Ameliorates Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and Pyroptosis by Nrf2/ROS Pathway.
Qingwen Hufei Granules Attenuate Lipopolysaccharide-Induced Acute Lung Injury by Suppressing NLRP3 Inflammasome-Dependent Pyroptosis.
Investigating the mechanisms of Sini San in alleviating inflammatory responses via multi-omics and the BDNF/TrkB/PI3K/AKT signaling pathway in depressive model rats.
Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.
Novel mitophagy inducer TJ0113 alleviates pulmonary inflammation during acute lung injury.
Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury.
Integrated proteomics analysis and network pharmacology to elucidate the mechanism of Zhilong Huoxue Tongyu Capsule alleviate hypertensive retinopathy in Ang II infusion mice model.
Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways.
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.
Effect and mechanism of Plantaginis Semen polysaccharides on intestinal microecology in rats with hyperuricemia.
Thlaspi arvense suppresses gut microbiota related TNF inflammatory pathway to alleviates ulcerative colitis.
Clusterin ameliorates diabetic atherosclerosis by suppressing macrophage pyroptosis and activation.
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
The anti-inflammatory effects of oridonin in resisting esophageal cancer.
Recombinant Antithrombin Alleviated Pulmonary Injury and Inflammation in LPS-Induced ARDS by Inhibiting IL17a/NF-κB Signaling.
NLRP3 inflammasome activation by turbulent shear stress drives right ventricular outflow tract fibrosis in pulmonary regurgitation.
Combined effects of quinic acid and isochlorogenic acid B on LPS-induced inflammation and pyroptosis in MAC-T cells and mouse mammary glands.
Aluminum adjuvant promotes liver inflammation and fibrosis in mice: A novel approach to establish a liver fibrosis animal model.
Anemoside B4 alleviates ulcerative colitis by attenuating intestinal oxidative stress and NLRP3 inflammasome via activating aryl hydrocarbon receptor through remodeling the gut microbiome and metabolites.
Tangzhiqing Exacerbates Oxidized Low-Density Lipoprotein-Induced Cell Pyroptosis Through Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells.
Oridonin Ameliorates Metabolic-Dysfunction-Associated Fatty Liver Disease by Inhibiting PANoptosis via Modulating SIRT2/NLRP3 Pathway.
Curcumin mitigates testicular ischemia-reperfusion injury by suppressing NLRP3-mediated pyroptosis.
IL-1β promotes IL-17A production of ILC3s to aggravate neutrophilic airway inflammation in mice.
Tongxinluo alleviates myocardial ischemia-reperfusion injury by inhibiting the pyroptosis of endothelial cells via the NLRP3/Caspase-1/GSDMD signaling pathway.
Distinct Inflammatory Responses of hiPSC-Derived Endothelial Cells and Cardiomyocytes to Cytokines Involved in Immune Checkpoint Inhibitor-Associated Myocarditis.
DCAAA mitigates neuroinflammation and microglial pyroptosis in spinal cord injury by inhibiting PI3K/AKT/NF-κB and NLRP3/caspase-1/GSDMD signaling.
FZD6 promotes 5-fluorouracil resistance through inhibiting pyroptosis in colorectal cancer.
M464 inhibits activation of NLRP3 inflammasome and inflammatory response in mice.
Mitochondrial damage is associated with an early immune response in inclusion body myositis.
Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway.
Ginsenoside Rg1 improves chronic neuropathic pain by inhibiting NLRP3 inflammasome activation and cell pyroptosis in microglia.
Tianlong kechuanling ameliorated COPD-PH through DNMT3A-GSDMD axis-dependent regulation of endothelial cell pyroptosis.
Effects of and mechanisms underlying qingwen baidu decoction in sepsis-associated acute kidney injury.
Astragaloside IV alleviates LPS-induced acute lung injury by regulating receptor C5aR1 and macrophage pyroptosis.
Targeting NEK7 modulates pyroptosis and gut microbiota to alleviate depression-like behavior in rats.
Targeting Bcl3/NF-κB p50 Pathway for Neuroinflammation Attenuation and RGCs Protection in Retinal Ischemia/Reperfusion Injury.
Picroside II-Encapsulated Nanoformulations as Pyroptosis Inhibitor Alleviate Cytokine Storms and Remodel Gut Microbiota Disturbances.
SVF Cell Sheets as a New Multicellular Material-Based Strategy for Promoting Angiogenesis and Regeneration in Diced Cartilage Grafts.
A phosphoproteomic study uncovers the importance of PP2A-B56α in liver injury precipitated by NLRP3 activation during MC-LR exposure.
Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation.
Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.
Bacterial infection in weaned piglets promotes diarrhea by inducing the NLRP3 inflammasome-pyroptosis pathway.
Oxytocin Regulated Neuroinflammation through OTR/Mitochondria Mediated Pathway to Improve Hypoxia-Induced Brain Injury.
The Protective Effects of Vanillic Acid on LPS-induced Acute Lung Injury by Inhibiting STIM1-mediated NLRP3 Inflammasome Activation.
Methamphetamine and HIV-1 Tat Synergistically Induce Microglial Pyroptosis Via Activation of the AIM2 Inflammasome.
Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.
Neutrophil Extracellular Traps Induce Pyroptosis of Gingival Fibroblasts in Peri-Implantitis.
NR4A1 mediates PRRSV-induced ileal injury in piglets by transcriptional regulation of NLRP3.
Acute high-altitude hypoxia induced NLRP3 inflammasome activation in pulmonary artery smooth muscle cells by BMAL1 targeting mitochondrial VDAC1-mediated MtDNA leakage.
FXR overexpression alleviates cholestasis via NLRC4 inflammasome suppression and bile acid homeostasis regulation.
Mesenchymal Stem Cells Derived from Different Adipose Tissue Depots Ameliorate Severe Acute Pancreatitis by Inhibiting NF-κB/NLRP3/Caspase-1 Pathways.
LILRB4 exacerbates myocardial ischemia-reperfusion injury by promoting inflammation and pyroptosis.
From Molecular Docking to Rat Models: Butyrate From a High-Fiber Diet Inhibits HDAC1 and NLRP3 Inflammasome to Alleviate Oxidative Stress and Inflammation After Spinal Cord Injury.
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Degradation of NLRP3 by selective ROCK2 inhibitor alleviates acute lung injury.
LncRNA MIR17HG accelerates the development of atherosclerosis by promoting macrophage pyroptosis through the miR-301a-3p/TXNIP pathway.
Oridonin alleviates SiNPs-induced pulmonary fibrosis by inhibiting pyroptosis via IRE1α-XBP1s-NLRP3 pathway.
The impact of PANoptosis-related genes on immune profiles and subtype classification in ischemic stroke.
Ginsenoside Ro Targets BCAT1/2 to Suppress Ferroptosis: A Novel Therapeutic Strategy for Ischemic Cardioprotection.
Bisphenol S as an emerging osteotoxicant: Mechanistic insights from osteoblasts and zebrafish models.
MicroRNA-29a attenuates inflammation and fibrosis in an animal model of NASH through MCJ inhibition and hippo pathway regulation.
The role of Lactobacillus rhamnosus in improving estrogen deficiency-induced osteoporosis by inhibiting NLRP3 inflammasome activation.
Pterostilbene as a pyroptosis inducer and tumor microenvironment regulator inhibits glioblastoma and enhances the efficacy of immunotherapy.
Rv2647-Mediated NLRP3 Ubiquitination Inhibits Macrophage Pyroptosis and Promotes Mycobacterium tuberculosis Survival.
Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury.
Sishen pill alleviates ulcerative colitis via the NLRP3/ASC/Caspase-1 signaling pathway: Comprehensive validation through UPLC-Q-TOF/MS, network pharmacology, molecular docking, and in vivo experiments.
Cytopathic bovine viral diarrhea virus-induced NLRP3 inflammasome activation triggers GSDMD-mediated pyroptosis, amplifying the inflammatory response.
Ellagic acid mediated pyroptosis in hepatocellular carcinoma via the ESR1/G6PD pathway.
Targeting STING alleviates pyroptosis of bladder epithelial cells and ameliorates bladder fibrosis in neurogenic bladder.
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.
Natural compound triptolide induces caspase-3/GSDME-mediated pyroptosis by promoting ROS accumulation in small cell lung cancer.
Irisolidone Ameliorates Cyclophosphamide-Induced POI via Inhibiting Inflammatory Response.
Shen Yuan Yi Qi Huo Xue capsules inhibit neutrophil NETosis by regulating the PAD4/NLRP3 signaling pathway to prevent heart failure after myocardial infarction.
Bushen Huatan formula alleviates polycystic ovary syndrome in rats by activating the PI3K/Akt pathway to inhibit GSDMD-mediated pyroptosis and mitochondrial damage.
A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer.
Targeting ICAM1 through LIF-mediated NF-κB/JAK2-STAT3 crosstalk protects nucleus pulposus from IL-1β-driven pyroptosis to ameliorate intervertebral disc degeneration.
Influenza a(H1N1) virus infection impairs syncytiotrophoblast functions by promoting ferroptosis through the TNF-α/ISG15/EGR1 axis.
Protective effects of taurochenodeoxycholic acid on aflatoxin B1-induced hepatic pyroptosis and gut-liver dysfunction.
Ligustilide ameliorates cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome-dependent pyroptosis through enhancing Nrf2 signaling.
PROM2 exacerbates CCl4-Induced liver fibrosis via NLRP3 inflammasome activation and hepatocyte pyroptosis.
Empagliflozin alleviates hepatic ischemia-reperfusion injury by inhibiting c-Myc through the JAK1-STAT3 signaling pathway.
The TWIK2-mtDNA-NLRP3 inflammasome signaling in hepatic macrophages facilitates exercise-induced attenuation of hepatic inflammation and insulin resistance in db/db mice.
Copper oxide nanoparticles disrupt lysosomal function and promote foam cell formation in RAW264.7 macrophages.
Low-intensity Pulsed Ultrasound Stimulation of the Intestine Improves Insulin Resistance in Type 2 Diabetes.
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Reno protective potential of taxifolin liposomes modified by chitosan in diabetic mice.
The therapeutic effect and mechanism of carnosic acid in Aspergillus fumigatus keratitis.
AIM2 exacerbates hypoxic-ischemic brain damage in neonatal rats via promoting neuronal pyroptosis.
Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/AMPK-mediated pyroptotic inhibition.
Deoxynivalenol-induced pyroptosis and autophagy inhibition collectively promote inflammatory injury in the glandular stomach of chicken embryos.
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages.
Hippocampal NLRP1 inflammasome mediates anxiety-like behavior in mice with hypothyroidism.
Poliumoside Exhibits Neuroprotective Effects against Cerebral Ischemia-Reperfusion Injury by Relieving Microglia-Mediated Neuronal Damage and Astrocytic Activation.
Heat stress enhances the expression of METTL3 to mediate N6-methyladenosine modification of SOS2 and NLRP3 inflammasome activation in boar Sertoli cells.
Ginsenoside Rg1 attenuates T2DM-induced renal damage and fibrosis by inhibiting TRPC6-ChREBP-TXNIP signaling.
Icariin alleviates cardiomyocyte pyroptosis through AMPK-NLRP3 pathway to ameliorates diabetic cardiomyopathy.
Pyroptosis of periodontal ligament stem cells aggravates periodontitis via Piezo1 channel.
miR-126-5p protects from URSA via inhibiting Caspase-1-dependent pyroptosis of trophoblast cells.
Galectin-3 activates microglia and promotes neurological impairment via NLRP3/pyroptosis pathway following traumatic brain injury.
Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis.
Understanding Propofol's Protective Mechanism in Tubular Epithelial Cells: Mitigating Pyroptosis via the miR-143-3p/ATPase Na + /K + Transporting Subunit Alpha 2 Pathway in Renal Ischemia-Reperfusion.
Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways.
IL-1β enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression.
Dihydrotanshinone I Attenuates Diet-Induced Nonalcoholic Fatty Liver Disease via Up-Regulation of IRG1.
Indoleamine 2, 3-dioxygenase 1 inhibition mediates the therapeutic effects in Parkinson's disease mice by modulating inflammation and neurogenesis in a gut microbiota dependent manner.
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
BRCC3 aggravates pulpitis by activating the NF-κB signaling pathway in dental pulp cells.
Exosomes derived from fibroblasts in DFUs delay wound healing by delivering miR-93-5p to target macrophage ATG16L1.
Vagus nerve stimulation inhibits PANoptosis and promotes neurofunctional recovery of cerebral ischemic stroke in a Sirt1-dependent manner.
Oxaliplatin induces pyroptosis in hepatoma cells and enhances antitumor immunity against hepatocellular carcinoma.
Piezo1 promotes intervertebral disc degeneration through the Ca(2+)/F-actin/Yap signaling axis.
Olfactory bulb microglia activation mediates neuronal pyroptosis in ozone-exposed mice with olfactory and cognitive dysfunction.
Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p.
Piperine inhibits fungal growth and protects against pyroptosis in Aspergillus fumigatus keratitis by regulating the mTOR/HIF-1α pathway.
Coal dust particles can upregulate the expression of NLRP3 inflammasome components in rat alveolar macrophages through phagocytosis.
H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes.
H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition in airway epithelial cells.
Signal-induced NLRP3 phase separation initiates inflammasome activation.
MicroRNA-9-3p inhibits endothelial pyroptosis in atherosclerosis by targeting the PTEN/AKT axis.
Lycium barbarum polysaccharide alleviate cadmium-induced mitochondrial dysfunction mediated pyroptosis in duck liver.
Mycobacterium bovis Mb3523c protein regulates host ferroptosis via chaperone-mediated autophagy.
Acupuncture protects against ischemic stroke by inhibiting the NF-κB pathway.
Construction of a toxicity pathway from activation of the TLR4/NF-κB/NLRP3 axis to Parkinson's disease-like non-motor symptoms in mice.
Pterostilbene Reduces Cyclophosphamide-Induced Interstitial Cystitis by Facilitating Nrf2 Activation and Suppressing the NLRP3 Inflammasome Pathway.
Association between endogenous lactate accumulation and dysregulated activation of the NLRP3 inflammasome pathway in schizophrenia.
Emodin influences pyroptosis-related Caspase 1-GSDMD axis alleviated cerebral ischemia-reperfusion injury in rats.
Lysosomal zinc nanomodulation blocks macrophage pyroptosis for counteracting atherosclerosis progression.
LINC01013 reverses bisphosphonate-impaired osteogenic differentiation of JBMMSCs by regulating intracellular translocation of ILF3.
HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway.
Oleoylethanolamide exerts neuroprotection following ischemic stroke through microglial PPARα signal.
Oxygen/sulfate radicals-generating CaS(2)O(8) nanosonosensitizers induce PANoptosis and calcium overload for enhanced peritoneal metastasis immunotherapy.
Mesenchymal stem cells attenuate hyperoxaluria-induced kidney injury and crystal depositions via inhibiting the activation of NLRP3 inflammasome.
M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis.
Xanthine Derivative KMUP-3 Alleviates Periodontal Bone Resorption by Inhibiting Osteoclastogenesis and Macrophage Pyroptosis.
Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.
HIV-1 Tat mediates microglial NLRP3 inflammasome activation and neurotoxicity by inducing cytosolic mtDNA stress.
Circular RNA-OGDH promotes PANoptosis in diabetic cardiomyopathy: A novel mechanistic insight.
Exploration of the Potential Bioactive Compounds and Functional Mechanism of Chaihu Sanshen Capsule in Ameliorating Myocardial Ischaemia-Reperfusion Injury: A Serum Pharmaco-Chemistry With Network Pharmacology Analysis.
Aerobic Exercise Restores Hippocampal Neurogenesis and Cognitive Function by Decreasing Microglia Inflammasome Formation Through Irisin/NLRP3 Pathway.
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.
UCP1 prevents the formation of thoracic aortic aneurysms and dissection by inhibiting the TLR4/NLRP3/IL-1β signaling pathway and VSMC phenotype switching in mice.
Andrographolide and its sulfated metabolite alleviated DSS-induced inflammatory bowel disease through regulating inflammation and immune via MAPK/NLRP3 pathways and the balance of Th17/Treg cells.
Antidepressant-Like Effects of Electroacupuncture by Regulating NLRP3-mediated Hippocampal Inflammation and Pyroptosis in Rats With Post-Stroke Depression.
FTO triggers NLRP3/GSDMD-dependent pyroptosis to enhance cisplatin-sensitivity in ovarian cancer.
TREM2 inhibits LPS-induced pyroptosis and inflammation by promoting mitophagy via SYK in BV2 cells.
Pharmacological inhibition of the cGAS-STING pathway suppresses microglia pyroptosis in sepsis-associated encephalopathy.
Vagus nerve stimulation inhibits pyroptosis and improves outcome of cerebral ischemic stroke by upregulating osteopontin (SPP1) to disturb ASC oligomerization.
Nuclear Receptor ERRγ Protects Against Cardiac Ischemic Injury by Suppressing GBP5-Mediated Myocardial Inflammation.
The Activation of the Microglial NLRP3 Inflammasome Is Involved in Tuberous Sclerosis Complex-Related Neuroinflammation.
Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis.
Cornus officinalis loganin attenuates acute lung injury in mice via regulating the PI3K/AKT/NLRP3 axis.
The Expression Pattern of the Splice Variants of Coxsackievirus and Adenovirus Receptor Impacts CV-B3-Induced Encephalitis and Myocarditis in Neonatal Mice.
HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression.
Botulinum toxin type A inhibits microglia pyroptosis by suppressing Cblb-mediated degradation of Pdlim1 to attenuate neuropathic pain.
Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18.
Integrated Multi-Omics Profiling Reveals That Highly Pyroptotic MDMs Contribute to Psoriasis Progression Through CXCL16.
Differences in macrophage pyroptosis and polarization induced by nano-/micro-calcium oxalate crystals.
Long-term exposure to silica nanoparticles induces cardiac hypertrophy through the pyroptosis pathway.
Defective RuO(2) Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway.
AK4 promotes nasopharyngeal carcinoma metastasis and chemoresistance by activating NLRP3 inflammatory complex.
Naringin mitigates experimental autoimmune prostatitis by modulating oxidative stress and the NLRP3 inflammasome via the PPAR-γ/NF-κB pathway.
Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice.
Selective Activation of G Protein-Coupled Estrogen Receptor 1 (GPER1) Reduces ER Stress and Pyroptosis via AMPK Signaling Pathway in Experimental Subarachnoid Hemorrhage.
Ginsenoside Rg1 improves hypoxia-induced pulmonary vascular endothelial dysfunction through TXNIP/NLRP3 pathway-modulated mitophagy.
Pyroptosis inhibition alleviates acute lung injury via E-twenty-six variant gene 5-mediated downregulation of gasdermin D.
Tanreqing Injection Inhibits Activation of NLRP3 Inflammasome in Macrophages Infected with Influenza A Virus by Promoting Mitophagy.
Remifentanil-induced inflammation in microglial cells: Activation of the PAK4-mediated NF-κB/NLRP3 pathway and onset of hyperalgesia.
Evaluation of the protective role of resveratrol on LPS-induced septic intestinal barrier function via TLR4/MyD88/NF-κB signaling pathways.
Upregulation of LXRβ/ABCA1 pathway alleviates cochlear hair cell senescence of C57BL/6 J mice via reducing lipid droplet accumulation.
Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway.
Sulforaphane regulation autophagy-mediated pyroptosis in autoimmune hepatitis via AMPK/mTOR pathway.
Combination of inorganic nitrate and vitamin C prevents collagen-induced arthritis in rats by inhibiting pyroptosis.
Ganoderic Acid A Alleviates Severe Acute Pancreatitis by Modulating Gut Homeostasis and Inhibiting TLR4-NLRP3 Signaling.
Macrophage NLRP3 inflammasome mediates the effects of sympathetic nerve on cardiac remodeling in obese rats.
FABP5 regulates ROS-NLRP3 inflammasome in glutamate-induced retinal excitotoxic glaucomatous model.
α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation.
Allogeneic platelet lysate activates the SIRT1-PINK1/Parkin pathway: A promising approach for improving mitochondrial function in an in vitro model of intervertebral disc degeneration.
NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats.
Complex immunotoxic effects of T-2 Toxin on the murine spleen and thymus: Oxidative damage, inflammasomes, apoptosis, and immunosuppression.
Donkey milk supplementation alleviates renal fibrosis of chronic kidney disease by enhancing anti-inflammatory ability.
Effects of canagliflozin preconditioning on post-resuscitation myocardial function in a diabetic rat model of cardiac arrest and cardiopulmonary resuscitation.
Jingui Shenqi Wan alleviates bone loss induced by primary osteoporosis by inhibiting osteoblast pyroptosis.
Circadian disruption by simulated shift work aggravates periodontitis via orchestrating BMAL1 and GSDMD-mediated pyroptosis.
LncRNA-Gm17586 inhibits S.typhimurium mediated pyroptosis by promoting NLRP3 and Tnip1 binding.
Mechanistic studies of Ca(2+)-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation.
α-Cyperone Alleviates LPS-Induced Pyroptosis in Rat Aortic Endothelial Cells via the PI3K/AKT Signaling Pathway.
Early Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infection Induces Necroptosis in Immune Cells of Peripheral Lymphoid Organs.
Long non-coding RNA NRIR inhibits osteogenesis in peri-implantitis by promoting NLRP3 inflammasome-mediated macrophage pyroptosis.
Anticancer effects of OSW-1 on colorectal cancer cells via the ROS/NLRP3/Caspase-1 pyroptosis signaling pathway.
NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury.
Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium.
Dihydromyricetin/montmorillonite intercalation compounds ameliorates DSS-induced colitis: Role of intestinal epithelial barrier, NLRP3 inflammasome pathway and gut microbiota.
Grape Seed Proanthocyanidins Mitigate Acute High-Altitude Hypoxia-Induced Brain Injury by Inhibiting NLRP3 Inflammasome via Autophagy Pathway.
PD-1 Attenuates Neuropathic Pain by Ameliorating NLRP3 Inflammasome-Mediated Microglia Pyroptosis.
METTL3 promotes podocyte pyroptosis in diabetic nephropathy through N(6)-methyladenosine modification of TRIM29 mRNA.
HMGB1 impairs nasal mucosa epithelial barrier function in allergic rhinitis by promoting BECN1-mediating autophagy.
Neutrophil CD11b is a pivotal PANoptosis marker correlated with disease activity in antineutrophil cytoplasmic antibody-associated vasculitis.
Docking and database screening identify manidipine as a potential modulator of matrix metalloproteinase-7 in chronic kidney disease.
Modulation of lipid droplet biogenesis by p38 MAPK and caspase-1 in docosahexaenoic acid-induced EA.hy926 endothelial cell apoptosis.
Anti-inflammatory Effects of Membrane Vesicles from Eubacterium rectale via the NLRP3 Signal Pathway.
Gut microbial Nordihydroguaiaretic acid suppresses macrophage pyroptosis to regulate epithelial homeostasis and inflammation.
CD44 is a macrophage receptor for TcdB from Clostridioides difficile that via its lysine-158 succinylation contributes to inflammation.
A20 Attenuates Inflammatory Injury in Bovine Endometrial Epithelial Cells Through Autophagy-Mediated NLRP3 Inflammasome Inactivation.
Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.
Chaize mixture alleviates NAFLD by regulating Glipr2-related autophagy/NLRP3 signaling.
ZIKV infection causes placental inflammation through activating PANoptosis.
Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling.
Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis.
Integrating Network Pharmacology, Molecular Docking, and Experimental Validation: Andrographolide Attenuates Acute Liver Injury via the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway.
Clostridium scindens attenuates acute kidney injury by producing indole-3-acetic acid.
miR-23a-5p Alleviates Gouty Inflammation by Targeting Interleukin-17A and Inhibiting NLR Family Pyrin Domain Containing 3 Inflammasome Activation.
Inhibition of BRD4 alleviates pyroptosis induced by testicular ischemia/reperfusion injury through the NLRP3 pathway.
Gegen Qinlian Decoction improves Alzheimer's disease through TLR4/NF-κB/NLRP3 pathway.
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling.
NOD3 Reduces Sepsis-Induced Acute Lung Injury by Regulating the Activation of NLRP3 Inflammasome and the Polarization of Alveolar Macrophages.
Paeoniflorin protected UVA-exposed skin fibroblasts from caspase-3/GSDME mediated pyroptosis.
Deoxynivalenol induces pyroptosis and IL-1β secretion via P2X7R signal in murine RAW264.7 macrophages.
Cilostazol attenuates vascular inflammation via the regulation of TICAM1/IRF3 signaling pathway.
Activation of HTR2B Suppresses Osteosarcoma Progression through the STAT1-NLRP3 Inflammasome Pathway and Promotes OASL1+ Macrophage Production to Enhance Antitumor Immunity.
SRPK1 is a significant factor in driving the progression of diabetic kidney fibrosis.
Solidago decurrens Lour. controls LPS-induced acute lung injury by reducing inflammatory responses and modulating the TLR4/NF-κB/NLRP3 signaling pathway.
Targeting Wnt/beta-catenin signaling to attenuate short-chain chlorinated paraffins-triggered hepatocyte mitochondrial fission and subsequent pyroptosis.
Caspase-8-driven NLRP3 inflammasome activation exacerbates bronchopulmonary dysplasia by increasing the apoptosis and pyroptosis crosstalk of alveolar epithelial cells.
5-ALA mediated PDT induces pyroptosis in colorectal cancer cells by targeting the caspase-1/GSDMD pathway.
Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism.
SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL.
Vitamin D improves diabetic cardiomyopathy by inhibiting pyroptosis through the NOX4/NLRP3 inflammasome pathway.
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood-Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation.
Schistosoma mansoni soluble egg antigen suppresses colorectal cancer growth in vitro and in vivo.
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy.
Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation.
Jinxin oral liquid reduced lung inflammation in influenza A virus infected mice through inhibiting NOD-like receptor protein 3 pathway.
Exercise-induced Sesn2 mediates autophagic flux to alleviate neural damage after ischemic stroke in mice.
TNFAIP3-interacting protein 1 (ABIN-1) negatively regulates caspase-8/FADD-dependent pyroptosis.
Systemic Lupus Erythematosus Exacerbates Hip Arthritis by Promoting Chondrocyte Pyroptosis in the Femoral Head via Activating the NF-κB Pathway.
Astaxanthin alleviates spinal nerve ligation-induced neuropathic pain by modulating propionic acid levels.
Qingyi decoction and its active ingredients ameliorate acute pancreatitis by regulating acinar cells and macrophages via NF-κB/NLRP3/Caspase-1 pathways.
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
Shuxuetong injection inhibits pyroptosis in acute ischemic stroke via CD44/NLRP3/GSDMD signal.
Urolithin A ameliorates schizophrenia-like behaviors and cognitive impairments in female rats by modulating NLRP3 signaling.
Punicalagin relieves hepatic injury by antioxidation and enhancement of autophagy in diet-induced nonalcoholic steatohepatitis.
Identification and Exploration of Pyroptosis-Related Genes in Macrophage Cells Reveal Necrotizing Enterocolitis Heterogeneity Through Single-Cell and Bulk-Sequencing.
N-acetylserotonin derivative ameliorates hypoxic-ischemic brain damage by promoting PINK1/Parkin-dependent mitophagy to inhibit NLRP3 inflammasome-induced pyroptosis.
Enriched environment alleviates NLRP3 inflammasome mediated neuroinflammation in diabetes complicated with depression rats.
TLR4-mediated endoplasmic reticulum stress regulates pyroptosis in macrophages infected with the Bacillus Calmette-Guérin mycobacterial.
Downregulation of the HCN1 Channel Alleviates Anxiety- and Depression-Like Behaviors in Mice With Cerebral Ischemia-Reperfusion Injury by Suppressing the NLRP3 Inflammasome.
VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway.
An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death.
TLR4/Rac1/NLRP3 Pathway Mediates Amyloid-β-Induced Neuroinflammation in Alzheimer's Disease.
Xuebijing improves inflammation and pyroptosis of acute lung injury by up-regulating miR-181d-5p-mediated SPP1 inactivation.
M2 Macrophage-Derived Small Extracellular Vesicles Ameliorate Pyroptosis and Intervertebral Disc Degeneration.
Exploring the effects of hypoxia and reoxygenation time on hepatocyte apoptosis and inflammation.
TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway.
Interleukin 1β Mediates the Pathogenesis of Nasal Mucosal Epithelial Barrier Dysfunction in Allergic Rhinitis.
Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways.
Shenfu Injection Mediated NLRP3/Caspase 1 Through (R)-Norcoclaurinee Alleviates Sepsis-Induced Cognitive Dysfunction.
Identification and Validation of a Necroptosis-Related Prognostic Model in Tumor Recurrence and Tumor Immune Microenvironment in Breast Cancer Management.
Augmented Cornus officinalis Levels in Liuwei Dihuang Decoction Inhibits Nucleus Pulposus Cell Pyroptosis to Enhance Therapeutic Efficacy Against Intervertebral Disc Degeneration.
Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway.
Elabela mitigates the early stage of inflammation in sepsis by inhibiting pyroptosis.
Exosomes from IH- Induced bEnd3 Cells Promote OSA Cognitive Impairment via miR-20a-5p/MFN2 Mediated Pyroptosis of HT22 Cells.
Cynaroside: a potential therapeutic agent targeting arachidonate 15-lipoxygenase to mitigate cerebral ischemia/reperfusion injury.
Spermidine attenuates chondrocyte inflammation and cellular pyroptosis through the AhR/NF-κB axis and the NLRP3/caspase-1/GSDMD pathway.
KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.
(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway.
Gasdermin D could be lost in the brain parenchyma infarct core and a pyroptosis-autophagy inhibition effect of Jie-Du-Huo-Xue decoction after stroke.
Yinqin Qingfei granules alleviate Mycoplasma pneumoniae pneumonia via inhibiting NLRP3 inflammasome-mediated macrophage pyroptosis.
Placental mesenchymal stem cells suppress inflammation and promote M2-like macrophage polarization through the IL-10/STAT3/NLRP3 axis in acute lung injury.
Erythrocyte membrane biomimetic EGCG nanoparticles attenuate renal injury induced by diquat through the NF-κB/NLRP3 inflammasome pathway.
Fexuprazan safeguards the esophagus from hydrochloric acid-induced damage by suppressing NLRP1/Caspase-1/GSDMD pyroptotic pathway.
Targeting the PANoptosis signaling pathway for myocardial protection: therapeutic potential of Xian Ling Gu Bao capsule.
Thonningianin A ameliorated renal interstitial fibrosis in diabetic nephropathy mice by modulating gut microbiota dysbiosis and repressing inflammation.
Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson's rats.
Corilagin alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation via the Olfr2 signaling pathway in vitro and in vivo.
USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis.
Single-cell RNA sequencing reveals S100a9(hi) macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia‒reperfusion.
Macrophage membrane‒biomimetic nanoparticles target inflammatory microenvironment for epilepsy treatment.
Cinobufotalin inhibits proliferation, migration and invasion in hepatocellular carcinoma by triggering NOX4/NLRP3/GSDMD-dependent pyroptosis.
Neuregulin-1, a member of the epidermal growth factor family, mitigates STING-mediated pyroptosis and necroptosis in ischaemic flaps.
Oxycodone attenuates lipopolysaccharide-induced myocardial injury by inhibiting inflammation, oxidation and pyroptosis via Nrf2/HO-1 signalling pathway.
Microglia and Astrocytes Responses Contribute to Alleviating Inflammatory Damage by Repetitive Transcranial Magnetic Stimulation in Rats with Traumatic Brain Injury.
Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome.
Mefunidone alleviates silica-induced inflammation and fibrosis by inhibiting the TLR4-NF-κB/MAPK pathway and attenuating pyroptosis in murine macrophages.
Inhibition of GBP1 alleviates pyroptosis of human pulmonary microvascular endothelial cells through STAT1/NLRP3/GSDMD pathway.
A Dual-Function CD47-Targeting Nano-Drug Delivery System Used to Regulate Immune and Anti-Inflammatory Activities in the Treatment of Atherosclerosis.
miR-155 induces sepsis-associated damage to the intestinal mucosal barrier via sirtuin 1/nuclear factor-κB-mediated intestinal pyroptosis.
DYZY01 alleviates pulmonary hypertension via inhibiting endothelial cell pyroptosis and rescuing endothelial dysfunction.
Adverse outcome pathway-based approach to reveal the mechanisms of skin sensitization and long-term aging effects of chlorothalonil.
Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening.
Pericentriolar material 1 promotes intestinal inflammation in ulcerative colitis by activating NLRP3/gasdermin D-mediated macrophage pyroptosis.
Elucidating PAR1 as a therapeutic target for delayed traumatic brain injury: Unveiling the PPAR-γ/Nrf2/HO-1/GPX4 axis to suppress ferroptosis and alleviate NLRP3 inflammasome activation in rats.
Macrophage WNK1 senses intracellular hypo-chlorine to regulate vulnerability to sepsis attack during hypochloremia.
Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE/PI3K/AKT/mTOR pathway.
Trehalose Rescues Postmenopausal Osteoporosis Induced by Ovariectomy through Alleviating Osteoblast Pyroptosis via Promoting Autophagy.
Disulfiram attenuates cell and tissue damage and blood‒brain barrier dysfunction after intracranial haemorrhage by inhibiting the classical pyroptosis pathway.
Ocotillol-Type Pseudoginsenoside-F11 Alleviates Lipopolysaccharide-Induced Acute Kidney Injury through Regulation of Macrophage Function by Suppressing the NF-κB/NLRP3/IL-1β Signaling Pathway.
Helicobacter pylori CagA mediated mitophagy to attenuate the NLRP3 inflammasome activation and enhance the survival of infected cells.
BV2 Microglial Cell Activation/Polarization Is Influenced by Extracellular Vesicles Released from Mutated SOD1 NSC-34 Motoneuron-like Cells.
Hydrogen combined with tetrandrine attenuates silica-induced pulmonary fibrosis via suppressing NF-kappaB/NLRP3 signaling pathway-mediated epithelial mesenchymal transition and inflammation.
Pyroptotic macrophages induce disruption of glutamate metabolism in periodontal ligament stem cells contributing to their compromised osteogenic potential.
Placental growth factor alleviates hyperglycemia-induced trophoblast pyroptosis by regulating mitophagy.
Blockage of the NLRP3 inflammasome by MCC950 inhibits migration and invasion in adenomyosis.
Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells.
Ginseng polysaccharide promotes the apoptosis of colon cancer cells via activating the NLRP3 inflammasome.
Targeting Mitochondrial Oxidative Stress to Protect Against Preterm Birth and Fetal Brain Injury via Nrf2 Induction.
Geraniol alleviates liver injury induced by bisphenol A via modulating NLRP3/caspase-1 pathway and gut microbiota in mice model.
Dynamics of the thymic transcriptome at stages of acute thymic involution in Japanese Black calves with a poor prognosis.
Fusobacterium nucleatum dysregulates inflammatory cytokines and NLRP3 inflammasomes in oral cells.
Therapeutic framework nucleic acid complexes targeting oxidative stress and pyroptosis for the treatment of osteoarthritis.
A preliminary study of T-2 toxin that cause liver injury in rats via the NF-kB and NLRP3-mediated pyroptosis pathway.
Caspase-1 Inhibition Ameliorates Photoreceptor Damage Following Retinal Detachment by Inhibiting Microglial Pyroptosis.
LncRNA H19/miR-107 regulates endothelial progenitor cell pyroptosis and promotes flow recovery of lower extremity ischemia through targeting FADD.
NEMO-Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase-Induced Lysosome Membrane Permeabilization.
PTP1B inhibitor alleviates deleterious septic lung injury through Src signaling.
Bergapten attenuates hemorrhagic shock induced multi-organ injury by inhibiting NLRP3 inflammasome activation and pyroptosis.
Weighted gene co-expression network analysis and single-cell sequence analysis uncover immune landscape and reveal hub genes of necroptosis in macrophages in myocardial ischaemia-reperfusion injury.
Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression.
LINC00365 promotes miR-221-5p to inhibit pyroptosis via Dicer in colorectal cancer.
The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring.
GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation.
Acupuncture ameliorates depression-like behavior of poststroke depression model rats through the regulation of gut microbiota and NLRP3 inflammasome in the colon.
Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease.
NLRP3 inhibitor combined with Yimusake improves erectile dysfunction in rats with diabetes mellitus through the attenuation of pyroptosis.
Role for NLRP3 inflammasome-mediated, Caspase1-dependent response in glaucomatous trabecular meshwork cell death and regulation of aqueous humor outflow.
Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight.
The phosphorylation of Smad3 by CaMKIIγ leads to the hepatocyte pyroptosis under perfluorooctane sulfonate exposure.
Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury.
Polystyrene Microplastics Induce Injury to the Vascular Endothelial Through NLRP3-Mediated Pyroptosis.
Ruscogenin Exerts Anxiolytic-Like Effect via Microglial NF-κB/MAPKs/NLRP3 Signaling Pathways in Mouse Model of Chronic Inflammatory Pain.
HSP90-regulated mitophagy can alleviate heat stress damage by inhibiting pyroptosis in the hepatocytes of Wenchang chickens.
Lycium barbarum polysaccharides (LBP) suppresses hypoxia/reoxygenation (H/R)-induced rat H9C2 cardiomyocytes pyroptosis via Nrf2/HO-1 signaling pathway.
Tetrahedral Framework Nucleic Acid-Based Delivery of Astaxanthin Suppresses Chondrocyte Pyroptosis and Modulates Oxidative Stress for the Treatment of Osteoarthritis.
Perinatal exposure to PBEB aggravates liver injury via macrophage-derived TWEAK in male adult offspring mice under western diet.
Microglia regulate cortical remyelination via TNFR1-dependent phenotypic polarization.
Ginsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy.
Paeoniflorin Inhibits the Activation of Microglia and Alleviates Depressive Behavior by Regulating SIRT1-NF-kB-NLRP3/Pyroptosis Pathway.
Microplastics Exposure Aggravates Synovitis and Pyroptosis in SLE by Activating NF-κB and NRF2/KEAP1 Signaling.
USP14 modulates cell pyroptosis and ameliorates doxorubicin-induced cardiotoxicity by deubiquitinating and stabilizing SIRT3.
Mechanism of epigallocatechin gallate in treating non-alcoholic fatty liver disease: Insights from network pharmacology and experimental validation.
β-Hydroxybutyrate alleviates brain aging through the MTA1 pathway in D-galactose injured mice.
Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
MANF inhibits NLRP3 inflammasome activation by competitively binding to DDX3X in paraquat-stimulated alveolar macrophages.
Carvacrol alleviates LPS-induced myocardial dysfunction by inhibiting the TLR4/MyD88/NF-κB and NLRP3 inflammasome in cardiomyocytes.
Effects on Synaptic Plasticity Markers in Fetal Mice and HT22 Neurons upon F-53B Exposure: The Role of PKA Cytoplasmic Retention.
Immune Checkpoint-Modulating Photosensitizer That Targets BRD4 for Cancer Photoimmunotherapy.
The attenuating effects of serine against cadmium induced immunotoxicity through regulating M1/M2 and Th1/Th2 balance in spleen of C57BL/6 mice.
The role of NLRP3 inflammasome-mediated neuroinflammation in chronic noise-induced impairment of learning and memory ability.
Neutrophil extracellular traps promote M1 macrophage polarization in gouty inflammation via targeting hexokinase-2.
Sodium butyrate alleviates experimental autoimmune prostatitis by inhibiting oxidative stress and NLRP3 inflammasome activation via the Nrf2/HO-1 pathway.
Protective Effect of Egg Yolk Lipids against Dextran Sulfate Sodium-Induced Colitis: The Key Role of Gut Microbiota and Short-Chain Fatty Acids.
Berberine alleviated contrast-induced acute kidney injury by mitophagy-mediated NLRP3 inflammasome inactivation in a mice model.
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching.
4-PBA exerts brain-protective effects against sepsis-associated encephalopathy in a mouse model of sepsis.
Nattokinase attenuates endothelial inflammation through the activation of SRF and THBS1.
Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models.
Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis.
Tumor necrosis factor-stimulated gene-6 ameliorates early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome-mediated astrocyte pyroptosis.
Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels.
Histone deacetylase-mediated silencing of PSTPIP2 expression contributes to aristolochic acid nephropathy-induced PANoptosis.
Isoliquiritigenin reduces experimental autoimmune prostatitis by facilitating Nrf2 activation and suppressing the NLRP3 inflammasome pathway.
Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia.
Semaglutide ameliorates pressure overload-induced cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome.
Transcriptomics confirms IRF1 as a key regulator of pyroptosis in diabetic retinopathy.
(+)-Catechin ameliorates diabetic nephropathy injury by inhibiting endoplasmic reticulum stress-related NLRP3-mediated inflammation.
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis.
Stenotrophomonas maltophilia contributes to smoking-related emphysema through IRF1-triggered PANoptosis of alveolar epithelial cells.
Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure.
Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies.
MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism.
TIMP2 protects against sepsis-associated acute kidney injury by cAMP/NLRP3 axis-mediated pyroptosis.
NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis.
ACT001 alleviates inflammation and pyroptosis through the PPAR-γ/NF-κB signaling pathway in LPS-induced alveolar macrophages.
Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis.
TXNIP-NLRP3-GSDMD axis-mediated inflammation and pyroptosis of islet β-cells is involved in cigarette smoke-induced hyperglycemia, which is alleviated by andrographolide.
Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway.
Oxymatrine mitigates Aspergillus fumigatus keratitis by suppressing fungal activity and restricting pyroptosis.
S100A9(-/-) alleviates LPS-induced acute lung injury by regulating M1 macrophage polarization and inhibiting pyroptosis via the TLR4/MyD88/NFκB signaling axis.
PI3K/AKT signaling pathway associates with pyroptosis and inflammation in patients with endometriosis.
Riboflavin Attenuates Fluoride-Induced Testicular Injury via Interleukin 17A-Mediated Classical Pyroptosis.
Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure.
Protective Effects and Mechanisms of Esculetin against H(2)O(2)-Induced Oxidative Stress, Apoptosis, and Pyroptosis in Human Hepatoma HepG2 Cells.
Triclosan induces liver injury in long-life exposed mice via activation of TLR4/NF-κB/NLRP3 pathway.
Atrazine exposure promotes cardiomyocyte pyroptosis to exacerbate cardiotoxicity by activating NF-κB pathway.
Kongensin a attenuates intervertebral disc degeneration by inhibiting TAK1-mediated PANoptosis of nucleus pulposus cells.
Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.
Taohong Siwu decoction reduces acute myocardial ischemia-reperfusion injury by promoting autophagy to inhibit pyroptosis.
Protection effects of mice liver and lung injury induced by coronavirus infection of Qingfei Paidu decoction involve inhibition of the NLRP3 signaling pathway.
Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice.
P2Y(13) receptor involved in HIV-1 gp120 induced neuropathy in superior cervical ganglia through NLRP3 inflammasome activation.
PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway.
Punicalagin Ameliorates Diabetic Liver Injury by Inhibiting Pyroptosis and Promoting Autophagy via Modulation of the FoxO1/TXNIP Signaling Pathway.
Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage.
Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway.
Long noncoding RNA TUG1 promotes malignant progression of osteosarcoma by enhancing ZBTB7C expression.
MiR-106a-5p targets PFKFB3 and improves sepsis through regulating macrophage pyroptosis and inflammatory response.
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy.
Co-exposure of microcystin and nitrite enhanced spermatogenic disorders: The role of mtROS-mediated pyroptosis and apoptosis.
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles.
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation.
Protective role of hydrogen sulfide against diabetic cardiomyopathy by inhibiting pyroptosis and myocardial fibrosis.
L- lactate inhibits lipopolysaccharide-induced inflammation of microglia in the hippocampus.
IRGM/Irgm1 increases autophagy to inhibit activation of NLRP3 inflammasome in inflammatory injury induced acute liver failure.
Chlormequat Chloride Inhibits TM3 Leydig Cell Growth via Ferroptosis-Initiated Inflammation.
Exogenous NADPH could mitigate pyroptosis-induced brain injury in fetal mice exposed to gestational intermittent hypoxia.
Network pharmacology and experimental validation to explore the mechanism of Changji'an formula against irritable bowel syndrome with predominant diarrhea.
Ameliorated Effects of Fucoidan on Dextran Sulfate Sodium-Induced Ulcerative Colitis and Accompanying Anxiety and Depressive Behaviors in Aged C57BL/6 Mice.
Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress.
Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2-NLRP3 signaling pathway in mice.
MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration.
Trim27 aggravates airway inflammation and oxidative stress in asthmatic mice via potentiating the NLRP3 inflammasome.
Mahuang Fuzi Xixin decoction alleviates allergic rhinitis by inhibiting NLRP3/Caspase-1/GSDMD-N-mediated pyroptosis.
Ginsenoside Rg1 Suppresses Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway to Alleviate Chronic Atrophic Gastritis In Vitro and In Vivo.
Calcitriol attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behaviors by suppressing the P2X7R/NLRP3/caspase-1 pathway.
Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration.
Astaxanthin alleviates fibromyalgia pain and depression via NLRP3 inflammasome inhibition.
4-Octyl itaconate inhibits inflammation via the NLRP3 pathway in neuromyelitis optica spectrum disorders.
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps.
Chikusetsu Saponin IVa liposomes modified with a retro-enantio peptide penetrating the blood-brain barrier to suppress pyroptosis in acute ischemic stroke rats.
Esaxerenone Attenuates Aldosterone-Induced Mitochondrial Damage-Mediated Pyroptosis in Mouse Aorta and Rat Vascular Smooth Muscle Cells.
Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3.
Baicalin and probenecid protect against Glaesserella parasuis challenge in a piglet model.
Urolithin A Protects against Hypoxia-Induced Pulmonary Hypertension by Inhibiting Pulmonary Arterial Smooth Muscle Cell Pyroptosis via AMPK/NF-κB/NLRP3 Signaling.
Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR.
Ursolic acid alleviates lupus nephritis by suppressing SUMO1-mediated stabilization of NLRP3.
Mesenchymal stem cells ameliorate inflammation and pyroptosis in diabetic cardiomyopathy via the miRNA-223-3p/NLRP3 pathway.
Disulfiram downregulates ferredoxin 1 to maintain copper homeostasis and inhibit inflammation in cerebral ischemia/reperfusion injury.
Dental pulp mesenchymal stem cell-derived exosomes inhibit neuroinflammation and microglial pyroptosis in subarachnoid hemorrhage via the miRNA-197-3p/FOXO3 axis.
TAT-beclin1 treatment accelerates the development of atherosclerotic lesions in ApoE-deficient mice.
Shengxian decoction improves lung function in rats with bleomycin-induced idiopathic pulmonary fibrosis through the inhibition of PANoptosis.
Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity.
CDK5-USP30 signaling pathway regulates MAVS-mediated inflammation via suppressing mitophagy in MPTP/MPP(+) PD model.
CHMP3 promotes the progression of hepatocellular carcinoma by inhibiting caspase‑1‑dependent pyroptosis.
FGF-18 Protects the Injured Spinal cord in mice by Suppressing Pyroptosis and Promoting Autophagy via the AKT-mTOR-TRPML1 axis.
Mitochondria-targeted SkQ1 nanoparticles for dry eye disease: Inhibiting NLRP3 inflammasome activation by preventing mitochondrial DNA oxidation.
Pyroptosis-related gene signature elicits immune response in rosacea.
Modified 5-aminolevulinic acid photodynamic therapy induces cutaneous squamous cell carcinoma cell pyroptosis via the JNK signaling pathway.
Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway.
Role and mechanism of MiR-542-3p in regulating TLR4 in nonylphenol-induced neuronal cell pyroptosis.
Study of hispidulin in the treatment of uric acid nephropathy based on NF-κB signaling pathway.
Mechanism of action of curcumin targeting TRPM2/NLRP3 signaling axis to mediate cell death in the treatment of knee osteoarthritis.
Macrophage-derived exosomal miRNA-141 triggers endothelial cell pyroptosis by targeting NLRP3 to accelerate sepsis progression.
Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease.
Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-κB pathway in a chronic migraine model.
Inhibition of circulating exosomes release with GW4869 mitigates severe acute pancreatitis-stimulated intestinal barrier damage through suppressing NLRP3 inflammasome-mediated pyroptosis.
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress.
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway.
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis.
Identification of key pyroptosis-related genes and microimmune environment among peripheral arterial beds in atherosclerotic arteries.
An integrated RNA-Seq and network pharmacology approach for exploring the preventive effect of Corydalis bungeana Turcz. Extract and Acetylcorynoline on LPS-induced acute lung injury.
Tetrastigma hemsleyanum suppresses neuroinflammation in febrile seizures rats via regulating PKC-δ/caspase-1 signaling pathway.
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
A High MCT-Based Ketogenic Diet Suppresses Th1 and Th17 Responses to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice by Inhibiting GSDMD and JAK2-STAT3/4 Pathways.
Egg Yolk Lipids Alleviated Dextran Sulfate Sodium-Induced Colitis by Inhibiting NLRP3 Inflammasome and Regulating Gut Microbiota.
Demethylase FTO-Mediated m6A Modification of lncRNA MEG3 Activates Neuronal Pyroptosis via NLRP3 Signaling in Cerebral Ischemic Stroke.
TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation.
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
NLRP3 activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis.
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
Palmatine ameliorated lipopolysaccharide-induced sepsis-associated encephalopathy mice by regulating the microbiota-gut-brain axis.
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice.
KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling.
Berberine inhibits NLRP3 inflammasome activation by regulating mTOR/mtROS axis to alleviate diabetic cardiomyopathy.
Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury.
The E3 ubiquitin ligase MARCH2 protects against myocardial ischemia-reperfusion injury through inhibiting pyroptosis via negative regulation of PGAM5/MAVS/NLRP3 axis.
PPAR γ activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement.
Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis.
Baicalin attenuates lipopolysaccharide-induced intestinal inflammatory injury via suppressing PARP1-mediated NF-κB and NLRP3 signalling pathway.
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
NLRP3-GSDMD-dependent IL-1β Secretion from Microglia Mediates Learning and Memory Impairment in a Chronic Intermittent Hypoxia-induced Mouse Model.
Serine synthesis sustains macrophage IL-1β production via NAD(+)-dependent protein acetylation.
Potential effects of different cell death inhibitors in protecting against ischemia-reperfusion injury in steatotic liver.
Calcitonin gene-related peptide attenuated discogenic low back pain in rats possibly via inhibiting microglia activation.
Machine learning and experiments revealed a novel pyroptosis-based classification linked to diagnosis and immune landscape in spinal cord injury.
Buyang Huanwu Decoction suppresses cardiac inflammation and fibrosis in mice after myocardial infarction through inhibition of the TLR4 signalling pathway.
CTRP3 inhibits myocardial fibrosis through the P2X7R-NLRP3 inflammasome pathway in SHR rats.
The role and mechanism of NLRP3 in wasp venom-induced acute kidney injury.
Tanshinone IIA alleviates inflammation-induced skeletal muscle atrophy by regulating mitochondrial dysfunction.
The role of Gαq in regulating NLRP3 inflammasome activation.
Mechanism of Resveratrol on LPS/ATP-induced pyroptosis and inflammatory response in HT29 cells.
Esaxerenone Inhibits Interferon-γ Induced Pyroptosis of Macrophages in the Lungs of Aldosterone-treated Mice.
Association between mitophagy and NLRP3 inflammasome in uric acid nephropathy.
Obeticholic acid ameliorates sepsis-induced renal mitochondrial damage by inhibiting the NF-κb signaling pathway.
Mesenchymal stem cell-loaded hydrogel to inhibit inflammatory reaction in surgical brain injury via mitochondria transfer.
Proliferative mechanism of benign prostatic hyperplasia by NLRP3 inflammasome through the complement pathway.
PANoptosis signaling enables broad immune response in psoriasis: From pathogenesis to new therapeutic strategies.
Activation of spleen tyrosine kinase (SYK) contributes to neuronal pyroptosis and cognitive impairment in diabetic mice via the NLRP3/Caspase-1/GSDMD signaling pathway.
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE(-/-) mice via MBOAT2-mediated endoplasmic reticulum stress.
Melatonin protects RPE cells from necroptosis and NLRP3 activation via promoting SERCA2-related intracellular Ca(2+) homeostasis.
Gelsevirine ameliorates sepsis-associated encephalopathy by inhibiting the STING signalling-mediated pyroptosis pathway in microglia.
Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway.
Jianwei Shoutai Pills alleviates miscarriage by modulating gut microbial production of BAs and NLRP3-inflammasome at the maternal-fetal interface of rats.
Transcriptomic changes in the hypothalamus of mice with chronic migraine: Activation of pathways associated with neuropathic inflammation and central sensitization.
NLRP12 c.1382dup promotes the development of Crohn's disease through the ERK/NLRP3/ IL-1β pathway.
Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine.
Nicotinamide adenine dinucleotide phosphate alleviates intestinal ischemia/reperfusion injury via Nrf2/HO-1 pathway.
CARD9 promotes cholangiocarcinoma by regulating the IL-17A/Hedgehog and the THEM4/AKT/mTOR signaling pathways.
Chlorogenic acid alleviates IPEC-J2 pyroptosis induced by deoxynivalenol by inhibiting activation of the NF-κB/NLRP3/caspase-1 pathway.
Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy.
Role of AhR-Hsp90-MDM2-mediated VDR ubiquitination in PM2.5-induced renal toxicity.
Comparison of Endoplasmic Reticulum Stress and Pyroptosis Induced by Pathogenic Calcium Oxalate Monohydrate and Physiologic Calcium Oxalate Dihydrate Crystals in HK-2 Cells: Insights into Kidney Stone Formation.
Porcine Epidemic Diarrhea Virus Infection of Porcine Intestinal Epithelial Cells Causes Mitochondrial DNA Release and the Activation of the NLRP3 Inflammasome to Mediate Interleukin-1β Secretion.
Exosomes derived from diabetic microenvironment-preconditioned mesenchymal stem cells ameliorate nonalcoholic fatty liver disease and inhibit pyroptosis of hepatocytes.
Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics.
Vaping/e-cigarette-induced pulmonary extracellular vesicles contribute to exacerbated cardiomyocyte impairment through the translocation of ERK5.
TRPM7 contributes to pyroptosis and its involvement in status epilepticus.
DL-3-n-Butylphthalide Ameliorates Post-stroke Emotional Disorders by Suppressing Neuroinflammation and PANoptosis.
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease.
Blockade of thromboxane A2 signaling attenuates ethanol-induced myocardial inflammatory response in mice.
Tongqiao Yizhi granule repress the nuclear factor kappa-b/nucleotide oligomerization domain-like receptors 3/caspase-1 pyroptosis pathway in the hippocampus to counter vascular dementia in rats.
Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment.
Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A.
Obstructive Sleep Apnea Plasma-Derived Exosomes Mediate Cognitive Impairment Through Hippocampal Neuronal Cell Pyroptosis.
Apoptosis and pyroptosis in the nasal mucosa of Syrian hamster during SARS-CoV-2 infection and reinfection.
The VDAC1 oligomerization regulated by ATP5B leads to the NLRP3 inflammasome activation in the liver cells under PFOS exposure.
Co-exposure of microcystin-LR and nitrite induced kidney injury through TLR4/NLRP3/GSDMD-mediated pyroptosis.
Oridonin ameliorates ocular surface inflammatory responses by inhibiting the NLRP3/caspase-1/GSDMD pyroptosis pathway in dry eye.
RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis.
Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats.
Inhibition of cGAS attenuates neonatal hypoxic-ischemic encephalopathy via regulating microglia polarization and pyroptosis.
Combined bacterial translocation and cholestasis aggravates liver injury by activation pyroptosis in obstructive jaundice.
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
HMGB1/TLR4 axis promotes pyroptosis after ICH by activating the NLRP3 inflammasome.
CCR5 antagonist maraviroc alleviates doxorubicin-induced neuroinflammation and neurobehavioral deficiency by regulating NF-κB/NLRP3 signaling in a breast cancer mouse model.
Syntaxin17 Restores Lysosomal Function and Inhibits Pyroptosis Caused by Acinetobacter baumannii.
Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model.
NLRP3 Inflammasome-dependent Pathway is Involved in the Pathogenesis of Polycystic Ovary Syndrome.
Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics.
SARS-CoV-2 virus-like particle variants alpha and delta mimic the native viruses in their differential inflammasome activating potential.
Methylmercury induces inflammatory response and autophagy in microglia through the activation of NLRP3 inflammasome.
A snake cathelicidin enhances transcription factor EB-mediated autophagy and alleviates ROS-induced pyroptosis after ischaemia-reperfusion injury of island skin flaps.
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus.
Baohuoside I suppresses the NLRP3 inflammasome activation via targeting GPER to fight against Parkinson's disease.
Research Note: The effect of photoperiod on the NLRP3 inflammasome and gut microbiota in broiler chickens.
TMAO promotes vascular endothelial cell pyroptosis via the LPEAT-mitophagy pathway.
Mycobacterium tuberculosis PE_PGRS38 Enhances Intracellular Survival of Mycobacteria by Inhibiting TLR4/NF-κB-Dependent Inflammation and Apoptosis of the Host.
MCC950 attenuates plasma cell mastitis in an MDSC-dependent manner.
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis.
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats.
Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome.
Mesenchymal Stem Cells-Derived Exosomes Alleviate Acute Lung Injury by Inhibiting Alveolar Macrophage Pyroptosis.
Protective role of forsythoside B in Kawasaki disease-induced cardiac injury: Inhibition of pyroptosis via the SIRT1-NF-κB-p65 signaling pathway.
Mechanically tough, adhesive, self-healing hydrogel promotes annulus fibrosus repair via autologous cell recruitment and microenvironment regulation.
LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
Role and significance of SIRT1 in regulating the LPS-activated pyroptosis pathway in children with congenital hydronephrosis.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Unresolved Excess Accumulation of Myelin-Derived Cholesterol Contributes to Scar Formation after Spinal Cord Injury.
Irisin Ameliorated Skeletal Muscle Atrophy by Inhibiting Fatty Acid Oxidation and Pyroptosis Induced by Palmitic Acid in Chronic Kidney Disease.
Butylphthalide improves brain damage induced by renal ischemia-reperfusion injury rats through Nrf2/HO-1 and NOD2/MAPK/NF-κB pathways.
Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor.
Trimethylamine-N-Oxide Promotes High-Glucose-Induced Dysfunction and NLRP3 Inflammasome Activation in Retinal Microvascular Endothelial Cells.
Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis.
Human Umbilical Cord Mesenchymal Stem Cells Inhibit Pyroptosis of Renal Tubular Epithelial Cells through miR-342-3p/Caspase1 Signaling Pathway in Diabetic Nephropathy.
Hemoglobin Derived from Subarachnoid Hemorrhage-Induced Pyroptosis of Neural Stem Cells via ROS/NLRP3/GSDMD Pathway.
HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model.
DDX3X Deficiency Attenuates Pyroptosis Induced by Oxygen-glucose Deprivation/Reoxygenation in N2a Cells.
High-dose remifentanil exacerbates myocardial ischemia-reperfusion injury through activation of calcium-sensing receptor-mediated pyroptosis.
NLRP3 Inflammasome Mediates Silica-induced Lung Epithelial Injury and Aberrant Regeneration in Lung Stem/Progenitor Cell-derived Organotypic Models.
Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease.
Network Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis.
Resolvin D1 Attenuates Inflammation and Pelvic Pain Associated with EAP by Inhibiting Oxidative Stress and NLRP3 Inflammasome Activation via the Nrf2/HO-1 Pathway.
Activation of the microglial P2X7R/NLRP3 inflammasome mediates central sensitization in a mouse model of medication overuse headache.
Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.
Aspirin-triggered Resolvin D1 ameliorates activation of the NLRP3 inflammasome via induction of autophagy in a rat model of neuropathic pain.
Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation.
A novel colchicine-myricetin heterozygous molecule: design, synthesis, and effective evaluations on the pathological models of acute lung injury in vitro and in vivo.
Identification of molecular subtypes based on PANoptosis-related genes and construction of a signature for predicting the prognosis and response to immunotherapy response in hepatocellular carcinoma.
Inhibition of neutrophil extracellular trap formation attenuates NLRP1-dependent neuronal pyroptosis via STING/IRE1α pathway after traumatic brain injury in mice.
Exercise training-attenuated insulin resistance and liver injury in elderly pre-diabetic patients correlates with NLRP3 inflammasome.
Investigation of He's Yang Chao recipe against oxidative stress-related mitophagy and pyroptosis to improve ovarian function.
Outer membrane vesicles derived from gut microbiota mediate tubulointerstitial inflammation: a potential new mechanism for diabetic kidney disease.
Ablation of NLRP3 inflammasome attenuates muscle atrophy via inhibiting pyroptosis, proteolysis and apoptosis following denervation.
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Role of NLRP3 inflammasome activation in HCC cell progression.
Protection of Oxygen Glucose Deprivation-Induced Human Brain Vascular Pericyte Injury: Beneficial Effects of Bellidifolin in Cellular Pyroptosis.
Sanguisorba officinalis L. promotes diabetic wound healing in rats through inflammation response mediated by macrophage.
Pinocembrin alleviates pyroptosis and apoptosis through ROS elimination in random skin flaps via activation of SIRT3.
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.
Functionalized Metal-Organic Framework-Modified Hydrogel That Breaks the Vicious Cycle of Inflammation and ROS for Repairing of Diabetic Bone Defects.
PM(2.5) induces the inflammatory response in rat spleen lymphocytes through autophagy activation of NLRP3 inflammasome.
Maslinic acid alleviates LPS-induced mice mastitis by inhibiting inflammatory response, maintaining the integrity of the blood-milk barrier and regulating intestinal flora.
3,4-benzo[a]pyrene aggravates myocardial infarction injury by activating NLRP3-related pyroptosis through PINK1/Parkin-mitophagy-mPTP opening axis.
Lunasin reduces the susceptibility of IL-10 deficient mice to inflammatory bowel disease and modulates the activation of the NLRP3 inflammasome.
Record-High Ultrasound-Sensitive NO Nanogenerators for Cascade Tumor Pyroptosis and Immunotherapy.
Aloe-Emodin Derivative, an Anthraquinone Compound, Attenuates Pyroptosis by Targeting NLRP3 Inflammasome in Diabetic Cardiomyopathy.
Bone marrow mesenchymal stem cellsderived exosomes stabilize atherosclerosis through inhibiting pyroptosis.
Jiedu Quyu Decoction mitigates monocrotaline-induced right-sided heart failure associated with pulmonary artery hypertension by inhibiting NLRP3 inflammasome in rats.
MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands.
Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis.
Toll-like receptor 4 promotes the inflammatory response in septic acute kidney injury by promoting p38 mitogen-activated protein kinase phosphorylation.
CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria.
Neuroprotection of NSC Therapy is Superior to Glibenclamide in Cardiac Arrest-Induced Brain Injury via Neuroinflammation Regulation.
Lianhua Qingke ameliorates lipopolysaccharide-induced lung injury by inhibiting neutrophil extracellular traps formation and pyroptosis.
CXCL5 promotes lipotoxicity of hepatocytes through upregulating NLRP3/Caspase-1/IL-1β signaling in Kupffer cells and exacerbates nonalcoholic steatohepatitis in mice.
Salvianolic acid B inhibits atherosclerosis and TNF-α-induced inflammation by regulating NF-κB/NLRP3 signaling pathway.
Down-regulation of OIP5-AS1 inhibits obesity-induced myocardial pyroptosis and miR-22/NLRP3 inflammasome axis.
Cordyceps militaris Solid Medium Extract Alleviates Lipoteichoic Acid-Induced MH-S Inflammation by Inhibiting TLR2/NF-κB/NLRP3 Pathways.
ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer.
CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis.
Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions.
Oroxylin a promoted apoptotic extracellular vesicles transfer of glycolytic kinases to remodel immune microenvironment in hepatocellular carcinoma model.
Colchicine protects against the development of experimental abdominal aortic aneurysm.
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
HDAC3 inhibitor (BRD3308) modulates microglial pyroptosis and neuroinflammation through PPARγ/NLRP3/GSDMD to improve neurological function after intraventricular hemorrhage in mice.
AR/PCC herb pair inhibits osteoblast pyroptosis to alleviate diabetes-related osteoporosis by activating Nrf2/Keap1 pathway.
Unraveling the protective mechanisms of Chuanfangyihao against acute lung injury: Insights from experimental validation.
Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells.
Effects of HMGB1/RAGE/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic-ischemic brain damage.
Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells.
Diallyl disulfide attenuates pyroptosis via NLRP3/Caspase-1/IL-1β signaling pathway to exert a protective effect on hypoxic-ischemic brain damage in neonatal rats.
The role of EndophilinA1 in chronic unpredicted mild stress-induced depression model mice.
Inhibition of Caspase-1-mediated pyroptosis promotes osteogenic differentiation, offering a therapeutic target for osteoporosis.
Melatonin alleviates intrarenal CaOx crystals deposition through inhibiting LPS-induced non-canonical inflammasome-mediated renal tubular epithelial cells pyroptosis.
Vasculoprotective Potential of Baicalein in Angiotensin II-Infused Abdominal Aortic Aneurysms through Inhibiting Inflammation and Oxidative Stress.
TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice.
[Inhibition of Histone Deacetylase 6 Ameliorates Podocyte Injury in Diabetic Kidney Disease in Mice].
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer.
GSK2656157, a PERK Inhibitor, Alleviates Pyroptosis of Macrophages Induced by Mycobacterium Bacillus Calmette-Guerin Infection.
STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.
Heme oxygenase‑1 inhibits renal tubular epithelial cell pyroptosis by regulating mitochondrial function through PINK1.
Rosuvastatin promotes survival of random skin flaps through AMPK-mTOR pathway-induced autophagy.
Supramolecular salicylic acid ameliorates rosacea-like eruptions by suppressing NLRP3-mediated inflammasome activation in mice.
CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice.
The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.
MALAT1 participates in the role of platelet-rich plasma exosomes in promoting wound healing of diabetic foot ulcer.
Adipolin protects against renal injury via PPARα-dependent reduction of inflammasome activation.
HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome.
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis.
Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
TMEM16F may be a new therapeutic target for Alzheimer's disease.
Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage.
The Effect of Gut Microbiota on the Progression of Intervertebral Disc Degeneration.
Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.
Melatonin protects human nucleus pulposus cells from pyroptosis by regulating Nrf2 via melatonin membrane receptors.
Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway.
Comprehensive analysis of autophagy-related gene expression profiles identified five gene biomarkers associated with immune infiltration and advanced plaques in carotid atherosclerosis.
Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.
Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.
Targeting hexokinase 1 alleviates NLRP3-mediated inflammation in apical periodontitis: A laboratory investigation.
Salmonella typhimurium exacerbates injuries but resolves fibrosis in liver and spleen during Schistosoma mansoni infection.
Exercise Mitigates Endothelial Pyroptosis and Atherosclerosis by Downregulating NEAT1 Through N6-Methyladenosine Modifications.
MicroRNA-29a-3p Prevents Drug-Induced Acute Liver Failure through Inflammation-Related Pyroptosis Inhibition.
Serum amyloid A and interleukin -1β facilitate LDL transcytosis across endothelial cells and atherosclerosis via NF-κB/caveolin-1/cavin-1 pathway.
Circulating exosomal miR-155-5p contributes to severe acute pancreatitis-associated intestinal barrier injury by targeting SOCS1 to activate NLRP3 inflammasome-mediated pyroptosis.
Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.
SS-31 Improves Cognitive Function in Sepsis-Associated Encephalopathy by Inhibiting the Drp1-NLRP3 Inflammasome Activation.
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Jinyinqingre Oral Liquid alleviates LPS-induced acute lung injury by inhibiting the NF-κB/NLRP3/GSDMD pathway.
Growth differentiation factor 15 protects the airway by inhibiting cell pyroptosis in obese asthmatic mice through the phosphoinositide 3-kinase/AKT pathway.
Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice.
Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain.
Baicalein Suppresses NLRP3 and AIM2 Inflammasome-Mediated Pyroptosis in Macrophages Infected by Mycobacterium tuberculosis via Induced Autophagy.
Metal-enriched HSP90 nanoinhibitor overcomes heat resistance in hyperthermic intraperitoneal chemotherapy used for peritoneal metastases.
Gastroprotective Effects of the Aqueous Extract of Finger Citron Pickled Products against Ethanol-Induced Gastric Damage: In Vitro and In Vivo Studies.
Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome.
Hydrogen-Rich Saline-A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral Ischemia via the ROS-NLRP3 Inflammasome Signaling Pathway In Vivo and In Vitro.
Translocator protein 18 kDa regulates retinal neuron apoptosis and pyroptosis in glaucoma.
Analgesic Effect of Perineural Injection of BoNT/A on Neuropathic Pain Induced by Chronic Constriction Injury of Sciatic Nerve in Rats.
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Oxidative Stress Initiates Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Mediated Corneal Epithelial Necroptosis and Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Signaling during Fungal Keratitis.
Combined exposure to lead and high-fat diet induced neuronal deficits in rats: Anti-neuroinflammatory role of SIRT1.
Parthenolide alleviates microglia-mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder.
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease.
Glucocorticoid receptor-mediated Nr1d1 chromatin circadian misalignment in stress-induced irritable bowel syndrome.
Dihydromyricetin inhibits African swine fever virus replication by downregulating toll-like receptor 4-dependent pyroptosis in vitro.
Attenuation of experimental osteoarthritis with human adipose-derived mesenchymal stem cell therapy: inhibition of the pyroptosis in chondrocytes.
SIRT3 attenuates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome via autophagy.
Activation of PINK1-mediated mitophagy protects bovine mammary epithelial cells against lipopolysaccharide-induced mitochondrial and inflammatory damage in vitro.
Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway.
Salidroside protects pancreatic β-cells against pyroptosis by regulating the NLRP3/GSDMD pathway in diabetic conditions.
Protective effects of leonurine hydrochloride on pyroptosis in premature ovarian insufficiency via regulating NLRP3/GSDMD pathway.
Matrine suppresses NLRP3 inflammasome activation via regulating PTPN2/JNK/SREBP2 pathway in sepsis.
[Methylophiopogonanone a Inhibits LPS/ATP-Induced Macrophage Pyroptosis via ROS/NLRP3 Pathway].
Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization.
TMBIM4 Deficiency Facilitates NLRP3 Inflammasome Activation-Induced Pyroptosis of Trophoblasts: A Potential Pathogenesis of Preeclampsia.
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury.
MicroRNA-29b regulates pyroptosis involving calcific aortic valve disease through the STAT3/SOCS1 pathway.
UFM1 inhibits the activation of the pyroptosis in LPS-induced goat endometritis.
Jatrorrhizine Suppresses Murine-Norovirus-Triggered N-GSDMD-Dependent Pyroptosis in RAW264.7 Macrophages.
Cadmium exposure promotes thyroid pyroptosis and endocrine dysfunction by inhibiting Nrf2/Keap1 signaling.
Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway.
Mitophagy-promoting miR-138-5p promoter demethylation inhibits pyroptosis in sepsis-associated acute lung injury.
Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia.
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223-3p/NLRP3 axis.
Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15.
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons.
Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K/Akt/NF-κB and NLRP3/caspase-1/GSDMD signaling.
Dimethyl fumarate ameliorates fungal keratitis by limiting fungal growth and inhibiting pyroptosis.
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Mace-Like Plasmonic Au-Pd Heterostructures Boost Near-Infrared Photoimmunotherapy.
Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis.
Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome.
Notopterol Ameliorates Hyperuricemia-Induced Cardiac Dysfunction in Mice.
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Lacrimal Gland Epithelial Cells Shape Immune Responses through the Modulation of Inflammasomes and Lipid Metabolism.
Piceatannol and 3'-Hydroxypterostilbene Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice.
DBDPE upregulates NOD-like receptor signaling to induce NLRP3 inflammasome-mediated HAECs pyroptosis.
Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling.
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway.
Yueliang Yin Ameliorates Endometrial Receptivity in Mice with Embryo Implantation Failure by Reducing Pyroptosis and Activating BDNF/TrkB Pathway.
Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways.
Regulating NLRP3 Inflammasome-Induced Pyroptosis via Nrf2: TBHQ Limits Hyperoxia-Induced Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia.
Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells.
HBx-induced PLA(2)R overexpression mediates podocyte pyroptosis through the ROS-NLRP3 signaling pathway.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Tryptophan alleviates lipopolysaccharide-induced liver injury and inflammation by modulating necroptosis and pyroptosis signaling pathways in piglets.
Clodronate liposomes may biases MSC differentiation toward adipogenesis through activation of NLRP3.
Hypoxia-inducible factor 1α activates the NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis.
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition.
Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis.
ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke.
ASC/inflammasome-independent pyroptosis in ovarian cancer cells through translational augmentation of caspase-1.
NLRP3 inflammasome-mediated pyroptosis involvement in cadmium exposure-induced cognitive deficits via the Sirt3-mtROS axis.
The role of ROS-pyroptosis in PM(2.5) induced air-blood barrier destruction.
Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3.
Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury.
Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Inulin-type oligosaccharides of Morinda officinalis exerted antidepressant effects by reducing hippocampal inflammation.
The Inhibitory Effect of RADKPS on Pyroptosis of Nucleus Pulposus-Derived Mesenchymal Stem Cells.
Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway.
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease.
Sodium houttuyfonate plays a protective role in the asthmatic airway by alleviating the NLRP3-related pyroptosis and Th1/Th2 immune imbalance.
Exploring the application of sildenafil for high-fat diet-induced erectile dysfunction based on interleukin-18-mediated NLRP3/Caspase-1 signaling pathway.
Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model.
Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia.
A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression.
Neuroprotective Effects of Vinpocetine Against Ischemia-Reperfusion Injury Via Inhibiting NLRP3 Inflammasome Signaling Pathway.
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.
Scutellaria baicalensis Pith-decayed Root Inhibits Macrophage-related Inflammation Through the NF-κB/NLRP3 Pathway to Alleviate LPS-induced Acute Lung Injury.
Sulforaphane reduces lipopolysaccharide-induced inflammation and enhances myogenic differentiation of mouse embryonic myoblasts via the toll-like receptor 4 and NLRP3 pathways.
Bufalin alleviates acute kidney injury by regulating NLRP3 inflammasome-mediated pyroptosis.
PRRSV infection activates NLRP3 inflammasome through inducing cytosolic mitochondrial DNA stress.
Bullatine A has an antidepressant effect in chronic social defeat stress mice; Implication of microglial inflammasome.
Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway.
Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model.
Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.
Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells.
Puerarin protects against sepsis-associated encephalopathy by inhibiting NLRP3/Caspase-1/GSDMD pyroptosis pathway and reducing blood-brain barrier damage.
Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B.
Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites.
3,4-benzopyrene aggravates myocardial ischemia-reperfusion injury-induced pyroptosis through inhibition of autophagy-dependent NLRP3 degradation.
Oroxin A ameliorates the oleic acid-induced A549 cell injury through the suppression of pyroptosis and degradation of alveolar surfactant.
β-hydroxybutyrate impairs monocyte function via the ROS-NLR family pyrin domain-containing three inflammasome (NLRP3) pathway in ketotic cows.
Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion.
Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.
Using Collagen Peptides From the Skin of Monkfish (Lophius litulon) to Ameliorate Kidney Damage in High-Fat Diet Fed Mice by Regulating the Nrf2 Pathway and NLRP3 Signaling.
Sinapic Acid Alleviates Acute Pancreatitis in Association with Attenuation of Inflammation, Pyroptosis, and the AMPK/NF-[Formula: see text]B Signaling Pathway.
Cadmium mediates pyroptosis of human dermal lymphatic endothelial cells in a NLRP3 inflammasome-dependent manner.
NLRP3 inflammasome inhibitor MCC950 can reduce the damage of pancreatic and intestinal barrier function in mice with acute pancreatitis.
Tanshinone IIA ameliorates myocardial ischemia/reperfusion injury in rats by regulation of NLRP3 inflammasome activation and Th17 cells differentiation.
HSPB8 Overexpression Ameliorates Cognitive Impairment in Diabetic Mice via Inhibiting NLRP3 Inflammation Activation.
Simvastatin Inhibits NLRP3 Inflammasome Activation and Ameliorates Lung Injury in Hyperoxia-Induced Bronchopulmonary Dysplasia via the KLF2-Mediated Mechanism.
Tanshinone IIA Improves Acute Gouty Arthritis in Rats through Regulating Neutrophil Activation and the NLRP3 Inflammasome.
Progesterone Reduces ATP-Induced Pyroptosis of SH-SY5Y Cells.
Luteolin Induced Hippocampal Neuronal Pyroptosis Inhibition by Regulation of miR-124-3p/TNF-α/TRAF6 Axis in Mice Affected by Breast-Cancer-Related Depression.
Polysaccharides from Polygonatum cyrtonema Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis.
Silencing of TLR4 Inhibits Atrial Fibrosis and Susceptibility to Atrial Fibrillation via Downregulation of NLRP3-TGF-β in Spontaneously Hypertensive Rats.
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.
Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury.
Nrf2 Inhibits the Progression of Parkinson's Disease by Upregulating AABR07032261.5 to Repress Pyroptosis.
Inhibition of Dectin-1 Alleviates Neuroinflammatory Injury by Attenuating NLRP3 Inflammasome-Mediated Pyroptosis After Intracerebral Hemorrhage in Mice: Preliminary Study Results.
Comprehensive Analysis of Prognostic Value and Immune Infiltration of NLRC4 and CASP1 in Colorectal Cancer.
Yishen Capsule Alleviated Symptoms of Diabetic Nephropathy via NOD-like Receptor Signaling Pathway.
Trimethylamine N-oxide promotes demyelination in spontaneous hypertension rats through enhancing pyroptosis of oligodendrocytes.
Trichodimerol inhibits inflammation through suppression of the nuclear transcription factor-kappaB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway.
Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral replication.
Taohong siwu decoction attenuates AIM2 and NLRC4 inflammasomes by ameliorates deoxyribonucleic acid damage after ischemic stroke.
Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia.
Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome.
Integrated pyroptosis measurement and metabolomics to elucidate the effect and mechanism of tangzhiqing on atherosclerosis.
NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.
Natural Compound Library Screening Identifies Oroxin A for the Treatment of Myocardial Ischemia/Reperfusion Injury.
Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation.
Neutrophil Extracellular Traps (NETs) Promote Non-Small Cell Lung Cancer Metastasis by Suppressing lncRNA MIR503HG to Activate the NF-κB/NLRP3 Inflammasome Pathway.
Stem Cells From Human Exfoliated Deciduous Teeth Alleviate Liver Cirrhosis via Inhibition of Gasdermin D-Executed Hepatocyte Pyroptosis.
Dendrobium Nobile Lindl. Alkaloid Suppresses NLRP3-Mediated Pyroptosis to Alleviate LPS-Induced Neurotoxicity.
Succinate/IL-1β Signaling Axis Promotes the Inflammatory Progression of Endothelial and Exacerbates Atherosclerosis.
Methamphetamine Disturbs Gut Homeostasis and Reshapes Serum Metabolome, Inducing Neurotoxicity and Abnormal Behaviors in Mice.
Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis.
Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis.
Modified Baihu decoction therapeutically remodels gut microbiota to inhibit acute gouty arthritis.
miR-513c-5p Suppression Aggravates Pyroptosis of Endothelial Cell in Deep Venous Thrombosis by Promoting Caspase-1.
Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis.
Mechanism of nonylphenol induced gastric inflammation through NF-κB/NLRP3 signaling pathway.
ROCK2 knockdown alleviates LPS-induced inflammatory injury and apoptosis of renal tubular epithelial cells via the NF-κB/NLRP3 signaling pathway.
Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway.
Activation of NLRP3 inflammasome contributes to the inflammatory response to allergic rhinitis via macrophage pyroptosis.
Aqueous extract of Scrophularia ningpoensis improves insulin sensitivity through AMPK-mediated inhibition of the NLRP3 inflammasome.
A20 inhibits periodontal bone resorption and NLRP3-mediated M1 macrophage polarization.
Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells.
Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy.
Salvianolic acid B ameliorates non-alcoholic fatty liver disease by inhibiting hepatic lipid accumulation and NLRP3 inflammasome in ob/ob mice.
GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma.
LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.
M378 exhibits anti-inflammatory activities through NLRP3 signaling pathway.
MicroRNA-122a aggravates intestinal ischemia/reperfusion injury by promoting pyroptosis via targeting EGFR-NLRP3 signaling pathway.
Aerobic exercise training alleviates renal injury in db/db mice through inhibiting Nox4-mediated NLRP3 inflammasome activation.
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner.
Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats.
Hypoxia-Induced HIF-1α Expression Promotes Neurogenic Bladder Fibrosis via EMT and Pyroptosis.
Taraxasterol inhibits inflammation in osteoarthritis rat model by regulating miRNAs and NF-κB signaling pathway.
Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway.
Schisandra chinensis (Turcz.) Baill. Protects against DSS-induced colitis in mice: Involvement of TLR4/NF-κB/NLRP3 inflammasome pathway and gut microbiota.
Neutrophil Extracellular Traps Mediate Bovine Endometrial Epithelial Cell Pyroptosis in Dairy Cows with Endometritis.
Adipose stem cells preincubated with theanine exert liver regeneration through increase of stem cell paracrine VEGF and suppression of ROS, pyroptosis as well as autophagy markers in liver damage induced by N-nitrosodiethylamine.
The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy.
LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1.
Leonurine inhibits the TXNIP/NLRP3 and NF-κB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.
LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes.
PM(2.5) induced lung injury through upregulating ROS-dependent NLRP3 Inflammasome-Mediated Pyroptosis.
Ghrelin ameliorates diabetes-associated behavioral deficits and NLRP3 inflammasome activation via autophagic flux enhancement.
Cynarin suppresses gouty arthritis induced by monosodium urate crystals.
CCDC50 suppresses NLRP3 inflammasome activity by mediating autophagic degradation of NLRP3.
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
Nrf2 and NF-κB/NLRP3 inflammasome pathways are involved in Prototheca bovis infections of mouse mammary gland tissue and mammary epithelial cells.
Nicotine promotes chronic obstructive pulmonary disease via inducing pyroptosis activation in bronchial epithelial cells.
Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation.
Fibronectin type III domain-containing 5 improves aging-related cardiac dysfunction in mice.
Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.
Klotho alleviates NLRP3 inflammasome-mediated neuroinflammation in a temporal lobe epilepsy rat model by activating the Nrf2 signaling pathway.
Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease.
Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.
Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome.
Effect of NLRP3 repression on NLRP3 inflammasome activation in human corneal epithelial cells with black carbon exposure.
MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to inhibit NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K cell pyroptosis, and inflammatory bowel disease in mice.
α(1) -Adrenoceptors activate the NLRP3 inflammasome through downregulation of Kir2.1 in cardiac inflammation.
Blockage of transient receptor potential vanilloid 4 prevents postoperative atrial fibrillation by inhibiting NLRP3-inflammasome in sterile pericarditis mice.
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice.
MMP2 and MMP9 contribute to lung ischemia-reperfusion injury via promoting pyroptosis in mice.
Carbenoxolone Ameliorates Allergic Airway Inflammation through NF-κB/NLRP3 Pathway in Mice.
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats.
Liraglutide Ameliorates Cerebral Ischemia in Mice via Antipyroptotic Pathways.
Human iPSC colon organoid function is improved by exposure to fecal fermentates.
Neuroprotective effects of CysLTR antagonist on Streptococcus pneumoniae-induced meningitis in rats.
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.
Malassezia globosa Activates NLRP3 Inflammasome in Human Sebocytes.
MCC950 attenuates inflammation-mediated damage in canines with Staphylococcus pseudintermedius keratitis by inhibiting the NLRP3 inflammasome.
Protein nanoparticle-induced osmotic pressure gradients modify pulmonary edema through hyperpermeability in acute respiratory distress syndrome.
Fudosteine attenuates acute lung injury in septic mice by inhibiting pyroptosis via the TXNIP/NLRP3/GSDMD pathway.
Akkermansia muciniphila Colonization Alleviating High Fructose and Restraint Stress-Induced Jejunal Mucosal Barrier Disruption.
CysLT(2)R Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils.
Circ_0000181 regulates miR-667-5p/NLRC4 axis to promote pyroptosis progression in diabetic nephropathy.
Protocatechuic aldehyde prevents ischemic injury by attenuating brain microvascular endothelial cell pyroptosis via lncRNA Xist.
H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion.
RBC-hitchhiking chitosan nanoparticles loading methylprednisolone for lung-targeting delivery.
Hepatitis B virus X mediates podocyte pyroptosis by regulating the ROS/NLRP3 signaling pathway in hepatitis B virus-associated glomerulonephritis.
Suppression of the caspase-1/GSDMD-mediated pyroptotic signaling pathway through dexamethasone alleviates corneal alkali injuries.
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway.
Skin damage induced by zinc oxide nanoparticles combined with UVB is mediated by activating cell pyroptosis via the NLRP3 inflammasome-autophagy-exosomal pathway.
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Ketogenic diet ameliorates lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1.
IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Staphylococcal Enterotoxin A Induces Intestinal Barrier Dysfunction and Activates NLRP3 Inflammasome via NF-κB/MAPK Signaling Pathways in Mice.
Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy.
The Role of NF-κB/NLRP3 Inflammasome Signaling Pathway in Attenuating Pyroptosis by Melatonin Upon Spinal Nerve Ligation Models.
Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.
IL-38-mediated NLRP3/caspase-1 inhibition is a disease-modifying treatment for TMJ inflammation.
The roles of mitochondrial dynamics and NLRP3 inflammasomes in the pathogenesis of retinal light damage.
Enhancement of anti-inflammatory effect of cattle bile by fermentation and its inhibition of neuroinflammation on microglia by inhibiting NLRP3 inflammasome.
Effect of nonylphenol on the colonic mucosa in rats and intervention with zinc-selenium green tea (Camellia sinensis).
Vagus nerve stimulation alleviated cerebral ischemia and reperfusion injury in rats by inhibiting pyroptosis via α7 nicotinic acetylcholine receptor.
Staphylococcus aureus mediates pyroptosis in bovine mammary epithelial cell via activation of NLRP3 inflammasome.
Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.
Downregulation of macrophage migration inhibitory factor attenuates NLRP3 inflammasome mediated pyroptosis in sepsis-induced AKI.
Neuropeptide Y and receptors are associated with the pyroptosis of nucleus pulposus in aging and degenerative intervertebral discs of rats.
Paeoniflorin alleviates inflammatory response in IBS-D mouse model via downregulation of the NLRP3 inflammasome pathway with involvement of miR-29a.
Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis.
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
Epigallocatechin-3-gallate (EGCG) attenuates inflammatory responses and oxidative stress in lipopolysaccharide (LPS)-induced endometritis via silent information regulator transcript-1 (SIRT1)/nucleotide oligomerization domain (NOD)-like receptor pyrin domain-containing 3 (NLRP3) pathway.
Сyclooxygenase-2 Inhibitor Parecoxib Reduces LPS-Induced Activation of BV2 Microglia Cells.
Identification of key proteins of cytopathic biotype bovine viral diarrhoea virus involved in activating NF-κB pathway in BVDV-induced inflammatory response.
GABA regulates IL-1β production in macrophages.
Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function.
Glucagon-like Peptide 1 Receptor Activation Inhibits Microglial Pyroptosis via Promoting Mitophagy to Alleviate Depression-like Behaviors in Diabetic Mice.
NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits.
Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis.
Inhibited transcription factor EB function induces reactive oxygen species overproduction to promote pyroptosis in cadmium-exposed renal tubular epithelial cells.
USP1 Inhibits NF-κB/NLRP3 Induced Pyroptosis through TRAF6 in Osteoblastic MC3T3-E1 Cells.
Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome.
Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis.
Mechanism of miR-126 in hypoxia-reoxygenation-induced cardiomyocyte pyroptosis by regulating HMGB1 and NLRP3 inflammasome.
ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment.
Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1(G93A) ALS mouse model.
N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways.
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.
Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.
Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo.
Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation.
Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy.
Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice.
EB1089 promotes the expression of vitamin D receptor in the intestinal epithelial cell line HT-29 and reduces lipopolysaccharide-induced inflammatory response.
Dihydromyricetin improves LPS-induced sickness and depressive-like behaviors in mice by inhibiting the TLR4/Akt/HIF1a/NLRP3 pathway.
ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation.
Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK/NF-κB/NLRP3 pathway.
Baclofen attenuates cognitive deficits in post-cardiac arrest brain injury.
Dietary Tryptophan Supplementation Improves Antioxidant Status and Alleviates Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Pyroptosis in the Intestine of Piglets after Lipopolysaccharide Challenge.
The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy.
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy.
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.
CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation.
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk.
Effect and Mechanism of Mycobacterium tuberculosis Lipoprotein LpqH in NLRP3 Inflammasome Activation in Mouse Ana-1 Macrophage.
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation.
Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation.
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Tongxinluo Exerts Inhibitory Effects on Pyroptosis and Amyloid-β Peptide Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NF-κB Signaling Pathway.
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways.
Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.
SOCS2 Suppresses Inflammation and Apoptosis during NASH Progression through Limiting NF-κB Activation in Macrophages.
Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer.
GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.
Punicalin Ameliorates Cell Pyroptosis Induced by LPS/ATP Through Suppression of ROS/NLRP3 Pathway.
Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes.
PARK2 attenuates house dust mite-induced inflammatory reaction, pyroptosis and barrier dysfunction in BEAS-2B cells by ubiquitinating NLRP3.
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.
Yi-Zhi-Fang-Dai Formula Exerts Neuroprotective Effects Against Pyroptosis and Blood-Brain Barrier-Glymphatic Dysfunctions to Prevent Amyloid-Beta Acute Accumulation After Cerebral Ischemia and Reperfusion in Rats.
Entinostat Improves Motor Function and Neuronal Damage Via Downregulating NLRP3 Inflammasome Activation After Spinal Cord Injury.
An Integrative Pharmacology Based Analysis of Refined Liuweiwuling Against Liver Injury: A Novel Component Combination and Hepaprotective Mechanism.
CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome-Pyroptosis Pathway.
AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation.
Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.
Oleanolic Acid Improves Obesity-Related Inflammation and Insulin Resistance by Regulating Macrophages Activation.
Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation.
Inflammasome-Induced Osmotic Pressure and the Mechanical Mechanisms Underlying Astrocytic Swelling and Membrane Blebbing in Pyroptosis.
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
LPS Mediates Bovine Endometrial Epithelial Cell Pyroptosis Directly Through Both NLRP3 Classical and Non-Classical Inflammasome Pathways.
Subicular Caspase-1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy.
Hypoxia-preconditioned mesenchymal stem cells attenuate microglial pyroptosis after intracerebral hemorrhage.
Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.
H(2)S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.
LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling.
MerTK inhibits the activation of the NLRP3 inflammasome after subarachnoid hemorrhage by inducing autophagy.
Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis.
Gardnerella vaginalis induces NLRP3 inflammasome-mediated pyroptosis in macrophages and THP-1 monocytes.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury.
Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-κB pathway.
LncRNA HOTAIR Promotes Neuronal Damage Through Facilitating NLRP3 Mediated-Pyroptosis Activation in Parkinson's Disease via Regulation of miR-326/ELAVL1 Axis.
Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Inflammatory and immune-related factor Caspase 1 contributes to the development of oral lichen planus.
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis.
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis.
Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase-1 signaling pathway and oxidative stress in Wistar rats.
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats.
NLRP3 inflammasome activation in alveolar epithelial cells promotes myofibroblast differentiation of lung-resident mesenchymal stem cells during pulmonary fibrogenesis.
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Cordyceps acid alleviates lung cancer in nude mice.
NLRP3 inflammasome-mediated endothelial cells pyroptosis is involved in decabromodiphenyl ethane-induced vascular endothelial injury.
Airborne particulate matter (PM(2.5)) triggers ocular hypertension and glaucoma through pyroptosis.
Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1.
Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway.
Golgi phosphoprotein 3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome.
IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
Wogonin Alleviates Cisplatin-induced Cardiotoxicity in Mice Via Inhibiting Gasdermin D-mediated Pyroptosis.
Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation.
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.
Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway.
MIF inhibitor ISO-1 alleviates severe acute pancreatitis-associated acute kidney injury by suppressing the NLRP3 inflammasome signaling pathway.
Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes.
N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia-reperfusion rats via the TLR4/NF-κB/NLRP3 pathway.
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.
Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis.
hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis.
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.
Toll‑like receptor 4 activates the NLRP3 inflammasome pathway and periodontal inflammaging by inhibiting Bmi‑1 expression.
Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway.
Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342-3p targeting of CASP1 in diabetic retinopathy.
Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice.
Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice.
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth.
Protection of hUC-MSCs against neuronal complement C3a receptor-mediated NLRP3 activation in CUMS-induced mice.
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis.
Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression.
lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome.
Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.
Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
Silenced microRNA-222 suppresses inflammatory response in gestational diabetes mellitus mice by promoting CXCR4.
An In-vivo Study into the Effects of Schisandrin B in the Liver, Spleen, Kidney, and Brain of Acute Thioacetamide-intoxicated Mice.
Huoxue Qianyang Qutan recipe attenuates cardiac fibrosis by inhibiting the NLRP3 inflammasome signalling pathway in obese hypertensive rats.
Dexmedetomidine inhibits endoplasmic reticulum stress to suppress pyroptosis of hypoxia/reoxygenation-induced intestinal epithelial cells via activating the SIRT1 expression.
Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM(2.5).
Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway.
MEHP induces pyroptosis and autophagy alternation by cathepsin B activation in INS-1 cells.
DDX3X deficiency alleviates LPS-induced H9c2 cardiomyocytes pyroptosis by suppressing activation of NLRP3 inflammasome.
MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice.
ESR2 regulates PINK1-mediated mitophagy via transcriptional repression of microRNA-423 expression to promote asthma development.
Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke.
Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway.
Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice.
Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice.
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.
Prototheca spp. induce an inflammatory response via mtROS-mediated activation of NF-κB and NLRP3 inflammasome pathways in bovine mammary epithelial cell cultures.
Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways.
Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome‑mediated inflammation.
Resveratrol affects the expression of uric acid transporter by improving inflammation.
Microtubule associated protein 4 (MAP4) phosphorylation reduces cardiac microvascular density through NLRP3-related pyroptosis.
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Carthamin yellow improves cerebral ischemia‑reperfusion injury by attenuating inflammation and ferroptosis in rats.
Therapeutic Effect of Endothelin-Converting Enzyme Inhibitor on Chronic Kidney Disease through the Inhibition of Endoplasmic Reticulum Stress and the NLRP3 Inflammasome.
Kupffer cell-targeting strategy for the protection of hepatic ischemia/reperfusion injury.
Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.
Absent in melanoma 2 suppresses gastric cancer cell proliferation and migration via inactivation of AKT signaling pathway.
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis.
Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats.
VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice.
Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R(-/-)) Mice via Its Anti-inflammatory and Antipyroptotic Effects.
Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia.
Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice.
Blocking the LncRNA MALAT1/miR-224-5p/NLRP3 Axis Inhibits the Hippocampal Inflammatory Response in T2DM With OSA.
Maresin 1 Attenuates Radicular Pain Through the Inhibition of NLRP3 Inflammasome-Induced Pyroptosis via NF-κB Signaling.
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux.
Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.
Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease.
Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway.
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome.
Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury.
Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats.
MiR-139 protects against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced nerve injury through targeting c-Jun to inhibit NLRP3 inflammasome activation.
Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity.
Mesenchymal stem cells-derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis.
Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor.
A novel mechanism of protection against isoproterenol-induced cardiac inflammation via regulation of the SIRT1/NRF2 signaling pathway with a natural SIRT1 agonist.
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice.
Cyanidin-3-O-β-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SirT1/NF-κB signaling pathway.
Polysaccharides from Armillariella tabescens mycelia ameliorate insulin resistance in type 2 diabetic mice.
Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo.
Antiviral mechanism of carvacrol on HSV-2 infectivity through inhibition of RIP3-mediated programmed cell necrosis pathway and ubiquitin-proteasome system in BSC-1 cells.
Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway.
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.
Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway.
Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages.
Dose-dependent structural and immunological changes in the placenta and fetal brain in response to systemic inflammation during pregnancy.
RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.
Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury.
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome.
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
H(2)S alleviates renal injury and fibrosis in response to unilateral ureteral obstruction by regulating macrophage infiltration via inhibition of NLRP3 signaling.
Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME.
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Salvianolic acid B alleviates myocardial ischemic injury by promoting mitophagy and inhibiting activation of the NLRP3 inflammasome.
Latcripin-7A, derivative of Lentinula edodes C(91-3), reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G(1) phase in breast cancer cells.
MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma.
Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm.
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.
A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.
FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis.
Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway.
Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice.
Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells.
Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.
Methylene Blue Attenuates Diabetic Retinopathy by Inhibiting NLRP3 Inflammasome Activation in STZ-Induced Diabetic Rats.
Purple Sweet Potato Color Attenuates Kidney Damage by Blocking VEGFR2/ROS/NLRP3 Signaling in High-Fat Diet-Treated Mice.
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Eplerenone Ameliorates Cell Pyroptosis in Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction.
Porous Se@SiO(2) nanospheres attenuate ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) and inflammation by antioxidative stress.
Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats.
NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.
Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation.
TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease.
Weighted Gene Co-expression Network Analysis for RNA-Sequencing Data of the Varicose Veins Transcriptome.
Sorghum Phenolics Inhibits Inflammasomes in Lipopolysaccharide (LPS)-Primed and Adenosine Triphosphate (ATP)-Activated Macrophages.
Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.
Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway.
Treatment with andrographolide sulfonate provides additional benefits to imipenem in a mouse model of Klebsiella pneumoniae pneumonia.
FNDC5 inhibits foam cell formation and monocyte adhesion in vascular smooth muscle cells via suppressing NFκB-mediated NLRP3 upregulation.
Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways.
Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation.
Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high-fat high cholesterol diet via regulating NF-κB and NLRP3 inflammasome pathway.
Iguratimod (T-614) attenuates severe acute pancreatitis by inhibiting the NLRP3 inflammasome and NF-κB pathway.
Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis.
Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli.
The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice.
OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway.
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice.
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3.
Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3.
NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.
MicroRNA-135b alleviates MPP(+)-mediated Parkinson's disease in in vitro model through suppressing FoxO1-induced NLRP3 inflammasome and pyroptosis.
LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF-κB/NLRP3 inflammasome pathway.
Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.
Granisetron protects polymicrobial sepsis-induced acute lung injury in mice.
Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.
LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.
Protective effects of acarbose against vascular endothelial dysfunction through inhibiting Nox4/NLRP3 inflammasome pathway in diabetic rats.
Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy.
Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.
UFL1 modulates NLRP3 inflammasome activation and protects against pyroptosis in LPS-stimulated bovine mammary epithelial cells.
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.
Chronic Kidney Disease Increases Atrial Fibrillation Inducibility: Involvement of Inflammation, Atrial Fibrosis, and Connexins.
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.
Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice.
Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway.
Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome.
Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3 inflammasome activation.
Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.
Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells.
Polybrominated Diphenyl Ethers Quinone Induced Parthanatos-like Cell Death through a Reactive Oxygen Species-Associated Poly(ADP-ribose) Polymerase 1 Signaling.
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
[Effect of vimentin on activation of NLRP3 inflammasome in the brain of mice with EV71 infection].
Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.
Salvianolate reduces atrial fibrillation through suppressing atrial interstitial fibrosis by inhibiting TGF-β1/Smad2/3 and TXNIP/NLRP3 inflammasome signaling pathways in post-MI rats.
2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease.
Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway.
A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells.
The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease.
Pepsin-pancreatin hydrolysis reduced the ability of lunasin-enriched material to inhibit activation of the inflammasomes in THP-1 human macrophages.
Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice.
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice.
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.
The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.
Deng Q, Bai Q, Yang Y, Tang W, Liu F, Zhang S, Wang H, Xing Z, Zhang C, Yang Y, Fu Q, Fan H
PloS one 2026;21(2):e0341867
PloS one 2026;21(2):e0341867
Enterotoxigenic Escherichia coli-induced intestinal epithelial necroptosis drives lamina propria immune cell pyroptosis and mucosal injury in piglets.
Wu X, Liu Y, Wu S, Wei H, Peng J
Frontiers in immunology 2026;17:1778258
Frontiers in immunology 2026;17:1778258
SLC31A1 knockdown mitigates post-MI heart failure via regulation of copper metabolism.
Wei Q, Zhou H, Sun J, Qin L
Frontiers in immunology 2026;17:1707203
Frontiers in immunology 2026;17:1707203
Identifying pyroptosis-related lncRNAs to predict prognosis and immune regulation in hepatocellular carcinoma.
Zhang W, Wang Y, Meng Q, Liu Z, Qu S, Zhou J
Frontiers in molecular biosciences 2026;13:1714966
Frontiers in molecular biosciences 2026;13:1714966
Cell membrane-encased thylakoid as white light triggered PDT therapy for facile and targeted choroidal melanoma treatment.
Wang J, Chen Z, Yang Y, Wang Y, Xie H, Hong W, Lin Q
Bioactive materials 2026 Sep;63:31-55
Bioactive materials 2026 Sep;63:31-55
Targeting methionine-induced pyroptosis enhances anti-tumor immunity.
Lei M, Zhu W, Wang C, Zhang F, Li M, Zhang Y, Qu J, Luo Z, Li J, Li ZX, Yin M, Lei QY
Science China. Life sciences 2026 May;69(5):1604-1619
Science China. Life sciences 2026 May;69(5):1604-1619
Canine adenovirus type 1 induces PANoptosis in canine splenocytes via AIM2 inflammasome activation.
Li Y, Zhao Y, Wang W, Qi B, Lv Y, Wang S, Wang C
Veterinary microbiology 2026 May;316:110965
Veterinary microbiology 2026 May;316:110965
Maresin 1 activates autophagy through SIRT1/PPAR-γ signaling to mitigate high glucose-induced pyroptosis in human retinal pigment epithelial cells.
Zhang J, Zhao D, Zhang Y, Sun H, Yan Z, Sun H
Experimental and therapeutic medicine 2026 May;31(5):141
Experimental and therapeutic medicine 2026 May;31(5):141
The "Tianyu" Formulation Alleviates Rheumatoid Arthritis by Modulating the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway.
Zhu Y, Cai X, Zheng Q, Fang C, Pan Z, Wang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 May 15;40(9):e71824
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 May 15;40(9):e71824
Trishizukaol A alleviates chronic kidney disease by restraining P2X7/PSME3-driven 20S proteasome hyperactivation.
Tang P, Zheng Z, Yu M, Zhang D, Xiao Z, Kong L, Luo J
Journal of ethnopharmacology 2026 May 10;362:121357
Journal of ethnopharmacology 2026 May 10;362:121357
CGRP regulates macrophage polarization through JAK-STAT pathway to improve Hashimoto's thyroiditis.
Qin Y, Ni T, Yan W, Wang Y, Yi M, Tu L, Wang Y, Zhang Q
International immunopharmacology 2026 May 1;176:116469
International immunopharmacology 2026 May 1;176:116469
Betaine improves hyperoxic lung injury through downregulating pulmonary macrophage pyroptosis in newborn mice.
Zhang J, Zhou L, Xu H, You Y, Xia S, Xia H
Pediatric research 2026 Mar;99(4):1613-1620
Pediatric research 2026 Mar;99(4):1613-1620
The sphingolipid metabolite sphingosine protects against hypertension by targeting metabolic-inflammatory crosstalk via the NLRP3 inflammasome.
Li W, Zhou D, Ji Y, Yang M, Yang Y, Dao M, He X, Jin X
International journal of cardiology. Cardiovascular risk and prevention 2026 Mar;28:200562
International journal of cardiology. Cardiovascular risk and prevention 2026 Mar;28:200562
Chromatin remodeling factor CHRAC1 regulates doxorubicin-induced cardiotoxicity via IRF9/GSDMD/CASP-1.
Zang T, Zhou C, Yu Y, Lin W, Xu Q, Shen L
Cellular signalling 2026 Mar;139:112290
Cellular signalling 2026 Mar;139:112290
Caspase-3/GSDME-Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early-Onset Preeclampsia.
Huang B, Deng W, Bi S, Wang Y, Tu Z, Huang L, Du L, Zhang L, Feng Z, Sun W, Liu T, Kzhyshkowska J, Wang H, Chen J, Chen D, Zhang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e16948
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e16948
Spared cognitive and social function following perinatal ablation of ATRX despite transient microglia dysregulation.
Mansour KY, Pena-Ortiz MA, Wu J, Shafiq S, Bérubé NG
Scientific reports 2026 Mar 9;16(1)
Scientific reports 2026 Mar 9;16(1)
USP16 drives psoriasis progression by deubiquitinating and stabilizing NLRP3 in keratinocytes.
Wang N, Guan F, Lin Y, Sun B, Dai J, Xu X, Tang W, Ren Y, Huang X, Gao W, Chen X, Jin L, Cong W, Zhu Z
JCI insight 2026 Mar 9;11(5)
JCI insight 2026 Mar 9;11(5)
SELENOF Mitigates Bovine Mastitis by Preserving Mitochondrial Homeostasis and Suppressing NLRP3-Mediated Pyroptosis.
Qi X, Shi L, Shi X, Hu C
Animals : an open access journal from MDPI 2026 Mar 4;16(5)
Animals : an open access journal from MDPI 2026 Mar 4;16(5)
FXR overexpression promotes liver regeneration through inducing FGF2 activation in APAP-induced acute liver injury.
Wang R, Chen J, Wang W, Li X, Xiao Y, Shi Y, Qv Y, Wang C, Fu T, Meng Q
Hepatology international 2026 Mar 29;
Hepatology international 2026 Mar 29;
Didymin alleviates neuropathic pain by targeting RKIP-mediated NF-κB/NLRP3 crosstalk to inhibit pyroptosis and neuroinflammation.
Wang K, Guo A, Chen Y, Xia C, Liang J, Zhang X, Huang L, Zhang Z, Wu L, Yan H
Journal of ethnopharmacology 2026 Mar 25;359:121046
Journal of ethnopharmacology 2026 Mar 25;359:121046
Hydrogen sulfide ameliorates oxalate crystal-related renal injury via inhibiting the activation of NOD-like receptor thermal protein domain associated protein 3 inflammasome in mice.
Shi Y, Chen L, Li M, Wang J, Yin P, Zhou X, Cong Q, Song K
Urolithiasis 2026 Mar 24;54(1)
Urolithiasis 2026 Mar 24;54(1)
Taurine attenuates Listeria monocytogenes-induced inflammation and pyroptosis in mouse model by regulating MAPK and NLRP3/caspase-1/GSDMD pathways.
Liu T, Zhang X, Qi Z, Zheng X, Weng Y, Han X
mSystems 2026 Mar 24;11(3):e0104325
mSystems 2026 Mar 24;11(3):e0104325
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression.
Yan K, Jiang Y, Yong Y, Zhang T, Zhang N, Zeng Q, Gong X, Meng L, Bi F, Liu Y
Annals of clinical and translational neurology 2026 Mar 24;
Annals of clinical and translational neurology 2026 Mar 24;
Hungatella hathewayi: A Tumor-Derived Bacterium Enriched in Colorectal Cancer Tissues and a Potential Diagnostic Biomarker.
Zhang W, Liu J, Sha S, Yan Q, Ma Y
Microorganisms 2026 Mar 21;14(3)
Microorganisms 2026 Mar 21;14(3)
Microglial NLRP3-dependent pyroptosis promotes cognitive dysfunction of diabetic encephalopathy by inhibiting adult hippocampal neurogenesis through the release of IL-1β.
Hua MY, Huang S, Zhuang ZY, Han XL, Liu XJ, Liang ZH, Lou NJ, Zheng FJ, Lv L, Zhuang XH, Yu SY, Chen SH
Acta pharmacologica Sinica 2026 Mar 20;
Acta pharmacologica Sinica 2026 Mar 20;
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
Yu Q, Guo K, Yang Y, Liu H, Han Y, Yu X, Wang J, Zhao Y, Su X, Zhu K, Zheng S, Wang S, Li W, Huang Y
Journal of nanobiotechnology 2026 Mar 14;24(1)
Journal of nanobiotechnology 2026 Mar 14;24(1)
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregulating Nrf2 to inhibit TGF-β1/Smad3 and NLRP3/ASC/Caspase-1 pathways.
Zhang K, Sun S, Qiu H, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2026 Mar 1;358:120981
Journal of ethnopharmacology 2026 Mar 1;358:120981
3D-MSCs apoptotic bodies-integrated conductive hydrogel mitigates spinal cord injury via immunoregulation and alleviating neuronal pyroptosis.
Zhang J, Xiang L, Cai X, Geng Y, Wu Y, Shi J, Zhang H, Hu X, Jiang X, Zhu P, Shu Y, Miao R, Zhao J, Zhu J, Li Z, Wang X, Xiao J, Zhou K, Yang L, Qi J
Bioactive materials 2026 Jun;60:704-723
Bioactive materials 2026 Jun;60:704-723
Dual-targeting nuclear and mitochondrial DNA damage drives immunogenic activation via PANoptosis for synergistic magneto-thermodynamic-chemotherapy.
Wu L, Su J, Cao Y, Yuan H, Li Z, Ren J, Xiao M, Yu K, Liang B
Biomaterials 2026 Jun;329:123924
Biomaterials 2026 Jun;329:123924
Modified Ganlu Xiaodu decoction attenuates airway barrier injury in Mycoplasma pneumoniae pneumonia by inhibiting ZBP1-mediated PANoptosis.
Zhang Y, Feng J, Diao J, Gou J, Liang Y, Wang X, Song Z, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158112
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158112
SSD: Targeting inflammasome and oxidative stress as a therapeutic strategy in inflammatory diseases.
Zhao Y, Fu X, Zuo H, Wang X, Li S, Wu T, Cheng C, Xu M, Xu G
Biochimica et biophysica acta. General subjects 2026 Jul;1870(7):130956
Biochimica et biophysica acta. General subjects 2026 Jul;1870(7):130956
Cathepsin B regulated via TFEB and lysosomal membrane permeabilization in adipose tissue macrophages aggravates obesity-related severe acute pancreatitis.
Ling X, Han C, Sheng L, Ding Z
International immunopharmacology 2026 Jul 1;180:116695
International immunopharmacology 2026 Jul 1;180:116695
Flutamide exacerbates hepatic insulin resistance in type 2 diabetic mice through overproduction of ROS and activation of NLRP3 signaling.
Zhang Y, Zhang Y, Xiang Q, Fu X, Zhang Y, Tan L, Tang H, Li S, Gong D, Guo X, Zhang Y, Wang Q, Chen L, Zheng T
International immunopharmacology 2026 Jul 1;180:116683
International immunopharmacology 2026 Jul 1;180:116683
A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition.
Yu S, Zhang Y, Xi J, Feng J, Xie T, Pan D, Zhao D, Ren J, Dong Z, Liu M, Wang S
International journal of biological macromolecules 2026 Jan;335(Pt 1):149351
International journal of biological macromolecules 2026 Jan;335(Pt 1):149351
Transferrin receptor serves a role in promoting PANoptosis in thyroid cancer.
Ma S, Ma Z, Shen J, Liu H, Yang H, Hu Y, Ying S
Oncology letters 2026 Jan;31(1):41
Oncology letters 2026 Jan;31(1):41
PAI-1 promotes thromboangiitis obliterans progression through NF-κB-NLRP3 pathway activation via HIF-1α-dependent signaling.
Xu X, Ge X, Ci H, Abulaihaiti M, Yang J, Li Y, Zhu F
Microvascular research 2026 Jan;163:104885
Microvascular research 2026 Jan;163:104885
Elucidating the mechanism of traditional Chinese medicine formula (Yifei-sanjie Pill) in alleviating the chemobrain based on network pharmacology and experimental verification.
Wu Y, Wang H, Liang Z, Cui J, Liu S, Chen Y, Pi D, Ouyang M
Journal of traditional and complementary medicine 2026 Jan;16(1):17-30
Journal of traditional and complementary medicine 2026 Jan;16(1):17-30
Caspase 1-deficient humans survive into late adulthood despite dramatically lower canonical inflammasome activity.
Dominy J, Koch C, Arnold C, George V, Khan MZ, Khalid S, Bano A, Mian MR, Gul W, Liaqat MB, Kamani L, Butt N, Dahar M, Saqib N, Jalal A, Abbas S, Sultana R, Siddiqeh M, Raza SS, Haroon M, Khan A, Iqbal J, Aslam F, Babar KP, Memon MS, Muddassir A, Raza Zaidi SA, Akram M, Rasheed A, Mohsin SN, Bugti S, Mehmood T, Rodeni AL, Mukhtar S, Rasool T, Mahmood A, Wazir MN, Khan SJ, Khan MA, Ghaffar R, Jan S, Hadi NU, Rasheed A, Jeanneau K, Le Meur T, Chassang A, Zierer J, Siegel RM, Bodendorf U, Gurtan A, Saleheen D
The Journal of allergy and clinical immunology 2026 Jan;157(1):217-225
The Journal of allergy and clinical immunology 2026 Jan;157(1):217-225
Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis.
Huang K, Xiao JL, Tang JY, Pu HY, Li FH, Gao K, Yu X, Guo SZ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157625
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157625
Yujie recipe attenuates bleomycin-induced pulmonary fibrosis via suppressing NF-κB/NLRP3 signaling in a Nrf2-dependent manner.
Qin L, Zhao B, Xiong Y, Chen L, Qi S, Ma Y, Zeng H, Song Y, Liu W, Tian T, Ge G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157607
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157607
Free Fatty Acids and Endotoxins Synergically Induce Pyroptosis in Bovine Hepatocytes.
Li D, Tian Y, Tian L, Yu H, Zhang L, Wang S, Lei C, Long P, Peng T, Liu L, Zhou Y
Metabolites 2026 Jan 8;16(1)
Metabolites 2026 Jan 8;16(1)
Nicotinamide adenine dinucleotide inhibits the production of reactive oxygen species and myocardial cell pyroptosis caused by hypoxia/re-oxygenation injury.
Dong S, Liu YQ, Tu YJ, Gao S, Liu YJ, Liu C, Pei ZW
World journal of cardiology 2026 Jan 26;18(1):114108
World journal of cardiology 2026 Jan 26;18(1):114108
Recombinant SARS-Cov-2 spike protein S1 subunit upregulates P2 × 7-NLRP3 leading to macrophage pyroptosis promoting acute lung injury.
Lu M, Li M, Zhou H, Zhu J, Jiao Q, Liu X, Wu J, Xu G, Lv C, Fan Y, Zhang B, Pan L
Respiratory research 2026 Jan 23;27(1):76
Respiratory research 2026 Jan 23;27(1):76
Acupuncture as a modulator of microglial polarization and pyroptosis in depression: evidence from a chronic unpredictable mild stress rat model.
Wu X, You Z, Zhang T, Zeng J, Li M, Yan S, Li J, Li P, Shen J, Liu S, Aslam MS, Li J, Ning L, Fang H, Li Y, Yao D, Hao C, Meng X
Metabolic brain disease 2026 Jan 16;41(1):20
Metabolic brain disease 2026 Jan 16;41(1):20
Size-dependent pyroptosis induction by calcium oxalate monohydrate crystals in HK-2 cells.
Chen XW, Tong XY, Tan RM, Ouyang JM
iScience 2026 Jan 16;29(1):114459
iScience 2026 Jan 16;29(1):114459
Thonningianin A derived from Penthorum chinense Pursh alleviates cerebral ischemia/reperfusion-mediated apoptosis and pyroptosis through the activation of PINK1/Parkin-dependent mitophagy.
Yao Q, Hu G, Yin C, Wu A, Hu G, Qin D, Zhou X, Law BY, Du X, Chen L, Li J, Lin H, Long X, Wu J, Yu L
Chinese medicine 2026 Jan 16;21(1):40
Chinese medicine 2026 Jan 16;21(1):40
Ecliptasaponin A alleviates inflammation and fibrosis in experimental MASH mice via targeting the NLRP3 inflammasome and YAP signaling pathway.
Gao K, Zhang W, Zhao M, Xu D, Tao X, Guo C, Du Y, Jin F, Li W, Liu M, Lu Y, Wang J
Chinese medicine 2026 Jan 13;21(1):32
Chinese medicine 2026 Jan 13;21(1):32
NLRP3/GSDMD-dependent neutrophil extracellular traps exacerbate microglia-mediated neuroinflammation following traumatic brain injury.
Liu L, Yuan B, Wang Y, Liu J, Li P, Zhang H, Zhang X, Wang J, Chai Y, Deng Q, Zhang J, Chen X
Cell communication and signaling : CCS 2026 Jan 12;24(1):65
Cell communication and signaling : CCS 2026 Jan 12;24(1):65
STING knockdown blocks disease progression and inflammation in mice with alcoholic liver disease by relieving pyroptosis via suppressing NLRP3.
Song Y, Liu M, Zhou M, Ren X, Feng B, Xie Y
International immunopharmacology 2026 Jan 1;168(Pt 2):115858
International immunopharmacology 2026 Jan 1;168(Pt 2):115858
Apelin-13 alleviated ischemia reperfusion injury via KLF2/NF-κB signaling pathway after kidney transplantation.
Zhang J, Yu C, Wang H, Xiao H, Wen S, Hua Y, Wei G
International immunopharmacology 2026 Jan 1;168(Pt 1):115802
International immunopharmacology 2026 Jan 1;168(Pt 1):115802
Knockdown of Lcn2 alleviates pyroptosis in a neonatal rat model of necrotizing enterocolitis through IL-17A signaling pathway suppression.
Chen S, Sun X, Xu S, Yang Z, Cui R
Tissue & cell 2026 Feb;98:103152
Tissue & cell 2026 Feb;98:103152
PTPN22 as a therapeutic target in intervertebral disc degeneration: Modulating mitophagy and pyroptosis through the PI3K/AKT/mTOR axis.
Liang H, Yang S, Huang Y, Zhu Y, Wu Q, Wu Z, Li S, Shi Y, Chen Z, Jin H, Wang X
Journal of advanced research 2026 Feb;80:775-789
Journal of advanced research 2026 Feb;80:775-789
Therapeutic Potential of Curcumin in Diabetic Cardiomyopathy: Modulation of Pyroptosis Pathways.
Wang F, Liu L, Wang J, Zhou Y, Feng X, Liu K
Cardiovascular drugs and therapy 2026 Feb;40(1):53-64
Cardiovascular drugs and therapy 2026 Feb;40(1):53-64
Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Loaded with Emodin Alleviate Intestinal Injury in Acute Pancreatitis.
Liu S, Xu Z, Liu X, Huang X, Huang X, Pan M, Lin J
Biotechnology journal 2026 Feb;21(2):e70198
Biotechnology journal 2026 Feb;21(2):e70198
NLK facilitates Caspase-8 activation to drive macrophage PANoptosis in sepsis.
Xia Y, Yao RQ, Liu HF, Jing GQ, Aidebaike D, Zuo J, Wan SQ, Wu D, Zhao PY, Gong HL, Wang X, Zhou HM, Dong N, Wu Y, Liu S, Wu XJ, Yao YM, Song XM
Clinical and translational medicine 2026 Feb;16(2):e70616
Clinical and translational medicine 2026 Feb;16(2):e70616
CUEDC2 improves pyroptosis and kidney damage in diabetic kidney disease by inhibiting NLRP3 inflammasome activation.
Yang P, Fan L, Yuan D, Xie J, Luo Y, Zeng Q, Lin W, Li Z, Huang Z, Jiang W, Wang M, Huang Y
Cellular signalling 2026 Feb;138:112239
Cellular signalling 2026 Feb;138:112239
Cathepsin B overexpression and lysosomal leakage in inflammatory microglia promote neuroinflammation in olfactory dysfunction by triggering mitochondrial dysfunction and pyroptosis.
Zhou H, Wang L, Yang Y, Ye F, Zhao X, Zhu K, Huang Z, Lv W, Yu H
Brain, behavior, and immunity 2026 Feb;132:106188
Brain, behavior, and immunity 2026 Feb;132:106188
Citrate-coated Prussian blue nanozyme hitchhikes neutrophils to ameliorate calcium oxalate crystal-induced kidney injury via inhibiting pyroptosis and NETosis.
Ba X, Yang X, He Y, Ye T, Zeng X, Zhong Z, Guo X, Tang K
Journal of nanobiotechnology 2026 Feb 7;24(1)
Journal of nanobiotechnology 2026 Feb 7;24(1)
Healthy young human plasma-derived exosomes enhance neural stem cell therapy by suppressing pyroptosis via TXNIP/NLRP3 after intracerebral hemorrhage.
Chen J, Chen Z, Zhang F, Wang P, Zhang Q, Wang H, Zhao F, Li H, Luo R, Ding N, Yao S, Hu R
Journal of nanobiotechnology 2026 Feb 5;24(1):131
Journal of nanobiotechnology 2026 Feb 5;24(1):131
Targeting macrophage glycogen metabolism attenuates ulcerative colitis by suppressing IL-1β production through UDPG-P2Y(14) signaling.
Tong S, Zhu T, Liang S, Cui Y, Ma Y, Zhang X, Bian Y, Wei K, Wu S, Ma J
Molecular medicine (Cambridge, Mass.) 2026 Feb 4;32(1):15
Molecular medicine (Cambridge, Mass.) 2026 Feb 4;32(1):15
Study on the mechanism of Sangbaipi Decoction in treating acute lung injury via the inflammasome NLRP3 signaling pathway.
Xu B, Wang Y, Xu Y, Zhang X, Wang X, Chen S, Li L, Bao H
Journal of ethnopharmacology 2026 Feb 28;357:120908
Journal of ethnopharmacology 2026 Feb 28;357:120908
Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway.
Ni J, Zhou H, Shen K, Xu H, Wang J, Liu J, Liu F
Journal of translational medicine 2026 Feb 26;24(1)
Journal of translational medicine 2026 Feb 26;24(1)
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome.
Duan R, Wang X, Wang Q, Zhou X, Gao S, Sun Y, Feng Q, Li Z, Yang Z, Ding J, Chen Z, Duan J, Yang Y
Cell reports 2026 Feb 24;45(2):116942
Cell reports 2026 Feb 24;45(2):116942
The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation.
Zhang H, Fu J, Guo Y, Liu S, Mei X, Zeng X, Ren W
Cell chemical biology 2026 Feb 19;33(2):169-182.e5
Cell chemical biology 2026 Feb 19;33(2):169-182.e5
TRPA1 promotes overactive bladder progression by activating the NLRP3 inflammasome and driving pyroptosis.
Rao Y, Wang Y, Gao J, Guan X, Lv S, Gu J, Wang K
Cell death & disease 2026 Feb 16;17(1):226
Cell death & disease 2026 Feb 16;17(1):226
Integrated stress response promotes acute liver failure by activating SETD7 and enhancing NLRP3 methylation.
Nie Z, Liu X, Zhang H, Chen Z, Sun X, Li Y, Kong Y, Shu H, Chen W
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 16;
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 16;
Carbon-based nanomaterials induce ovarian dysfunction via NLRP3 inflammasome-mediated pyroptosis in granulosa cells.
Wei S, Chen D, Wang J, Wu C, Tang W, Xue L, Feng Y, Dai Y, Guo Y, Zheng P, Song Y, Dai J, Wang S, Wu M
Journal of advanced research 2026 Feb 12;
Journal of advanced research 2026 Feb 12;
HIFU postoperative hypoxia-activated metal-organic frameworks modulate the tumor microenvironment to augment immunotherapy.
Luo C, Wu D, Peng S, Xu S, Zhang D, Huang X, Qin W, Li H, Li H
Journal of nanobiotechnology 2026 Feb 1;24(1)
Journal of nanobiotechnology 2026 Feb 1;24(1)
Micro/nanoplastics induce thyroid follicular cell pyroptosis to trigger thyrotoxicity by activating NF-κB signaling.
Fu F, Chen Y, Luo H, Ruan H
Annals of medicine 2026 Dec;58(1):2624175
Annals of medicine 2026 Dec;58(1):2624175
Shh-S100A10 axis curbs neuronal PANoptosis after ischemic stroke.
Wang L, Tang H, Wen J, Yang Q, Huang J, Zhao Y, Ren Y, Yang Q
Neural regeneration research 2026 Aug 1;21(8):3579-3587
Neural regeneration research 2026 Aug 1;21(8):3579-3587
Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1.
Xu LT, Han QT, Xu ZP, Wang XN, Zhang H, Shen T
Journal of advanced research 2026 Apr;82:1149-1162
Journal of advanced research 2026 Apr;82:1149-1162
Fruit-Derived Citri Reticulatae Semen Extract Attenuates Alzheimer's Disease Neuroinflammation and Cognitive Impairment via Modulation of the PI3K/Akt/FoxO1 Pathway.
Li S, Zhang X, Zhang P, Wang X, Yang Y, Qin D, Law BY, Pan Y, Tang Y
Molecular nutrition & food research 2026 Apr;70(7):e70452
Molecular nutrition & food research 2026 Apr;70(7):e70452
TRIM25 triggers pyroptosis through mitochondrial DNA release in intestinal ischemia-reperfusion injury.
Song Y, Lu X, Ren X, Li M, Meng F, Miao Y, Ding D, Liu Y
Free radical biology & medicine 2026 Apr;247:333-347
Free radical biology & medicine 2026 Apr;247:333-347
Poly (ADP-ribose) polymerase 1-targeted photosensitizer as a dual-activator of pyroptosis and the STING pathway for enhanced cancer photoimmunotherapy.
Li P, Du Y, Chen B, Qiu J, Song L, Lv Z, Liu Q, Jiang Q, Zhang S, Mu Y, Li D, Guo L, Shan G, Li G
Acta biomaterialia 2026 Apr;214:512-526
Acta biomaterialia 2026 Apr;214:512-526
Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway.
Sun F, She R, Yang T, Chen B, Liao Z, Liao J, Mei Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157928
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157928
Characterization of NLRP3 Inflammasome-Associated Hub Genes in the Progression of Diabetic Nephropathy.
Zhao S, Li Y, Li W, Dong L, Lian R, Luo Q, Lian X, Li J, He F
Immunity, inflammation and disease 2026 Apr;14(4):e70424
Immunity, inflammation and disease 2026 Apr;14(4):e70424
Dehydroepiandrosterone alleviates pulmonary fibrosis by modulating the TLR4/NF-κB/NLRP3 signaling cascade in macrophages.
Xie Q, Zhao X, Lu Y, Shuai S
The Journal of steroid biochemistry and molecular biology 2026 Apr 27;262:107028
The Journal of steroid biochemistry and molecular biology 2026 Apr 27;262:107028
Identification and validation of key PANoptosis-related genes via integrative machine learning and single-cell sequencing in AILI.
Li S, He C, Wang M, Ran B, Li G, Dong G, Zhang H, Mei C, Song Y, Yu Q, Chen S, Zhu C, Li J
iScience 2026 Apr 17;29(4):115183
iScience 2026 Apr 17;29(4):115183
Resveratrol improves follicular development in PCOS rats by inhibiting the inflammatory response and pyroptosis of granulosa cells†.
Wei H, Zhang Z, Zhang S, Wang J, Cui X, Zhang Z, Yu J, Lei X, Xiuhong Z, Huo P
Biology of reproduction 2026 Apr 13;114(4):1227-1240
Biology of reproduction 2026 Apr 13;114(4):1227-1240
KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling.
Cui Y, Wu S, Peng Y, Liu Y, Che L, Chen S, Zhang F, Qin D, Li S, Ran P, Yin W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 10;:e17666
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 10;:e17666
LncRNA RP11-510J16.3 exacerbates sepsis-associated encephalopathy by facilitating NLRP3-dependent pyroptosis through miR-1290 sequestering.
Liu X, Xiao Y, Lai Y, Ding H, Wen Y, He Z, Chen M, Han Y, Jing Y, Wen M
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Apr 1;75(1)
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Apr 1;75(1)
GM-CSF exacerbates pulmonary arterial hypertension via CCL2/CCR2-axis-mediated macrophage NLRP3 inflammasome activation.
Jiang R, Li L, Luo Y, Wang W, Zeng X, Qian C, Gong C, Sheng J
International immunopharmacology 2026 Apr 1;174:116394
International immunopharmacology 2026 Apr 1;174:116394
Perfluorooctane sulfonate induces hepatotoxicity through promoting inflammation, cell death and autophagy in a rat model.
Tang L, Zhu J, Zhuge S, Yu J, Jiang G
The Journal of toxicological sciences 2025;50(2):45-55
The Journal of toxicological sciences 2025;50(2):45-55
Breaking the Chains of Therapeutic Blockade: Pyroptosis-Induced Photothermal-Chemotherapy with Targeted Nanoprobes in Triple-Negative Breast Cancer.
Li Z, Yu K, Cao Y, Yuan H, Wu L, Xiong L, Tang Y, Liang B
Biomaterials research 2025;29:0200
Biomaterials research 2025;29:0200
Correlation Analysis of Pyroptosis-Related Genes CASP1, NLRP3, AIM2, and NLRP1 With Lung Adenocarcinoma.
Zhu L, Zhang Y, Chen X, Li Y, Pan H, Wang Y, Chen N, Wu Y, Li Y, Zhao M
International journal of genomics 2025;2025:8282590
International journal of genomics 2025;2025:8282590
Human Umbilical Cord Mesenchymal Stem Cells Inhibit the Progression of Osteoarthritis by Suppressing NLRP3-Mediated Synovial Inflammation in the Early Stages of the Disease.
Li Y, Ouyang Y, Lang R, He J, Zheng S, Ao C, Jiang Y, Xiao H, Li M, Li C, Wu D
Stem cells international 2025;2025:7558817
Stem cells international 2025;2025:7558817
MIF-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Spinal Neurons and Microglial Polarization Facilitate Neuropathic Pain Progression.
Zhou F, Tian Y, Liao W, Ma Q, Bao H, Meng F, Jiang J
Anesthesiology research and practice 2025;2025:6624776
Anesthesiology research and practice 2025;2025:6624776
G Protein-Coupled Receptor 30 Attenuates Neuronal Pyroptosis Induced by Subarachnoid Hemorrhage.
Peng J, Hu X, He J, Xia Y
Mediators of inflammation 2025;2025:3585885
Mediators of inflammation 2025;2025:3585885
Oncosis is the predominant type of cell death in rhabdomyolysis following exertional heat stroke.
Li C, Liu Y, Mao H, Yang W, Liu S, Shan Y
PloS one 2025;20(3):e0308586
PloS one 2025;20(3):e0308586
Subchronic Chlorpyrifos Exposure Induces Thyroid Follicular Cell Pyroptosis to Exacerbate Thyroid Toxicity by Modulating Nrf2/Keap1/NF-κB Pathway in Male Mice.
Gu B, Chen Y, Xu H, Zhan K, Zhu K, Luo H, Huang Y, Zeng H, Zheng W, Tian K, Ruan H
Journal of inflammation research 2025;18:9307-9320
Journal of inflammation research 2025;18:9307-9320
TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway.
Xia L, Wang Z, Chen X
Journal of inflammation research 2025;18:8719-8733
Journal of inflammation research 2025;18:8719-8733
Gubi Decoction Ameliorates Porous Cartilage Endplate in an Intervertebral Disc Degeneration Model Mouse Through Inhibition of NF-κB Activity and Pyroptosis.
Yao S, Li Y, Ruan H, Wu L, Zeng H
Journal of inflammation research 2025;18:5293-5309
Journal of inflammation research 2025;18:5293-5309
Effect of Acupotomy Modulation of NLRP3/Caspase-1/GSDMD Pathway on Chondrocyte Pyroptosis in Knee Osteoarthritis.
Wang Y, Chen Y, Yang Y, Zhou Y, Yang Y, Zhu J
Journal of pain research 2025;18:4935-4945
Journal of pain research 2025;18:4935-4945
Systemic Lupus Erythematosus Stimulates Chondrocyte Pyroptosis to Aggravate Arthritis via Suppression of NRF-2/KEAP-1 and NF-κB Pathway.
Shen S, Fang X, Zhang H, Lang T, Fu F, Du Y, Xu T, Jin H, Tong P, Wu C, Hu C, Ruan H
Journal of inflammation research 2025;18:4233-4250
Journal of inflammation research 2025;18:4233-4250
Fingolimod Suppresses NLRP3 Inflammasome Activation and Alleviates Oxidative Stress in Traumatic Brain Injury-Induced Acute Lung Injury.
Shi Q, Hu T, Xu L, Fu J, Fang Y, Lan Y, Fan W, Wu Q, Tong X, Yan H
Journal of inflammation research 2025;18:2229-2245
Journal of inflammation research 2025;18:2229-2245
Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells.
Li J, Han L, Feng S, Lin G, Zou G, Huang T, Ran T, Zhao X
Journal of inflammation research 2025;18:15429-15440
Journal of inflammation research 2025;18:15429-15440
Electroacupuncture Regulates Oxidative Stress-Mediated NLRP3/ASC/Caspase-1 Pathway to Inhibit Microglial Activation: Alleviating Neuroinflammation and Depression in IBD.
Li Z, Cao S, Yang J, Chen L, Jia L, Lu P, Liu J, Liu M, Liu Q
Journal of inflammation research 2025;18:11935-11950
Journal of inflammation research 2025;18:11935-11950
Electroacupuncture Inhibits NLRP3-Mediated Microglial Pyroptosis to Ameliorate Chronic Neuropathic Pain in Rats.
Kui W, Li Y, Gu Z, Xie L, Huang A, Kong S, Song L, Li L, Yu J, Xue CC, Wang K
Journal of pain research 2025;18:1115-1129
Journal of pain research 2025;18:1115-1129
ALDH2 Ameliorates Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and Pyroptosis by Nrf2/ROS Pathway.
Tong S, Li X, Wang F, Cheng Q, Zhang P, Chen M, Xie Y, Lu X, Wu H
Journal of inflammation research 2025;18:11095-11108
Journal of inflammation research 2025;18:11095-11108
Qingwen Hufei Granules Attenuate Lipopolysaccharide-Induced Acute Lung Injury by Suppressing NLRP3 Inflammasome-Dependent Pyroptosis.
Long K, Yang Y, Wang Y, Wang B, Zhou H, Liu Y, Li Y, Yang S, Cao L, Huang T, Liu Y, Zhang H
Journal of inflammation research 2025;18:10425-10443
Journal of inflammation research 2025;18:10425-10443
Investigating the mechanisms of Sini San in alleviating inflammatory responses via multi-omics and the BDNF/TrkB/PI3K/AKT signaling pathway in depressive model rats.
Zeng JW, Han ZJ, He XT, Liu XJ, Wang HY, Yang SS, Bai J, Duan YJ, Lin L
Frontiers in psychiatry 2025;16:1628634
Frontiers in psychiatry 2025;16:1628634
Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.
Zhang Y, Wu Q, Pan Y, Xin M, Wang W, Zhai X, Zhou P, Zhang C, Wang Y
Frontiers in pharmacology 2025;16:1596087
Frontiers in pharmacology 2025;16:1596087
Novel mitophagy inducer TJ0113 alleviates pulmonary inflammation during acute lung injury.
Liu Z, Fang D, Chen K, Dong L, Huang H, Chen Z
Frontiers in pharmacology 2025;16:1590458
Frontiers in pharmacology 2025;16:1590458
Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury.
Zhang H, Zhu C, Zhou X, Wang L, Deng L, He B, Li J
Frontiers in pharmacology 2025;16:1581320
Frontiers in pharmacology 2025;16:1581320
Integrated proteomics analysis and network pharmacology to elucidate the mechanism of Zhilong Huoxue Tongyu Capsule alleviate hypertensive retinopathy in Ang II infusion mice model.
Wu J, Xie W, Xie Y, Mazhar M, Duan J
Frontiers in pharmacology 2025;16:1573693
Frontiers in pharmacology 2025;16:1573693
Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways.
Yang X, Wang X, Li K, Deng Q, Hou Y, Xi G, Lu K, Liu Z, Bai Y, Wu J, Yu J, Zhang P
Frontiers in immunology 2025;16:1569210
Frontiers in immunology 2025;16:1569210
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.
Li H, Gao Y, Huang M, Zhang H, Wu Q, Huang Y, Ye X, Chen W
Frontiers in pharmacology 2025;16:1557681
Frontiers in pharmacology 2025;16:1557681
Effect and mechanism of Plantaginis Semen polysaccharides on intestinal microecology in rats with hyperuricemia.
Zhao J, Fu Y, Qiu H
Frontiers in microbiology 2025;16:1555734
Frontiers in microbiology 2025;16:1555734
Thlaspi arvense suppresses gut microbiota related TNF inflammatory pathway to alleviates ulcerative colitis.
Wang W, Zhao Y, Wang Z, Wang C, Bi L, Wang Y
Frontiers in immunology 2025;16:1537325
Frontiers in immunology 2025;16:1537325
Clusterin ameliorates diabetic atherosclerosis by suppressing macrophage pyroptosis and activation.
Xuan L, Ren L, Kang X, Chang R, Zhang W, Gong L, Liu L
Frontiers in pharmacology 2025;16:1536132
Frontiers in pharmacology 2025;16:1536132
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
Sun H, Qiao X, Peng X, Zhu H, Zhang L, Jiang L, Wang L, Xue C, Yang J, Yi W, Zhang B, Liu J, Duan W
Theranostics 2025;15(8):3532-3550
Theranostics 2025;15(8):3532-3550
The anti-inflammatory effects of oridonin in resisting esophageal cancer.
Peng M, Zhang X, Yang L, Liu B
Frontiers in oncology 2025;15:1585057
Frontiers in oncology 2025;15:1585057
Recombinant Antithrombin Alleviated Pulmonary Injury and Inflammation in LPS-Induced ARDS by Inhibiting IL17a/NF-κB Signaling.
Yang C, Fu C, Wang M, Zheng J, Gao Y, Zhu H, Li H, Li D, Guo L, Yu B, Dai Q
ImmunoTargets and therapy 2025;14:433-449
ImmunoTargets and therapy 2025;14:433-449
NLRP3 inflammasome activation by turbulent shear stress drives right ventricular outflow tract fibrosis in pulmonary regurgitation.
Fan Q, Wang Y, Zhu D, An Q, Ling Y
Frontiers in cardiovascular medicine 2025;12:1546581
Frontiers in cardiovascular medicine 2025;12:1546581
Combined effects of quinic acid and isochlorogenic acid B on LPS-induced inflammation and pyroptosis in MAC-T cells and mouse mammary glands.
Lv X, Long Q, Kang Y, Lin T, Jiang C
Frontiers in veterinary science 2025;12:1476302
Frontiers in veterinary science 2025;12:1476302
Aluminum adjuvant promotes liver inflammation and fibrosis in mice: A novel approach to establish a liver fibrosis animal model.
Zhu Z, Liang S, Zhao N, Zou H, Zhang L, Zhang X, Chai J
Liver research (Beijing, China) 2025 Sep;9(3):209-220
Liver research (Beijing, China) 2025 Sep;9(3):209-220
Anemoside B4 alleviates ulcerative colitis by attenuating intestinal oxidative stress and NLRP3 inflammasome via activating aryl hydrocarbon receptor through remodeling the gut microbiome and metabolites.
Wu H, Li YL, Wang Y, Wang YG, Hong JH, Pang MM, Liu PM, Yang JJ
Redox biology 2025 Sep;85:103746
Redox biology 2025 Sep;85:103746
Tangzhiqing Exacerbates Oxidized Low-Density Lipoprotein-Induced Cell Pyroptosis Through Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells.
Chen R, Zhou Z, Song Z, Feng W, Ding X, Zhang H, Wang Y
Cell biology international 2025 Sep;49(9):1173-1183
Cell biology international 2025 Sep;49(9):1173-1183
Oridonin Ameliorates Metabolic-Dysfunction-Associated Fatty Liver Disease by Inhibiting PANoptosis via Modulating SIRT2/NLRP3 Pathway.
Wang Z, Sun Y, Wang C, Yao J, Hao R, Wang Y, Sun H
Phytotherapy research : PTR 2025 Sep;39(9):4181-4198
Phytotherapy research : PTR 2025 Sep;39(9):4181-4198
Curcumin mitigates testicular ischemia-reperfusion injury by suppressing NLRP3-mediated pyroptosis.
Hu Z, Wang J, Ning J, Cheng F
Molecular immunology 2025 Sep;185:71-80
Molecular immunology 2025 Sep;185:71-80
IL-1β promotes IL-17A production of ILC3s to aggravate neutrophilic airway inflammation in mice.
Yang D, Li Y, Liu T, Yang L, He L, Huang T, Zhang L, Luo J, Liu C
Immunology 2025 Sep;176(1):16-32
Immunology 2025 Sep;176(1):16-32
Tongxinluo alleviates myocardial ischemia-reperfusion injury by inhibiting the pyroptosis of endothelial cells via the NLRP3/Caspase-1/GSDMD signaling pathway.
Wu X, Hou YL, Wang TX, Chang LP, Zhou HR, Wang MY, Wu YL
Journal of molecular histology 2025 Sep 8;56(5):302
Journal of molecular histology 2025 Sep 8;56(5):302
Distinct Inflammatory Responses of hiPSC-Derived Endothelial Cells and Cardiomyocytes to Cytokines Involved in Immune Checkpoint Inhibitor-Associated Myocarditis.
Conte S, Firoaguer I, Lledo S, Tran TT, El Yazidi C, Simoncini S, Rebaoui Z, Guiol C, Chevillard C, Guieu R, Puthier D, Thuny F, Cautela J, Lalevée N
Cells 2025 Sep 7;14(17)
Cells 2025 Sep 7;14(17)
DCAAA mitigates neuroinflammation and microglial pyroptosis in spinal cord injury by inhibiting PI3K/AKT/NF-κB and NLRP3/caspase-1/GSDMD signaling.
Gao J, Liu Y, Li R, Liu Y, Qi Z, Zhang Z
European journal of pharmacology 2025 Sep 5;1002:177816
European journal of pharmacology 2025 Sep 5;1002:177816
FZD6 promotes 5-fluorouracil resistance through inhibiting pyroptosis in colorectal cancer.
He Z, Yang J, Zhang Y, Zhang T, Guo T, Jin L, Mao Y, Wang T
Carcinogenesis 2025 Sep 4;46(3)
Carcinogenesis 2025 Sep 4;46(3)
M464 inhibits activation of NLRP3 inflammasome and inflammatory response in mice.
Wang W, Zhao Y, Li S, Wu T, Hu K, Liu W, Cheng C, Fu X, Xu G
Scientific reports 2025 Sep 30;15(1):33878
Scientific reports 2025 Sep 30;15(1):33878
Mitochondrial damage is associated with an early immune response in inclusion body myositis.
Kleefeld F, Cross E, Lagos D, Walli S, Schoser B, Hentschel A, Ruck T, Nelke C, Hahn K, Hathazi D, Mammen AL, Casal-Dominguez M, Gut M, Gut IG, Heath S, Schänzer A, Goebel HH, Pinal-Fernandez I, Roos A, Preuße C, Stenzel W, Horvath R
Brain : a journal of neurology 2025 Sep 3;148(9):3199-3214
Brain : a journal of neurology 2025 Sep 3;148(9):3199-3214
Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway.
Duan H, Zhang Y, Shen A, Ren J, Zhang F, Lu Y, Wei X, Yang C, Gong J, Wang X, Du Y, Pei Q, Zhang A
Veterinary research 2025 Sep 25;56(1):182
Veterinary research 2025 Sep 25;56(1):182
Ginsenoside Rg1 improves chronic neuropathic pain by inhibiting NLRP3 inflammasome activation and cell pyroptosis in microglia.
Wu L, Lin T, Zhang Z, Peng D, Xiao S, Liang J, Yu H, Wang Y, Huang F, Yan H
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120346
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120346
Tianlong kechuanling ameliorated COPD-PH through DNMT3A-GSDMD axis-dependent regulation of endothelial cell pyroptosis.
Li H, Li Z, Gong J, Yan Y, Cui X, Yu Q, Shi Y, Tian X, Jiang Q, Tan Z, Yang Y, Zhou W, Ding Q, Wang P
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120332
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120332
Effects of and mechanisms underlying qingwen baidu decoction in sepsis-associated acute kidney injury.
Zhao Y, Zhang M, Dong L, Zhang Q, Bai J, Hao Y, Yi Z, Zhou Y
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120310
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120310
Astragaloside IV alleviates LPS-induced acute lung injury by regulating receptor C5aR1 and macrophage pyroptosis.
Xu ZH, Li M, Liu L, Wu SJ, Wei RA, Inobubele Sitholumusa MU, Zhao XP, Liu JQ, Kai GY
International immunopharmacology 2025 Sep 23;162:115176
International immunopharmacology 2025 Sep 23;162:115176
Targeting NEK7 modulates pyroptosis and gut microbiota to alleviate depression-like behavior in rats.
Lang W, Wang C, Wen J, Chen M, Wei D, Jiang Y, Li X, Wei P, Jin G, Zhu Q
International immunopharmacology 2025 Sep 23;162:115148
International immunopharmacology 2025 Sep 23;162:115148
Targeting Bcl3/NF-κB p50 Pathway for Neuroinflammation Attenuation and RGCs Protection in Retinal Ischemia/Reperfusion Injury.
Chen M, Zhang X, Zeng Z, Fan C, Chen S, Quan C, Chen J, You M, Xia X
Investigative ophthalmology & visual science 2025 Sep 2;66(12):63
Investigative ophthalmology & visual science 2025 Sep 2;66(12):63
Picroside II-Encapsulated Nanoformulations as Pyroptosis Inhibitor Alleviate Cytokine Storms and Remodel Gut Microbiota Disturbances.
Wu Q, Tang AL, Dong QQ, Chen BQ, Shi Y, Xu XL, Chen W, Chen W
ACS nano 2025 Sep 16;19(36):32569-32584
ACS nano 2025 Sep 16;19(36):32569-32584
SVF Cell Sheets as a New Multicellular Material-Based Strategy for Promoting Angiogenesis and Regeneration in Diced Cartilage Grafts.
Wei Y, Xie C, Wei Y, Li Z, Li L, Chen Y, Jia C, Xie H, Liao J
The Journal of craniofacial surgery 2025 Sep 1;36(6):1889-1898
The Journal of craniofacial surgery 2025 Sep 1;36(6):1889-1898
A phosphoproteomic study uncovers the importance of PP2A-B56α in liver injury precipitated by NLRP3 activation during MC-LR exposure.
Yin H, Jiang H, Zhao R, Zhang Y, Fan X, Zhai X, Yang X, Zhang Y
Ecotoxicology and environmental safety 2025 Sep 1;302:118752
Ecotoxicology and environmental safety 2025 Sep 1;302:118752
Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation.
Xu H, He TQ, Chen SY, Shi RR, Xu J, Xing YR, Shi D, Liu YQ, He BS, Gu JH
Redox biology 2025 Oct;86:103803
Redox biology 2025 Oct;86:103803
Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.
Zhang M, Liu S, Wu Z, Wang C, Zhang H, Yang J, Guo C, Dai M, Wang X, Ren W
Science China. Life sciences 2025 Oct;68(10):3037-3050
Science China. Life sciences 2025 Oct;68(10):3037-3050
Bacterial infection in weaned piglets promotes diarrhea by inducing the NLRP3 inflammasome-pyroptosis pathway.
Fu J, Jiang Z, Wen C, Su W, Yang M, He H, Liu Y, Gong T, Jiang S, Wang F, Lu Z, Jin M, Wang Y
Science China. Life sciences 2025 Oct;68(10):3021-3036
Science China. Life sciences 2025 Oct;68(10):3021-3036
Oxytocin Regulated Neuroinflammation through OTR/Mitochondria Mediated Pathway to Improve Hypoxia-Induced Brain Injury.
Yang X, Li K, Chen L, Wang L, Wang X, Lu K, Bai Y, Hou Y, Hou J, Wang C, Cheng X, Oldam J, Yu J, Wu J, Sun B
Molecular neurobiology 2025 Oct;62(10):12907-12923
Molecular neurobiology 2025 Oct;62(10):12907-12923
The Protective Effects of Vanillic Acid on LPS-induced Acute Lung Injury by Inhibiting STIM1-mediated NLRP3 Inflammasome Activation.
Wang L, Li HD, Sun X, Ni JH, Feng GZ, Shen XY, Weng HB, Fang H
Inflammation 2025 Oct;48(5):3710-3725
Inflammation 2025 Oct;48(5):3710-3725
Methamphetamine and HIV-1 Tat Synergistically Induce Microglial Pyroptosis Via Activation of the AIM2 Inflammasome.
Miao L, Wang H, Yang X, Xu L, Xu R, Teng H, Zhang Y, Zhao Y, Yang G, Zeng X
Inflammation 2025 Oct;48(5):3300-3313
Inflammation 2025 Oct;48(5):3300-3313
Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.
Li S, Wang J, Chen Y, Cheng Y, Wang Y, Xu N, Wang H, Wang L, Chi Y, Ye X, Shi Y, Fang J, Yao X, Huang J, Xia Q, Bai T, Zhu B
Inflammation 2025 Oct;48(5):3180-3193
Inflammation 2025 Oct;48(5):3180-3193
Neutrophil Extracellular Traps Induce Pyroptosis of Gingival Fibroblasts in Peri-Implantitis.
Li J, Li Z, Abuduwaili K, Song J, Sun Y, Chen Z, Chen D, Huang B
Clinical oral implants research 2025 Oct;36(10):1296-1311
Clinical oral implants research 2025 Oct;36(10):1296-1311
NR4A1 mediates PRRSV-induced ileal injury in piglets by transcriptional regulation of NLRP3.
Meng F, Zhu C, Zhu C, Yuan L, Li C, Sun M, Cai D
Veterinary microbiology 2025 Oct;309:110677
Veterinary microbiology 2025 Oct;309:110677
Acute high-altitude hypoxia induced NLRP3 inflammasome activation in pulmonary artery smooth muscle cells by BMAL1 targeting mitochondrial VDAC1-mediated MtDNA leakage.
He SY, Bu YR, Xu J, Wang YM, Feng TX, Li PJ, Zhao YX, Ge YL, Xie MJ
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2225-2237
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2225-2237
FXR overexpression alleviates cholestasis via NLRC4 inflammasome suppression and bile acid homeostasis regulation.
Wang W, Li L, Li X, Chen J, Wang R, Yang Q, Qu Y, Wang C, Fu T, Meng Q
Free radical biology & medicine 2025 Oct;238:152-168
Free radical biology & medicine 2025 Oct;238:152-168
Mesenchymal Stem Cells Derived from Different Adipose Tissue Depots Ameliorate Severe Acute Pancreatitis by Inhibiting NF-κB/NLRP3/Caspase-1 Pathways.
Wang A, An Y, Wang X, Gou W, Xu F, Li Y, Wang C, Tu Z, Hou W, Cui Y
Stem cell reviews and reports 2025 Oct;21(7):2200-2217
Stem cell reviews and reports 2025 Oct;21(7):2200-2217
LILRB4 exacerbates myocardial ischemia-reperfusion injury by promoting inflammation and pyroptosis.
Yang J, Zhang M, Liu L, Zhang P, Liu H, Yang Z, Chen C, Li R, Zhai Y, Li W, Wang W, Yang J, Huang C, Zhang J
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167959
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167959
From Molecular Docking to Rat Models: Butyrate From a High-Fiber Diet Inhibits HDAC1 and NLRP3 Inflammasome to Alleviate Oxidative Stress and Inflammation After Spinal Cord Injury.
Ganggang K, Cheng G, Gang L, Wenwu Z, Di Z, Yan L, Baoshu X, Yiqin W
Journal of neurochemistry 2025 Oct;169(10):e70250
Journal of neurochemistry 2025 Oct;169(10):e70250
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Li L, Zuo A, Yin R, Liu Q, Liu C, Li N, Xu D, Zhang S, Li J, Lei S, Ruan S, Li T, Guo Y
Cell death & disease 2025 Oct 7;16(1):710
Cell death & disease 2025 Oct 7;16(1):710
Degradation of NLRP3 by selective ROCK2 inhibitor alleviates acute lung injury.
Zhan S, Zhang N, Lou Y, Ding X, Chen Z, Huang Y, Ding W
European journal of pharmacology 2025 Oct 5;1004:178009
European journal of pharmacology 2025 Oct 5;1004:178009
LncRNA MIR17HG accelerates the development of atherosclerosis by promoting macrophage pyroptosis through the miR-301a-3p/TXNIP pathway.
Wang YP, Liu X, Xu XD, Hui L, Xu GH, Ma MQ, Zhu L, Ren K
International immunopharmacology 2025 Oct 30;164:115407
International immunopharmacology 2025 Oct 30;164:115407
Oridonin alleviates SiNPs-induced pulmonary fibrosis by inhibiting pyroptosis via IRE1α-XBP1s-NLRP3 pathway.
Ban J, Peng X, Zhang Y, Liu Y, Wei Y, Ao L, Tian H, He X, Zhao H, Li J
International immunopharmacology 2025 Oct 30;164:115388
International immunopharmacology 2025 Oct 30;164:115388
The impact of PANoptosis-related genes on immune profiles and subtype classification in ischemic stroke.
Cai X, Ren Y, Wu H, Tan Y, Zhou L, Wang Y, Yang Q, Wang J, Tang H, Wen J, Zhao Y, Wang L, Xu X, Huang J, Yang Q
Scientific reports 2025 Oct 24;15(1):37245
Scientific reports 2025 Oct 24;15(1):37245
Ginsenoside Ro Targets BCAT1/2 to Suppress Ferroptosis: A Novel Therapeutic Strategy for Ischemic Cardioprotection.
Liu J, Wang F, Bai J, Qu S, Tao S, Liu C, Wang Q, Ding W, Lai Q, Zhang J
Journal of agricultural and food chemistry 2025 Oct 22;73(42):26683-26699
Journal of agricultural and food chemistry 2025 Oct 22;73(42):26683-26699
Bisphenol S as an emerging osteotoxicant: Mechanistic insights from osteoblasts and zebrafish models.
Shi X, Xie H, Liu C, Wu K, Huang W
Ecotoxicology and environmental safety 2025 Oct 15;305:119240
Ecotoxicology and environmental safety 2025 Oct 15;305:119240
MicroRNA-29a attenuates inflammation and fibrosis in an animal model of NASH through MCJ inhibition and hippo pathway regulation.
Yang YL, Huang YH
European journal of pharmacology 2025 Oct 15;1005:178107
European journal of pharmacology 2025 Oct 15;1005:178107
The role of Lactobacillus rhamnosus in improving estrogen deficiency-induced osteoporosis by inhibiting NLRP3 inflammasome activation.
Xiong K, Pan Y, Liu Y, Li J, Zhan D, Zhang L, Li J, Sun H
Biochemical and biophysical research communications 2025 Oct 10;784:152652
Biochemical and biophysical research communications 2025 Oct 10;784:152652
Pterostilbene as a pyroptosis inducer and tumor microenvironment regulator inhibits glioblastoma and enhances the efficacy of immunotherapy.
Chen Z, Fang XG, Jia LJ, Feng Y, Cheng JH, Luo S, Wen S, Wei JR, Ma SN, Guo XR, Luo J
International immunopharmacology 2025 Oct 10;163:115247
International immunopharmacology 2025 Oct 10;163:115247
Rv2647-Mediated NLRP3 Ubiquitination Inhibits Macrophage Pyroptosis and Promotes Mycobacterium tuberculosis Survival.
Jin X, Yan H, Chen X, Feng J, Li G, Yao J, Du X, Feng G
ACS infectious diseases 2025 Oct 10;11(10):2739-2753
ACS infectious diseases 2025 Oct 10;11(10):2739-2753
Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury.
Zhang W, Lu Y, Shen R, Wu Y, Liu C, Fang X, Zhang L, Liu B, Rong L
Neural regeneration research 2025 Oct 1;20(10):2955-2968
Neural regeneration research 2025 Oct 1;20(10):2955-2968
Sishen pill alleviates ulcerative colitis via the NLRP3/ASC/Caspase-1 signaling pathway: Comprehensive validation through UPLC-Q-TOF/MS, network pharmacology, molecular docking, and in vivo experiments.
Luo Q, Long H, Guo C, Wei X, Wang X, Zhang H, Luo S, Liu Z, Liu J, Zhou S, Lin X
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2025 Oct 1;1264:124735
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2025 Oct 1;1264:124735
Cytopathic bovine viral diarrhea virus-induced NLRP3 inflammasome activation triggers GSDMD-mediated pyroptosis, amplifying the inflammatory response.
Yao X, Li Y, Wang J, Liu Z, Chen J, Feng Z, Wang Z, Xiang J, Xu R, Jia S, Qi Z, Xu Y
Veterinary microbiology 2025 Nov;310:110736
Veterinary microbiology 2025 Nov;310:110736
Ellagic acid mediated pyroptosis in hepatocellular carcinoma via the ESR1/G6PD pathway.
Wang S, Cai Y, Zhou F, Zhang M, Li J, Shang L, Huang J, Chen L, Yang S
Biochemical pharmacology 2025 Nov;241:117178
Biochemical pharmacology 2025 Nov;241:117178
Targeting STING alleviates pyroptosis of bladder epithelial cells and ameliorates bladder fibrosis in neurogenic bladder.
Wang R, Wang M, Chen J, Sun M, Zhao P, Zheng X, Li D, Long C, Shen L, Wei G, Wu S
Biochemical pharmacology 2025 Nov;241:117177
Biochemical pharmacology 2025 Nov;241:117177
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.
Zhang F, Xie Y, Dang RN, Yu J, Tian XX, Li LJ, Zhou QM, An XM, Chen PL, Luo YQ, Wu YS, Liu J, Zou HM
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.
Liu R, Chen Y, Huang H, Li X, Lv J, Jiang L, Jiang H, Wu C, Chen W, Xu H, Zhu Z, Cai H, Xiao J, Yin L, Ni W
British journal of pharmacology 2025 Nov;182(22):5489-5516
British journal of pharmacology 2025 Nov;182(22):5489-5516
Natural compound triptolide induces caspase-3/GSDME-mediated pyroptosis by promoting ROS accumulation in small cell lung cancer.
Yan Y, Xu Z, Wang C, Liu Y, Long Y, Yuan X, Chu Q
Cancer cell international 2025 Nov 28;25(1):426
Cancer cell international 2025 Nov 28;25(1):426
Irisolidone Ameliorates Cyclophosphamide-Induced POI via Inhibiting Inflammatory Response.
Li M, Wei Z, Chen X, Wu H, Han X, Pei Y, Chen J, Ma S
Frontiers in bioscience (Landmark edition) 2025 Nov 26;30(11):45744
Frontiers in bioscience (Landmark edition) 2025 Nov 26;30(11):45744
Shen Yuan Yi Qi Huo Xue capsules inhibit neutrophil NETosis by regulating the PAD4/NLRP3 signaling pathway to prevent heart failure after myocardial infarction.
Lian YJ, Zhang HY, Liu HX, Shang JJ, Lai XL, Xing WL, Li SN
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157462
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157462
Bushen Huatan formula alleviates polycystic ovary syndrome in rats by activating the PI3K/Akt pathway to inhibit GSDMD-mediated pyroptosis and mitochondrial damage.
Xiong Q, Yang J, Liu Q, Yu P, Shen M, Liang J
Journal of ovarian research 2025 Nov 24;18(1):309
Journal of ovarian research 2025 Nov 24;18(1):309
A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer.
Zhang Y, Yang E, Zhang X, Shi Y, Fan G, Wang Y, Tian J, Wang H, Dong Z, Wang Y, Cheng L, Zhao Z, Zhang Y, Wang B, Wang Z
Journal of nanobiotechnology 2025 Nov 22;23(1):795
Journal of nanobiotechnology 2025 Nov 22;23(1):795
Targeting ICAM1 through LIF-mediated NF-κB/JAK2-STAT3 crosstalk protects nucleus pulposus from IL-1β-driven pyroptosis to ameliorate intervertebral disc degeneration.
Wang Z, Liu J, Xu H, Sun Y, Xu S, He X
Journal of orthopaedic surgery and research 2025 Nov 22;20(1):1096
Journal of orthopaedic surgery and research 2025 Nov 22;20(1):1096
Influenza a(H1N1) virus infection impairs syncytiotrophoblast functions by promoting ferroptosis through the TNF-α/ISG15/EGR1 axis.
Zhao Y, Wang Y, Huang K, Wang F, Wang Y
Virology journal 2025 Nov 17;22(1):379
Virology journal 2025 Nov 17;22(1):379
Protective effects of taurochenodeoxycholic acid on aflatoxin B1-induced hepatic pyroptosis and gut-liver dysfunction.
Xu C, Wang X, Zhang X, Yao J, Lu Y, Wu G, Li W, Yang J
Ecotoxicology and environmental safety 2025 Nov 15;307:119432
Ecotoxicology and environmental safety 2025 Nov 15;307:119432
Ligustilide ameliorates cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome-dependent pyroptosis through enhancing Nrf2 signaling.
Wang Y, Wan Z, Wang N, Wu Q, Seto S
Neuropharmacology 2025 Nov 15;279:110642
Neuropharmacology 2025 Nov 15;279:110642
PROM2 exacerbates CCl4-Induced liver fibrosis via NLRP3 inflammasome activation and hepatocyte pyroptosis.
Guo J, Lin Y, Gong X, Kuang G, Hu J, Du H, Liu H, Zhang J, Zhang L, Wan J, Wang T
Cellular and molecular life sciences : CMLS 2025 Nov 14;82(1):403
Cellular and molecular life sciences : CMLS 2025 Nov 14;82(1):403
Empagliflozin alleviates hepatic ischemia-reperfusion injury by inhibiting c-Myc through the JAK1-STAT3 signaling pathway.
Tulahong A, Xu X, Zhou T, Ruze R, Yuan Z, Qiao P, Jiang T, Aji T, Shao Y
International immunopharmacology 2025 Nov 14;165:115508
International immunopharmacology 2025 Nov 14;165:115508
The TWIK2-mtDNA-NLRP3 inflammasome signaling in hepatic macrophages facilitates exercise-induced attenuation of hepatic inflammation and insulin resistance in db/db mice.
Zhang T, Fan J, Wen X, Duan X
Journal of physiology and biochemistry 2025 May;81(2):313-328
Journal of physiology and biochemistry 2025 May;81(2):313-328
Copper oxide nanoparticles disrupt lysosomal function and promote foam cell formation in RAW264.7 macrophages.
Luo Y, Zhang K, Mao L, Tan M, Dong X, Li N, Zhou Y, Chen C, Zou Z, Zhang J
Toxicology 2025 May;513:154101
Toxicology 2025 May;513:154101
Low-intensity Pulsed Ultrasound Stimulation of the Intestine Improves Insulin Resistance in Type 2 Diabetes.
Wang H, He M, Bat-Erdene B, Li Y, Ta D
Ultrasound in medicine & biology 2025 May;51(5):797-806
Ultrasound in medicine & biology 2025 May;51(5):797-806
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Zhu Y, Yang S, Su S, Huang Y, Chen Y, Liang H, Miao J, Wu Z, Li X, Xiao J, Wang X
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Reno protective potential of taxifolin liposomes modified by chitosan in diabetic mice.
Zhao Y, Ding Q, He Q, Zu T, Rong Z, Wu Y, Shmanai VV, Jiao J, Zheng R
International journal of biological macromolecules 2025 May;306(Pt 2):141464
International journal of biological macromolecules 2025 May;306(Pt 2):141464
The therapeutic effect and mechanism of carnosic acid in Aspergillus fumigatus keratitis.
Chi M, Gu L, Zhang L, Lin J, Wang Q, Fu X, Tian X, Wang Z, Yu B, Liu W, Li C, Zhao G
Experimental eye research 2025 May;254:110338
Experimental eye research 2025 May;254:110338
AIM2 exacerbates hypoxic-ischemic brain damage in neonatal rats via promoting neuronal pyroptosis.
Li Q, Wang Z, Li F, Liu S, Ding Y, Yan J, Feng X, Li M
Brain research bulletin 2025 May;224:111305
Brain research bulletin 2025 May;224:111305
Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/AMPK-mediated pyroptotic inhibition.
Wang N, Gao Z, Zhan H, Jing L, Meng F, Chen M
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 May;199:115335
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 May;199:115335
Deoxynivalenol-induced pyroptosis and autophagy inhibition collectively promote inflammatory injury in the glandular stomach of chicken embryos.
Chen F, Yang G, Qiu H, Gao S, Hou L, Dong J, Zhao P, Dong W
Poultry science 2025 May;104(5):105052
Poultry science 2025 May;104(5):105052
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages.
Zhou M, Pei B, Cai P, Yi C, Akanyibah FA, Lyu C, Mao F
Stem cell research & therapy 2025 May 9;16(1):233
Stem cell research & therapy 2025 May 9;16(1):233
Hippocampal NLRP1 inflammasome mediates anxiety-like behavior in mice with hypothyroidism.
Cheng YW, Zou ZH, Lou CL, Tong MR, Li JK, Zhu WH, Lu YL, Zhu DF, Xu Q, Xu YX
Scientific reports 2025 May 9;15(1):16176
Scientific reports 2025 May 9;15(1):16176
Poliumoside Exhibits Neuroprotective Effects against Cerebral Ischemia-Reperfusion Injury by Relieving Microglia-Mediated Neuronal Damage and Astrocytic Activation.
Bai L, Guan Z, Zhang J, Lv Z, Duan Y, Tian S
ACS chemical neuroscience 2025 May 7;16(9):1780-1791
ACS chemical neuroscience 2025 May 7;16(9):1780-1791
Heat stress enhances the expression of METTL3 to mediate N6-methyladenosine modification of SOS2 and NLRP3 inflammasome activation in boar Sertoli cells.
Zhang X, Tang Y, Wang J, Yang M, Jiang J, Xue H, Wang Y, Zhang J, Wang X
Journal of hazardous materials 2025 May 5;488:137432
Journal of hazardous materials 2025 May 5;488:137432
Ginsenoside Rg1 attenuates T2DM-induced renal damage and fibrosis by inhibiting TRPC6-ChREBP-TXNIP signaling.
Zhang H, Liang H, Fan L, Zhu X, Ji P, Su Y, Li W, Li W
Journal of ethnopharmacology 2025 May 28;348:119863
Journal of ethnopharmacology 2025 May 28;348:119863
Icariin alleviates cardiomyocyte pyroptosis through AMPK-NLRP3 pathway to ameliorates diabetic cardiomyopathy.
Cai Z, Sun F, Wang Q, Li S, Wang L, Li H, Su Y, Yang H, Dong B
International immunopharmacology 2025 May 27;156:114690
International immunopharmacology 2025 May 27;156:114690
Pyroptosis of periodontal ligament stem cells aggravates periodontitis via Piezo1 channel.
Chen P, Liu D, Zhou YK, Jiang JH, Yang RL
iScience 2025 May 16;28(5):112395
iScience 2025 May 16;28(5):112395
miR-126-5p protects from URSA via inhibiting Caspase-1-dependent pyroptosis of trophoblast cells.
Zhu X, Xu K, Ai S, Zhang Y, Chu C, Wei R, Gao S, Liu L, Li W, Zhang Y, Kikete S, Liu X, Zhang Z, Li X
Cellular and molecular life sciences : CMLS 2025 May 15;82(1):204
Cellular and molecular life sciences : CMLS 2025 May 15;82(1):204
Galectin-3 activates microglia and promotes neurological impairment via NLRP3/pyroptosis pathway following traumatic brain injury.
Sun Y, Gao SQ, Wang X, Li T, Han YL, Miao SH, Zhao R, Zheng XB, Qiu JY, Jin WX, Gao CC, Zhou ML
Brain research 2025 May 15;1855:149560
Brain research 2025 May 15;1855:149560
Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis.
Kocot J, Kosa P, Ashida S, Pirjanian NA, Goldbach-Mansky R, Peterson K, Fossati V, Holland SM, Bielekova B
The Journal of clinical investigation 2025 May 15;135(10)
The Journal of clinical investigation 2025 May 15;135(10)
Understanding Propofol's Protective Mechanism in Tubular Epithelial Cells: Mitigating Pyroptosis via the miR-143-3p/ATPase Na + /K + Transporting Subunit Alpha 2 Pathway in Renal Ischemia-Reperfusion.
Kan H, Zhao M, Wang W, Sun B
Molecular biotechnology 2025 Mar;67(3):1165-1177
Molecular biotechnology 2025 Mar;67(3):1165-1177
Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways.
Xu H, Pang M, Hu C, Xu T, Chen G, Zhang G, Han X, Hua Y, Wu Y, Zhang J, Bi Y, Liu B, Zhou Y
Journal of ginseng research 2025 Mar;49(2):197-207
Journal of ginseng research 2025 Mar;49(2):197-207
IL-1β enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression.
Moreno-Loaiza O, Soares VC, de Assumpção Souza M, Vera-Nuñez N, Rodriguez de Yurre Guirao A, da Silva TP, Pozes AB, Perticarrari L, Monteiro E, Albino MC, Silva SB, Dias SSG, Maciel L, Muzi-Filho H, de Oliveira DF, Braga BC, Diniz LP, Cruz MC, Barbosa SR, Castro-Junior AB, Conde L, Cabral-Castro MJ, de Souza OF, Tavares Pinheiro MV, Araújo de Oliveira Junior N, Rezende de Siqueira L, Cosenza RP, Munhoz da Fontoura C, Secco JCP, da Rocha Ferreira J, Silvestre de Sousa A, Albuquerque D, Luiz RR, Nicolau-Neto P, Pretti MA, Boroni M, Bonamino MH, Kasai-Brunswick TH, Mello DB, Gonçalves-Silva T, Ramos IP, Bozza FA, Madeiro JPDV, Pedrosa RC, Carneiro-Ramos MS, da Silva Martinho H, Bozza PT, Mesquita de Souza F, Victor Lucena da Silva G, Cunha TM, Uzelac I, Fenton F, Moll-Bernardes R, Paiva CN, Escobar AL, Medei E
Nature cardiovascular research 2025 Mar;4(3):312-329
Nature cardiovascular research 2025 Mar;4(3):312-329
Dihydrotanshinone I Attenuates Diet-Induced Nonalcoholic Fatty Liver Disease via Up-Regulation of IRG1.
Xiang Y, Kuang G, Gong X, Xie H, Lin Y, Zhang X, Chen Z, Wan J, Li Z
Phytotherapy research : PTR 2025 Mar;39(3):1531-1548
Phytotherapy research : PTR 2025 Mar;39(3):1531-1548
Indoleamine 2, 3-dioxygenase 1 inhibition mediates the therapeutic effects in Parkinson's disease mice by modulating inflammation and neurogenesis in a gut microbiota dependent manner.
Qiao CM, Ma XY, Tan LL, Xia YM, Li T, Wu J, Cui C, Zhao WJ, Shen YQ
Experimental neurology 2025 Mar;385:115142
Experimental neurology 2025 Mar;385:115142
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
Li S, Yin Y, Dong X, Xu L, Yang Z, Li H, Zou Y, Wu Z
Biological trace element research 2025 Mar;203(3):1539-1554
Biological trace element research 2025 Mar;203(3):1539-1554
BRCC3 aggravates pulpitis by activating the NF-κB signaling pathway in dental pulp cells.
Zhang X, Zhang L, Zhou L, Tao H, Chen Z
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167698
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167698
Exosomes derived from fibroblasts in DFUs delay wound healing by delivering miR-93-5p to target macrophage ATG16L1.
Xu Z, Ni T, Zhang Q, Sun X, Zhao L, Lin J, Gao W, Yi M, Zhang L, Tu L, Wu G, Yan W
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167640
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167640
Vagus nerve stimulation inhibits PANoptosis and promotes neurofunctional recovery of cerebral ischemic stroke in a Sirt1-dependent manner.
Tang H, Wen J, Wang L, Yang Q, Qin T, Ren Y, Zhao Y, Li C, Li J, Cao H, Xu J, Yang Q
Neurochemistry international 2025 Mar;184:105950
Neurochemistry international 2025 Mar;184:105950
Oxaliplatin induces pyroptosis in hepatoma cells and enhances antitumor immunity against hepatocellular carcinoma.
Deng M, Zhao R, Zou H, Guan R, Wang J, Lee C, He B, Zhou J, Li S, Wei W, Cai H, Guo R
British journal of cancer 2025 Mar;132(4):371-383
British journal of cancer 2025 Mar;132(4):371-383
Piezo1 promotes intervertebral disc degeneration through the Ca(2+)/F-actin/Yap signaling axis.
Peng F, Sun M, Jing X, Chen F, Cao T, Li Z, Li T
Molecular medicine (Cambridge, Mass.) 2025 Mar 8;31(1):90
Molecular medicine (Cambridge, Mass.) 2025 Mar 8;31(1):90
Olfactory bulb microglia activation mediates neuronal pyroptosis in ozone-exposed mice with olfactory and cognitive dysfunction.
Xu R, Chen H, Wang Y, Qi H, Chen Y, Dai A, Yang S, Wang Y, Zeng Y, Li J
Journal of hazardous materials 2025 Mar 5;485:136901
Journal of hazardous materials 2025 Mar 5;485:136901
Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p.
Yang Q, Chen Q, Zhang KB, Liu Y, Zheng JC, Hu DX, Luo J
Acta neuropathologica communications 2025 Mar 5;13(1):48
Acta neuropathologica communications 2025 Mar 5;13(1):48
Piperine inhibits fungal growth and protects against pyroptosis in Aspergillus fumigatus keratitis by regulating the mTOR/HIF-1α pathway.
Li H, Yu B, Lin J, Wang Q, Zhang L, Li Y, Liu X, Liu Y, Li C, Zhao G
International immunopharmacology 2025 Mar 26;150:114286
International immunopharmacology 2025 Mar 26;150:114286
Coal dust particles can upregulate the expression of NLRP3 inflammasome components in rat alveolar macrophages through phagocytosis.
Zhang Y, Yan J, Ren Y, Cheng Y, Qin H, Hu Y, Zhao H
Scientific reports 2025 Mar 15;15(1):8989
Scientific reports 2025 Mar 15;15(1):8989
H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes.
Li J, Li S, Sun Q, Li L, Zhang Y, Hua Z
Journal of neuroinflammation 2025 Mar 12;22(1):76
Journal of neuroinflammation 2025 Mar 12;22(1):76
H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition in airway epithelial cells.
Liu S, He Y, Jin L, Shi S, Zhang J, Xie W, Yang M, Zhang Q, Kong H
Toxicology 2025 Jun;514:154109
Toxicology 2025 Jun;514:154109
Signal-induced NLRP3 phase separation initiates inflammasome activation.
Zou G, Tang Y, Yang J, Fu S, Li Y, Ren X, Zhou N, Zhao W, Gao J, Ruan Z, Jiang Z
Cell research 2025 Jun;35(6):437-452
Cell research 2025 Jun;35(6):437-452
MicroRNA-9-3p inhibits endothelial pyroptosis in atherosclerosis by targeting the PTEN/AKT axis.
Wu Y, Ma Q, Meng X, Sun Q, Wang Z, Zhang W
International journal of biological macromolecules 2025 Jun;315(Pt 1):144289
International journal of biological macromolecules 2025 Jun;315(Pt 1):144289
Lycium barbarum polysaccharide alleviate cadmium-induced mitochondrial dysfunction mediated pyroptosis in duck liver.
Song J, Luo X, Xiong L, Li S, Chen Y, Liu W, Yuan Y, Ma Y, Bian J, Liu Z, Zou H
International journal of biological macromolecules 2025 Jun;311(Pt 4):143989
International journal of biological macromolecules 2025 Jun;311(Pt 4):143989
Mycobacterium bovis Mb3523c protein regulates host ferroptosis via chaperone-mediated autophagy.
Wang H, Liu D, Ge X, Wang Y, Zhou X
Autophagy 2025 Jun;21(6):1335-1352
Autophagy 2025 Jun;21(6):1335-1352
Acupuncture protects against ischemic stroke by inhibiting the NF-κB pathway.
Wang L, Chen L, Wu J, Liu C, Chi C, Wang S
IBRO neuroscience reports 2025 Jun;18:370-377
IBRO neuroscience reports 2025 Jun;18:370-377
Construction of a toxicity pathway from activation of the TLR4/NF-κB/NLRP3 axis to Parkinson's disease-like non-motor symptoms in mice.
Wang K, Shi G, Li Y, Liu Q, Zhang Q, Wu C, Jiao Y, Ma Y, Qi A, Huang M
Environmental toxicology and pharmacology 2025 Jun;116:104706
Environmental toxicology and pharmacology 2025 Jun;116:104706
Pterostilbene Reduces Cyclophosphamide-Induced Interstitial Cystitis by Facilitating Nrf2 Activation and Suppressing the NLRP3 Inflammasome Pathway.
Zhang J, Wang J, Wang X, Yan Z, Meng L, Zhang Y
International journal of molecular sciences 2025 Jun 8;26(12)
International journal of molecular sciences 2025 Jun 8;26(12)
Association between endogenous lactate accumulation and dysregulated activation of the NLRP3 inflammasome pathway in schizophrenia.
Zhang Y, Wang Y, Xing H, Bai Y, Li M, Zhao H, Ding L, Wang W, Bao T
Scientific reports 2025 Jun 4;15(1):19609
Scientific reports 2025 Jun 4;15(1):19609
Emodin influences pyroptosis-related Caspase 1-GSDMD axis alleviated cerebral ischemia-reperfusion injury in rats.
Zhang G, Hu X, Qian J, Shi Y, Ling Z, Xu P, Xu Z, Zhang J, Liang T
Scientific reports 2025 Jun 3;15(1):19397
Scientific reports 2025 Jun 3;15(1):19397
Lysosomal zinc nanomodulation blocks macrophage pyroptosis for counteracting atherosclerosis progression.
Hu R, Qin J, Feng W, Song X, Huang H, Dai C, Zhang B, Chen Y
Science advances 2025 Jun 27;11(26):eadu3919
Science advances 2025 Jun 27;11(26):eadu3919
LINC01013 reverses bisphosphonate-impaired osteogenic differentiation of JBMMSCs by regulating intracellular translocation of ILF3.
Song J, Wang W, Feng X, Yang H, Shan Z, Fan Z
Stem cell research & therapy 2025 Jun 23;16(1):319
Stem cell research & therapy 2025 Jun 23;16(1):319
HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway.
Yang H, Liu M, Song S, Xu Q, Lee J, Sun J, Xue S, Sun X, Che C
Investigative ophthalmology & visual science 2025 Jun 2;66(6):32
Investigative ophthalmology & visual science 2025 Jun 2;66(6):32
Oleoylethanolamide exerts neuroprotection following ischemic stroke through microglial PPARα signal.
Li Y, Wu C, Zhang Y, Wang Q, Huang Y, Xie Y, Yang L, Xu L, Wang S
International immunopharmacology 2025 Jun 17;158:114824
International immunopharmacology 2025 Jun 17;158:114824
Oxygen/sulfate radicals-generating CaS(2)O(8) nanosonosensitizers induce PANoptosis and calcium overload for enhanced peritoneal metastasis immunotherapy.
Wang Q, Wen Y, Bi B, Li K, Liu Y, Li B, Zhou S, Li Z, Xu J, Qiu M, Li Y, Wu M, Chen Y, Wu W, Zhao J
Science bulletin 2025 Jun 15;70(11):1804-1821
Science bulletin 2025 Jun 15;70(11):1804-1821
Mesenchymal stem cells attenuate hyperoxaluria-induced kidney injury and crystal depositions via inhibiting the activation of NLRP3 inflammasome.
Zou B, Wang D, Zhong J, He Z, Zhou Y, Yang H, Liu Y, Zeng G, Duan X
Life sciences 2025 Jun 15;371:123608
Life sciences 2025 Jun 15;371:123608
M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis.
Zhang H, Jiang N, Xu M, Jing D, Dong T, Liu Q, Lv Q, Huo R, Chen P, Li L, Wang X
Life sciences 2025 Jun 1;370:123561
Life sciences 2025 Jun 1;370:123561
Xanthine Derivative KMUP-3 Alleviates Periodontal Bone Resorption by Inhibiting Osteoclastogenesis and Macrophage Pyroptosis.
Huang SE, Hu KF, Lin MX, Tseng CJ, Wu BN, Dai ZK, Hsu JH, Yeh JL
Journal of periodontal research 2025 Jul;60(7):723-736
Journal of periodontal research 2025 Jul;60(7):723-736
Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.
Ma MQ, Yang C, Jin SY, Yang Y, Pan YY, Lin XH
Molecular medicine reports 2025 Jul;32(1)
Molecular medicine reports 2025 Jul;32(1)
HIV-1 Tat mediates microglial NLRP3 inflammasome activation and neurotoxicity by inducing cytosolic mtDNA stress.
Yang X, Han P, Li M, Xue Y, Yu X, Jiang M, Wang H, Zhang J, Liu H, Bao D
International journal of biological macromolecules 2025 Jul;318(Pt 3):145093
International journal of biological macromolecules 2025 Jul;318(Pt 3):145093
Circular RNA-OGDH promotes PANoptosis in diabetic cardiomyopathy: A novel mechanistic insight.
Guan J, Shi X, Ma J, Yin Y, Song G, Li Y, Chen X, Yan Y, Wang D, Liu S, Liu G, Zheng M, Ma F
The Journal of biological chemistry 2025 Jul;301(7):110280
The Journal of biological chemistry 2025 Jul;301(7):110280
Exploration of the Potential Bioactive Compounds and Functional Mechanism of Chaihu Sanshen Capsule in Ameliorating Myocardial Ischaemia-Reperfusion Injury: A Serum Pharmaco-Chemistry With Network Pharmacology Analysis.
Wang W, Zhang Z, Liu R, Zheng Y, Hu Y, Li X, Shen Z, Yuan H, Liu J
Journal of cellular and molecular medicine 2025 Jul;29(14):e70666
Journal of cellular and molecular medicine 2025 Jul;29(14):e70666
Aerobic Exercise Restores Hippocampal Neurogenesis and Cognitive Function by Decreasing Microglia Inflammasome Formation Through Irisin/NLRP3 Pathway.
Zhao R, Tian X, Xu H, Wang Y, Lin J, Wang B
Aging cell 2025 Jul;24(7):e70061
Aging cell 2025 Jul;24(7):e70061
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.
Tang H, Ning K, Wu B, Wang X, He J, Li P, Pan L, Zhang J, He Y, Bian S, Ma X, Zhang J, Liu C, Qin Z, Hu H
Biochemical pharmacology 2025 Jul;237:116932
Biochemical pharmacology 2025 Jul;237:116932
UCP1 prevents the formation of thoracic aortic aneurysms and dissection by inhibiting the TLR4/NLRP3/IL-1β signaling pathway and VSMC phenotype switching in mice.
Xiang J, Yue H, Jiang D, Zheng S, Wu Z
Biochemical pharmacology 2025 Jul;237:116929
Biochemical pharmacology 2025 Jul;237:116929
Andrographolide and its sulfated metabolite alleviated DSS-induced inflammatory bowel disease through regulating inflammation and immune via MAPK/NLRP3 pathways and the balance of Th17/Treg cells.
Zhang HL, Chang J, Sun CP, Huo ZP, Feng YL, Li PY, Jia YX, Hui SW, Zhu QM, Cai JY, He Y, Qiu F, Zhang J
Molecular immunology 2025 Jul;183:313-320
Molecular immunology 2025 Jul;183:313-320
Antidepressant-Like Effects of Electroacupuncture by Regulating NLRP3-mediated Hippocampal Inflammation and Pyroptosis in Rats With Post-Stroke Depression.
Cai W, Wei XF, Tao L, Shen WD
Brain and behavior 2025 Jul;15(7):e70670
Brain and behavior 2025 Jul;15(7):e70670
FTO triggers NLRP3/GSDMD-dependent pyroptosis to enhance cisplatin-sensitivity in ovarian cancer.
Zhang F, Zhu T, Gan L, Du Y, Liu L, Ding H, Chen X, Guan Y
Cellular signalling 2025 Jul;131:111698
Cellular signalling 2025 Jul;131:111698
TREM2 inhibits LPS-induced pyroptosis and inflammation by promoting mitophagy via SYK in BV2 cells.
Jiang W, Fan X, Wu H, Song J, Yang C, Zhao Z
Neurotoxicology and teratology 2025 Jul-Aug;110:107500
Neurotoxicology and teratology 2025 Jul-Aug;110:107500
Pharmacological inhibition of the cGAS-STING pathway suppresses microglia pyroptosis in sepsis-associated encephalopathy.
Zeng QQ, Qi Y, Yu H, Xu Y, Chen JX, Zheng YW, Zhang GF, Zhang QL, Zheng YH, Guo J, Zhao ZH, Wang FS, Jin GL
Journal of neuroinflammation 2025 Jul 9;22(1):176
Journal of neuroinflammation 2025 Jul 9;22(1):176
Vagus nerve stimulation inhibits pyroptosis and improves outcome of cerebral ischemic stroke by upregulating osteopontin (SPP1) to disturb ASC oligomerization.
Wen J, Tang H, Wang L, Yang Q, Zhao Y, Ren Y, Qin T, Li X, Xu J, Jia G, Yang Q
BMC medicine 2025 Jul 7;23(1):407
BMC medicine 2025 Jul 7;23(1):407
Nuclear Receptor ERRγ Protects Against Cardiac Ischemic Injury by Suppressing GBP5-Mediated Myocardial Inflammation.
Qiu J, Che Q, Zhang Y, Chen M, Wei Z, Bai Y, Zhao T, Yan J, Wu Z, Fei Z, Wang Y, Wang Q, Li YG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70819
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70819
The Activation of the Microglial NLRP3 Inflammasome Is Involved in Tuberous Sclerosis Complex-Related Neuroinflammation.
Ding R, Zhang S, Meng L, Wang L, Han Z, Gui J, Yang J, Cheng L, Xie L, Jiang L
International journal of molecular sciences 2025 Jul 26;26(15)
International journal of molecular sciences 2025 Jul 26;26(15)
Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis.
Liu S, Yang Y, Zong Y, Chen W, Geng J, Zhao Y, Du R, He Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156838
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156838
Cornus officinalis loganin attenuates acute lung injury in mice via regulating the PI3K/AKT/NLRP3 axis.
Liu Y, Wang C, Hui T, Yuan Y, Chen S, Li Y, Wang G, Kang J, Xue X
Journal of ethnopharmacology 2025 Jul 24;351:120104
Journal of ethnopharmacology 2025 Jul 24;351:120104
The Expression Pattern of the Splice Variants of Coxsackievirus and Adenovirus Receptor Impacts CV-B3-Induced Encephalitis and Myocarditis in Neonatal Mice.
Zhang X, Zhang X, Zhang Y, Li H, Zheng H, Wang J, Liao Y, Yu L, Li D, Zhao H, Li J, Zhang Z, Shi H, Liu L
International journal of molecular sciences 2025 Jul 24;26(15)
International journal of molecular sciences 2025 Jul 24;26(15)
HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression.
Padia R, Sun L, Liao YF, Calbay O, Chi C, Akter M, Wu L, Fu Z, Zhang DD, Huang S
Cell death & disease 2025 Jul 23;16(1):552
Cell death & disease 2025 Jul 23;16(1):552
Botulinum toxin type A inhibits microglia pyroptosis by suppressing Cblb-mediated degradation of Pdlim1 to attenuate neuropathic pain.
Tian S, Wu L, Zheng H, Cheng Z, Liu J, Liu M, Yu X, Tu J, Wu W
The journal of headache and pain 2025 Jul 22;26(1):165
The journal of headache and pain 2025 Jul 22;26(1):165
Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18.
Fan F, Wang J, Liu K, Zhang S, Gao J, Li X, Ma J, Zhao Y, Li T, Su H, Yang X, Han H, Huang Q, Zhang Y, Pan Y, Ye T, Hu H, Sun Y, Li F, Cao Z, Zhang Y, Zhang X, Chen H
Nature communications 2025 Jul 2;16(1):6074
Nature communications 2025 Jul 2;16(1):6074
Integrated Multi-Omics Profiling Reveals That Highly Pyroptotic MDMs Contribute to Psoriasis Progression Through CXCL16.
Jin L, Xie X, Zhang M, Zhu W, Zhang G, Chen W
Biomedicines 2025 Jul 18;13(7)
Biomedicines 2025 Jul 18;13(7)
Differences in macrophage pyroptosis and polarization induced by nano-/micro-calcium oxalate crystals.
Tong XY, Nong WJ, Tan RM, Ouyang JM
Journal of nanobiotechnology 2025 Jul 10;23(1):499
Journal of nanobiotechnology 2025 Jul 10;23(1):499
Long-term exposure to silica nanoparticles induces cardiac hypertrophy through the pyroptosis pathway.
Wang F, Li Y, Liu R, Li T, Liu L, Wu Y, Su X, Wang X
Toxicological sciences : an official journal of the Society of Toxicology 2025 Jul 1;206(1):158-168
Toxicological sciences : an official journal of the Society of Toxicology 2025 Jul 1;206(1):158-168
Defective RuO(2) Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway.
Lv J, Muhammad F, Wang Z, Qiao C, Gu X, Liu Y, Li W, Gong W, Lv Z, Fei Y, Peng L, Lu Z, Xu N, Hu C, Zhang H, Wu R, Xu X, Wei H, Sun Z, Shi D
ACS nano 2025 Jul 1;19(25):23080-23095
ACS nano 2025 Jul 1;19(25):23080-23095
AK4 promotes nasopharyngeal carcinoma metastasis and chemoresistance by activating NLRP3 inflammatory complex.
Liu SL, Yuan L, Sun XS, Xiao BB, Lan KQ, Lu ZJ, Lin DF, Li XY, Yan JJ, Yan SM, Chen QY, Tang LQ, Mai HQ
Cell death & disease 2025 Jul 1;16(1):480
Cell death & disease 2025 Jul 1;16(1):480
Naringin mitigates experimental autoimmune prostatitis by modulating oxidative stress and the NLRP3 inflammasome via the PPAR-γ/NF-κB pathway.
Zhou W, Zhang XR, Qin XC, Xie YC, Zhang D, Wang ZC, Zhang CX
Scientific reports 2025 Jul 1;15(1):20843
Scientific reports 2025 Jul 1;15(1):20843
Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice.
Ma J, Hu X, Zhang W, Tao M, Wang M, Lu W
Endocrine 2025 Jan;87(1):159-169
Endocrine 2025 Jan;87(1):159-169
Selective Activation of G Protein-Coupled Estrogen Receptor 1 (GPER1) Reduces ER Stress and Pyroptosis via AMPK Signaling Pathway in Experimental Subarachnoid Hemorrhage.
Liang Y, Fu W, Tang Y, Ye H, Wang Y, Sun C, Xiang Y, Xiong W, Cui M, Chen Y, Wang T, Deng Y
Molecular neurobiology 2025 Jan;62(1):871-884
Molecular neurobiology 2025 Jan;62(1):871-884
Ginsenoside Rg1 improves hypoxia-induced pulmonary vascular endothelial dysfunction through TXNIP/NLRP3 pathway-modulated mitophagy.
Zhang R, Lu M, Ran C, Niu L, Qi Q, Wang H
Journal of ginseng research 2025 Jan;49(1):80-91
Journal of ginseng research 2025 Jan;49(1):80-91
Pyroptosis inhibition alleviates acute lung injury via E-twenty-six variant gene 5-mediated downregulation of gasdermin D.
Zhang W, Wang X, Ma C, Liang B, Ma L, Wang Y, Lin Y, Han S
Respiratory physiology & neurobiology 2025 Jan;331:104346
Respiratory physiology & neurobiology 2025 Jan;331:104346
Tanreqing Injection Inhibits Activation of NLRP3 Inflammasome in Macrophages Infected with Influenza A Virus by Promoting Mitophagy.
Liu TY, Hao Y, Mao Q, Zhou N, Liu MH, Wu J, Wang Y, Yang MR
Chinese journal of integrative medicine 2025 Jan;31(1):19-27
Chinese journal of integrative medicine 2025 Jan;31(1):19-27
Remifentanil-induced inflammation in microglial cells: Activation of the PAK4-mediated NF-κB/NLRP3 pathway and onset of hyperalgesia.
Cui C, Wu X, Dong S, Chen B, Zhang T
Brain, behavior, and immunity 2025 Jan;123:334-352
Brain, behavior, and immunity 2025 Jan;123:334-352
Evaluation of the protective role of resveratrol on LPS-induced septic intestinal barrier function via TLR4/MyD88/NF-κB signaling pathways.
Shi Z, Jiao Y, Lai Z, Liu J, Yang B, Hu M, Meng J
Scientific reports 2025 Jan 4;15(1):828
Scientific reports 2025 Jan 4;15(1):828
Upregulation of LXRβ/ABCA1 pathway alleviates cochlear hair cell senescence of C57BL/6 J mice via reducing lipid droplet accumulation.
Guo D, Wu J, Shen C, Zhang A, Zou T, Chen K, Huang W, Pan Y, Shen Y, Ji P, Zhong Y, Wen Q, Kong B, Xiang M, Ye B
Biogerontology 2025 Jan 31;26(2):49
Biogerontology 2025 Jan 31;26(2):49
Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway.
Li B, Yu K, Zhou X, Sun J, Qi L, Li W, Yang T, Li W, Wang N, Gu X, Cui S, Cao R
The journal of headache and pain 2025 Jan 27;26(1):16
The journal of headache and pain 2025 Jan 27;26(1):16
Sulforaphane regulation autophagy-mediated pyroptosis in autoimmune hepatitis via AMPK/mTOR pathway.
Yang W, Zeng S, Shao R, Jin R, Huang J, Wang X, Liu E, Zhou T, Li F, Chen Y, Chen D
International immunopharmacology 2025 Jan 27;146:113826
International immunopharmacology 2025 Jan 27;146:113826
Combination of inorganic nitrate and vitamin C prevents collagen-induced arthritis in rats by inhibiting pyroptosis.
Zhang H, Zhang Y, Zhang Y, Wei H, Jin S, Huo T, Qin L
Food & function 2025 Jan 20;16(2):673-690
Food & function 2025 Jan 20;16(2):673-690
Ganoderic Acid A Alleviates Severe Acute Pancreatitis by Modulating Gut Homeostasis and Inhibiting TLR4-NLRP3 Signaling.
Zhang L, Wang K, Huang L, Deng B, Chen C, Zhao K, Wang W
Journal of agricultural and food chemistry 2025 Jan 15;73(2):1563-1579
Journal of agricultural and food chemistry 2025 Jan 15;73(2):1563-1579
Macrophage NLRP3 inflammasome mediates the effects of sympathetic nerve on cardiac remodeling in obese rats.
Xi Z, Shu L, Xiao L, Fang X, Dai M, Wang J, Wu Y, Zhang J, Bao M
Molecular and cellular endocrinology 2025 Jan 15;596:112417
Molecular and cellular endocrinology 2025 Jan 15;596:112417
FABP5 regulates ROS-NLRP3 inflammasome in glutamate-induced retinal excitotoxic glaucomatous model.
Zeng Z, You M, Fan C, Jang J, Xia X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 15;39(1):e70281
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 15;39(1):e70281
α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation.
Wang H, Zhang H, Miao L, Wang C, Teng H, Li X, Zhang X, Yang G, Wang S, Zeng X
Ecotoxicology and environmental safety 2025 Jan 15;290:117749
Ecotoxicology and environmental safety 2025 Jan 15;290:117749
Allogeneic platelet lysate activates the SIRT1-PINK1/Parkin pathway: A promising approach for improving mitochondrial function in an in vitro model of intervertebral disc degeneration.
Ding Z, Du W, Huang J, Han J, Bai J, Yang G, Zhang Y, Ding Y
International immunopharmacology 2025 Jan 10;144:113700
International immunopharmacology 2025 Jan 10;144:113700
NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats.
Liu Y, Wang W, Liang B, Zou Z, Zhang A
Ecotoxicology and environmental safety 2025 Jan 1;289:117504
Ecotoxicology and environmental safety 2025 Jan 1;289:117504
Complex immunotoxic effects of T-2 Toxin on the murine spleen and thymus: Oxidative damage, inflammasomes, apoptosis, and immunosuppression.
Chen M, Zhang Y, Zhao Y, Cao K, Niu R, Guo D, Sun Z
Ecotoxicology and environmental safety 2025 Jan 1;289:117476
Ecotoxicology and environmental safety 2025 Jan 1;289:117476
Donkey milk supplementation alleviates renal fibrosis of chronic kidney disease by enhancing anti-inflammatory ability.
Huimin C, Peng W, Man C, Hong L, Yuxin Z, Zhiyu P, Jianjun Y
Journal of dairy science 2025 Feb;108(2):1198-1210
Journal of dairy science 2025 Feb;108(2):1198-1210
Effects of canagliflozin preconditioning on post-resuscitation myocardial function in a diabetic rat model of cardiac arrest and cardiopulmonary resuscitation.
Wang M, Hua T, Zhang Y, Huang Q, Shi W, Chu Y, Hu Y, Pan S, Ling B, Tang W, Yang M
European journal of pharmacology 2025 Feb 5;988:177212
European journal of pharmacology 2025 Feb 5;988:177212
Jingui Shenqi Wan alleviates bone loss induced by primary osteoporosis by inhibiting osteoblast pyroptosis.
Qian Y, Yu Y, Yang F, Liang Q, Xu D, Chen J, Hu X
Journal of orthopaedic surgery and research 2025 Feb 5;20(1):141
Journal of orthopaedic surgery and research 2025 Feb 5;20(1):141
Circadian disruption by simulated shift work aggravates periodontitis via orchestrating BMAL1 and GSDMD-mediated pyroptosis.
Wang Y, Li R, Ye Q, Fei D, Zhang X, Huang J, Liu T, Wang J, Wang Q
International journal of oral science 2025 Feb 25;17(1):14
International journal of oral science 2025 Feb 25;17(1):14
LncRNA-Gm17586 inhibits S.typhimurium mediated pyroptosis by promoting NLRP3 and Tnip1 binding.
An Z, Ding W
Scientific reports 2025 Feb 25;15(1):6713
Scientific reports 2025 Feb 25;15(1):6713
Mechanistic studies of Ca(2+)-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation.
Xiang J, Lv M, Luo Y, Ke K, Zhang B, Wang M, Zhang K, Li H
Scientific reports 2025 Feb 24;15(1):6669
Scientific reports 2025 Feb 24;15(1):6669
α-Cyperone Alleviates LPS-Induced Pyroptosis in Rat Aortic Endothelial Cells via the PI3K/AKT Signaling Pathway.
Liu S, Zhang Y, Liang X, Yin L, He C
Pharmaceuticals (Basel, Switzerland) 2025 Feb 22;18(3)
Pharmaceuticals (Basel, Switzerland) 2025 Feb 22;18(3)
Early Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infection Induces Necroptosis in Immune Cells of Peripheral Lymphoid Organs.
Xu J, Huo C, Yang Y, Han J, Zhou L, Hu Y, Yang H
Viruses 2025 Feb 20;17(3)
Viruses 2025 Feb 20;17(3)
Long non-coding RNA NRIR inhibits osteogenesis in peri-implantitis by promoting NLRP3 inflammasome-mediated macrophage pyroptosis.
Wang L, Zhao R, Xiao K, Zhou Y, Liu Q, Yu K
International immunopharmacology 2025 Feb 20;148:114180
International immunopharmacology 2025 Feb 20;148:114180
Anticancer effects of OSW-1 on colorectal cancer cells via the ROS/NLRP3/Caspase-1 pyroptosis signaling pathway.
Yao Y, Chen Y, Yao T, Li C, Li S, Wang N
International immunopharmacology 2025 Feb 20;148:114054
International immunopharmacology 2025 Feb 20;148:114054
NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury.
Zheng XB, Wang X, Gao SQ, Gao CC, Li T, Han YL, Zhao R, Sun Y, Miao SH, Qiu JY, Jin WX, Zhou ML
Cell death discovery 2025 Feb 20;11(1):69
Cell death discovery 2025 Feb 20;11(1):69
Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium.
Wu MF, Peng X, Zhang MC, Guo H, Xie HT
Free radical biology & medicine 2025 Feb 16;228:173-182
Free radical biology & medicine 2025 Feb 16;228:173-182
Dihydromyricetin/montmorillonite intercalation compounds ameliorates DSS-induced colitis: Role of intestinal epithelial barrier, NLRP3 inflammasome pathway and gut microbiota.
Jiang L, Ma X, Yan Q, Pu D, Fu X, Zhang D
International journal of pharmaceutics 2025 Feb 10;670:125155
International journal of pharmaceutics 2025 Feb 10;670:125155
Grape Seed Proanthocyanidins Mitigate Acute High-Altitude Hypoxia-Induced Brain Injury by Inhibiting NLRP3 Inflammasome via Autophagy Pathway.
Huang D, Ai C, Guo Y, Chen J, Qin Z, Li X, Niu S, Qumu M, Chen Z, Liu W, Li R, Wang X
Molecular neurobiology 2025 Dec;62(12):15715-15729
Molecular neurobiology 2025 Dec;62(12):15715-15729
PD-1 Attenuates Neuropathic Pain by Ameliorating NLRP3 Inflammasome-Mediated Microglia Pyroptosis.
Deng D, Ma L, Shen J, Huang L, Zhang T, Yang X, Huang S, Zhao W, Zhou Y, Fan S, Wang K, Chen X
Molecular neurobiology 2025 Dec;62(12):15478-15493
Molecular neurobiology 2025 Dec;62(12):15478-15493
METTL3 promotes podocyte pyroptosis in diabetic nephropathy through N(6)-methyladenosine modification of TRIM29 mRNA.
Xu X, Huang X, Zhang C, Mi X, Zhang C, Hua F, Zhang L
Renal failure 2025 Dec;47(1):2497492
Renal failure 2025 Dec;47(1):2497492
HMGB1 impairs nasal mucosa epithelial barrier function in allergic rhinitis by promoting BECN1-mediating autophagy.
Ma Z, Tu L, Yang X, Mao M, Chen G, Chen F, Liao L, Xu Y
Biochemistry and biophysics reports 2025 Dec;44:102351
Biochemistry and biophysics reports 2025 Dec;44:102351
Neutrophil CD11b is a pivotal PANoptosis marker correlated with disease activity in antineutrophil cytoplasmic antibody-associated vasculitis.
Han XY, Zhao YY, Chen SF, Li ZY, Zhao MH, Chen M
Apoptosis : an international journal on programmed cell death 2025 Dec;30(11-12):3115-3128
Apoptosis : an international journal on programmed cell death 2025 Dec;30(11-12):3115-3128
Docking and database screening identify manidipine as a potential modulator of matrix metalloproteinase-7 in chronic kidney disease.
Liao CT, Lin YC, Huang HJ, Liu WC, Kan WC, Chiu HW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Dec;193:118748
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Dec;193:118748
Modulation of lipid droplet biogenesis by p38 MAPK and caspase-1 in docosahexaenoic acid-induced EA.hy926 endothelial cell apoptosis.
Du Y, Lv X, Shen Y, Ren X, Ye S
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Dec;1870(8):159683
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Dec;1870(8):159683
Anti-inflammatory Effects of Membrane Vesicles from Eubacterium rectale via the NLRP3 Signal Pathway.
Zhang H, Zhao Y, Li D, Li H, Wang Z, Zhang L, Niu H, Huang Y, Zhao C, Jin Y, Zhou D
Probiotics and antimicrobial proteins 2025 Dec;17(6):4841-4850
Probiotics and antimicrobial proteins 2025 Dec;17(6):4841-4850
Gut microbial Nordihydroguaiaretic acid suppresses macrophage pyroptosis to regulate epithelial homeostasis and inflammation.
Wang J, Tan H, Ye Z, Weng S, Shi Y, Xu J, Liu H, Li J, Huang L, Zhai L, Luo H, Lin Z, Zhong C, Tang J, Wang Z, Zhang H, Zhang B, Huang C
Gut microbes 2025 Dec;17(1):2518338
Gut microbes 2025 Dec;17(1):2518338
CD44 is a macrophage receptor for TcdB from Clostridioides difficile that via its lysine-158 succinylation contributes to inflammation.
Chen Z, Zhang W, Wang D, Luo R, Yao Y, Tao X, Li L, Pan Q, Sun X
Gut microbes 2025 Dec;17(1):2506192
Gut microbes 2025 Dec;17(1):2506192
A20 Attenuates Inflammatory Injury in Bovine Endometrial Epithelial Cells Through Autophagy-Mediated NLRP3 Inflammasome Inactivation.
Jiang Y, Fei F, Wang X, Jiang Y, Liu K, Guo L, Cui L, Wang H, Dong J, Li J
Animals : an open access journal from MDPI 2025 Dec 5;15(24)
Animals : an open access journal from MDPI 2025 Dec 5;15(24)
Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.
Sun B, Wu J, Li Z, Zhang Y, Lu X, Wang J, Xu X
International immunopharmacology 2025 Dec 3;166:115639
International immunopharmacology 2025 Dec 3;166:115639
Chaize mixture alleviates NAFLD by regulating Glipr2-related autophagy/NLRP3 signaling.
Zhang X, Shi J, Liu Y, Lu Y, Ji J, Wang X, Liu J, Cheng F, Zhang Q, Ma C
International immunopharmacology 2025 Dec 3;166:115600
International immunopharmacology 2025 Dec 3;166:115600
ZIKV infection causes placental inflammation through activating PANoptosis.
Zhang S, Chen D, Zhang K, Liu M, Liang H, Liang L, Liang J, Liang M, An S, Lyu M, Zhu J, Li S, Hu D, Zhu X, Wu J, He Z, Li M
Journal of virology 2025 Dec 23;99(12):e0175925
Journal of virology 2025 Dec 23;99(12):e0175925
Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling.
Ning P, Wu J, Long Q, Zheng Y, Gan J, Hu X, Song S, Li X, Jiang M, Ye H, Yu W, He Y, Zheng Y, Gao Z
Inflammation 2025 Dec 20;49(1):11
Inflammation 2025 Dec 20;49(1):11
Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis.
Yu K, Liu M, Zhang T, Guo C, Du L, Li M, Wang Q, Han N, Chi Y, Li Y
Diabetology & metabolic syndrome 2025 Dec 2;18(1):7
Diabetology & metabolic syndrome 2025 Dec 2;18(1):7
Integrating Network Pharmacology, Molecular Docking, and Experimental Validation: Andrographolide Attenuates Acute Liver Injury via the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway.
Zhang Y, Liu S, Liang X, Yin L, He C
Biomolecules 2025 Dec 16;15(12)
Biomolecules 2025 Dec 16;15(12)
Clostridium scindens attenuates acute kidney injury by producing indole-3-acetic acid.
Cao YZ, Li JY, Hu JM, Su K, Chen JL, Liu Y, Wei JL, Zhang ZH
NPJ biofilms and microbiomes 2025 Dec 15;12(1):16
NPJ biofilms and microbiomes 2025 Dec 15;12(1):16
miR-23a-5p Alleviates Gouty Inflammation by Targeting Interleukin-17A and Inhibiting NLR Family Pyrin Domain Containing 3 Inflammasome Activation.
Yuan X, Lin C, Zhang Y, He H, Li L
Archives of rheumatology 2025 Dec 1;40(4):443-451
Archives of rheumatology 2025 Dec 1;40(4):443-451
Inhibition of BRD4 alleviates pyroptosis induced by testicular ischemia/reperfusion injury through the NLRP3 pathway.
Wang J, Ning J, Zhou Z, Li H
Tissue & cell 2025 Aug;95:102919
Tissue & cell 2025 Aug;95:102919
Gegen Qinlian Decoction improves Alzheimer's disease through TLR4/NF-κB/NLRP3 pathway.
Zhang B, Chen L, Kang M, Ai L, Tao Y
Tissue & cell 2025 Aug;95:102818
Tissue & cell 2025 Aug;95:102818
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling.
Chen X, Zhang F, Zhou Z, Jiang D, Wen L
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):789-800
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):789-800
NOD3 Reduces Sepsis-Induced Acute Lung Injury by Regulating the Activation of NLRP3 Inflammasome and the Polarization of Alveolar Macrophages.
Zhao Y, Wu Y, Qu L, Hu Y, Sun S, Yao R, Li R
Inflammation 2025 Aug;48(4):2395-2406
Inflammation 2025 Aug;48(4):2395-2406
Paeoniflorin protected UVA-exposed skin fibroblasts from caspase-3/GSDME mediated pyroptosis.
Shi D, Chu H, Sun Y, He H, Huang W, Pan H, Ma C, Yao S, Shi M, Wang H, Wu Y
Journal of photochemistry and photobiology. B, Biology 2025 Aug;269:113188
Journal of photochemistry and photobiology. B, Biology 2025 Aug;269:113188
Deoxynivalenol induces pyroptosis and IL-1β secretion via P2X7R signal in murine RAW264.7 macrophages.
Qin Z, Zhang H, Zhang J, Li T, Kuca K, Liu J, Wu W
Toxicon : official journal of the International Society on Toxinology 2025 Aug;263:108418
Toxicon : official journal of the International Society on Toxinology 2025 Aug;263:108418
Cilostazol attenuates vascular inflammation via the regulation of TICAM1/IRF3 signaling pathway.
Chiu HW, Shih CC, Huang HJ, Huang TH, Sung LC
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Aug;189:118275
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Aug;189:118275
Activation of HTR2B Suppresses Osteosarcoma Progression through the STAT1-NLRP3 Inflammasome Pathway and Promotes OASL1+ Macrophage Production to Enhance Antitumor Immunity.
Huang Z, Zhu J, Hu J, Wang X, Ma X, Xu E, Zhu K, Zhang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e15276
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e15276
SRPK1 is a significant factor in driving the progression of diabetic kidney fibrosis.
Han S, Ma S, Liu K, Qi R, Wang G, Qin W, Zhang X
Diabetology & metabolic syndrome 2025 Aug 6;17(1):316
Diabetology & metabolic syndrome 2025 Aug 6;17(1):316
Solidago decurrens Lour. controls LPS-induced acute lung injury by reducing inflammatory responses and modulating the TLR4/NF-κB/NLRP3 signaling pathway.
Ma DY, Peng LF, Gao XY, Xing TJ, Hao ZH
Journal of ethnopharmacology 2025 Aug 29;352:120172
Journal of ethnopharmacology 2025 Aug 29;352:120172
Targeting Wnt/beta-catenin signaling to attenuate short-chain chlorinated paraffins-triggered hepatocyte mitochondrial fission and subsequent pyroptosis.
Xiao J, Huang D, Wang F, Gan L, Zhang W, Zhang F, Tang J, Shen Z, Jiang M, Egbobe JO, Shao J, Wang X, Zhang Y, Ju L, Zhao X
International immunopharmacology 2025 Aug 28;161:115102
International immunopharmacology 2025 Aug 28;161:115102
Caspase-8-driven NLRP3 inflammasome activation exacerbates bronchopulmonary dysplasia by increasing the apoptosis and pyroptosis crosstalk of alveolar epithelial cells.
Huang D, Xu D, You C, Li B, Li L, Yang Q, Zhou W, Meng Q, Liang Z
International immunopharmacology 2025 Aug 28;161:115025
International immunopharmacology 2025 Aug 28;161:115025
5-ALA mediated PDT induces pyroptosis in colorectal cancer cells by targeting the caspase-1/GSDMD pathway.
Zhang DY, Gu Z, Shi L, Li Z, Du X, Li Y
Lasers in medical science 2025 Aug 27;40(1):344
Lasers in medical science 2025 Aug 27;40(1):344
Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism.
Ji J, An ZY, Khan A, Peng L, Kulshreshtha S, Salama ES, Yun H, Liu P, Jin WL, Li X
NPJ science of food 2025 Aug 23;9(1):183
NPJ science of food 2025 Aug 23;9(1):183
SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL.
Xiong X, Zhi Y, Yang N, Zhao W, Wang S, Zhu H, Tang J, Yi J, Sun X, Yang J
iScience 2025 Aug 15;28(8):113067
iScience 2025 Aug 15;28(8):113067
Vitamin D improves diabetic cardiomyopathy by inhibiting pyroptosis through the NOX4/NLRP3 inflammasome pathway.
Wang D, Sun Z, Zhang H, Xiang J, Wu H, Lu C, Li M, Ma Y, Liu G, Wang L
Food & function 2025 Aug 11;16(16):6718-6732
Food & function 2025 Aug 11;16(16):6718-6732
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood-Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation.
Luo L, Hu Q, Yan R, Gao X, Zhang D, Yan Y, Liu Q, Mao S
Molecular neurobiology 2025 Apr;62(4):5252-5272
Molecular neurobiology 2025 Apr;62(4):5252-5272
Schistosoma mansoni soluble egg antigen suppresses colorectal cancer growth in vitro and in vivo.
Pekkle Lam HY, Liang TR, Jiang SJ, Peng SY
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2025 Apr;58(2):241-250
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2025 Apr;58(2):241-250
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy.
Zheng YY, Shen DN, Peng XL, San WQ, Zhou QY, Yang SJ, Meng GL, Shi JH, Chen Y
Acta pharmacologica Sinica 2025 Apr;46(4):940-950
Acta pharmacologica Sinica 2025 Apr;46(4):940-950
Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation.
Yan LJ, Qi S, Wu C, Jin R, Hu C, Wang AL, Wang BL, Yu HW, Wang L, Liu J, Qi ZP, Wang WC, Liu QS
Acta pharmacologica Sinica 2025 Apr;46(4):1016-1029
Acta pharmacologica Sinica 2025 Apr;46(4):1016-1029
Jinxin oral liquid reduced lung inflammation in influenza A virus infected mice through inhibiting NOD-like receptor protein 3 pathway.
Tao LI, Xianzheng W, Yingcai X, Qigang D, Shouchuan W, Jianjian JI
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Apr;45(2):281-290
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Apr;45(2):281-290
Exercise-induced Sesn2 mediates autophagic flux to alleviate neural damage after ischemic stroke in mice.
Zhao Y, Ying X, Pang X, Lin Y, Shen J, Zhao Y, Shen W, Yang Y, Hong Z, Wu W, Hu X, Xie Q
Experimental neurology 2025 Apr;386:115174
Experimental neurology 2025 Apr;386:115174
TNFAIP3-interacting protein 1 (ABIN-1) negatively regulates caspase-8/FADD-dependent pyroptosis.
Li X, Wang D, Su Z, Mao X
The FEBS journal 2025 Apr;292(8):1972-1990
The FEBS journal 2025 Apr;292(8):1972-1990
Systemic Lupus Erythematosus Exacerbates Hip Arthritis by Promoting Chondrocyte Pyroptosis in the Femoral Head via Activating the NF-κB Pathway.
Fang X, Zhang H, Zhou H, Shen S, Lao Z, Zhang Z, Bian Y, Zhou C, Jin H, Tong P, Huang Y, Zhou H, Zeng H, Fu F, Wu C, Zheng W, Ruan H
Journal of cellular and molecular medicine 2025 Apr;29(7):e70531
Journal of cellular and molecular medicine 2025 Apr;29(7):e70531
Astaxanthin alleviates spinal nerve ligation-induced neuropathic pain by modulating propionic acid levels.
Li J, Dong D, Sun Y, Wang Q, Li Y, Tao X, Wang K, Zhao L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156448
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156448
Qingyi decoction and its active ingredients ameliorate acute pancreatitis by regulating acinar cells and macrophages via NF-κB/NLRP3/Caspase-1 pathways.
An Y, Tu Z, Wang A, Gou W, Yu H, Wang X, Xu F, Li Y, Wang C, Li J, Zhang M, Xiao M, Di Y, Hou W, Cui Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156424
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156424
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
Li X, Jin S, Wang D, Wu Y, Tang X, Liu Y, Yao T, Han S, Sun L, Wang Y, Hou SX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2414260
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2414260
Shuxuetong injection inhibits pyroptosis in acute ischemic stroke via CD44/NLRP3/GSDMD signal.
Shang J, Huang G, Wang B, Wang J, Wei W, Cui Y, Liu X
Journal of ethnopharmacology 2025 Apr 9;345:119618
Journal of ethnopharmacology 2025 Apr 9;345:119618
Urolithin A ameliorates schizophrenia-like behaviors and cognitive impairments in female rats by modulating NLRP3 signaling.
Huang Z, Chen G, Ren Z, Xiao L, Chen Z, Xie Y, Wang G, Zhou B
International immunopharmacology 2025 Apr 4;151:114336
International immunopharmacology 2025 Apr 4;151:114336
Punicalagin relieves hepatic injury by antioxidation and enhancement of autophagy in diet-induced nonalcoholic steatohepatitis.
Ma L, Sun H, Xiang N, Xu Q
Scientific reports 2025 Apr 25;15(1):14516
Scientific reports 2025 Apr 25;15(1):14516
Identification and Exploration of Pyroptosis-Related Genes in Macrophage Cells Reveal Necrotizing Enterocolitis Heterogeneity Through Single-Cell and Bulk-Sequencing.
Zhang P, Li Y, Xu P, Zou P, Sheng S, Xiao R, Xu P, Chen Y, Du Y, Ma L, Wang Y
International journal of molecular sciences 2025 Apr 24;26(9)
International journal of molecular sciences 2025 Apr 24;26(9)
N-acetylserotonin derivative ameliorates hypoxic-ischemic brain damage by promoting PINK1/Parkin-dependent mitophagy to inhibit NLRP3 inflammasome-induced pyroptosis.
Fang F, Tang J, Geng J, Fang C, Zhang B
International immunopharmacology 2025 Apr 24;153:114469
International immunopharmacology 2025 Apr 24;153:114469
Enriched environment alleviates NLRP3 inflammasome mediated neuroinflammation in diabetes complicated with depression rats.
Wang H, Liang Q, Wen Z, Ma W, Ji S, Zhang H, Zhang X
Scientific reports 2025 Apr 23;15(1):14214
Scientific reports 2025 Apr 23;15(1):14214
TLR4-mediated endoplasmic reticulum stress regulates pyroptosis in macrophages infected with the Bacillus Calmette-Guérin mycobacterial.
Nie X, Miao S, Hou Y, Ma Y, Li M, Liu Y, Yang Y, Xu J, Wang Y
International immunopharmacology 2025 Apr 16;152:114346
International immunopharmacology 2025 Apr 16;152:114346
Downregulation of the HCN1 Channel Alleviates Anxiety- and Depression-Like Behaviors in Mice With Cerebral Ischemia-Reperfusion Injury by Suppressing the NLRP3 Inflammasome.
Zhou M, Tao X, Lin K, Leng C, Yang Y, Gui Y, Sun Y, Zhou M, Sun B, Xia Y, Shu X, Liu W
Journal of the American Heart Association 2025 Apr 15;14(8):e038263
Journal of the American Heart Association 2025 Apr 15;14(8):e038263
VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway.
Zhang X, Liu T, Ma Z, Li G, Ding N, Wang Z, Guan Y, Zhang Y, Liu L, Chen X
Journal of translational medicine 2025 Apr 12;23(1):437
Journal of translational medicine 2025 Apr 12;23(1):437
An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death.
Terraza-Silvestre E, Villamuera R, Bandera-Linero J, Letek M, Oña-Sánchez D, Ramón-Barros C, Moyano-Jimeno C, Pimentel-Muiños FX
Nature communications 2025 Apr 10;16(1):3409
Nature communications 2025 Apr 10;16(1):3409
TLR4/Rac1/NLRP3 Pathway Mediates Amyloid-β-Induced Neuroinflammation in Alzheimer's Disease.
Zhu M, Liu Y, Chen C, Chen H, Ni W, Song Y, Lv B, Hua F, Cui G, Zhang Z
Journal of Alzheimer's disease : JAD 2024;99(3):911-925
Journal of Alzheimer's disease : JAD 2024;99(3):911-925
Xuebijing improves inflammation and pyroptosis of acute lung injury by up-regulating miR-181d-5p-mediated SPP1 inactivation.
Wu X, Xin R, Zhang Y, Yang C, Sun F, Wang Y, Zheng F
Clinics (Sao Paulo, Brazil) 2024;79:100336
Clinics (Sao Paulo, Brazil) 2024;79:100336
M2 Macrophage-Derived Small Extracellular Vesicles Ameliorate Pyroptosis and Intervertebral Disc Degeneration.
Zhang K, Du L, Li Z, Huo Z, Shen L, Gao S, Jia Y, Zhu M, Xu B
Biomaterials research 2024;28:0047
Biomaterials research 2024;28:0047
Exploring the effects of hypoxia and reoxygenation time on hepatocyte apoptosis and inflammation.
Xu X, Zhou T, Tulahong A, Ruze R, Shao Y
PloS one 2024;19(11):e0310535
PloS one 2024;19(11):e0310535
TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway.
Zhao X, Zhang J, Xu F, Shang L, Liu Q, Shen C
Open life sciences 2024;19(1):20220957
Open life sciences 2024;19(1):20220957
Interleukin 1β Mediates the Pathogenesis of Nasal Mucosal Epithelial Barrier Dysfunction in Allergic Rhinitis.
Wang H, Song X, Wang Y, Yang T, Liu W, Mou Y, Ren C, Song X
Journal of inflammation research 2024;17:9071-9085
Journal of inflammation research 2024;17:9071-9085
Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways.
Li J, Du X, Mu Z, Han X
Journal of inflammation research 2024;17:8009-8026
Journal of inflammation research 2024;17:8009-8026
Shenfu Injection Mediated NLRP3/Caspase 1 Through (R)-Norcoclaurinee Alleviates Sepsis-Induced Cognitive Dysfunction.
Liu X, Ding H, Chen M, Li X, Xiao Y, Han Y, Zeng H
Journal of inflammation research 2024;17:7295-7310
Journal of inflammation research 2024;17:7295-7310
Identification and Validation of a Necroptosis-Related Prognostic Model in Tumor Recurrence and Tumor Immune Microenvironment in Breast Cancer Management.
Wang X, Chen Z, Tang J, Cao J
Journal of inflammation research 2024;17:5057-5076
Journal of inflammation research 2024;17:5057-5076
Augmented Cornus officinalis Levels in Liuwei Dihuang Decoction Inhibits Nucleus Pulposus Cell Pyroptosis to Enhance Therapeutic Efficacy Against Intervertebral Disc Degeneration.
Ge Y, Xie Y, Chai J, Ji W, Lou X, Tian K, Bao R, Wu C, Ruan H
Journal of inflammation research 2024;17:4453-4465
Journal of inflammation research 2024;17:4453-4465
Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway.
Sun M, Wang F, Li H, Li M, Wang Y, Wang C, Zhang Y, Zhang D, Li J, Yao S
Journal of inflammation research 2024;17:1349-1364
Journal of inflammation research 2024;17:1349-1364
Elabela mitigates the early stage of inflammation in sepsis by inhibiting pyroptosis.
Huang Y, Yu Y, Wang T, Zhao J, Zhang X
American journal of translational research 2024;16(4):1165-1176
American journal of translational research 2024;16(4):1165-1176
Exosomes from IH- Induced bEnd3 Cells Promote OSA Cognitive Impairment via miR-20a-5p/MFN2 Mediated Pyroptosis of HT22 Cells.
Chen Z, Shang Y, Ou Y, Zhou L, Liu T, Gong S, Xiang X, Peng Y, Ouyang R
Nature and science of sleep 2024;16:2063-2082
Nature and science of sleep 2024;16:2063-2082
Cynaroside: a potential therapeutic agent targeting arachidonate 15-lipoxygenase to mitigate cerebral ischemia/reperfusion injury.
Cao W, Hu Y, Yu X, Long T, Sun B, Lei S, Xie P, Yu W
Frontiers in neurology 2024;15:1490640
Frontiers in neurology 2024;15:1490640
Spermidine attenuates chondrocyte inflammation and cellular pyroptosis through the AhR/NF-κB axis and the NLRP3/caspase-1/GSDMD pathway.
Guo X, Feng X, Yang Y, Zhang H, Bai L
Frontiers in immunology 2024;15:1462777
Frontiers in immunology 2024;15:1462777
KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.
Chen Y, Wu X, Jiang Z, Li X
Frontiers in pharmacology 2024;15:1461931
Frontiers in pharmacology 2024;15:1461931
(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway.
Li S, Zhang J, Zhao Y, Kang L, Jie H, Dong B
Frontiers in pharmacology 2024;15:1453647
Frontiers in pharmacology 2024;15:1453647
Gasdermin D could be lost in the brain parenchyma infarct core and a pyroptosis-autophagy inhibition effect of Jie-Du-Huo-Xue decoction after stroke.
Zhou C, Qiu SW, Wang FM, Liu YC, Hu W, Yang ML, Liu WH, Li H
Frontiers in pharmacology 2024;15:1449452
Frontiers in pharmacology 2024;15:1449452
Yinqin Qingfei granules alleviate Mycoplasma pneumoniae pneumonia via inhibiting NLRP3 inflammasome-mediated macrophage pyroptosis.
Song Z, Han C, Luo G, Jia G, Wang X, Zhang B
Frontiers in pharmacology 2024;15:1437475
Frontiers in pharmacology 2024;15:1437475
Placental mesenchymal stem cells suppress inflammation and promote M2-like macrophage polarization through the IL-10/STAT3/NLRP3 axis in acute lung injury.
Nie Z, Fan Q, Jiang W, Wei S, Luo R, Hu H, Liu G, Lei Y, Xie S
Frontiers in immunology 2024;15:1422355
Frontiers in immunology 2024;15:1422355
Erythrocyte membrane biomimetic EGCG nanoparticles attenuate renal injury induced by diquat through the NF-κB/NLRP3 inflammasome pathway.
Qu J, Pei H, Li XZ, Li Y, Chen JM, Zhang M, Lu ZQ
Frontiers in pharmacology 2024;15:1414918
Frontiers in pharmacology 2024;15:1414918
Fexuprazan safeguards the esophagus from hydrochloric acid-induced damage by suppressing NLRP1/Caspase-1/GSDMD pyroptotic pathway.
Kim SY, Yoon JH, Jung DH, Kim GH, Kim CH, Lee SK
Frontiers in immunology 2024;15:1410904
Frontiers in immunology 2024;15:1410904
Targeting the PANoptosis signaling pathway for myocardial protection: therapeutic potential of Xian Ling Gu Bao capsule.
Wu X, Wei J, Zhang W, Yi Y, Wang T, Gong Q, Liu X, Li H, Gao J
Frontiers in pharmacology 2024;15:1391511
Frontiers in pharmacology 2024;15:1391511
Thonningianin A ameliorated renal interstitial fibrosis in diabetic nephropathy mice by modulating gut microbiota dysbiosis and repressing inflammation.
Zhang S, Zhang S, Bai X, Wang Y, Liu Y, Liu W
Frontiers in pharmacology 2024;15:1389654
Frontiers in pharmacology 2024;15:1389654
Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson's rats.
Wang J, Li H, Wang C, Li D, Zhang Y, Shen M, Xu X, Wu T
Frontiers in neurology 2024;15:1367973
Frontiers in neurology 2024;15:1367973
Corilagin alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation via the Olfr2 signaling pathway in vitro and in vivo.
Mao J, Chen Y, Zong Q, Liu C, Xie J, Wang Y, Fisher D, Hien NTT, Pronyuk K, Musabaev E, Li Y, Zhao L, Dang Y
Frontiers in immunology 2024;15:1364161
Frontiers in immunology 2024;15:1364161
USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis.
Zhao C, Mu M, Li X, Dong Z, Wang J, Yao C, Zheng J, Sun X, Yu J
Frontiers in immunology 2024;15:1326137
Frontiers in immunology 2024;15:1326137
Single-cell RNA sequencing reveals S100a9(hi) macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia‒reperfusion.
Shen S, Zhang M, Wang X, Liu Q, Su H, Sun B, Guo Z, Tian B, Gan H, Gong C, Ma L
Theranostics 2024;14(3):1241-1259
Theranostics 2024;14(3):1241-1259
Macrophage membrane‒biomimetic nanoparticles target inflammatory microenvironment for epilepsy treatment.
Geng C, Ren X, Cao P, Chu X, Wei P, Liu Q, Lu Y, Fu B, Li W, Li Y, Zhao G
Theranostics 2024;14(17):6652-6670
Theranostics 2024;14(17):6652-6670
Cinobufotalin inhibits proliferation, migration and invasion in hepatocellular carcinoma by triggering NOX4/NLRP3/GSDMD-dependent pyroptosis.
Liu C, Wu J, Li Z, Huang X, Xie X, Huang Y
Frontiers in oncology 2024;14:1438306
Frontiers in oncology 2024;14:1438306
Neuregulin-1, a member of the epidermal growth factor family, mitigates STING-mediated pyroptosis and necroptosis in ischaemic flaps.
Zhu X, Yu G, Lv Y, Yang N, Zhao Y, Li F, Zhao J, Chen Z, Lai Y, Chen L, Wang X, Xiao J, Cai Y, Feng Y, Ding J, Gao W, Zhou K, Xu H
Burns & trauma 2024;12:tkae035
Burns & trauma 2024;12:tkae035
Oxycodone attenuates lipopolysaccharide-induced myocardial injury by inhibiting inflammation, oxidation and pyroptosis via Nrf2/HO-1 signalling pathway.
Wang Y, Feng W, Li S, Liu C, Jia L, Wang P, Li L, Du H, Yu W
Clinical and experimental pharmacology & physiology 2024 Sep;51(9):e13910
Clinical and experimental pharmacology & physiology 2024 Sep;51(9):e13910
Microglia and Astrocytes Responses Contribute to Alleviating Inflammatory Damage by Repetitive Transcranial Magnetic Stimulation in Rats with Traumatic Brain Injury.
Qian F, He R, Du X, Wei Y, Zhou Z, Fan J, He Y
Neurochemical research 2024 Sep;49(9):2636-2651
Neurochemical research 2024 Sep;49(9):2636-2651
Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome.
Li Y, Tian L, Li S, Chen X, Lei F, Bao J, Wu Q, Wen Y, Jie Y
Free radical biology & medicine 2024 Sep;222:106-121
Free radical biology & medicine 2024 Sep;222:106-121
Mefunidone alleviates silica-induced inflammation and fibrosis by inhibiting the TLR4-NF-κB/MAPK pathway and attenuating pyroptosis in murine macrophages.
Long L, Dai X, Yao T, Zhang X, Jiang G, Cheng X, Jiang M, He Y, Peng Z, Hu G, Tao L, Meng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117216
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117216
Inhibition of GBP1 alleviates pyroptosis of human pulmonary microvascular endothelial cells through STAT1/NLRP3/GSDMD pathway.
Hao Y, Fu H, Li K, Zou X, Zhou X, Tang X, Liu C, Zhou F
Molecular immunology 2024 Sep;173:1-9
Molecular immunology 2024 Sep;173:1-9
A Dual-Function CD47-Targeting Nano-Drug Delivery System Used to Regulate Immune and Anti-Inflammatory Activities in the Treatment of Atherosclerosis.
Wang H, Zhao R, Peng L, Yu A, Wang Y
Advanced healthcare materials 2024 Sep;13(22):e2400752
Advanced healthcare materials 2024 Sep;13(22):e2400752
miR-155 induces sepsis-associated damage to the intestinal mucosal barrier via sirtuin 1/nuclear factor-κB-mediated intestinal pyroptosis.
Li Z, Wang Y, Huang W, Shi X, Ma T, Yu X
Acta biochimica et biophysica Sinica 2024 Sep 9;56(11):1618-1632
Acta biochimica et biophysica Sinica 2024 Sep 9;56(11):1618-1632
DYZY01 alleviates pulmonary hypertension via inhibiting endothelial cell pyroptosis and rescuing endothelial dysfunction.
Dai X, Liu Y, Wu Y, Wang S, Guo Q, Feng X, Zhao F, Li Y, Lan L, Li X
European journal of pharmacology 2024 Sep 5;978:176785
European journal of pharmacology 2024 Sep 5;978:176785
Adverse outcome pathway-based approach to reveal the mechanisms of skin sensitization and long-term aging effects of chlorothalonil.
Cheng YH, Wu HI, Chen YY, Lee YH, Wang BJ, Wang YJ
Journal of hazardous materials 2024 Sep 5;476:135176
Journal of hazardous materials 2024 Sep 5;476:135176
Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening.
Zhou C, Kuang M, Tao Y, Wang J, Luo Y, Fu Y, Chen Z, Liu Y, Li Z, Wu W, Wang L, Dou Y, Wang J, Hou Y
Cell stem cell 2024 Sep 5;31(9):1359-1375.e8
Cell stem cell 2024 Sep 5;31(9):1359-1375.e8
Pericentriolar material 1 promotes intestinal inflammation in ulcerative colitis by activating NLRP3/gasdermin D-mediated macrophage pyroptosis.
Niu J, Wen Y, Zhang F, Li S, Miao J, Liang H, Bai X, Zeng Z, Guo X, Miao Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 30;38(18):e70054
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 30;38(18):e70054
Elucidating PAR1 as a therapeutic target for delayed traumatic brain injury: Unveiling the PPAR-γ/Nrf2/HO-1/GPX4 axis to suppress ferroptosis and alleviate NLRP3 inflammasome activation in rats.
El-Gazar AA, Soubh AA, Abdallah DM, Ragab GM, El-Abhar HS
International immunopharmacology 2024 Sep 30;139:112774
International immunopharmacology 2024 Sep 30;139:112774
Macrophage WNK1 senses intracellular hypo-chlorine to regulate vulnerability to sepsis attack during hypochloremia.
Yin T, He L, Du Y, Liu J, Peng L, Yang M, Sun S, Liu J, Li J, Cao J, Zhu H, Wang S
International immunopharmacology 2024 Sep 30;139:112721
International immunopharmacology 2024 Sep 30;139:112721
Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE/PI3K/AKT/mTOR pathway.
Qin Y, Li W, Liu J, Wang F, Zhou W, Xiao L, Zhou P, Wu F, Chen X, Xu S, Liu L, Xiao X, Zhang D
International immunopharmacology 2024 Sep 30;139:112719
International immunopharmacology 2024 Sep 30;139:112719
Trehalose Rescues Postmenopausal Osteoporosis Induced by Ovariectomy through Alleviating Osteoblast Pyroptosis via Promoting Autophagy.
Hu X, Wang W, Chen X, Kong C, Zhao X, Wang Z, Zhang H, Lu S
Biomedicines 2024 Sep 29;12(10)
Biomedicines 2024 Sep 29;12(10)
Disulfiram attenuates cell and tissue damage and blood‒brain barrier dysfunction after intracranial haemorrhage by inhibiting the classical pyroptosis pathway.
Xu C, Jiang F, Mao Y, Wei W, Song J, Jia F, Du X, Zhong D, Li G
Scientific reports 2024 Sep 19;14(1):21860
Scientific reports 2024 Sep 19;14(1):21860
Ocotillol-Type Pseudoginsenoside-F11 Alleviates Lipopolysaccharide-Induced Acute Kidney Injury through Regulation of Macrophage Function by Suppressing the NF-κB/NLRP3/IL-1β Signaling Pathway.
Wang Y, Zhang J, Yang Z, Li C, Zhang C, Sun S, Jiao Z, Che G, Gao H, Liu J, Li J
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20496-20512
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20496-20512
Helicobacter pylori CagA mediated mitophagy to attenuate the NLRP3 inflammasome activation and enhance the survival of infected cells.
Chen D, Wu L, Liu X, Wang Q, Gui S, Bao L, Wang Z, He X, Zhao Y, Zhou J, Xie Y
Scientific reports 2024 Sep 17;14(1):21648
Scientific reports 2024 Sep 17;14(1):21648
BV2 Microglial Cell Activation/Polarization Is Influenced by Extracellular Vesicles Released from Mutated SOD1 NSC-34 Motoneuron-like Cells.
Carata E, Muci M, Mariano S, Panzarini E
Biomedicines 2024 Sep 11;12(9)
Biomedicines 2024 Sep 11;12(9)
Hydrogen combined with tetrandrine attenuates silica-induced pulmonary fibrosis via suppressing NF-kappaB/NLRP3 signaling pathway-mediated epithelial mesenchymal transition and inflammation.
Li J, Cui P, Jing H, Chen S, Ma L, Zhang W, Wang T, Ma J, Cao M, Yang Y, Bai J, Shao H, Du Z
International immunopharmacology 2024 Sep 10;138:112563
International immunopharmacology 2024 Sep 10;138:112563
Pyroptotic macrophages induce disruption of glutamate metabolism in periodontal ligament stem cells contributing to their compromised osteogenic potential.
Sun LJ, Qu HL, He XT, Tian BM, Wu RX, Yin Y, Zou JK, Sun HH, Li X, Chen FM
Cell proliferation 2024 Oct;57(10):e13663
Cell proliferation 2024 Oct;57(10):e13663
Placental growth factor alleviates hyperglycemia-induced trophoblast pyroptosis by regulating mitophagy.
Tao J, Rao Y, Wang J, Tan S, Zhao J, Cao Z, He L, Meng J, Wu P, Wang Z
The journal of obstetrics and gynaecology research 2024 Oct;50(10):1813-1829
The journal of obstetrics and gynaecology research 2024 Oct;50(10):1813-1829
Blockage of the NLRP3 inflammasome by MCC950 inhibits migration and invasion in adenomyosis.
Liu Y, Jiang Z, Zhang L, Tian W, Lin A, Li M
Reproductive biomedicine online 2024 Oct;49(4):104319
Reproductive biomedicine online 2024 Oct;49(4):104319
Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells.
Ren C, Wang Q, Fan S, Mi T, Zhang Z, He D
Inflammation 2024 Oct;47(5):1744-1761
Inflammation 2024 Oct;47(5):1744-1761
Ginseng polysaccharide promotes the apoptosis of colon cancer cells via activating the NLRP3 inflammasome.
Tian X, Zhang C, Wang D, Li X, Wang Q
Immunopharmacology and immunotoxicology 2024 Oct;46(5):715-726
Immunopharmacology and immunotoxicology 2024 Oct;46(5):715-726
Targeting Mitochondrial Oxidative Stress to Protect Against Preterm Birth and Fetal Brain Injury via Nrf2 Induction.
Chen C, Zhu S, Fu T, Chen Y, Bai L, Chen D
Antioxidants & redox signaling 2024 Oct;41(10-12):597-615
Antioxidants & redox signaling 2024 Oct;41(10-12):597-615
Geraniol alleviates liver injury induced by bisphenol A via modulating NLRP3/caspase-1 pathway and gut microbiota in mice model.
Zhou B, Niu Y, Wang D, Liu L, Guo J
Food science and biotechnology 2024 Oct;33(13):3119-3130
Food science and biotechnology 2024 Oct;33(13):3119-3130
Dynamics of the thymic transcriptome at stages of acute thymic involution in Japanese Black calves with a poor prognosis.
Furukawa R, Wakitani S, Kawabata R, Yasuda M
Veterinary journal (London, England : 1997) 2024 Oct;307:106225
Veterinary journal (London, England : 1997) 2024 Oct;307:106225
Fusobacterium nucleatum dysregulates inflammatory cytokines and NLRP3 inflammasomes in oral cells.
Sun J, Feng S, Ding T, Wang T, Du L, Kang W, Ge S
Oral diseases 2024 Oct;30(7):4767-4781
Oral diseases 2024 Oct;30(7):4767-4781
Therapeutic framework nucleic acid complexes targeting oxidative stress and pyroptosis for the treatment of osteoarthritis.
Li J, Li Y, Shang X, Xu S, Zhang Z, Xu S, Wang X, Shen M
Materials today. Bio 2024 Oct;28:101202
Materials today. Bio 2024 Oct;28:101202
A preliminary study of T-2 toxin that cause liver injury in rats via the NF-kB and NLRP3-mediated pyroptosis pathway.
Zheng S, Li H, Dong H, Qi F, Zhang B, Yu Q, Lin B, Jiang H, Du H, Liu Y, Yu J
Toxicon : official journal of the International Society on Toxinology 2024 Oct;249:108060
Toxicon : official journal of the International Society on Toxinology 2024 Oct;249:108060
Caspase-1 Inhibition Ameliorates Photoreceptor Damage Following Retinal Detachment by Inhibiting Microglial Pyroptosis.
Cao Y, Qiao L, Song Y, Yan Y, Ni Y, Xi H, Chen J, Li S, Liu H
The American journal of pathology 2024 Oct;194(10):1924-1937
The American journal of pathology 2024 Oct;194(10):1924-1937
LncRNA H19/miR-107 regulates endothelial progenitor cell pyroptosis and promotes flow recovery of lower extremity ischemia through targeting FADD.
Huang L, Ye Y, Sun Y, Zhou Z, Deng T, Liu Y, Wu R, Wang K, Yao C
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167323
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167323
NEMO-Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase-Induced Lysosome Membrane Permeabilization.
Geng Y, Lou J, Wu J, Tao Z, Yang N, Kuang J, Wu Y, Zhang J, Xiang L, Shi J, Cai Y, Wang X, Chen J, Xiao J, Zhou K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(40):e2405759
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(40):e2405759
PTP1B inhibitor alleviates deleterious septic lung injury through Src signaling.
Qiu C, Sun Z, Liu F, Deng W, Ouyang X, Zhang Q, Tao W
Functional & integrative genomics 2024 Oct 25;24(6):200
Functional & integrative genomics 2024 Oct 25;24(6):200
Bergapten attenuates hemorrhagic shock induced multi-organ injury by inhibiting NLRP3 inflammasome activation and pyroptosis.
Rao T, Yang W, Ma X, Jiang X, Jiang S, Xu S
International immunopharmacology 2024 Oct 25;140:112839
International immunopharmacology 2024 Oct 25;140:112839
Weighted gene co-expression network analysis and single-cell sequence analysis uncover immune landscape and reveal hub genes of necroptosis in macrophages in myocardial ischaemia-reperfusion injury.
Ma X, Xie J, Li B, Shan H, Jia Z, Liu W, Dong Y, Han S, Jin Q
International immunopharmacology 2024 Oct 25;140:112761
International immunopharmacology 2024 Oct 25;140:112761
Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression.
Zhao R, Guo Z, Lu K, Chen Q, Riaz F, Zhou Y, Yang L, Cheng X, Wu L, Cheng K, Feng L, Liu S, Wu X, Zheng M, Yin C, Li D
Cell death & disease 2024 Oct 23;15(10):770
Cell death & disease 2024 Oct 23;15(10):770
LINC00365 promotes miR-221-5p to inhibit pyroptosis via Dicer in colorectal cancer.
Yang W, Huang X, Lv W, Jin Y, Zhu Y
Acta biochimica et biophysica Sinica 2024 Oct 22;57(4):529-541
Acta biochimica et biophysica Sinica 2024 Oct 22;57(4):529-541
The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring.
Shen C, Zhu X, Chang H, Li C, Hou M, Chen L, Lu Chen, Zhou Z, Ji M, Xu Z
Cell reports 2024 Oct 22;43(10):114787
Cell reports 2024 Oct 22;43(10):114787
GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation.
Liu C, Zhang Q, Zhou H, Jin L, Liu C, Yang M, Zhao X, Ding W, Xie W, Kong H
Journal of translational medicine 2024 Oct 21;22(1):954
Journal of translational medicine 2024 Oct 21;22(1):954
Acupuncture ameliorates depression-like behavior of poststroke depression model rats through the regulation of gut microbiota and NLRP3 inflammasome in the colon.
Cai W, Wei XF, Zhang JR, Tao L, Li D, Zhang K, Shen WD
Neuroreport 2024 Oct 2;35(14):883-894
Neuroreport 2024 Oct 2;35(14):883-894
Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease.
Zhang Z, Li M, Li X, Feng Z, Luo G, Wang Y, Gao X
Journal of neuroinflammation 2024 Oct 15;21(1):261
Journal of neuroinflammation 2024 Oct 15;21(1):261
NLRP3 inhibitor combined with Yimusake improves erectile dysfunction in rats with diabetes mellitus through the attenuation of pyroptosis.
Zhu B, Zhang X, Niu L, Yang C, Jin X, Liu F
Heliyon 2024 Oct 15;10(19):e38626
Heliyon 2024 Oct 15;10(19):e38626
Role for NLRP3 inflammasome-mediated, Caspase1-dependent response in glaucomatous trabecular meshwork cell death and regulation of aqueous humor outflow.
Feng X, Chen Z, Cheng W, Liu C, Liu Q
Heliyon 2024 Oct 15;10(19):e38258
Heliyon 2024 Oct 15;10(19):e38258
Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight.
Wang H, Ma Y, Jin D, Yang X, Xu X
Heliyon 2024 Oct 15;10(19):e38050
Heliyon 2024 Oct 15;10(19):e38050
The phosphorylation of Smad3 by CaMKIIγ leads to the hepatocyte pyroptosis under perfluorooctane sulfonate exposure.
Ren S, Liang P, Feng R, Yang W, Qiu T, Zhang J, Li Q, Yang G, Sun X, Yao X
Ecotoxicology and environmental safety 2024 Oct 1;284:116924
Ecotoxicology and environmental safety 2024 Oct 1;284:116924
Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury.
Zhang B, Yu J, Bao L, Feng D, Qin Y, Fan D, Hong X, Chen Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Nov;73(11):1981-1994
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Nov;73(11):1981-1994
Polystyrene Microplastics Induce Injury to the Vascular Endothelial Through NLRP3-Mediated Pyroptosis.
Huo C, Zhu Y, Fang X, Cui J, Ye H, Zhao H, Ye L, Zhou L
Environmental toxicology 2024 Nov;39(11):5086-5098
Environmental toxicology 2024 Nov;39(11):5086-5098
Ruscogenin Exerts Anxiolytic-Like Effect via Microglial NF-κB/MAPKs/NLRP3 Signaling Pathways in Mouse Model of Chronic Inflammatory Pain.
Qi JY, Jin YC, Wang XS, Yang LK, Lu L, Yue J, Yang F, Liu YS, Jiang YL, Song DK, Lv T, Li XB, Zhang K, Liu SB
Phytotherapy research : PTR 2024 Nov;38(11):5417-5440
Phytotherapy research : PTR 2024 Nov;38(11):5417-5440
HSP90-regulated mitophagy can alleviate heat stress damage by inhibiting pyroptosis in the hepatocytes of Wenchang chickens.
Shi J, Li C, Liang Q, Yao Y, Ji Z, Zhou M, Cai J, Yao X, Zhang X
International journal of biological macromolecules 2024 Nov;280(Pt 4):135979
International journal of biological macromolecules 2024 Nov;280(Pt 4):135979
Lycium barbarum polysaccharides (LBP) suppresses hypoxia/reoxygenation (H/R)-induced rat H9C2 cardiomyocytes pyroptosis via Nrf2/HO-1 signaling pathway.
Gao Y, Li H, Que Y, Chen W, Huang SY, Liu W, Ye X
International journal of biological macromolecules 2024 Nov;280(Pt 4):135924
International journal of biological macromolecules 2024 Nov;280(Pt 4):135924
Tetrahedral Framework Nucleic Acid-Based Delivery of Astaxanthin Suppresses Chondrocyte Pyroptosis and Modulates Oxidative Stress for the Treatment of Osteoarthritis.
Li Y, Li J, Xu S, Li D, Zhang Z, Huang Q, Wang X, Shen M, Xu S
Advanced healthcare materials 2024 Nov;13(28):e2401452
Advanced healthcare materials 2024 Nov;13(28):e2401452
Perinatal exposure to PBEB aggravates liver injury via macrophage-derived TWEAK in male adult offspring mice under western diet.
Wang W, Shi X, Feng J, Le Y, Jin L, Lu D, Zhang Q, Wang C
Journal of hazardous materials 2024 Nov 5;479:135735
Journal of hazardous materials 2024 Nov 5;479:135735
Microglia regulate cortical remyelination via TNFR1-dependent phenotypic polarization.
Boutou A, Roufagalas I, Politopoulou K, Tastsoglou S, Abouzeid M, Skoufos G, Verdu de Juan L, Ko JH, Kyrargyri V, Hatzigeorgiou AG, Barnum CJ, Tesi RJ, Bauer J, Lassmann H, Johnson MR, Probert L
Cell reports 2024 Nov 26;43(11):114894
Cell reports 2024 Nov 26;43(11):114894
Ginsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy.
Yang S, Fang Z, Duan H, Dong W, Xiao L
Antioxidants (Basel, Switzerland) 2024 Nov 24;13(12)
Antioxidants (Basel, Switzerland) 2024 Nov 24;13(12)
Paeoniflorin Inhibits the Activation of Microglia and Alleviates Depressive Behavior by Regulating SIRT1-NF-kB-NLRP3/Pyroptosis Pathway.
Wang X, Su L, Liu S, He Z, Li J, Zong Y, Chen W, Du R
International journal of molecular sciences 2024 Nov 22;25(23)
International journal of molecular sciences 2024 Nov 22;25(23)
Microplastics Exposure Aggravates Synovitis and Pyroptosis in SLE by Activating NF-κB and NRF2/KEAP1 Signaling.
Zeng W, He S, Zhao Y, Jiang M, Wang W, Yang L, Du W, Zhuang W
Toxics 2024 Nov 22;12(12)
Toxics 2024 Nov 22;12(12)
USP14 modulates cell pyroptosis and ameliorates doxorubicin-induced cardiotoxicity by deubiquitinating and stabilizing SIRT3.
Zhang Z, Jin B, Zhang Y, Yang M, Wang C, Zhu Y, Li T, Lin J, Yang M, Cheng Y, Xu S, He K, Xu J, Mi Y, Jiang J, Sun Z
Free radical biology & medicine 2024 Nov 20;225:741-757
Free radical biology & medicine 2024 Nov 20;225:741-757
Mechanism of epigallocatechin gallate in treating non-alcoholic fatty liver disease: Insights from network pharmacology and experimental validation.
Mao D, Guo J, Yang K, Yang F, Peng J, Jia X, Luo Z, Liu L, Yang E, Tang R, Lan H, Zheng Q
Biochemical and biophysical research communications 2024 Nov 19;734:150424
Biochemical and biophysical research communications 2024 Nov 19;734:150424
β-Hydroxybutyrate alleviates brain aging through the MTA1 pathway in D-galactose injured mice.
Wang R, Yang X, Wang L, Wang R, Zhang W, Ji Y, Li Z, Li H, Cui L
European journal of pharmacology 2024 Nov 15;983:176959
European journal of pharmacology 2024 Nov 15;983:176959
Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
Ren C, Xi L, Li H, Pan Z, Li Y, Wang G, Dai J, He D, Fan S, Wang Q
Life sciences 2024 Nov 15;357:123084
Life sciences 2024 Nov 15;357:123084
MANF inhibits NLRP3 inflammasome activation by competitively binding to DDX3X in paraquat-stimulated alveolar macrophages.
Pu Y, Han S, Chen J, Liu Z
Ecotoxicology and environmental safety 2024 Nov 15;287:117331
Ecotoxicology and environmental safety 2024 Nov 15;287:117331
Carvacrol alleviates LPS-induced myocardial dysfunction by inhibiting the TLR4/MyD88/NF-κB and NLRP3 inflammasome in cardiomyocytes.
Xu L, Yang X, Liu XT, Li XY, Zhu HZ, Xie YH, Wang SW, Li Y, Zhao Y
Journal of inflammation (London, England) 2024 Nov 15;21(1):47
Journal of inflammation (London, England) 2024 Nov 15;21(1):47
Effects on Synaptic Plasticity Markers in Fetal Mice and HT22 Neurons upon F-53B Exposure: The Role of PKA Cytoplasmic Retention.
Li SP, Zeng HX, Qin SJ, Li QQ, Wu LY, Wu QZ, Lin LZ, Dong GH, Zeng XW
Environment & health (Washington, D.C.) 2024 Nov 15;2(11):776-785
Environment & health (Washington, D.C.) 2024 Nov 15;2(11):776-785
Immune Checkpoint-Modulating Photosensitizer That Targets BRD4 for Cancer Photoimmunotherapy.
Li P, Du Y, Qiu J, Jiang Q, Chen W, Zhang X, Li G, Li D, Shan G
Journal of medicinal chemistry 2024 Nov 14;67(21):18930-18942
Journal of medicinal chemistry 2024 Nov 14;67(21):18930-18942
The attenuating effects of serine against cadmium induced immunotoxicity through regulating M1/M2 and Th1/Th2 balance in spleen of C57BL/6 mice.
Wang X, Ali W, Zhang K, Ma Y, Zou H, Tong X, Zhu J, Song R, Zhao H, Liu Z, Dong W
Ecotoxicology and environmental safety 2024 Nov 1;286:117216
Ecotoxicology and environmental safety 2024 Nov 1;286:117216
The role of NLRP3 inflammasome-mediated neuroinflammation in chronic noise-induced impairment of learning and memory ability.
Ren Y, Wu K, He Y, Zhang H, Ma J, Li C, Ruan Y, Zhang J, Wen Y, Wu X, Chen S, Qiu H, Zhang Y, Zhou L, Ou Z, Liang J, Wang Z
Ecotoxicology and environmental safety 2024 Nov 1;286:117183
Ecotoxicology and environmental safety 2024 Nov 1;286:117183
Neutrophil extracellular traps promote M1 macrophage polarization in gouty inflammation via targeting hexokinase-2.
Tan H, Zhang S, Zhang Z, Zhang J, Wang Z, Liao J, Qiu X, Jia E
Free radical biology & medicine 2024 Nov 1;224:540-553
Free radical biology & medicine 2024 Nov 1;224:540-553
Sodium butyrate alleviates experimental autoimmune prostatitis by inhibiting oxidative stress and NLRP3 inflammasome activation via the Nrf2/HO-1 pathway.
Hua X, Zhang J, Chen J, Feng R, Zhang L, Chen X, Jiang Q, Yang C, Liang C
The Prostate 2024 May;84(7):666-681
The Prostate 2024 May;84(7):666-681
Protective Effect of Egg Yolk Lipids against Dextran Sulfate Sodium-Induced Colitis: The Key Role of Gut Microbiota and Short-Chain Fatty Acids.
Xiao N, He W, Chen S, Yao Y, Wu N, Xu M, Du H, Zhao Y, Tu Y
Molecular nutrition & food research 2024 May;68(9):e2400048
Molecular nutrition & food research 2024 May;68(9):e2400048
Berberine alleviated contrast-induced acute kidney injury by mitophagy-mediated NLRP3 inflammasome inactivation in a mice model.
Yang Y, Jiang S, Mu Y, Liu C, Han Y, Jiang J, Wang Y
Toxicology and applied pharmacology 2024 May;486:116952
Toxicology and applied pharmacology 2024 May;486:116952
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching.
Shen SC, Xu J, Cheng C, Xiang XJ, Hong BY, Zhang M, Gong C, Ma LK
Acta pharmacologica Sinica 2024 May;45(5):959-974
Acta pharmacologica Sinica 2024 May;45(5):959-974
4-PBA exerts brain-protective effects against sepsis-associated encephalopathy in a mouse model of sepsis.
Xiong F, Wang C, Lu J, Bai G, Zhou D, Ling J
Experimental neurology 2024 May;375:114738
Experimental neurology 2024 May;375:114738
Nattokinase attenuates endothelial inflammation through the activation of SRF and THBS1.
Chiu HW, Chou CL, Lee KT, Shih CC, Huang TH, Sung LC
International journal of biological macromolecules 2024 May;268(Pt 2):131779
International journal of biological macromolecules 2024 May;268(Pt 2):131779
Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models.
Duan L, Hao Z, Ji R, Li X, Wang H, Su Y, Guan F, Ma S
International journal of biological macromolecules 2024 May;268(Pt 1):131739
International journal of biological macromolecules 2024 May;268(Pt 1):131739
Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis.
Liu T, Ma Z, Liu L, Pei Y, Wu Q, Xu S, Liu Y, Ding N, Guan Y, Zhang Y, Chen X
Neural regeneration research 2024 May;19(5):1105-1111
Neural regeneration research 2024 May;19(5):1105-1111
Tumor necrosis factor-stimulated gene-6 ameliorates early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome-mediated astrocyte pyroptosis.
Ding M, Jin L, Wei B, Cheng W, Liu W, Li X, Duan C
Neural regeneration research 2024 May;19(5):1064-1071
Neural regeneration research 2024 May;19(5):1064-1071
Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels.
Liang Q, Jing J, He H, Huang X, Liu J, Wang M, Qi Z, Zhang L, Huang Z, Yan Y, Liu S, Gao M, Zou Y
Environment international 2024 May;187:108672
Environment international 2024 May;187:108672
Histone deacetylase-mediated silencing of PSTPIP2 expression contributes to aristolochic acid nephropathy-induced PANoptosis.
Xu C, Wang Q, Du C, Chen L, Zhou Z, Zhang Z, Cai N, Li J, Huang C, Ma T
British journal of pharmacology 2024 May;181(9):1452-1473
British journal of pharmacology 2024 May;181(9):1452-1473
Isoliquiritigenin reduces experimental autoimmune prostatitis by facilitating Nrf2 activation and suppressing the NLRP3 inflammasome pathway.
Feng R, Meng T, Zhao X, Yu W, Li H, Wang Z, Chen J, Yang C
Molecular immunology 2024 May;169:37-49
Molecular immunology 2024 May;169:37-49
Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia.
Gao S, Li N, Lin Z, Zhong Y, Wang Y, Shen X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23671
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23671
Semaglutide ameliorates pressure overload-induced cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome.
He W, Wei J, Liu X, Zhang Z, Huang R, Jiang Z
Scientific reports 2024 May 23;14(1):11824
Scientific reports 2024 May 23;14(1):11824
Transcriptomics confirms IRF1 as a key regulator of pyroptosis in diabetic retinopathy.
Xian Y, Wang X, Yu Y, Chen X
Biochemical and biophysical research communications 2024 May 21;709:149760
Biochemical and biophysical research communications 2024 May 21;709:149760
(+)-Catechin ameliorates diabetic nephropathy injury by inhibiting endoplasmic reticulum stress-related NLRP3-mediated inflammation.
Zhang X, Huo Z, Jia X, Xiong Y, Li B, Zhang L, Li X, Li X, Fang Y, Dong X, Chen G
Food & function 2024 May 20;15(10):5450-5465
Food & function 2024 May 20;15(10):5450-5465
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis.
Peng F, Liao M, Jin W, Liu W, Li Z, Fan Z, Zou L, Chen S, Zhu L, Zhao Q, Zhan G, Ouyang L, Peng C, Han B, Zhang J, Fu L
Signal transduction and targeted therapy 2024 May 15;9(1):133
Signal transduction and targeted therapy 2024 May 15;9(1):133
Stenotrophomonas maltophilia contributes to smoking-related emphysema through IRF1-triggered PANoptosis of alveolar epithelial cells.
Xia H, Lin J, Wang Y, Yu J, Wang H, Cheng C, Yang Y, Bian T, Wu Y, Liu Q
Environmental pollution (Barking, Essex : 1987) 2024 May 15;349:123913
Environmental pollution (Barking, Essex : 1987) 2024 May 15;349:123913
Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure.
Li YS, Xia J, Chen CY, Ren SH, He MR
BMC molecular and cell biology 2024 May 15;25(1):16
BMC molecular and cell biology 2024 May 15;25(1):16
Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies.
Zhang M, Liu H, Xu L, Zhang X, Chen W, Wang C
Foods (Basel, Switzerland) 2024 May 14;13(10)
Foods (Basel, Switzerland) 2024 May 14;13(10)
MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism.
Ma Y, She X, Liu Y, Qin X
Communications biology 2024 May 11;7(1):562
Communications biology 2024 May 11;7(1):562
TIMP2 protects against sepsis-associated acute kidney injury by cAMP/NLRP3 axis-mediated pyroptosis.
Xu D, Jiang J, Liu Y, Pang J, Suo J, Li Y, Peng Z
American journal of physiology. Cell physiology 2024 May 1;326(5):C1353-C1366
American journal of physiology. Cell physiology 2024 May 1;326(5):C1353-C1366
NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis.
Zhou H, Zhang Q, Liu C, Fan J, Huang W, Li N, Yang M, Wang H, Xie W, Kong H
International journal of molecular medicine 2024 Mar;53(3)
International journal of molecular medicine 2024 Mar;53(3)
ACT001 alleviates inflammation and pyroptosis through the PPAR-γ/NF-κB signaling pathway in LPS-induced alveolar macrophages.
Fu Q, Shen N, Fang T, Zhang H, Di Y, Liu X, Du C, Guo J
Genes & genomics 2024 Mar;46(3):323-332
Genes & genomics 2024 Mar;46(3):323-332
Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis.
Zhang L, Tan M, Mao J, Zhang J, Wang XY, Zhang Y, Duo RX, Hao JY, Shen HL
Clinical rheumatology 2024 Mar;43(3):959-969
Clinical rheumatology 2024 Mar;43(3):959-969
TXNIP-NLRP3-GSDMD axis-mediated inflammation and pyroptosis of islet β-cells is involved in cigarette smoke-induced hyperglycemia, which is alleviated by andrographolide.
Xu W, Wang H, Sun Q, Hua T, Bai J, Zhang Q, Liu Q, Ni X
Environmental toxicology 2024 Mar;39(3):1415-1428
Environmental toxicology 2024 Mar;39(3):1415-1428
Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway.
Che J, Wang H, Dong J, Wu Y, Zhang H, Fu L, Zhang J
CNS neuroscience & therapeutics 2024 Mar;30(3):e14454
CNS neuroscience & therapeutics 2024 Mar;30(3):e14454
Oxymatrine mitigates Aspergillus fumigatus keratitis by suppressing fungal activity and restricting pyroptosis.
Liu W, Tian X, Gu L, Yu B, Wang Z, Chi M, Lin J, Wang Q, Liu G, Zhao G, Cui Li
Experimental eye research 2024 Mar;240:109830
Experimental eye research 2024 Mar;240:109830
S100A9(-/-) alleviates LPS-induced acute lung injury by regulating M1 macrophage polarization and inhibiting pyroptosis via the TLR4/MyD88/NFκB signaling axis.
Gong C, Ma J, Deng Y, Liu Q, Zhan Z, Gan H, Xiang X, Zhang M, Cao K, Shen T, Fang L, Shen B, Shen S, Ding S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116233
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116233
PI3K/AKT signaling pathway associates with pyroptosis and inflammation in patients with endometriosis.
An M, Fu X, Meng X, Liu H, Ma Y, Li Y, Li Q, Chen J
Journal of reproductive immunology 2024 Mar;162:104213
Journal of reproductive immunology 2024 Mar;162:104213
Riboflavin Attenuates Fluoride-Induced Testicular Injury via Interleukin 17A-Mediated Classical Pyroptosis.
Li X, Yang J, Luo H, Qiao Y, Zhao L, Cheng C, Fu W, Tan Y, Wang J, Liang C, Zhang J
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6143-6154
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6143-6154
Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure.
Li XY, Yin X, Lu JJ, Li QR, Xing WQ, Han Q, Ji H, Li SZ, Yang HM, Guo JR, Wang ZQ, Xu B
Cells 2024 Mar 25;13(7)
Cells 2024 Mar 25;13(7)
Protective Effects and Mechanisms of Esculetin against H(2)O(2)-Induced Oxidative Stress, Apoptosis, and Pyroptosis in Human Hepatoma HepG2 Cells.
Luo Y, Chang T, Huang S, Xiang J, Tang S, Shen H
Molecules (Basel, Switzerland) 2024 Mar 22;29(7)
Molecules (Basel, Switzerland) 2024 Mar 22;29(7)
Triclosan induces liver injury in long-life exposed mice via activation of TLR4/NF-κB/NLRP3 pathway.
Peng Y, Cui H, Shu C, Wei Z, Ni X, Liu J
Ecotoxicology and environmental safety 2024 Mar 15;273:116115
Ecotoxicology and environmental safety 2024 Mar 15;273:116115
Atrazine exposure promotes cardiomyocyte pyroptosis to exacerbate cardiotoxicity by activating NF-κB pathway.
Zhao X, Luo H, Yao S, Yang T, Fu F, Yue M, Ruan H
The Science of the total environment 2024 Mar 10;915:170028
The Science of the total environment 2024 Mar 10;915:170028
Kongensin a attenuates intervertebral disc degeneration by inhibiting TAK1-mediated PANoptosis of nucleus pulposus cells.
Chen Y, Hu B, Ni F, Han Y, Shu S, Xiong L, Shao Z, Wei Y
International immunopharmacology 2024 Mar 10;129:111661
International immunopharmacology 2024 Mar 10;129:111661
Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.
Li W, Zhang W, Zhang D, Shi C, Wang Y
International immunopharmacology 2024 Mar 10;129:111612
International immunopharmacology 2024 Mar 10;129:111612
Taohong Siwu decoction reduces acute myocardial ischemia-reperfusion injury by promoting autophagy to inhibit pyroptosis.
Yang Y, Zhu Y, Liu C, Cheng J, He F
Journal of ethnopharmacology 2024 Mar 1;321:117515
Journal of ethnopharmacology 2024 Mar 1;321:117515
Protection effects of mice liver and lung injury induced by coronavirus infection of Qingfei Paidu decoction involve inhibition of the NLRP3 signaling pathway.
Huang W, Chen X, Yin M, Li J, Luo M, Ai Y, Xie L, Li W, Liu Y, Xie X, Chen Y, Zhang X, He J
Journal of ethnopharmacology 2024 Mar 1;321:117512
Journal of ethnopharmacology 2024 Mar 1;321:117512
Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice.
Wang R, Wang Y, Yang Q, Liu J, Lu Z, Xu W, Zhu J, Liu H, He W, Yan Y, Ruan Y, Zhou M
Journal of ethnopharmacology 2024 Mar 1;321:117490
Journal of ethnopharmacology 2024 Mar 1;321:117490
P2Y(13) receptor involved in HIV-1 gp120 induced neuropathy in superior cervical ganglia through NLRP3 inflammasome activation.
Yin S, Yang X, Li H, Li C, Li C, Chen C, Ye S, Zou L, Liang S, Liu S
Neuropharmacology 2024 Mar 1;245:109818
Neuropharmacology 2024 Mar 1;245:109818
PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway.
Li J, Teng D, Jia W, Gong L, Dong H, Wang C, Zhang L, Xu B, Wang W, Zhong L, Wang J, Yang J
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jun;73(6):1033-1046
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jun;73(6):1033-1046
Punicalagin Ameliorates Diabetic Liver Injury by Inhibiting Pyroptosis and Promoting Autophagy via Modulation of the FoxO1/TXNIP Signaling Pathway.
Tan X, Long Y, Zhang R, Zhang Y, You Z, Yang L
Molecular nutrition & food research 2024 Jun;68(12):e2300912
Molecular nutrition & food research 2024 Jun;68(12):e2300912
Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage.
Wang Y, Zhao M, Li J, Liu Y
Clinical and experimental pharmacology & physiology 2024 Jun;51(6):e13858
Clinical and experimental pharmacology & physiology 2024 Jun;51(6):e13858
Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway.
Lv Y, Jiang Z, Zhou W, Yang H, Jin G, Wang D, Kong C, Qian Z, Gu Y, Chen S, Zhu L
Inflammation 2024 Jun;47(3):1053-1066
Inflammation 2024 Jun;47(3):1053-1066
Long noncoding RNA TUG1 promotes malignant progression of osteosarcoma by enhancing ZBTB7C expression.
An X, Wu W, Wang P, Mahmut A, Guo J, Dong J, Gong W, Liu B, Yang L, Ma Y, Xu X, Chen J, Cao W, Jiang Q
Biomedical journal 2024 Jun;47(3):100651
Biomedical journal 2024 Jun;47(3):100651
MiR-106a-5p targets PFKFB3 and improves sepsis through regulating macrophage pyroptosis and inflammatory response.
Chen Y, Zhang P, Han F, Zhou Y, Wei J, Wang C, Song M, Lin S, Xu Y, Chen X
The Journal of biological chemistry 2024 Jun;300(6):107334
The Journal of biological chemistry 2024 Jun;300(6):107334
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy.
Su L, Guo P, Guo X, He Z, Zhao Y, Zong Y, Li J, Chen W, DU R
Chinese journal of natural medicines 2024 Jun;22(6):515-529
Chinese journal of natural medicines 2024 Jun;22(6):515-529
Co-exposure of microcystin and nitrite enhanced spermatogenic disorders: The role of mtROS-mediated pyroptosis and apoptosis.
Liu H, Du X, Zhang Z, Ge K, Chen X, Losiewicz MD, Guo H, Zhang H
Environment international 2024 Jun;188:108771
Environment international 2024 Jun;188:108771
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles.
Qi W, Jin L, Huang S, Aikebaier A, Xue S, Wang Q, Chen Q, Lu Y, Ding C
Acta biomaterialia 2024 Jun;181:425-439
Acta biomaterialia 2024 Jun;181:425-439
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation.
Feng S, Xie X, Li J, Xu X, Chen C, Zou G, Lin G, Huang T, Hu R, Ran T, Han L, Zhang Q, Li Y, Zhao X
Hepatology international 2024 Jun;18(3):1040-1052
Hepatology international 2024 Jun;18(3):1040-1052
Protective role of hydrogen sulfide against diabetic cardiomyopathy by inhibiting pyroptosis and myocardial fibrosis.
Liu M, Zeng C, Zhang Y, Xin Y, Deng S, Hu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116613
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116613
L- lactate inhibits lipopolysaccharide-induced inflammation of microglia in the hippocampus.
Liang L, Liu P, Deng Y, Li J, Zhao S
The International journal of neuroscience 2024 Jun;134(1):45-52
The International journal of neuroscience 2024 Jun;134(1):45-52
IRGM/Irgm1 increases autophagy to inhibit activation of NLRP3 inflammasome in inflammatory injury induced acute liver failure.
Zhang X, Hu Y, Wang W, Ji R, Li Z, Yu W, Wu Z, Xiao Y, Guo T, Qi Z, Wang Y, Zhao C
Cell death discovery 2024 Jun 7;10(1):272
Cell death discovery 2024 Jun 7;10(1):272
Chlormequat Chloride Inhibits TM3 Leydig Cell Growth via Ferroptosis-Initiated Inflammation.
Wang X, Kang C, Guo W, Zhang H, Xiao Q, Hao W
Cells 2024 Jun 5;13(11)
Cells 2024 Jun 5;13(11)
Exogenous NADPH could mitigate pyroptosis-induced brain injury in fetal mice exposed to gestational intermittent hypoxia.
Wei J, Zheng W, Teng C, An X, Li L, Zhong P, Peng C, Zhuge S, Akoto Ampadu J, Yu C, Cai X
International immunopharmacology 2024 Jun 30;135:112311
International immunopharmacology 2024 Jun 30;135:112311
Network pharmacology and experimental validation to explore the mechanism of Changji'an formula against irritable bowel syndrome with predominant diarrhea.
Ke W, Wu J, Li H, Huang S, Li H, Wang Y, Wu Y, Yuan J, Zhang S, Tang H, Lei K
Heliyon 2024 Jun 30;10(12):e33102
Heliyon 2024 Jun 30;10(12):e33102
Ameliorated Effects of Fucoidan on Dextran Sulfate Sodium-Induced Ulcerative Colitis and Accompanying Anxiety and Depressive Behaviors in Aged C57BL/6 Mice.
Li S, Qian Q, Xie Y, Wu Z, Yang H, Yin Y, Cui Y, Li X
Journal of agricultural and food chemistry 2024 Jun 26;72(25):14199-14215
Journal of agricultural and food chemistry 2024 Jun 26;72(25):14199-14215
Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress.
Zhang JR, Shen SY, Zhai MY, Shen ZQ, Li W, Liang LF, Yin SY, Han QQ, Li B, Zhang YQ, Yu J
Nature communications 2024 Jun 18;15(1):5199
Nature communications 2024 Jun 18;15(1):5199
Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2-NLRP3 signaling pathway in mice.
Wen Y, Deng S, Wang B, Zhang F, Luo T, Kuang H, Kuang X, Yuan Y, Huang J, Zhang D
Ecotoxicology and environmental safety 2024 Jun 15;278:116439
Ecotoxicology and environmental safety 2024 Jun 15;278:116439
MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration.
Zhan K, Zhu K, Gu B, Yao S, Fu F, Zeng H, Tian K, Ji W, Jin H, Tong P, Wu C, Yue M, Ruan H
International immunopharmacology 2024 Jun 15;134:112202
International immunopharmacology 2024 Jun 15;134:112202
Trim27 aggravates airway inflammation and oxidative stress in asthmatic mice via potentiating the NLRP3 inflammasome.
Liu K, Gu Y, Gu S, Song L, Hua S, Li D, Tang M
International immunopharmacology 2024 Jun 15;134:112199
International immunopharmacology 2024 Jun 15;134:112199
Mahuang Fuzi Xixin decoction alleviates allergic rhinitis by inhibiting NLRP3/Caspase-1/GSDMD-N-mediated pyroptosis.
Ding M, Wei X, Liu C, Tan X
Journal of ethnopharmacology 2024 Jun 12;327:118041
Journal of ethnopharmacology 2024 Jun 12;327:118041
Ginsenoside Rg1 Suppresses Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway to Alleviate Chronic Atrophic Gastritis In Vitro and In Vivo.
Zhou Z, Hu C, Cui B, You L, An R, Liang K, Wang X
Journal of agricultural and food chemistry 2024 Jun 10;
Journal of agricultural and food chemistry 2024 Jun 10;
Calcitriol attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behaviors by suppressing the P2X7R/NLRP3/caspase-1 pathway.
Wang C, Cui C, Xie X, Chen B, Feng L, Jiang P
Psychopharmacology 2024 Jul;241(7):1329-1343
Psychopharmacology 2024 Jul;241(7):1329-1343
Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration.
Sun J, Zeng Q, Wu Z, Huang L, Sun T, Ling C, Zhang B, Chen C, Wang H
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Jul;21(4):e00347
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Jul;21(4):e00347
Astaxanthin alleviates fibromyalgia pain and depression via NLRP3 inflammasome inhibition.
Zhao L, Tao X, Wang K, Song Y, Zhang B, Yang L, Wang Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116856
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116856
4-Octyl itaconate inhibits inflammation via the NLRP3 pathway in neuromyelitis optica spectrum disorders.
Li T, Li JW, Qin YH, Liu R, Xu XN, Li X, Li LM, Feng B, Yang L, Yang CS
Annals of clinical and translational neurology 2024 Jul;11(7):1732-1749
Annals of clinical and translational neurology 2024 Jul;11(7):1732-1749
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps.
Lai Y, Yang N, Shi D, Ma X, Huang Y, Lu J, Zhang X, Zhou H, Gao W, Mao C, Wang L
European journal of pharmacology 2024 Jul 5;974:176621
European journal of pharmacology 2024 Jul 5;974:176621
Chikusetsu Saponin IVa liposomes modified with a retro-enantio peptide penetrating the blood-brain barrier to suppress pyroptosis in acute ischemic stroke rats.
Liang Y, Fan T, Bai M, Cui N, Li W, Wang J, Guan Y
Journal of nanobiotechnology 2024 Jul 4;22(1):393
Journal of nanobiotechnology 2024 Jul 4;22(1):393
Esaxerenone Attenuates Aldosterone-Induced Mitochondrial Damage-Mediated Pyroptosis in Mouse Aorta and Rat Vascular Smooth Muscle Cells.
Xian Y, Wang X, Chang Y, Qiang P, Han Y, Hao J, Gao X, Shimosawa T, Xu Q, Yang F
Life (Basel, Switzerland) 2024 Jul 31;14(8)
Life (Basel, Switzerland) 2024 Jul 31;14(8)
Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3.
Zhu G, Yu H, Peng T, Yang K, Xu X, Gu W
Respiratory research 2024 Jul 30;25(1):291
Respiratory research 2024 Jul 30;25(1):291
Baicalin and probenecid protect against Glaesserella parasuis challenge in a piglet model.
Fu S, Liu S, Li J, Dong Q, Fu Y, Luo R, Sun Y, Tian X, Liu W, Zong B, Ye C, Lu Q, Qiu Y, Guo L
Veterinary research 2024 Jul 29;55(1):96
Veterinary research 2024 Jul 29;55(1):96
Urolithin A Protects against Hypoxia-Induced Pulmonary Hypertension by Inhibiting Pulmonary Arterial Smooth Muscle Cell Pyroptosis via AMPK/NF-κB/NLRP3 Signaling.
He X, Wu Z, Jiang J, Xu W, Yuan A, Liao F, Ding S, Pu J
International journal of molecular sciences 2024 Jul 28;25(15)
International journal of molecular sciences 2024 Jul 28;25(15)
Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR.
Li L, Xu S, Wang W, Li X, Wang H, Yang Q, Wang C, Gu J, Luo H, Meng Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155693
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155693
Ursolic acid alleviates lupus nephritis by suppressing SUMO1-mediated stabilization of NLRP3.
Chen L, Li F, Ni JH, Hao YX, Feng G, Shen XY, You Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155556
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155556
Mesenchymal stem cells ameliorate inflammation and pyroptosis in diabetic cardiomyopathy via the miRNA-223-3p/NLRP3 pathway.
Yang Q, Chen Q, Li S, Luo J
Diabetology & metabolic syndrome 2024 Jul 2;16(1):146
Diabetology & metabolic syndrome 2024 Jul 2;16(1):146
Disulfiram downregulates ferredoxin 1 to maintain copper homeostasis and inhibit inflammation in cerebral ischemia/reperfusion injury.
Yang S, Li X, Yan J, Jiang F, Fan X, Jin J, Zhang W, Zhong D, Li G
Scientific reports 2024 Jul 2;14(1):15175
Scientific reports 2024 Jul 2;14(1):15175
Dental pulp mesenchymal stem cell-derived exosomes inhibit neuroinflammation and microglial pyroptosis in subarachnoid hemorrhage via the miRNA-197-3p/FOXO3 axis.
Liang X, Miao Y, Tong X, Chen J, Liu H, He Z, Liu A, Hu Z
Journal of nanobiotechnology 2024 Jul 19;22(1):426
Journal of nanobiotechnology 2024 Jul 19;22(1):426
TAT-beclin1 treatment accelerates the development of atherosclerotic lesions in ApoE-deficient mice.
Liu L, Wang Q, Li Y, Cai J, Wang Y, Li Y, Wang R, Sun L, Zheng X, Yin A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23765
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23765
Shengxian decoction improves lung function in rats with bleomycin-induced idiopathic pulmonary fibrosis through the inhibition of PANoptosis.
Liang Y, Yan Y, Liu N, Wang J, Fang C
Journal of ethnopharmacology 2024 Jul 15;329:118153
Journal of ethnopharmacology 2024 Jul 15;329:118153
Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity.
Li P, Wang T, Guo H, Liu Y, Zhao H, Ren T, Tang Y, Wang Y, Zou M
Journal of affective disorders 2024 Jul 1;356:586-596
Journal of affective disorders 2024 Jul 1;356:586-596
CDK5-USP30 signaling pathway regulates MAVS-mediated inflammation via suppressing mitophagy in MPTP/MPP(+) PD model.
Ren Y, Wu X, Bai T, Yang N, Yuan Y, Xu L, Wen Y, Wen Y, Wang Z, Zhou L, Zou F, Li W
Ecotoxicology and environmental safety 2024 Jul 1;279:116446
Ecotoxicology and environmental safety 2024 Jul 1;279:116446
CHMP3 promotes the progression of hepatocellular carcinoma by inhibiting caspase‑1‑dependent pyroptosis.
Zheng Y, Yang S, Dai W, Wang J, Bi S, Zhang X, Zheng Z, Sun Y, Wu S, Kong J
International journal of oncology 2024 Jan;64(1)
International journal of oncology 2024 Jan;64(1)
FGF-18 Protects the Injured Spinal cord in mice by Suppressing Pyroptosis and Promoting Autophagy via the AKT-mTOR-TRPML1 axis.
Li F, Cai T, Yu L, Yu G, Zhang H, Geng Y, Kuang J, Wang Y, Cai Y, Xiao J, Wang X, Ding J, Xu H, Ni W, Zhou K
Molecular neurobiology 2024 Jan;61(1):55-73
Molecular neurobiology 2024 Jan;61(1):55-73
Mitochondria-targeted SkQ1 nanoparticles for dry eye disease: Inhibiting NLRP3 inflammasome activation by preventing mitochondrial DNA oxidation.
Huang B, Zhang N, Qiu X, Zeng R, Wang S, Hua M, Li Q, Nan K, Lin S
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:1-15
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:1-15
Pyroptosis-related gene signature elicits immune response in rosacea.
Hu XM, Zheng SY, Mao R, Zhang Q, Wan XX, Zhang YY, Li J, Yang RH, Xiong K
Experimental dermatology 2024 Jan;33(1):e14812
Experimental dermatology 2024 Jan;33(1):e14812
Modified 5-aminolevulinic acid photodynamic therapy induces cutaneous squamous cell carcinoma cell pyroptosis via the JNK signaling pathway.
Chen D, Wang B, Zhao Z, Zhang G, Wang P, Zhang L, Liu X, Zhang H, Zeng Q, Wang X
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119603
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119603
Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway.
Tong Z, Kong L, Zhang Y, Hu T, Dai R, Wang Y, Ji J, Huang Z, Hu L
Bioorganic chemistry 2024 Jan;142:106955
Bioorganic chemistry 2024 Jan;142:106955
Role and mechanism of MiR-542-3p in regulating TLR4 in nonylphenol-induced neuronal cell pyroptosis.
Yu J, Tang L, Yang L, Zheng M, Yu H, Luo Y, Liu J, Xu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155123
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155123
Study of hispidulin in the treatment of uric acid nephropathy based on NF-κB signaling pathway.
Li X, Gu Y, Ren L, Cai Q, Qiu Y, He J, Qu W, Ji W
Chemical biology & drug design 2024 Jan;103(1):e14367
Chemical biology & drug design 2024 Jan;103(1):e14367
Mechanism of action of curcumin targeting TRPM2/NLRP3 signaling axis to mediate cell death in the treatment of knee osteoarthritis.
Zhu K, Bi J, Zhang Q, Yang Y, Li J, Liang Y
Human & experimental toxicology 2024 Jan-Dec;43:9603271241308798
Human & experimental toxicology 2024 Jan-Dec;43:9603271241308798
Macrophage-derived exosomal miRNA-141 triggers endothelial cell pyroptosis by targeting NLRP3 to accelerate sepsis progression.
Zhan F, Zhang J, He P, Chen W, Ouyang Y
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241234736
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241234736
Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease.
Huang J, Zhang X, Yang X, Yv Q, Ye F, Chen S, Cui Y, Gu L, Zhu M, Li W
Chemico-biological interactions 2024 Jan 5;387:110820
Chemico-biological interactions 2024 Jan 5;387:110820
Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-κB pathway in a chronic migraine model.
Sun S, Fan Z, Liu X, Wang L, Ge Z
The journal of headache and pain 2024 Jan 5;25(1):3
The journal of headache and pain 2024 Jan 5;25(1):3
Inhibition of circulating exosomes release with GW4869 mitigates severe acute pancreatitis-stimulated intestinal barrier damage through suppressing NLRP3 inflammasome-mediated pyroptosis.
Shao Y, Jiang Y, Wang J, Li H, Li C, Zhang D
International immunopharmacology 2024 Jan 5;126:111301
International immunopharmacology 2024 Jan 5;126:111301
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress.
Liu C, Xu Y, Yang G, Tao Y, Chang J, Wang S, Cheung TH, Chen J, Zeng YA
Cell stem cell 2024 Jan 4;31(1):89-105.e6
Cell stem cell 2024 Jan 4;31(1):89-105.e6
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway.
Zhou Y, Yan J, Qiao L, Zeng J, Cao F, Sheng X, Qi X, Long C, Liu B, Wang X, Yao H, Xiao L
Antioxidants (Basel, Switzerland) 2024 Jan 31;13(2)
Antioxidants (Basel, Switzerland) 2024 Jan 31;13(2)
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Zhang B, He Z, Guo J, Li F, Huang Z, Zheng W, Xing W, Li M, Zhu Y, Yang X
Aging 2024 Jan 26;16(2):1145-1160
Aging 2024 Jan 26;16(2):1145-1160
Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis.
Zhang J, Cai H, Sun W, Wu W, Nan Y, Ni Y, Wu X, Chen M, Xu H, Wang Y
Arthritis research & therapy 2024 Jan 25;26(1):36
Arthritis research & therapy 2024 Jan 25;26(1):36
Identification of key pyroptosis-related genes and microimmune environment among peripheral arterial beds in atherosclerotic arteries.
Liu JW, Zhang ZH, Lv XS, Xu MY, Ni B, He B, Wang F, Chen J, Zhang JB, Ye ZD, Liu P, Wen JY
Scientific reports 2024 Jan 2;14(1):233
Scientific reports 2024 Jan 2;14(1):233
An integrated RNA-Seq and network pharmacology approach for exploring the preventive effect of Corydalis bungeana Turcz. Extract and Acetylcorynoline on LPS-induced acute lung injury.
Li Q, Xiang Y, Zhang Z, Qu X, Wu J, Fu J, Zhu F, Tang H
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117048
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117048
Tetrastigma hemsleyanum suppresses neuroinflammation in febrile seizures rats via regulating PKC-δ/caspase-1 signaling pathway.
Ji W, Zhu H, Xing B, Chu C, Ji T, Ge W, Wang J, Peng X
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116912
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116912
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Qin DE, Liang W, Yu Y, Whelan EC, Yuan X, Wang ZL, Wu XW, Cao ZR, Hua SY, Yin L, Shi L, Liang T
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116906
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116906
A High MCT-Based Ketogenic Diet Suppresses Th1 and Th17 Responses to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice by Inhibiting GSDMD and JAK2-STAT3/4 Pathways.
Zhang Q, Sun W, Wang Q, Zheng X, Zhang R, Zhang N
Molecular nutrition & food research 2024 Feb;68(3):e2300602
Molecular nutrition & food research 2024 Feb;68(3):e2300602
Egg Yolk Lipids Alleviated Dextran Sulfate Sodium-Induced Colitis by Inhibiting NLRP3 Inflammasome and Regulating Gut Microbiota.
Xiao N, He W, Chen S, Yao Y, Wu N, Xu M, Du H, Zhao Y, Tu Y
Molecular nutrition & food research 2024 Feb;68(3):e2300509
Molecular nutrition & food research 2024 Feb;68(3):e2300509
Demethylase FTO-Mediated m6A Modification of lncRNA MEG3 Activates Neuronal Pyroptosis via NLRP3 Signaling in Cerebral Ischemic Stroke.
Yan H, Huang W, Rao J, Yan D, Yuan J
Molecular neurobiology 2024 Feb;61(2):1023-1043
Molecular neurobiology 2024 Feb;61(2):1023-1043
TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation.
Hao X, Zhao B, Towers M, Liao L, Monteiro EL, Xu X, Freeman C, Peng H, Tang HY, Havas A, Kossenkov AV, Berger SL, Adams PD, Speicher DW, Schultz D, Marmorstein R, Zaret KS, Zhang R
Nature aging 2024 Feb;4(2):185-197
Nature aging 2024 Feb;4(2):185-197
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
Li M, Huang Z, Zhou Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
NLRP3 activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis.
Shi B, Lyu CJ, Le ZK, Ji HS, Xiao Y, Zhang YY, Huang SJ, Yu LJ, Shu Q, Tou JF, Lai DM
World journal of pediatrics : WJP 2024 Feb;20(2):153-164
World journal of pediatrics : WJP 2024 Feb;20(2):153-164
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
Xu S, Kong L, Li L, Wang C, Gu J, Luo H, Meng Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
Li L, Kong L, Xu S, Wang C, Gu J, Luo H, Meng Q
Hepatology international 2024 Feb;18(1):188-205
Hepatology international 2024 Feb;18(1):188-205
Palmatine ameliorated lipopolysaccharide-induced sepsis-associated encephalopathy mice by regulating the microbiota-gut-brain axis.
Xu Y, Shen B, Pan X, Liu C, Wang Y, Chen X, Wang T, Chen G, Chen J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155307
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155307
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice.
Zhou Y, Zhao Q, Zhang Y, Di L, Xue F, Xu W, Gao W, Guo Y, He Y, Kou J, Qin Y, Xie X, Du L, Han G, Pang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155298
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155298
KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling.
Chen Y, Sun L, Liu H, Li J, Guo L, Wang Z
Immunity, inflammation and disease 2024 Feb;12(2):e1199
Immunity, inflammation and disease 2024 Feb;12(2):e1199
Berberine inhibits NLRP3 inflammasome activation by regulating mTOR/mtROS axis to alleviate diabetic cardiomyopathy.
Zhong C, Xie Y, Wang H, Chen W, Yang Z, Zhang L, Deng Q, Cheng T, Li M, Ju J, Liu Y, Liang H
European journal of pharmacology 2024 Feb 5;964:176253
European journal of pharmacology 2024 Feb 5;964:176253
Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury.
Wang BJ, Chen YY, Chang HH, Chen RJ, Wang YJ, Lee YH
Particle and fibre toxicology 2024 Feb 28;21(1):9
Particle and fibre toxicology 2024 Feb 28;21(1):9
The E3 ubiquitin ligase MARCH2 protects against myocardial ischemia-reperfusion injury through inhibiting pyroptosis via negative regulation of PGAM5/MAVS/NLRP3 axis.
Liu S, Bi Y, Han T, Li YE, Wang Q, Wu NN, Xu C, Ge J, Hu R, Zhang Y
Cell discovery 2024 Feb 27;10(1):24
Cell discovery 2024 Feb 27;10(1):24
PPAR γ activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement.
Wu D, Shen Z, Gou Y, Yu T, Hong J, Wang Y, Ni F, Qiqige N, Lu H, Xue E
Chemico-biological interactions 2024 Feb 25;390:110877
Chemico-biological interactions 2024 Feb 25;390:110877
Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis.
Li S, Xue X, Zhang H, Jiang L, Zhang Y, Zhu X, Wang Y
Chemico-biological interactions 2024 Feb 25;390:110868
Chemico-biological interactions 2024 Feb 25;390:110868
Baicalin attenuates lipopolysaccharide-induced intestinal inflammatory injury via suppressing PARP1-mediated NF-κB and NLRP3 signalling pathway.
Lu Q, Wang N, Wen D, Guo P, Liu Y, Fu S, Ye C, Wu Z, Qiu Y
Toxicon : official journal of the International Society on Toxinology 2024 Feb 23;239:107612
Toxicon : official journal of the International Society on Toxinology 2024 Feb 23;239:107612
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
Lou J, Jin M, Zhou C, Fan Y, Ni L, Mao Y, Shen H, Li J, Zhang H, Fu C, Mao X, Chen Y, Zhong J, Zhou K, Wang L, Wu J
Free radical biology & medicine 2024 Feb 20;212:133-148
Free radical biology & medicine 2024 Feb 20;212:133-148
NLRP3-GSDMD-dependent IL-1β Secretion from Microglia Mediates Learning and Memory Impairment in a Chronic Intermittent Hypoxia-induced Mouse Model.
Li C, Zhao Z, Jin J, Zhao C, Zhao B, Liu Y
Neuroscience 2024 Feb 16;539:51-65
Neuroscience 2024 Feb 16;539:51-65
Serine synthesis sustains macrophage IL-1β production via NAD(+)-dependent protein acetylation.
Wang C, Chen Q, Chen S, Fan L, Gan Z, Zhao M, Shi L, Bin P, Yang G, Zhou X, Ren W
Molecular cell 2024 Feb 15;84(4):744-759.e6
Molecular cell 2024 Feb 15;84(4):744-759.e6
Potential effects of different cell death inhibitors in protecting against ischemia-reperfusion injury in steatotic liver.
Junzhe J, Meng L, Weifan H, Min X, Jiacheng L, Yihan Q, Ke Z, Fang W, Dongwei X, Hailong W, Xiaoni K
International immunopharmacology 2024 Feb 15;128:111545
International immunopharmacology 2024 Feb 15;128:111545
Calcitonin gene-related peptide attenuated discogenic low back pain in rats possibly via inhibiting microglia activation.
Xie W, Li F, Han Y, Chi X, Qin Y, Ye F, Li Z, Xiao J
Heliyon 2024 Feb 15;10(3):e25906
Heliyon 2024 Feb 15;10(3):e25906
Machine learning and experiments revealed a novel pyroptosis-based classification linked to diagnosis and immune landscape in spinal cord injury.
Zhang Z, Zhu Z, Liu D, Wang X, Liu X, Mi Z, Fu J, Fan H
Heliyon 2024 Feb 15;10(3):e24974
Heliyon 2024 Feb 15;10(3):e24974
Buyang Huanwu Decoction suppresses cardiac inflammation and fibrosis in mice after myocardial infarction through inhibition of the TLR4 signalling pathway.
Zhang G, Han X, Xu T, Liu M, Chen G, Xie L, Xu H, Hua Y, Pang M, Hu C, Wu Y, Liu B, Zhou Y
Journal of ethnopharmacology 2024 Feb 10;320:117388
Journal of ethnopharmacology 2024 Feb 10;320:117388
CTRP3 inhibits myocardial fibrosis through the P2X7R-NLRP3 inflammasome pathway in SHR rats.
Liu N, Gong Z, Li Y, Xu Y, Guo Y, Chen W, Sun X, Yin X, Liu W
Journal of hypertension 2024 Feb 1;42(2):315-328
Journal of hypertension 2024 Feb 1;42(2):315-328
The role and mechanism of NLRP3 in wasp venom-induced acute kidney injury.
Li H, Gong J, Bian F, Yu F, Yuan H, Hu F
Toxicon : official journal of the International Society on Toxinology 2024 Feb 1;238:107570
Toxicon : official journal of the International Society on Toxinology 2024 Feb 1;238:107570
Tanshinone IIA alleviates inflammation-induced skeletal muscle atrophy by regulating mitochondrial dysfunction.
Han D, Chen YB, Zhao K, Li HZ, Chen XY, Zhu GZ, Tu C, Gao JW, Zhuang JS, Wu ZY, Zhong ZM
Archives of biochemistry and biophysics 2024 Dec;762:110215
Archives of biochemistry and biophysics 2024 Dec;762:110215
The role of Gαq in regulating NLRP3 inflammasome activation.
Kong R, Peng L, Bao H, Sun L, Feng Y, Li H, Wang D
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Dec;73(12):2249-2261
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Dec;73(12):2249-2261
Mechanism of Resveratrol on LPS/ATP-induced pyroptosis and inflammatory response in HT29 cells.
Zhao P, Ning J, Huang J, Huang X
Autoimmunity 2024 Dec;57(1):2427094
Autoimmunity 2024 Dec;57(1):2427094
Esaxerenone Inhibits Interferon-γ Induced Pyroptosis of Macrophages in the Lungs of Aldosterone-treated Mice.
Chang J, Gao X, Yang F, Qiang P, Fan L, Liu Z, Shimosawa T, Xu Q, Chang Y
Inflammation 2024 Dec;47(6):2145-2158
Inflammation 2024 Dec;47(6):2145-2158
Association between mitophagy and NLRP3 inflammasome in uric acid nephropathy.
Li XQ, Gu YQ, Ling YY, Wang M, Miao J, Xue L, Ji W, Liu J
Renal failure 2024 Dec;46(2):2438847
Renal failure 2024 Dec;46(2):2438847
Obeticholic acid ameliorates sepsis-induced renal mitochondrial damage by inhibiting the NF-κb signaling pathway.
Jing D, Liu J, Qin D, Lin J, Li T, Li Y, Duan M
Renal failure 2024 Dec;46(2):2368090
Renal failure 2024 Dec;46(2):2368090
Mesenchymal stem cell-loaded hydrogel to inhibit inflammatory reaction in surgical brain injury via mitochondria transfer.
Wang Y, Yang X, Liu M, Yan Y, Kong F, Wang J, Zhang Z, Chen Y, Chen L, Liang Z, Peng X, Liu F
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:231-240
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:231-240
Proliferative mechanism of benign prostatic hyperplasia by NLRP3 inflammasome through the complement pathway.
Hata J, Matsuoka K, Harigane Y, Yaginuma K, Akaihata H, Meguro S, Honda-Takinami R, Onagi A, Sato Y, Ogawa S, Uemura M, Kojima Y
International journal of urology : official journal of the Japanese Urological Association 2024 Dec;31(12):1429-1437
International journal of urology : official journal of the Japanese Urological Association 2024 Dec;31(12):1429-1437
PANoptosis signaling enables broad immune response in psoriasis: From pathogenesis to new therapeutic strategies.
Hu XM, Zheng S, Zhang Q, Wan X, Li J, Mao R, Yang R, Xiong K
Computational and structural biotechnology journal 2024 Dec;23:64-76
Computational and structural biotechnology journal 2024 Dec;23:64-76
Activation of spleen tyrosine kinase (SYK) contributes to neuronal pyroptosis and cognitive impairment in diabetic mice via the NLRP3/Caspase-1/GSDMD signaling pathway.
Zhou C, Li J, Wu X, Liu F
Experimental gerontology 2024 Dec;198:112626
Experimental gerontology 2024 Dec;198:112626
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE(-/-) mice via MBOAT2-mediated endoplasmic reticulum stress.
Yu B, Yuan C, Chen J, Zhou Z, Zhang Y, Su M, Wei D, Wu P
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Dec;1869(8):159559
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Dec;1869(8):159559
Melatonin protects RPE cells from necroptosis and NLRP3 activation via promoting SERCA2-related intracellular Ca(2+) homeostasis.
Ren C, Hu C, Hu M, Wu Y, Yang Y, Lu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156088
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156088
Gelsevirine ameliorates sepsis-associated encephalopathy by inhibiting the STING signalling-mediated pyroptosis pathway in microglia.
Zeng QQ, Wang J, Yue RC, Wang FS, Xu Y, Su YP, Zhang QL, Zheng YW, Zhang GF, Li B, Yu CX, Jin GL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156071
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156071
Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway.
Li W, Zhong Y, Lin Z, Deng Z, Long D, Li M, Li C, Mao G, Kang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156052
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156052
Jianwei Shoutai Pills alleviates miscarriage by modulating gut microbial production of BAs and NLRP3-inflammasome at the maternal-fetal interface of rats.
Chen S, Xue X, Zhang H, Huang X, Lin X, He J, Chen L, Luo S, Gao J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156000
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156000
Transcriptomic changes in the hypothalamus of mice with chronic migraine: Activation of pathways associated with neuropathic inflammation and central sensitization.
Gong J, Duan X, Xiang B, Qin L, Hu J
Molecular and cellular neurosciences 2024 Dec;131:103968
Molecular and cellular neurosciences 2024 Dec;131:103968
NLRP12 c.1382dup promotes the development of Crohn's disease through the ERK/NLRP3/ IL-1β pathway.
Huang Y, Xu L, Yang Q, Xiao X, Ye Z, Li R, Guan Y, Wu X
Gene 2024 Dec 30;931:148855
Gene 2024 Dec 30;931:148855
Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine.
Fan Z, Su D, Li ZC, Sun S, Ge Z
Journal of neuroinflammation 2024 Dec 3;21(1):318
Journal of neuroinflammation 2024 Dec 3;21(1):318
Nicotinamide adenine dinucleotide phosphate alleviates intestinal ischemia/reperfusion injury via Nrf2/HO-1 pathway.
Chen SY, Xu H, Qin Y, He TQ, Shi RR, Xing YR, Xu J, Cong RC, Wang MR, Yang JS, Gu JH, He BS
International immunopharmacology 2024 Dec 25;143(Pt 2):113478
International immunopharmacology 2024 Dec 25;143(Pt 2):113478
CARD9 promotes cholangiocarcinoma by regulating the IL-17A/Hedgehog and the THEM4/AKT/mTOR signaling pathways.
Zhang T, Zhu LX, Sun QK, Chen LJ, Qian YB
International immunopharmacology 2024 Dec 25;143(Pt 2):113399
International immunopharmacology 2024 Dec 25;143(Pt 2):113399
Chlorogenic acid alleviates IPEC-J2 pyroptosis induced by deoxynivalenol by inhibiting activation of the NF-κB/NLRP3/caspase-1 pathway.
Xue Y, Li F, Li R, Zhang X, Guo H, Wang C
Journal of animal science and biotechnology 2024 Dec 2;15(1):159
Journal of animal science and biotechnology 2024 Dec 2;15(1):159
Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy.
Hu Z, Zhou Y, Gao C, Liu J, Pan C, Guo J
Diabetology & metabolic syndrome 2024 Dec 18;16(1):296
Diabetology & metabolic syndrome 2024 Dec 18;16(1):296
Role of AhR-Hsp90-MDM2-mediated VDR ubiquitination in PM2.5-induced renal toxicity.
Zhang P, Wang L, Zhang J, An Q, Wang Y, Hu N, Pu D, He L, Huang J
Environmental research 2024 Dec 15;263(Pt 2):120174
Environmental research 2024 Dec 15;263(Pt 2):120174
Comparison of Endoplasmic Reticulum Stress and Pyroptosis Induced by Pathogenic Calcium Oxalate Monohydrate and Physiologic Calcium Oxalate Dihydrate Crystals in HK-2 Cells: Insights into Kidney Stone Formation.
Nong WJ, Tong XY, Ouyang JM
Cells 2024 Dec 15;13(24)
Cells 2024 Dec 15;13(24)
Porcine Epidemic Diarrhea Virus Infection of Porcine Intestinal Epithelial Cells Causes Mitochondrial DNA Release and the Activation of the NLRP3 Inflammasome to Mediate Interleukin-1β Secretion.
Bao D, Yi S, Zhao L, Zhao H, Liu J, Wei Y, Hu G, Liu X
Veterinary sciences 2024 Dec 12;11(12)
Veterinary sciences 2024 Dec 12;11(12)
Exosomes derived from diabetic microenvironment-preconditioned mesenchymal stem cells ameliorate nonalcoholic fatty liver disease and inhibit pyroptosis of hepatocytes.
Wang A, Li B, Su W, Zhang H, Hu R, Zhang Y, Zhao J, Ren R, Mu Y, Cheng Y, Lyu Z
Experimental cell research 2024 Dec 1;443(2):114325
Experimental cell research 2024 Dec 1;443(2):114325
Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics.
Zhao M, Xie J, Zhang J, Zhao B, Zhang Y, Xue J, Zhang R, Zhang R, Wang H, Li Y, Ge W, Zhou X
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124935
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124935
Vaping/e-cigarette-induced pulmonary extracellular vesicles contribute to exacerbated cardiomyocyte impairment through the translocation of ERK5.
Liu C, Zhang Y, Zhao J, Zhang J, Meng Z, Yang Y, Xie Y, Jiao X, Liang B, Cao J, Wang Y
Life sciences 2024 Dec 1;358:123195
Life sciences 2024 Dec 1;358:123195
TRPM7 contributes to pyroptosis and its involvement in status epilepticus.
Tong X, Tong Y, Zheng J, Shi R, Liang H, Li M, Meng Y, Shi J, Zhao D, Seehus CR, Wang J, Xu X, Boczek T, Suzuki S, Fleig A, Penner R, Zhang N, Xu J, Duan J, Yu Z, Wang W, Zhao W, Guo F
Journal of neuroinflammation 2024 Dec 1;21(1):315
Journal of neuroinflammation 2024 Dec 1;21(1):315
DL-3-n-Butylphthalide Ameliorates Post-stroke Emotional Disorders by Suppressing Neuroinflammation and PANoptosis.
Cui Y, Hu Z, Wang L, Zhu B, Deng L, Zhang H, Wang X
Neurochemical research 2024 Aug;49(8):2215-2227
Neurochemical research 2024 Aug;49(8):2215-2227
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease.
Wang XF, Xiang XH, Wei J, Zhang PB, Xu Q, Liu MH, Qu LQ, Wang XX, Yu L, Wu AG, Qing DL, Wu JM, Law BY, Yu CL, Yong-Tang
Neurochemical research 2024 Aug;49(8):2197-2214
Neurochemical research 2024 Aug;49(8):2197-2214
Blockade of thromboxane A2 signaling attenuates ethanol-induced myocardial inflammatory response in mice.
Ai W, Casey CA, Mishra PK, Alnouti Y, Daria S, Saraswathi V
Alcohol, clinical & experimental research 2024 Aug;48(8):1529-1540
Alcohol, clinical & experimental research 2024 Aug;48(8):1529-1540
Tongqiao Yizhi granule repress the nuclear factor kappa-b/nucleotide oligomerization domain-like receptors 3/caspase-1 pyroptosis pathway in the hippocampus to counter vascular dementia in rats.
Yanjiao LI, Linyao H, Shuangyang LI, Yanqi L, Juan W, Raoqiong W, Xue B
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Aug;44(4):680-687
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Aug;44(4):680-687
Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment.
Ye Z, Sheu WC, Qu H, Peng B, Liu J, Zhang L, Yuan F, Wei Y, Zhou J, Chen Q, Xiao X, Zhang S
Small science 2024 Aug;4(8):2400081
Small science 2024 Aug;4(8):2400081
Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A.
Dong Y, Shao E, Li S, Wang R, Wang D, Wang L, Yang H, He Y, Luan T, Chen Y, Wang Y, Lin L, Wang Y, Zhong Z, Zhao W
Virologica Sinica 2024 Aug;39(4):685-693
Virologica Sinica 2024 Aug;39(4):685-693
Obstructive Sleep Apnea Plasma-Derived Exosomes Mediate Cognitive Impairment Through Hippocampal Neuronal Cell Pyroptosis.
Chen Z, Shang Y, Ou Y, Shen C, Cao Y, Hu H, Yang R, Liu T, Liu Q, Song M, Zong D, Xiang X, Peng Y, Ouyang R
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2024 Aug;32(8):922-939
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2024 Aug;32(8):922-939
Apoptosis and pyroptosis in the nasal mucosa of Syrian hamster during SARS-CoV-2 infection and reinfection.
Li H, Zhao X, Zhang X, Zheng H, Wang Y, Hou J, Li J, Zhao Y, Peng S, Li Y, Zhang X, Zhang Y, Yang J, Zhang Z, Shi H, Liu L
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1246-1259
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1246-1259
The VDAC1 oligomerization regulated by ATP5B leads to the NLRP3 inflammasome activation in the liver cells under PFOS exposure.
Ma Y, Yang W, Liang P, Feng R, Qiu T, Zhang J, Sun X, Li Q, Yang G, Yao X
Ecotoxicology and environmental safety 2024 Aug;281:116647
Ecotoxicology and environmental safety 2024 Aug;281:116647
Co-exposure of microcystin-LR and nitrite induced kidney injury through TLR4/NLRP3/GSDMD-mediated pyroptosis.
Guo Y, Du X, Wang F, Fu Y, Guo X, Meng R, Ge K, Zhang S
Ecotoxicology and environmental safety 2024 Aug;281:116629
Ecotoxicology and environmental safety 2024 Aug;281:116629
Oridonin ameliorates ocular surface inflammatory responses by inhibiting the NLRP3/caspase-1/GSDMD pyroptosis pathway in dry eye.
Li X, Chen C, Chen Y, Jiang K, Zhao X, Zhang F, Li Y
Experimental eye research 2024 Aug;245:109955
Experimental eye research 2024 Aug;245:109955
RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis.
Guan Z, Li H, Zhang C, Huang Z, Ye M, Zhang Y, Li S, Peng K
PLoS pathogens 2024 Aug;20(8):e1012387
PLoS pathogens 2024 Aug;20(8):e1012387
Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats.
Liang JH, Yu H, Xia CP, Zheng YH, Zhang Z, Chen Y, Raza MA, Wu L, Yan H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117006
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117006
Inhibition of cGAS attenuates neonatal hypoxic-ischemic encephalopathy via regulating microglia polarization and pyroptosis.
Shen H, Lu H, Mao L, Song L
Translational pediatrics 2024 Aug 31;13(8):1378-1394
Translational pediatrics 2024 Aug 31;13(8):1378-1394
Combined bacterial translocation and cholestasis aggravates liver injury by activation pyroptosis in obstructive jaundice.
Shen X, Zhang X, Li K, Huang G, Li X, Hou Y, Ge X
Heliyon 2024 Aug 30;10(16):e35793
Heliyon 2024 Aug 30;10(16):e35793
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Xie X, Wang K, Shen X, Li X, Wang S, Yuan S, Li B, Wang Z
Journal of hazardous materials 2024 Aug 15;475:134854
Journal of hazardous materials 2024 Aug 15;475:134854
HMGB1/TLR4 axis promotes pyroptosis after ICH by activating the NLRP3 inflammasome.
Lei C, Chen K, Gu Y, Li Y, Wang L, Zhu X, Deng Q
Journal of neuroimmunology 2024 Aug 15;393:578401
Journal of neuroimmunology 2024 Aug 15;393:578401
CCR5 antagonist maraviroc alleviates doxorubicin-induced neuroinflammation and neurobehavioral deficiency by regulating NF-κB/NLRP3 signaling in a breast cancer mouse model.
Wu Y, Che J, Dong J, Zhang X, Deng Y, Chen W, Zhang J
Neuropharmacology 2024 Aug 15;254:109981
Neuropharmacology 2024 Aug 15;254:109981
Syntaxin17 Restores Lysosomal Function and Inhibits Pyroptosis Caused by Acinetobacter baumannii.
An Z, Ding W
Journal of microbiology (Seoul, Korea) 2024 Apr;62(4):315-325
Journal of microbiology (Seoul, Korea) 2024 Apr;62(4):315-325
Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model.
Wen G, Zhan X, Xu X, Xia X, Jiang S, Ren X, Ren W, Lou H, Lu L, Hermenean A, Yao J, Gao L, Li B, Lu Y, Wu X
Molecular neurobiology 2024 Apr;61(4):2049-2062
Molecular neurobiology 2024 Apr;61(4):2049-2062
NLRP3 Inflammasome-dependent Pathway is Involved in the Pathogenesis of Polycystic Ovary Syndrome.
Wang B, Shi M, Yu C, Pan H, Shen H, Du Y, Zhang Y, Liu B, Xi D, Sheng J, Huang H, Ding G
Reproductive sciences (Thousand Oaks, Calif.) 2024 Apr;31(4):1017-1027
Reproductive sciences (Thousand Oaks, Calif.) 2024 Apr;31(4):1017-1027
Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics.
Zhang A, Pan Y, Wang H, Ding R, Zou T, Guo D, Shen Y, Ji P, Huang W, Wen Q, Wang Q, Hu H, Wu J, Xiang M, Ye B
Aging cell 2024 Apr;23(4):e14091
Aging cell 2024 Apr;23(4):e14091
SARS-CoV-2 virus-like particle variants alpha and delta mimic the native viruses in their differential inflammasome activating potential.
Bandyszewska M, Ambrożek-Latecka M, Hoser G, Grzanka M, Hornung F, Deinhardt-Emmer S, Skirecki T
Antiviral research 2024 Apr;224:105857
Antiviral research 2024 Apr;224:105857
Methylmercury induces inflammatory response and autophagy in microglia through the activation of NLRP3 inflammasome.
Li X, Ma K, Tian T, Pang H, Liu T, Li M, Li J, Luo Z, Hu H, Hou S, Yu J, Hou Q, Song X, Zhao C, Du H, Li J, Du Z, Jin M
Environment international 2024 Apr;186:108631
Environment international 2024 Apr;186:108631
A snake cathelicidin enhances transcription factor EB-mediated autophagy and alleviates ROS-induced pyroptosis after ischaemia-reperfusion injury of island skin flaps.
Yang N, Yu G, Lai Y, Zhao J, Chen Z, Chen L, Fu Y, Fang P, Gao W, Cai Y, Li Z, Xiao J, Zhou K, Ding J
British journal of pharmacology 2024 Apr;181(7):1068-1090
British journal of pharmacology 2024 Apr;181(7):1068-1090
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
Xu Y, Sun D, Xiong L, Zhang Z, Li Y, Liu K, Li H, Chen L
Bioorganic chemistry 2024 Apr;145:107190
Bioorganic chemistry 2024 Apr;145:107190
Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus.
Wang TB, He Y, Li RC, Yu YX, Liu Y, Qi ZQ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155448
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155448
Baohuoside I suppresses the NLRP3 inflammasome activation via targeting GPER to fight against Parkinson's disease.
Gu Y, Hu ZF, Zheng DW, Yang YQ, Dong XL, Chen WF
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155435
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155435
Research Note: The effect of photoperiod on the NLRP3 inflammasome and gut microbiota in broiler chickens.
Ma D, Yu M, Zhang M, Feng J
Poultry science 2024 Apr;103(4):103507
Poultry science 2024 Apr;103(4):103507
TMAO promotes vascular endothelial cell pyroptosis via the LPEAT-mitophagy pathway.
Chen Y, Yuan C, Qin W, Yu B, Wei D, Wu P
Biochemical and biophysical research communications 2024 Apr 9;703:149667
Biochemical and biophysical research communications 2024 Apr 9;703:149667
Mycobacterium tuberculosis PE_PGRS38 Enhances Intracellular Survival of Mycobacteria by Inhibiting TLR4/NF-κB-Dependent Inflammation and Apoptosis of the Host.
Ullah H, Shi X, Taj A, Cheng L, Yan Q, Sha S, Ahmad, Kang J, Haris M, Ma X, Ma Y
Biology 2024 Apr 30;13(5)
Biology 2024 Apr 30;13(5)
MCC950 attenuates plasma cell mastitis in an MDSC-dependent manner.
Sun X, Hou J, Ni T, Xu Z, Yan W, Kong L, Zhang Q
International immunopharmacology 2024 Apr 20;131:111803
International immunopharmacology 2024 Apr 20;131:111803
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis.
Zhao J, Yang T, Yi J, Hu H, Lai Q, Nie L, Liu M, Chu C, Yang J
iScience 2024 Apr 19;27(4):109321
iScience 2024 Apr 19;27(4):109321
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats.
Jia X, Ju J, Li Z, Peng X, Wang J, Gao F
European journal of pharmacology 2024 Apr 15;969:176428
European journal of pharmacology 2024 Apr 15;969:176428
Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome.
Zhang GL, Liu Y, Liu YF, Huang XT, Tao Y, Chen ZH, Lai HL
World journal of diabetes 2024 Apr 15;15(4):724-734
World journal of diabetes 2024 Apr 15;15(4):724-734
Mesenchymal Stem Cells-Derived Exosomes Alleviate Acute Lung Injury by Inhibiting Alveolar Macrophage Pyroptosis.
Liu P, Yang S, Shao X, Li C, Wang Z, Dai H, Wang C
Stem cells translational medicine 2024 Apr 15;13(4):371-386
Stem cells translational medicine 2024 Apr 15;13(4):371-386
Protective role of forsythoside B in Kawasaki disease-induced cardiac injury: Inhibition of pyroptosis via the SIRT1-NF-κB-p65 signaling pathway.
Yang Y, Wang N, Wang Z, Zhao M, Chen L, Shi Z
Chemico-biological interactions 2024 Apr 1;392:110953
Chemico-biological interactions 2024 Apr 1;392:110953
Mechanically tough, adhesive, self-healing hydrogel promotes annulus fibrosus repair via autologous cell recruitment and microenvironment regulation.
Wei Z, Ye H, Li Y, Li X, Liu Y, Chen Y, Yu J, Wang J, Ye X
Acta biomaterialia 2024 Apr 1;178:50-67
Acta biomaterialia 2024 Apr 1;178:50-67
LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
Zhang YH, Sun TT, Liu ZH, Li X, Fan XF, Han LP
Scientific reports 2024 Apr 1;14(1):7652
Scientific reports 2024 Apr 1;14(1):7652
Role and significance of SIRT1 in regulating the LPS-activated pyroptosis pathway in children with congenital hydronephrosis.
Wang Z, Weizhong G, Zhou J, Tang D
World journal of pediatric surgery 2023;6(4):e000602
World journal of pediatric surgery 2023;6(4):e000602
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
Unresolved Excess Accumulation of Myelin-Derived Cholesterol Contributes to Scar Formation after Spinal Cord Injury.
Zheng B, He Y, Yin S, Zhu X, Zhao Q, Yang H, Wang Z, Zhu R, Cheng L
Research (Washington, D.C.) 2023;6:0135
Research (Washington, D.C.) 2023;6:0135
Irisin Ameliorated Skeletal Muscle Atrophy by Inhibiting Fatty Acid Oxidation and Pyroptosis Induced by Palmitic Acid in Chronic Kidney Disease.
Zhou T, Wang S, Pan Y, Dong X, Wu L, Meng J, Zhang J, Pang Q, Zhang A
Kidney & blood pressure research 2023;48(1):628-641
Kidney & blood pressure research 2023;48(1):628-641
Butylphthalide improves brain damage induced by renal ischemia-reperfusion injury rats through Nrf2/HO-1 and NOD2/MAPK/NF-κB pathways.
Min J, Chen Q, Pan M, Liu T, Gu Q, Zhang D, Sun R
Renal failure 2023;45(2):2259234
Renal failure 2023;45(2):2259234
Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor.
Huang HJ, Lee YH, Sung LC, Chen YJ, Chiu YJ, Chiu HW, Zheng CM
Computational and structural biotechnology journal 2023;21:3490-3502
Computational and structural biotechnology journal 2023;21:3490-3502
Trimethylamine-N-Oxide Promotes High-Glucose-Induced Dysfunction and NLRP3 Inflammasome Activation in Retinal Microvascular Endothelial Cells.
Xue L, Huang L, Tian Y, Cao X, Song Y
Journal of ophthalmology 2023;2023:8224752
Journal of ophthalmology 2023;2023:8224752
Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis.
He J, Cui J, Shi Y, Wang T, Xin J, Li Y, Shan X, Zhu Z, Gao Y
Journal of diabetes research 2023;2023:7423661
Journal of diabetes research 2023;2023:7423661
Human Umbilical Cord Mesenchymal Stem Cells Inhibit Pyroptosis of Renal Tubular Epithelial Cells through miR-342-3p/Caspase1 Signaling Pathway in Diabetic Nephropathy.
Zheng S, Zhang K, Zhang Y, He J, Ouyang Y, Lang R, Ao C, Jiang Y, Xiao H, Li Y, Li M, Li C, Wu D
Stem cells international 2023;2023:5584894
Stem cells international 2023;2023:5584894
Hemoglobin Derived from Subarachnoid Hemorrhage-Induced Pyroptosis of Neural Stem Cells via ROS/NLRP3/GSDMD Pathway.
Yue T, Li X, Chen X, Zhu T, Li W, Wang B, Hang C
Oxidative medicine and cellular longevity 2023;2023:4383332
Oxidative medicine and cellular longevity 2023;2023:4383332
HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model.
He YF, Hu XM, Khan MA, Yu BY, Sheng YC, Xiao XZ, Wan XX, Tan SP, Xiong K
Mediators of inflammation 2023;2023:2252255
Mediators of inflammation 2023;2023:2252255
DDX3X Deficiency Attenuates Pyroptosis Induced by Oxygen-glucose Deprivation/Reoxygenation in N2a Cells.
Liu Y, Gui Y, Tang H, Yu J, Yuan Z, Liu L, Ma X, Li C
Current neurovascular research 2023;20(2):197-206
Current neurovascular research 2023;20(2):197-206
High-dose remifentanil exacerbates myocardial ischemia-reperfusion injury through activation of calcium-sensing receptor-mediated pyroptosis.
Zhu Y, Chi J, Cai S, Liu S, Yuan J, Xu H, Zhou H
International journal of medical sciences 2023;20(12):1570-1583
International journal of medical sciences 2023;20(12):1570-1583
NLRP3 Inflammasome Mediates Silica-induced Lung Epithelial Injury and Aberrant Regeneration in Lung Stem/Progenitor Cell-derived Organotypic Models.
Zhou H, Zhang Q, Huang W, Zhou S, Wang Y, Zeng X, Wang H, Xie W, Kong H
International journal of biological sciences 2023;19(6):1875-1893
International journal of biological sciences 2023;19(6):1875-1893
Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease.
Lou Q, Pan L, Xiang S, Li Y, Jin J, Tan J, Huang B, Nan K, Lin S
International journal of nanomedicine 2023;18:2447-2463
International journal of nanomedicine 2023;18:2447-2463
Network Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis.
Feng M, Luo F, Wu H, Chen Y, Zuo J, Weng X, Chen G, Zhong J
Drug design, development and therapy 2023;17:3169-3192
Drug design, development and therapy 2023;17:3169-3192
Resolvin D1 Attenuates Inflammation and Pelvic Pain Associated with EAP by Inhibiting Oxidative Stress and NLRP3 Inflammasome Activation via the Nrf2/HO-1 Pathway.
Zhang J, Chen J, Jiang Q, Feng R, Zhao X, Li H, Yang C, Hua X
Journal of inflammation research 2023;16:3365-3379
Journal of inflammation research 2023;16:3365-3379
Activation of the microglial P2X7R/NLRP3 inflammasome mediates central sensitization in a mouse model of medication overuse headache.
Wang Y, Dong L, Zhang Y, Zhang Y, Qin G, Zhang D, Chen L, He W, Zhou J
Frontiers in molecular neuroscience 2023;16:1177171
Frontiers in molecular neuroscience 2023;16:1177171
Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.
Zhang Q, Su X, Zhang C, Chen W, Wang Y, Yang X, Liu D, Zhang Y, Yang R
Cellular and molecular gastroenterology and hepatology 2023;15(3):613-632
Cellular and molecular gastroenterology and hepatology 2023;15(3):613-632
Aspirin-triggered Resolvin D1 ameliorates activation of the NLRP3 inflammasome via induction of autophagy in a rat model of neuropathic pain.
Wang YH, Tang YR, Gao X, Zhang NN, Lv QQ, Liu J, Li Y
Frontiers in pharmacology 2023;14:971136
Frontiers in pharmacology 2023;14:971136
Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation.
Tang S, Liang Y, Wang M, Lei J, Peng Y, Tao Q, Ming T, Yang W, Zhang C, Guo J, Xu H
Frontiers in immunology 2023;14:1285550
Frontiers in immunology 2023;14:1285550
A novel colchicine-myricetin heterozygous molecule: design, synthesis, and effective evaluations on the pathological models of acute lung injury in vitro and in vivo.
Li Z, Yan X, Wei J, Pu L, Zhu G, Cao Y, Liu Z, Liu Y, Li Y, Li L, Li X, Wu Z
Frontiers in pharmacology 2023;14:1224906
Frontiers in pharmacology 2023;14:1224906
Identification of molecular subtypes based on PANoptosis-related genes and construction of a signature for predicting the prognosis and response to immunotherapy response in hepatocellular carcinoma.
Zhu J, Huang Q, Peng X, Luo C, Liu Z, Liu D, Yuan H, Yuan R, Cheng X
Frontiers in immunology 2023;14:1218661
Frontiers in immunology 2023;14:1218661
Inhibition of neutrophil extracellular trap formation attenuates NLRP1-dependent neuronal pyroptosis via STING/IRE1α pathway after traumatic brain injury in mice.
Cao Y, Shi M, Liu L, Zuo Y, Jia H, Min X, Liu X, Chen Z, Zhou Y, Li S, Yang G, Liu X, Deng Q, Chen F, Chen X, Zhang S, Zhang J
Frontiers in immunology 2023;14:1125759
Frontiers in immunology 2023;14:1125759
Exercise training-attenuated insulin resistance and liver injury in elderly pre-diabetic patients correlates with NLRP3 inflammasome.
Zhang T, Tian J, Fan J, Liu X, Wang R
Frontiers in immunology 2023;14:1082050
Frontiers in immunology 2023;14:1082050
Investigation of He's Yang Chao recipe against oxidative stress-related mitophagy and pyroptosis to improve ovarian function.
Miao C, Zhao Y, Chen Y, Wang R, Ren N, Chen B, Dong P, Zhang Q
Frontiers in endocrinology 2023;14:1077315
Frontiers in endocrinology 2023;14:1077315
Outer membrane vesicles derived from gut microbiota mediate tubulointerstitial inflammation: a potential new mechanism for diabetic kidney disease.
Chen PP, Zhang JX, Li XQ, Li L, Wu QY, Liu L, Wang GH, Ruan XZ, Ma KL
Theranostics 2023;13(12):3988-4003
Theranostics 2023;13(12):3988-4003
Ablation of NLRP3 inflammasome attenuates muscle atrophy via inhibiting pyroptosis, proteolysis and apoptosis following denervation.
You Z, Huang X, Xiang Y, Dai J, Xu L, Jiang J, Xu J
Theranostics 2023;13(1):374-390
Theranostics 2023;13(1):374-390
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Xu L, Zeng Z, Niu C, Liu D, Lin S, Liu X, Szabó G, Lu J, Zheng S, Zhou P
Frontiers in cardiovascular medicine 2023;10:1126391
Frontiers in cardiovascular medicine 2023;10:1126391
Role of NLRP3 inflammasome activation in HCC cell progression.
Dai B, Cao H, Hu Y, Gong Z, Huang X, Chen Y, Liu F, Peng X, Zhang Y, Lei X
Heliyon 2023 Sep;9(9):e19542
Heliyon 2023 Sep;9(9):e19542
Protection of Oxygen Glucose Deprivation-Induced Human Brain Vascular Pericyte Injury: Beneficial Effects of Bellidifolin in Cellular Pyroptosis.
An D, Xu W, Ge Y, Ge Y, Zhang L, Zhu Y, Zhang Z, Fan J, Gao R, Jiang L, Huang P, Wang J, Chen X
Neurochemical research 2023 Sep;48(9):2794-2807
Neurochemical research 2023 Sep;48(9):2794-2807
Sanguisorba officinalis L. promotes diabetic wound healing in rats through inflammation response mediated by macrophage.
Song J, Zeng J, Zheng S, Jiang N, Wu A, Guo S, Ye R, Hu L, Huang F, Wang L, Xiaogang Z, Liu B, Wu J, Chen Q
Phytotherapy research : PTR 2023 Sep;37(9):4265-4281
Phytotherapy research : PTR 2023 Sep;37(9):4265-4281
Pinocembrin alleviates pyroptosis and apoptosis through ROS elimination in random skin flaps via activation of SIRT3.
Li J, Li Y, Wang X, Xie Y, Lou J, Yang Y, Jiang S, Ye M, Chen H, Diao W, Xu S
Phytotherapy research : PTR 2023 Sep;37(9):4059-4075
Phytotherapy research : PTR 2023 Sep;37(9):4059-4075
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.
An X, Wu W, Yang L, Dong J, Liu B, Guo J, Chen J, Guo B, Cao W, Jiang Q
Translational research : the journal of laboratory and clinical medicine 2023 Sep;259:62-71
Translational research : the journal of laboratory and clinical medicine 2023 Sep;259:62-71
Functionalized Metal-Organic Framework-Modified Hydrogel That Breaks the Vicious Cycle of Inflammation and ROS for Repairing of Diabetic Bone Defects.
Lao A, Wu J, Li D, Shen A, Li Y, Zhuang Y, Lin K, Wu J, Liu J
Small (Weinheim an der Bergstrasse, Germany) 2023 Sep;19(36):e2206919
Small (Weinheim an der Bergstrasse, Germany) 2023 Sep;19(36):e2206919
PM(2.5) induces the inflammatory response in rat spleen lymphocytes through autophagy activation of NLRP3 inflammasome.
Guan L, Shi H, Tian J, Wang X, Liu N, Wang C, Zhang Z
Molecular immunology 2023 Sep;161:74-81
Molecular immunology 2023 Sep;161:74-81
Maslinic acid alleviates LPS-induced mice mastitis by inhibiting inflammatory response, maintaining the integrity of the blood-milk barrier and regulating intestinal flora.
Li K, Ran X, Zeng Y, Li S, Hu G, Wang X, Li Y, Yang Z, Liu J, Fu S
International immunopharmacology 2023 Sep;122:110551
International immunopharmacology 2023 Sep;122:110551
3,4-benzo[a]pyrene aggravates myocardial infarction injury by activating NLRP3-related pyroptosis through PINK1/Parkin-mitophagy-mPTP opening axis.
Wu BS, Xiang HQ, Yu YW, Liu S, Song DY, Wu C, Lin ZH, Zhu CX, Xue YJ, Ji KT
International immunopharmacology 2023 Sep;122:110481
International immunopharmacology 2023 Sep;122:110481
Lunasin reduces the susceptibility of IL-10 deficient mice to inflammatory bowel disease and modulates the activation of the NLRP3 inflammasome.
Nieto-Veloza A, Hong S, Reeder M, Sula MJ, D'Souza DH, Zhong Q, Dia VP
The Journal of nutritional biochemistry 2023 Sep;119:109383
The Journal of nutritional biochemistry 2023 Sep;119:109383
Record-High Ultrasound-Sensitive NO Nanogenerators for Cascade Tumor Pyroptosis and Immunotherapy.
Bao Y, Ge Y, Wu M, Mao Z, Ye J, Tong W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(26):e2302278
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(26):e2302278
Aloe-Emodin Derivative, an Anthraquinone Compound, Attenuates Pyroptosis by Targeting NLRP3 Inflammasome in Diabetic Cardiomyopathy.
Hu Y, Zhang S, Lou H, Mikaye MS, Xu R, Meng Z, Du M, Tang P, Chen Z, Chen Y, Liu X, Du Z, Zhang Y
Pharmaceuticals (Basel, Switzerland) 2023 Sep 8;16(9)
Pharmaceuticals (Basel, Switzerland) 2023 Sep 8;16(9)
Bone marrow mesenchymal stem cellsderived exosomes stabilize atherosclerosis through inhibiting pyroptosis.
Bai Z, Hu H, Hu F, Ji J, Ji Z
BMC cardiovascular disorders 2023 Sep 7;23(1):441
BMC cardiovascular disorders 2023 Sep 7;23(1):441
Jiedu Quyu Decoction mitigates monocrotaline-induced right-sided heart failure associated with pulmonary artery hypertension by inhibiting NLRP3 inflammasome in rats.
Ma Q, Wang M, Li L, Zhang X, Cui L, Mou J, Sun G, Zhang Q
Journal of ethnopharmacology 2023 Sep 15;313:116556
Journal of ethnopharmacology 2023 Sep 15;313:116556
MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands.
Zhou M, Barkema HW, Gao J, Yang J, Wang Y, Kastelic JP, Khan S, Liu G, Han B
Veterinary research 2023 Sep 14;54(1):78
Veterinary research 2023 Sep 14;54(1):78
Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis.
Kong X, Zhao Y, Wang X, Yu Y, Meng Y, Yan G, Yu M, Jiang L, Song W, Wang B, Wang X
Chemico-biological interactions 2023 Sep 1;382:110640
Chemico-biological interactions 2023 Sep 1;382:110640
Toll-like receptor 4 promotes the inflammatory response in septic acute kidney injury by promoting p38 mitogen-activated protein kinase phosphorylation.
Yue L, Liu X, Wu C, Lai J, Wang J, Zhong H, Chen F
Journal of bioenergetics and biomembranes 2023 Oct;55(5):353-363
Journal of bioenergetics and biomembranes 2023 Oct;55(5):353-363
CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria.
Yao Y, Cao Y, Xu Y, Chen G, Liu Y, Jiang H, Fan R, Qin W, Wang X, Chai H, Chen X, Qiu Z, Chen W
The Canadian journal of cardiology 2023 Oct;39(10):1449-1462
The Canadian journal of cardiology 2023 Oct;39(10):1449-1462
Neuroprotection of NSC Therapy is Superior to Glibenclamide in Cardiac Arrest-Induced Brain Injury via Neuroinflammation Regulation.
Wang Z, Zhang S, Du J, Lachance BB, Chen S, Polster BM, Jia X
Translational stroke research 2023 Oct;14(5):723-739
Translational stroke research 2023 Oct;14(5):723-739
Lianhua Qingke ameliorates lipopolysaccharide-induced lung injury by inhibiting neutrophil extracellular traps formation and pyroptosis.
Peng W, Qi H, Zhu W, Tong L, Rouzi A, Wu Y, Han L, He L, Yan Y, Pan T, Liu J, Wang Q, Jia Z, Song Y, Zhu Q, Zhou J
Pulmonary circulation 2023 Oct;13(4):e12295
Pulmonary circulation 2023 Oct;13(4):e12295
CXCL5 promotes lipotoxicity of hepatocytes through upregulating NLRP3/Caspase-1/IL-1β signaling in Kupffer cells and exacerbates nonalcoholic steatohepatitis in mice.
Qi J, Yan X, Li L, Qiu K, Huang W, Zhou Z
International immunopharmacology 2023 Oct;123:110752
International immunopharmacology 2023 Oct;123:110752
Salvianolic acid B inhibits atherosclerosis and TNF-α-induced inflammation by regulating NF-κB/NLRP3 signaling pathway.
Zhao Y, Shao C, Zhou H, Yu L, Bao Y, Mao Q, Yang J, Wan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155002
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155002
Down-regulation of OIP5-AS1 inhibits obesity-induced myocardial pyroptosis and miR-22/NLRP3 inflammasome axis.
Yue Q, Liu Y, Ji J, Hu T, Lin T, Yu S, Li S, Wu N
Immunity, inflammation and disease 2023 Oct;11(10):e1066
Immunity, inflammation and disease 2023 Oct;11(10):e1066
Cordyceps militaris Solid Medium Extract Alleviates Lipoteichoic Acid-Induced MH-S Inflammation by Inhibiting TLR2/NF-κB/NLRP3 Pathways.
Wang X, Peng Z, Wang L, Zhang J, Zhang K, Guo Z, Xu G, Li J
International journal of molecular sciences 2023 Oct 24;24(21)
International journal of molecular sciences 2023 Oct 24;24(21)
ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer.
Su P, Mao X, Ma J, Huang L, Yu L, Tang S, Zhuang M, Lu Z, Osafo KS, Ren Y, Wang X, Lin X, Huang L, Huang X, Braicu EI, Sehouli J, Sun P
Journal of experimental & clinical cancer research : CR 2023 Oct 20;42(1):274
Journal of experimental & clinical cancer research : CR 2023 Oct 20;42(1):274
CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis.
Zhang H, Deng Z, Wang Y, Zheng X, Zhou L, Yan S, Wang Y, Dai Y, Kanwar YS, Deng F
iScience 2023 Oct 20;26(10):107762
iScience 2023 Oct 20;26(10):107762
Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions.
Shah W, Zhao Q, Wang S, Zhang M, Ma H, Guan Y, Zhang Y, Liu Y, Zhu C, Wang S, Zhang X, Dong J, Ma H
Scientific reports 2023 Oct 2;13(1):16550
Scientific reports 2023 Oct 2;13(1):16550
Oroxylin a promoted apoptotic extracellular vesicles transfer of glycolytic kinases to remodel immune microenvironment in hepatocellular carcinoma model.
Wang P, Cao J, Feng Z, Tang Y, Han X, Mao T, Li S, Guo Q, Ke X, Zhang X
European journal of pharmacology 2023 Oct 15;957:176037
European journal of pharmacology 2023 Oct 15;957:176037
Colchicine protects against the development of experimental abdominal aortic aneurysm.
Zhao Y, Shen QR, Chen YX, Shi Y, Wu WB, Li Q, Li DJ, Shen FM, Fu H
Clinical science (London, England : 1979) 2023 Oct 11;137(19):1533-1545
Clinical science (London, England : 1979) 2023 Oct 11;137(19):1533-1545
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
Hao W, Zhu X, Liu Z, Song Y, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
HDAC3 inhibitor (BRD3308) modulates microglial pyroptosis and neuroinflammation through PPARγ/NLRP3/GSDMD to improve neurological function after intraventricular hemorrhage in mice.
Li Y, Liu C, Wang G, Wang H, Liu X, Huang C, Chen Y, Fan L, Zhou L, Tong A
Neuropharmacology 2023 Oct 1;237:109633
Neuropharmacology 2023 Oct 1;237:109633
AR/PCC herb pair inhibits osteoblast pyroptosis to alleviate diabetes-related osteoporosis by activating Nrf2/Keap1 pathway.
Fu F, Luo H, Du Y, Chen Y, Tian K, Pan J, Li J, Wang N, Bao R, Jin H, Tong P, Ruan H, Wu C
Journal of cellular and molecular medicine 2023 Nov;27(22):3601-3613
Journal of cellular and molecular medicine 2023 Nov;27(22):3601-3613
Unraveling the protective mechanisms of Chuanfangyihao against acute lung injury: Insights from experimental validation.
Fu H, Liang X, Tan W, Hu X
Experimental and therapeutic medicine 2023 Nov;26(5):535
Experimental and therapeutic medicine 2023 Nov;26(5):535
Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells.
Zhuang C, Zhao J, Zhang S, Shahid M
Microbial pathogenesis 2023 Nov;184:106338
Microbial pathogenesis 2023 Nov;184:106338
Effects of HMGB1/RAGE/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic-ischemic brain damage.
Zhu K, Zhu X, Yu J, Chen L, Liu S, Yan M, Yang W, Sun Y, Zhang Z, Li J, Shen T, Hei M
Journal of neurochemistry 2023 Nov;167(3):410-426
Journal of neurochemistry 2023 Nov;167(3):410-426
Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells.
Song D, Tao W, Liu F, Wu X, Bi H, Shu J, Wang D, Li X
Molecular immunology 2023 Nov;163:127-135
Molecular immunology 2023 Nov;163:127-135
Diallyl disulfide attenuates pyroptosis via NLRP3/Caspase-1/IL-1β signaling pathway to exert a protective effect on hypoxic-ischemic brain damage in neonatal rats.
Zheng Y, Zhu T, Chen B, Fang Y, Wu Y, Feng X, Pang M, Wang H, Zhu J, Lin Z
International immunopharmacology 2023 Nov;124(Pt B):111030
International immunopharmacology 2023 Nov;124(Pt B):111030
The role of EndophilinA1 in chronic unpredicted mild stress-induced depression model mice.
Liu M, Ling Y, Zhang Y, Liu L, Qiu Y, Liu Y, Yin Y
International immunopharmacology 2023 Nov;124(Pt B):111023
International immunopharmacology 2023 Nov;124(Pt B):111023
Inhibition of Caspase-1-mediated pyroptosis promotes osteogenic differentiation, offering a therapeutic target for osteoporosis.
Ruan H, Zhang H, Feng J, Luo H, Fu F, Yao S, Zhou C, Zhang Z, Bian Y, Jin H, Zhang Y, Wu C, Tong P
International immunopharmacology 2023 Nov;124(Pt B):110901
International immunopharmacology 2023 Nov;124(Pt B):110901
Melatonin alleviates intrarenal CaOx crystals deposition through inhibiting LPS-induced non-canonical inflammasome-mediated renal tubular epithelial cells pyroptosis.
Yao K, Zhang ZH, Liu MD, Niu FW, Li X, Ding DM, Wang DM, Yu DX, Xu DX, Xie DD
International immunopharmacology 2023 Nov;124(Pt A):110796
International immunopharmacology 2023 Nov;124(Pt A):110796
Vasculoprotective Potential of Baicalein in Angiotensin II-Infused Abdominal Aortic Aneurysms through Inhibiting Inflammation and Oxidative Stress.
Sulistyowati E, Huang SE, Cheng TL, Chao YY, Li CY, Chang CW, Lin MX, Lin MC, Yeh JL
International journal of molecular sciences 2023 Nov 6;24(21)
International journal of molecular sciences 2023 Nov 6;24(21)
TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice.
Gao Z, Lv H, Wang Y, Xie Y, Guan M, Xu Y
Molecular medicine (Cambridge, Mass.) 2023 Nov 27;29(1):160
Molecular medicine (Cambridge, Mass.) 2023 Nov 27;29(1):160
[Inhibition of Histone Deacetylase 6 Ameliorates Podocyte Injury in Diabetic Kidney Disease in Mice].
Hou Q, Kan S, Zhang M, Xu F, Liu Z, Jiang S
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2023 Nov 20;54(6):1097-1104
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2023 Nov 20;54(6):1097-1104
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer.
Xie W, Peng M, Liu Y, Zhang B, Yi L, Long Y
Cell communication and signaling : CCS 2023 Nov 16;21(1):329
Cell communication and signaling : CCS 2023 Nov 16;21(1):329
GSK2656157, a PERK Inhibitor, Alleviates Pyroptosis of Macrophages Induced by Mycobacterium Bacillus Calmette-Guerin Infection.
Ma B, Nie X, Liu L, Li M, Chen Q, Liu Y, Hou Y, Yang Y, Xu J
International journal of molecular sciences 2023 Nov 12;24(22)
International journal of molecular sciences 2023 Nov 12;24(22)
STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.
Sun Z, Liu H, Hu Y, Luo G, Yuan Z, Tu B, Ruan H, Li J, Fan C
Clinical immunology (Orlando, Fla.) 2023 May;250:109300
Clinical immunology (Orlando, Fla.) 2023 May;250:109300
Heme oxygenase‑1 inhibits renal tubular epithelial cell pyroptosis by regulating mitochondrial function through PINK1.
Li HB, Mo YS, Zhang XZ, Zhou Q, Liang XD, Song JN, Hou LN, Wu JN, Guo Y, Feng DD, Sun Y, Yu JB
Experimental and therapeutic medicine 2023 May;25(5):213
Experimental and therapeutic medicine 2023 May;25(5):213
Rosuvastatin promotes survival of random skin flaps through AMPK-mTOR pathway-induced autophagy.
Ye H, Li F, Shen Y, Wu X, Zhao L, Zhang H, Yang J, Shui X
International immunopharmacology 2023 May;118:110059
International immunopharmacology 2023 May;118:110059
Supramolecular salicylic acid ameliorates rosacea-like eruptions by suppressing NLRP3-mediated inflammasome activation in mice.
Wang J, Sun Y, Chen L, Wang Y, Shi D, Wu Y, Gao X
International immunopharmacology 2023 May;118:110057
International immunopharmacology 2023 May;118:110057
CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice.
Li J, Wang H, Liu D, Li X, He L, Pan J, Shen Q, Peng Y
Brain, behavior, and immunity 2023 May;110:60-79
Brain, behavior, and immunity 2023 May;110:60-79
The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.
Chi S, Li S, Xu Z, Yang G, Song Y, Liao Z, Yang C, Wu X
Biochemical and biophysical research communications 2023 May 7;655:1-10
Biochemical and biophysical research communications 2023 May 7;655:1-10
MALAT1 participates in the role of platelet-rich plasma exosomes in promoting wound healing of diabetic foot ulcer.
Chen C, Wang Q, Li D, Qi Z, Chen Y, Wang S
International journal of biological macromolecules 2023 May 31;238:124170
International journal of biological macromolecules 2023 May 31;238:124170
Adipolin protects against renal injury via PPARα-dependent reduction of inflammasome activation.
Fang L, Ohashi K, Hayakawa S, Ogawa H, Otaka N, Kawanishi H, Takikawa T, Ozaki Y, Takahara K, Tatsumi M, Takefuji M, Shimizu Y, Bando YK, Fujishima Y, Maeda N, Shimomura I, Murohara T, Ouchi N
iScience 2023 May 19;26(5):106591
iScience 2023 May 19;26(5):106591
HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome.
Chen N, Chen P, Zhou Y, Chen S, Gong S, Fu M, Geng L
Vaccines 2023 May 17;11(5)
Vaccines 2023 May 17;11(5)
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis.
Jiang H, Bai Z, Ou Y, Liu H, Si Z, Liu Y, Liu X, Liu X, Zhang Z, Tan N
Journal of ethnopharmacology 2023 May 10;307:116013
Journal of ethnopharmacology 2023 May 10;307:116013
Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.
Fan HX, Sheng S, Li DD, Li JJ, Wang GQ, Zhang F
Bioengineering & translational medicine 2023 Mar;8(2):e10455
Bioengineering & translational medicine 2023 Mar;8(2):e10455
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
Chen Y, Liu Y, Jiang K, Wen Z, Cao X, Wu S
Journal of orthopaedic translation 2023 Mar;39:1-11
Journal of orthopaedic translation 2023 Mar;39:1-11
TMEM16F may be a new therapeutic target for Alzheimer's disease.
Cui ZQ, Hu XY, Yang T, Guan JW, Gu Y, Li HY, Zhang HY, Xiao QH, Sun XH
Neural regeneration research 2023 Mar;18(3):643-651
Neural regeneration research 2023 Mar;18(3):643-651
Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage.
Hu LT, Wang BY, Fan YH, He ZY, Zheng WX
Neural regeneration research 2023 Mar;18(3):560-567
Neural regeneration research 2023 Mar;18(3):560-567
The Effect of Gut Microbiota on the Progression of Intervertebral Disc Degeneration.
Yao B, Cai Y, Wang W, Deng J, Zhao L, Han Z, Wan L
Orthopaedic surgery 2023 Mar;15(3):858-867
Orthopaedic surgery 2023 Mar;15(3):858-867
Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.
Chen Y, Wang L, Huang ZS, Feng JX, Li SX, Du ZJ, Zhang ZB, Liu J, Yang J, Hu ZM, Wang ZL, Chen J
Andrology 2023 Mar;11(3):591-610
Andrology 2023 Mar;11(3):591-610
Melatonin protects human nucleus pulposus cells from pyroptosis by regulating Nrf2 via melatonin membrane receptors.
Bai Z, Shou Z, Hu K, Yu J, Meng H, Chen C
Bone & joint research 2023 Mar 7;12(3):202-211
Bone & joint research 2023 Mar 7;12(3):202-211
Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway.
Guan X, Shen S, Liu J, Song H, Chang J, Mao X, Song J, Zhang L, Liu C
BMC complementary medicine and therapies 2023 Mar 6;23(1):72
BMC complementary medicine and therapies 2023 Mar 6;23(1):72
Comprehensive analysis of autophagy-related gene expression profiles identified five gene biomarkers associated with immune infiltration and advanced plaques in carotid atherosclerosis.
Ma C, Lu T, He Y, Guo D, Duan L, Jia R, Cai D, Gao T, Chen Z, Xue B, Li T, He Y
Orphanet journal of rare diseases 2023 Mar 23;18(1):66
Orphanet journal of rare diseases 2023 Mar 23;18(1):66
Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.
Yang X, Dong S, Li C, Li M, Xing C, He J, Peng C, Shao H, Jia Q
Toxicology letters 2023 Mar 1;376:39-50
Toxicology letters 2023 Mar 1;376:39-50
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.
Zhang H, Xie Z, Peng Y, Xie A, Fu C, Zheng D, Cai Z, Zhong J, Ming Q, Li M, Lu R, Liu X, Chen J
Ecotoxicology and environmental safety 2023 Mar 1;252:114630
Ecotoxicology and environmental safety 2023 Mar 1;252:114630
Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.
Zeng Z, You M, Fan C, Rong R, Li H, Xia X
Redox biology 2023 Jun;62:102687
Redox biology 2023 Jun;62:102687
Targeting hexokinase 1 alleviates NLRP3-mediated inflammation in apical periodontitis: A laboratory investigation.
Qian Y, Chen D, Zhu Y, Wu J, Wang Y, Yang W
International endodontic journal 2023 Jun;56(6):734-747
International endodontic journal 2023 Jun;56(6):734-747
Salmonella typhimurium exacerbates injuries but resolves fibrosis in liver and spleen during Schistosoma mansoni infection.
Lam HYP, Wu WJ, Liang TR, Li HC, Chang KC, Peng SY
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2023 Jun;56(3):477-489
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2023 Jun;56(3):477-489
Exercise Mitigates Endothelial Pyroptosis and Atherosclerosis by Downregulating NEAT1 Through N6-Methyladenosine Modifications.
Yang Q, Chen S, Wang X, Yang X, Chen L, Huang T, Zheng Y, Zheng X, Wu X, Sun Y, Wu J
Arteriosclerosis, thrombosis, and vascular biology 2023 Jun;43(6):910-926
Arteriosclerosis, thrombosis, and vascular biology 2023 Jun;43(6):910-926
MicroRNA-29a-3p Prevents Drug-Induced Acute Liver Failure through Inflammation-Related Pyroptosis Inhibition.
Xiang DD, Liu JT, Zhong ZB, Xiong Y, Kong HY, Yu HJ, Peng T, Huang JQ
Current medical science 2023 Jun;43(3):456-468
Current medical science 2023 Jun;43(3):456-468
Serum amyloid A and interleukin -1β facilitate LDL transcytosis across endothelial cells and atherosclerosis via NF-κB/caveolin-1/cavin-1 pathway.
Jia X, Liu Z, Wang Y, Li G, Bai X
Atherosclerosis 2023 Jun;375:87-97
Atherosclerosis 2023 Jun;375:87-97
Circulating exosomal miR-155-5p contributes to severe acute pancreatitis-associated intestinal barrier injury by targeting SOCS1 to activate NLRP3 inflammasome-mediated pyroptosis.
Shao Y, Li Y, Jiang Y, Li H, Wang J, Zhang D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jun;37(6):e23003
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jun;37(6):e23003
Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
Wang F, Fan X, Kong J, Wang C, Ma B, Sun W, Ye Z, Liu P, Wen J
Vascular 2023 Jun;31(3):533-543
Vascular 2023 Jun;31(3):533-543
BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.
Yao B, Cai Y, Wan L, Deng J, Zhao L, Wang W, Han Z
The journal of gene medicine 2023 Jun;25(6):e3488
The journal of gene medicine 2023 Jun;25(6):e3488
SS-31 Improves Cognitive Function in Sepsis-Associated Encephalopathy by Inhibiting the Drp1-NLRP3 Inflammasome Activation.
Zhong L, Ren X, Ai Y, Liu Z
Neuromolecular medicine 2023 Jun;25(2):230-241
Neuromolecular medicine 2023 Jun;25(2):230-241
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Wang W, Gu Y, Ni H, Quan Q, Guo L
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Jinyinqingre Oral Liquid alleviates LPS-induced acute lung injury by inhibiting the NF-κB/NLRP3/GSDMD pathway.
Wang S, Lei P, Feng Y, Jiang M, Liu Z, Shen T, Ma S, Wang L, Guo X, DU S
Chinese journal of natural medicines 2023 Jun;21(6):423-435
Chinese journal of natural medicines 2023 Jun;21(6):423-435
Growth differentiation factor 15 protects the airway by inhibiting cell pyroptosis in obese asthmatic mice through the phosphoinositide 3-kinase/AKT pathway.
Li N, He F, Shang Y
International immunopharmacology 2023 Jun;119:110149
International immunopharmacology 2023 Jun;119:110149
Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice.
Chen WJ, Zhuang Y, Peng W, Cui W, Zhang SJ, Wang JW
Chinese medicine 2023 Jun 29;18(1):80
Chinese medicine 2023 Jun 29;18(1):80
Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain.
Cheng Y, Dempsey RE, Roodsari SK, Shuboni-Mulligan DD, George O, Sanford LD, Guo ML
Biomedicines 2023 Jun 23;11(7)
Biomedicines 2023 Jun 23;11(7)
Baicalein Suppresses NLRP3 and AIM2 Inflammasome-Mediated Pyroptosis in Macrophages Infected by Mycobacterium tuberculosis via Induced Autophagy.
Ning B, Shen J, Liu F, Zhang H, Jiang X
Microbiology spectrum 2023 Jun 15;11(3):e0471122
Microbiology spectrum 2023 Jun 15;11(3):e0471122
Metal-enriched HSP90 nanoinhibitor overcomes heat resistance in hyperthermic intraperitoneal chemotherapy used for peritoneal metastases.
Wang Q, Liu P, Wen Y, Li K, Bi B, Li BB, Qiu M, Zhang S, Li Y, Li J, Chen H, Yin Y, Zeng L, Zhang C, He Y, Zhao J
Molecular cancer 2023 Jun 14;22(1):95
Molecular cancer 2023 Jun 14;22(1):95
Gastroprotective Effects of the Aqueous Extract of Finger Citron Pickled Products against Ethanol-Induced Gastric Damage: In Vitro and In Vivo Studies.
Chen X, Yang D, Wang Q, Zhou A
Foods (Basel, Switzerland) 2023 Jun 13;12(12)
Foods (Basel, Switzerland) 2023 Jun 13;12(12)
Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome.
Zhang X, Wang Z, Li X, Chen J, Yu Z, Li X, Sun C, Hu L, Wu M, Liu L
Journal of ethnopharmacology 2023 Jun 12;309:116304
Journal of ethnopharmacology 2023 Jun 12;309:116304
Hydrogen-Rich Saline-A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral Ischemia via the ROS-NLRP3 Inflammasome Signaling Pathway In Vivo and In Vitro.
Du Y, Chen L, Qiao H, Zhang L, Yang L, Zhang P, Wang J, Zhang C, Jiang W, Xu R, Zhang X
Brain sciences 2023 Jun 10;13(6)
Brain sciences 2023 Jun 10;13(6)
Translocator protein 18 kDa regulates retinal neuron apoptosis and pyroptosis in glaucoma.
Zeng Z, You M, Rong R, Fan C, Chen M, Li H, Ji D, Xia X
Redox biology 2023 Jul;63:102713
Redox biology 2023 Jul;63:102713
Analgesic Effect of Perineural Injection of BoNT/A on Neuropathic Pain Induced by Chronic Constriction Injury of Sciatic Nerve in Rats.
He JJ, Wei XM, Wu ML, Song ZB, Jiang L, Zhang WX
Neurochemical research 2023 Jul;48(7):2161-2174
Neurochemical research 2023 Jul;48(7):2161-2174
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Hom LM, Sun S, Campbell J, Liu P, Culbert S, Murphy IM, Schafer ZT
The Journal of biological chemistry 2023 Jul;299(7):104922
The Journal of biological chemistry 2023 Jul;299(7):104922
Oxidative Stress Initiates Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Mediated Corneal Epithelial Necroptosis and Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Signaling during Fungal Keratitis.
Wang B, Yang X, Zuo X, Zeng H, Wang X, Huang H, He D, Wang L, Ouyang H, Yuan J
The American journal of pathology 2023 Jul;193(7):883-898
The American journal of pathology 2023 Jul;193(7):883-898
Combined exposure to lead and high-fat diet induced neuronal deficits in rats: Anti-neuroinflammatory role of SIRT1.
Liu M, Liu R, Yang M, Ba Y, Deng Q, Zhang Y, Han L, Gao L, Huang H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113857
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113857
Parthenolide alleviates microglia-mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder.
Fan M, Wang C, Zhao X, Jiang Y, Wang C
International immunopharmacology 2023 Jul;120:110287
International immunopharmacology 2023 Jul;120:110287
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Liu P, Zhou Y, Shi J, Wang F, Yang X, Zheng X, Wang Y, He Y, Xie X, Pang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
Bao J, Gao W, Zhang W, Wang D, Pan H
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Bai Y, Zhang L, Zheng B, Zhang X, Zhang H, Zhao A, Yu J, Yang Z, Wen J
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Song D, Zhang A, Hu X, Zeng M, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease.
Chen S, Liu X, Wang Z, Zheng D, Wang Y, Yan Y, Peng X, Ye Q, Chen Y
Journal of translational medicine 2023 Jul 24;21(1):497
Journal of translational medicine 2023 Jul 24;21(1):497
Glucocorticoid receptor-mediated Nr1d1 chromatin circadian misalignment in stress-induced irritable bowel syndrome.
Zheng G, Pang S, Wang J, Wang F, Wang Q, Yang L, Ji M, Xie D, Zhu S, Chen Y, Zhou Y, Higgins GA, Wiley JW, Hou X, Lin R
iScience 2023 Jul 21;26(7):107137
iScience 2023 Jul 21;26(7):107137
Dihydromyricetin inhibits African swine fever virus replication by downregulating toll-like receptor 4-dependent pyroptosis in vitro.
Chen Y, Song Z, Chang H, Guo Y, Wei Z, Sun Y, Gong L, Zheng Z, Zhang G
Veterinary research 2023 Jul 12;54(1):58
Veterinary research 2023 Jul 12;54(1):58
Attenuation of experimental osteoarthritis with human adipose-derived mesenchymal stem cell therapy: inhibition of the pyroptosis in chondrocytes.
Xu L, Zhang F, Cheng G, Yuan X, Wu Y, Wu H, Wang Q, Chen J, Kuai J, Chang Y, Wei W, Yan S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jan;72(1):89-105
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jan;72(1):89-105
SIRT3 attenuates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome via autophagy.
Sun Z, Fang C, Xu S, Wang B, Li D, Liu X, Mi Y, Guo H, Jiang J
Biochemical pharmacology 2023 Jan;207:115354
Biochemical pharmacology 2023 Jan;207:115354
Activation of PINK1-mediated mitophagy protects bovine mammary epithelial cells against lipopolysaccharide-induced mitochondrial and inflammatory damage in vitro.
Chang R, Tang Y, Jia H, Dong Z, Gao S, Song Q, Dong H, Xu Q, Jiang Q, Loor JJ, Sun X, Xu C
Free radical biology & medicine 2023 Jan;194:172-183
Free radical biology & medicine 2023 Jan;194:172-183
Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway.
Jiang X, Li Y, Fu D, You T, Wu S, Xin J, Wen J, Huang Y, Hu C
International immunopharmacology 2023 Jan;114:109558
International immunopharmacology 2023 Jan;114:109558
Salidroside protects pancreatic β-cells against pyroptosis by regulating the NLRP3/GSDMD pathway in diabetic conditions.
Zhou J, Yan S, Guo X, Gao Y, Chen S, Li X, Zhang Y, Wang Q, Zheng T, Chen L
International immunopharmacology 2023 Jan;114:109543
International immunopharmacology 2023 Jan;114:109543
Protective effects of leonurine hydrochloride on pyroptosis in premature ovarian insufficiency via regulating NLRP3/GSDMD pathway.
Chi YN, Hai DM, Ma L, Cui YH, Hu HT, Liu N, Juan-Du, Lan XB, Yu JQ, Yang JM
International immunopharmacology 2023 Jan;114:109520
International immunopharmacology 2023 Jan;114:109520
Matrine suppresses NLRP3 inflammasome activation via regulating PTPN2/JNK/SREBP2 pathway in sepsis.
Wang X, Wu FP, Huang YR, Li HD, Cao XY, You Y, Meng ZF, Sun KY, Shen XY
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154574
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154574
[Methylophiopogonanone a Inhibits LPS/ATP-Induced Macrophage Pyroptosis via ROS/NLRP3 Pathway].
Zeng HB, Zhang LH, Yuan DP, Wang W, Su XM, Weng WX, Miao R, Xu JY, Long J, Song YH
Molekuliarnaia biologiia 2023 Jan-Feb;57(1):106-108
Molekuliarnaia biologiia 2023 Jan-Feb;57(1):106-108
Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization.
Zhang H, Chen Y, Li F, Wu C, Cai W, Ye H, Su H, He M, Yang L, Wang X, Zhou K, Ni W
Journal of neuroinflammation 2023 Jan 7;20(1):6
Journal of neuroinflammation 2023 Jan 7;20(1):6
TMBIM4 Deficiency Facilitates NLRP3 Inflammasome Activation-Induced Pyroptosis of Trophoblasts: A Potential Pathogenesis of Preeclampsia.
Chen Y, Xiao L, Sun G, Li M, Yang H, Ming Z, Zhao K, Shang X, Zhang H, Liu C
Biology 2023 Jan 29;12(2)
Biology 2023 Jan 29;12(2)
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Tian Y, Feng X, Zhou Z, Qin S, Chen S, Zhao J, Hou J, Liu D
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury.
Rao X, Zhou D, Deng H, Chen Y, Wang J, Zhou X, Jie X, Xu Y, Wu Z, Wang G, Dong X, Zhang S, Meng R, Wu C, Xing S, Fan K, Wu G, Zhou R
Respiratory research 2023 Jan 24;24(1):25
Respiratory research 2023 Jan 24;24(1):25
MicroRNA-29b regulates pyroptosis involving calcific aortic valve disease through the STAT3/SOCS1 pathway.
Fang M, Li B, Li X, Wang Y, Zhuang Y
International journal of cardiology 2023 Jan 15;371:319-328
International journal of cardiology 2023 Jan 15;371:319-328
UFM1 inhibits the activation of the pyroptosis in LPS-induced goat endometritis.
Wang Z, Huang S, Xue Z, Gao K, Sun M, Wang A, Lin P, Jin Y
Theriogenology 2023 Jan 15;196:50-58
Theriogenology 2023 Jan 15;196:50-58
Jatrorrhizine Suppresses Murine-Norovirus-Triggered N-GSDMD-Dependent Pyroptosis in RAW264.7 Macrophages.
Fu M, Chen N, Zhou Y, Chen S, Xu W, Gong S, Geng L
Vaccines 2023 Jan 12;11(1)
Vaccines 2023 Jan 12;11(1)
Cadmium exposure promotes thyroid pyroptosis and endocrine dysfunction by inhibiting Nrf2/Keap1 signaling.
Chen Y, Zhou C, Bian Y, Fu F, Zhu B, Zhao X, Zhang M, Zhou C, Yao S, Zhang Z, Luo H, Ge Y, Wu C, Ruan H
Ecotoxicology and environmental safety 2023 Jan 1;249:114376
Ecotoxicology and environmental safety 2023 Jan 1;249:114376
Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway.
Zhu X, Hao W, Liu Z, Song Y, Hao C, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Jan 1;249:114373
Ecotoxicology and environmental safety 2023 Jan 1;249:114373
Mitophagy-promoting miR-138-5p promoter demethylation inhibits pyroptosis in sepsis-associated acute lung injury.
Liu F, Yang Y, Peng W, Zhao N, Chen J, Xu Z, Cui Y, Qian K
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Feb;72(2):329-346
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Feb;72(2):329-346
Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia.
Yan M, Jin H, Pan C, Han X
Molecular neurobiology 2023 Feb;60(2):884-900
Molecular neurobiology 2023 Feb;60(2):884-900
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223-3p/NLRP3 axis.
Hou L, Zhu Z, Jiang F, Zhao J, Jia Q, Jiang Q, Wang H, Xue W, Wang Y, Tian L
Ecotoxicology and environmental safety 2023 Feb;251:114537
Ecotoxicology and environmental safety 2023 Feb;251:114537
Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15.
Zeng B, Chen Y, Chen H, Zhao Q, Sun Z, Liu D, Li X, Zhang Y, Wang J, Xing HR
Pharmacological research 2023 Feb;188:106660
Pharmacological research 2023 Feb;188:106660
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons.
Yan WT, Zhao WJ, Hu XM, Ban XX, Ning WY, Wan H, Zhang Q, Xiong K
Neural regeneration research 2023 Feb;18(2):357-363
Neural regeneration research 2023 Feb;18(2):357-363
Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K/Akt/NF-κB and NLRP3/caspase-1/GSDMD signaling.
Liu J, Jia S, Yang Y, Piao L, Wang Z, Jin Z, Bai L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114118
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114118
Dimethyl fumarate ameliorates fungal keratitis by limiting fungal growth and inhibiting pyroptosis.
Gu L, Lin J, Wang Q, Zhang L, Yin M, Lin H, Zheng H, Zhao G, Li C
International immunopharmacology 2023 Feb;115:109721
International immunopharmacology 2023 Feb;115:109721
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Jiang X, Lu Z, Zhang Q, Yu J, Han D, Liu J, Li P, Li F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Mace-Like Plasmonic Au-Pd Heterostructures Boost Near-Infrared Photoimmunotherapy.
Feng Y, Ning X, Wang J, Wen Z, Cao F, You Q, Zou J, Zhou X, Sun T, Cao J, Chen X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(6):e2204842
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(6):e2204842
Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis.
Liu D, Tian Q, Liu K, Ren F, Liu G, Zhou J, Yuan L, Fang Z, Zou B, Wang S
Journal of agricultural and food chemistry 2023 Feb 8;
Journal of agricultural and food chemistry 2023 Feb 8;
Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome.
Shu X, Wei C, Tu WY, Zhong K, Qi S, Wang A, Bai L, Zhang SX, Luo B, Xu ZZ, Zhang K, Shen C
Cell reports 2023 Feb 28;42(2):112133
Cell reports 2023 Feb 28;42(2):112133
Notopterol Ameliorates Hyperuricemia-Induced Cardiac Dysfunction in Mice.
Wang Q, Peng D, Huang B, Men L, Jiang T, Huo S, Wang M, Guo J, Lv J, Lin L
Pharmaceuticals (Basel, Switzerland) 2023 Feb 27;16(3)
Pharmaceuticals (Basel, Switzerland) 2023 Feb 27;16(3)
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Hom LM, Sun S, Campbell J, Liu P, Culbert S, Murphy IM, Schafer ZT
bioRxiv : the preprint server for biology 2023 Feb 22;
bioRxiv : the preprint server for biology 2023 Feb 22;
Lacrimal Gland Epithelial Cells Shape Immune Responses through the Modulation of Inflammasomes and Lipid Metabolism.
Delcroix V, Mauduit O, Yang M, Srivastava A, Umazume T, de Paiva CS, Shestopalov VI, Dartt DA, Makarenkova HP
International journal of molecular sciences 2023 Feb 21;24(5)
International journal of molecular sciences 2023 Feb 21;24(5)
Piceatannol and 3'-Hydroxypterostilbene Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice.
Lin WS, Chueh TL, Nagabhushanam K, Ho CT, Pan MH
Journal of agricultural and food chemistry 2023 Feb 1;71(4):1994-2005
Journal of agricultural and food chemistry 2023 Feb 1;71(4):1994-2005
DBDPE upregulates NOD-like receptor signaling to induce NLRP3 inflammasome-mediated HAECs pyroptosis.
Jing L, Zheng D, Sun X, Shi Z
Environmental pollution (Barking, Essex : 1987) 2023 Feb 1;318:120882
Environmental pollution (Barking, Essex : 1987) 2023 Feb 1;318:120882
Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling.
Yan J, Feng G, Yang Y, Ding D, Ma L, Zhao X, Chen X, Wang H, Chen Z, Jin Q
Biomolecules & biomedicine 2023 Feb 1;23(1):77-88
Biomolecules & biomedicine 2023 Feb 1;23(1):77-88
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Chen JW, Shan TK, Wei TW, Jiang QQ, Du C, Gu LF, Yang TT, Zhou LH, Wang SB, Bao YL, Wang H, Ji Y, Xie LP, Gu AH, Sun CQ, Wang QM, Wang LS
Archives of toxicology 2023 Dec;97(12):3209-3226
Archives of toxicology 2023 Dec;97(12):3209-3226
Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway.
Song G, Wang J, Liu J, Ruan Y
Redox biology 2023 Dec;68:102938
Redox biology 2023 Dec;68:102938
Yueliang Yin Ameliorates Endometrial Receptivity in Mice with Embryo Implantation Failure by Reducing Pyroptosis and Activating BDNF/TrkB Pathway.
Jiang M, Huang L, Wang Y, Wang Y, Kang Q, Chen C, Hu Y, Li J, Wang T
Molecular nutrition & food research 2023 Dec;67(23):e2300339
Molecular nutrition & food research 2023 Dec;67(23):e2300339
Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways.
Li J, Yu J, Guo J, Liu J, Wan G, Wei X, Yang X, Shi J
Pharmaceutical biology 2023 Dec;61(1):1175-1185
Pharmaceutical biology 2023 Dec;61(1):1175-1185
Regulating NLRP3 Inflammasome-Induced Pyroptosis via Nrf2: TBHQ Limits Hyperoxia-Induced Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia.
Wang M, Zhang F, Ning X, Wu C, Zhou Y, Gou Z, Fan Y, Duan R, Li Z, Shao C, Lu L
Inflammation 2023 Dec;46(6):2386-2401
Inflammation 2023 Dec;46(6):2386-2401
Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells.
Wan Y, Yu Y, Yu C, Luo J, Wen S, Shen L, Wei G, Hua Y
Renal failure 2023 Dec;45(1):2221138
Renal failure 2023 Dec;45(1):2221138
HBx-induced PLA(2)R overexpression mediates podocyte pyroptosis through the ROS-NLRP3 signaling pathway.
Feng M, Yu Y, Chen Y, Yang X, Li B, Jiang W
Renal failure 2023 Dec;45(1):2170808
Renal failure 2023 Dec;45(1):2170808
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
Tryptophan alleviates lipopolysaccharide-induced liver injury and inflammation by modulating necroptosis and pyroptosis signaling pathways in piglets.
Gu K, Wang F, Sun W, Liu G, Jia G, Zhao H, Chen X, Wu C, Tian G, Cai J, Zhang R, Wang J
Animal biotechnology 2023 Dec;34(8):4069-4080
Animal biotechnology 2023 Dec;34(8):4069-4080
Clodronate liposomes may biases MSC differentiation toward adipogenesis through activation of NLRP3.
Ding S, Wang Y, Liu Z, Du Y, Zhou Y, Liu Y, Sun J, Li Y, Zeng L
Regenerative therapy 2023 Dec;24:54-63
Regenerative therapy 2023 Dec;24:54-63
Hypoxia-inducible factor 1α activates the NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis.
Zhong B, Sun S, Tan KS, Ong HH, Du J, Liu F, Liu Y, Liu S, Ba L, Li J, Wang Y, Liu J
The Journal of allergy and clinical immunology 2023 Dec;152(6):1444-1459.e14
The Journal of allergy and clinical immunology 2023 Dec;152(6):1444-1459.e14
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
Lu D, Liu Y, Huang H, Hu M, Li T, Wang S, Shen S, Wu R, Cai W, Lu T, Lu Z
Translational stroke research 2023 Dec;14(6):910-928
Translational stroke research 2023 Dec;14(6):910-928
Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition.
Jiang X, Yu G, Zhu L, Siddique A, Zhan D, Zhou L, Yue M
Virulence 2023 Dec;14(1):2249779
Virulence 2023 Dec;14(1):2249779
Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis.
Xu J, Tian Z, Li Z, Du X, Cui Y, Wang J, Gao M, Hou Y
Journal of ethnopharmacology 2023 Dec 5;317:116675
Journal of ethnopharmacology 2023 Dec 5;317:116675
ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
Zheng S, Que X, Wang S, Zhou Q, Xing X, Chen L, Hou C, Ma J, An P, Peng Y, Yao Y, Song Q, Li J, Zhang P, Pei H
Molecular cell 2023 Dec 21;83(24):4570-4585.e7
Molecular cell 2023 Dec 21;83(24):4570-4585.e7
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Pei X, Tang S, Jiang H, Zhang W, Xu G, Zuo Z, Ren Z, Chen C, Shen Y, Li C, Li D
The Science of the total environment 2023 Dec 15;904:166885
The Science of the total environment 2023 Dec 15;904:166885
Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke.
Liu L, Cai Y, Deng C
European journal of medical research 2023 Dec 15;28(1):596
European journal of medical research 2023 Dec 15;28(1):596
ASC/inflammasome-independent pyroptosis in ovarian cancer cells through translational augmentation of caspase-1.
Calbay O, Padia R, Akter M, Sun L, Li B, Qian N, Guo J, Fu Z, Jin L, Huang S
iScience 2023 Dec 15;26(12):108408
iScience 2023 Dec 15;26(12):108408
NLRP3 inflammasome-mediated pyroptosis involvement in cadmium exposure-induced cognitive deficits via the Sirt3-mtROS axis.
Wang D, Wu Y, Sun S, Zhao P, Zhou X, Liang C, Ma Y, Li S, Zhu X, Hao X, Shi J, Fan H
The Science of the total environment 2023 Dec 10;903:166478
The Science of the total environment 2023 Dec 10;903:166478
The role of ROS-pyroptosis in PM(2.5) induced air-blood barrier destruction.
Wei M, Cong Y, Lei J, Du R, Yang M, Lu X, Jiang Y, Cao R, Meng X, Jiang Z, Song L
Chemico-biological interactions 2023 Dec 1;386:110782
Chemico-biological interactions 2023 Dec 1;386:110782
Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3.
Song L, Wang L, Li X, Xiao L
Animals : an open access journal from MDPI 2023 Dec 1;13(23)
Animals : an open access journal from MDPI 2023 Dec 1;13(23)
Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury.
Xu Y, Geng Y, Wang H, Zhang H, Qi J, Li F, Hu X, Chen Y, Si H, Li Y, Wang X, Xu H, Kong J, Cai Y, Wu A, Ni W, Xiao J, Zhou K
Redox biology 2023 Aug;64:102767
Redox biology 2023 Aug;64:102767
Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Zhu C, Zhou Q, Wang Z, Zhang J, Xu C, Ruan D
Molecular biology reports 2023 Aug;50(8):6337-6347
Molecular biology reports 2023 Aug;50(8):6337-6347
Inulin-type oligosaccharides of Morinda officinalis exerted antidepressant effects by reducing hippocampal inflammation.
Lai ZK, Yin YY, Yan JZ, Wei QQ, Wang B, Li YF, Zhang LM, Wang YL
Metabolic brain disease 2023 Aug;38(6):2065-2075
Metabolic brain disease 2023 Aug;38(6):2065-2075
The Inhibitory Effect of RADKPS on Pyroptosis of Nucleus Pulposus-Derived Mesenchymal Stem Cells.
Zhu C, Zhou Q, Tang L, Xuan A, Xu C, Wang Z, Ruan D
Tissue engineering. Part A 2023 Aug;29(15-16):424-438
Tissue engineering. Part A 2023 Aug;29(15-16):424-438
Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway.
He B, Nie Q, Wang F, Wang X, Zhou Y, Wang C, Guo J, Fan X, Ye Z, Liu P, Wen J
Journal of cellular physiology 2023 Aug;238(8):1808-1822
Journal of cellular physiology 2023 Aug;238(8):1808-1822
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease.
Yu HY, Sun T, Wang Z, Li H, Xu D, An J, Wen LL, Li JY, Li W, Feng J
Neural regeneration research 2023 Aug;18(8):1818-1826
Neural regeneration research 2023 Aug;18(8):1818-1826
Sodium houttuyfonate plays a protective role in the asthmatic airway by alleviating the NLRP3-related pyroptosis and Th1/Th2 immune imbalance.
Li M, Wang C, Xu WT, Zhong X
Molecular immunology 2023 Aug;160:103-111
Molecular immunology 2023 Aug;160:103-111
Exploring the application of sildenafil for high-fat diet-induced erectile dysfunction based on interleukin-18-mediated NLRP3/Caspase-1 signaling pathway.
Zhu B, Niu Y, Niu L, Zhang X, Liu F
Sexual medicine 2023 Aug;11(4):qfad044
Sexual medicine 2023 Aug;11(4):qfad044
Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model.
Cao H, Yang D, Nie K, Lin R, Peng L, Zhou X, Zhang M, Zeng Y, Liu L, Huang W
European journal of pharmacology 2023 Aug 5;952:175670
European journal of pharmacology 2023 Aug 5;952:175670
Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia.
Xu X, Zhang DD, Kong P, Gao YK, Huang XF, Song Y, Zhang WD, Guo RJ, Li CL, Chen BW, Sun Y, Zhao YB, Jia FY, Wang X, Zhang F, Han M
Cell reports 2023 Aug 29;42(8):112869
Cell reports 2023 Aug 29;42(8):112869
A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression.
Zhang L, Zhang J, Xuan X, Wu D, Yu J, Wang P, Yang X, Zhang J, Gan W, He M, Liu XM, Zhou J, Wang D, Gu W, Li D
Cell reports 2023 Aug 29;42(8):112833
Cell reports 2023 Aug 29;42(8):112833
Neuroprotective Effects of Vinpocetine Against Ischemia-Reperfusion Injury Via Inhibiting NLRP3 Inflammasome Signaling Pathway.
Hou B, Li D, Wang D, Jiang C, Wang G, Wang D, Yan G, Guo X, Zhao L, Wan Z, Fan C, Cao W, Ren H
Neuroscience 2023 Aug 21;526:74-84
Neuroscience 2023 Aug 21;526:74-84
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Gao Z, Zhan H, Zong W, Sun M, Linghu L, Wang G, Meng F, Chen M
Life sciences 2023 Aug 15;327:121793
Life sciences 2023 Aug 15;327:121793
Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.
Sun MX, Qiao FX, Xu ZR, Liu YC, Xu CL, Wang HL, Qi ZQ, Liu Y
Free radical biology & medicine 2023 Aug 1;204:313-324
Free radical biology & medicine 2023 Aug 1;204:313-324
Scutellaria baicalensis Pith-decayed Root Inhibits Macrophage-related Inflammation Through the NF-κB/NLRP3 Pathway to Alleviate LPS-induced Acute Lung Injury.
Zhang F, Ke C, Zhou Z, Xu K, Wang Y, Liu Y, Tu J
Planta medica 2023 Apr;89(5):493-507
Planta medica 2023 Apr;89(5):493-507
Sulforaphane reduces lipopolysaccharide-induced inflammation and enhances myogenic differentiation of mouse embryonic myoblasts via the toll-like receptor 4 and NLRP3 pathways.
Wang M, Liu M, Xu W, Teng Z, Wu X, Gan L, Zhang Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Apr;32(4):457-467
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Apr;32(4):457-467
Bufalin alleviates acute kidney injury by regulating NLRP3 inflammasome-mediated pyroptosis.
Ding L, Yin J, Xu X, Xie D, Xiang D, Tong P, Liu S, Yang X
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):539-548
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):539-548
PRRSV infection activates NLRP3 inflammasome through inducing cytosolic mitochondrial DNA stress.
Li H, Yang X, Song Y, Zhu Q, Liao Z, Liang Y, Guo J, Wan B, Bao D
Veterinary microbiology 2023 Apr;279:109673
Veterinary microbiology 2023 Apr;279:109673
Bullatine A has an antidepressant effect in chronic social defeat stress mice; Implication of microglial inflammasome.
Zhang JR, Yin SY, Shen ZQ, Li B, Zhang YQ, Yu J
Brain research bulletin 2023 Apr;195:130-140
Brain research bulletin 2023 Apr;195:130-140
Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway.
Xu Z, Zhang G, Zhang X, Lei Y, Sun Y, He Y, Yang F, Nan W, Xing X, Li Y, Lin J
The international journal of biochemistry & cell biology 2023 Apr;157:106386
The international journal of biochemistry & cell biology 2023 Apr;157:106386
Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model.
Yu Z, Yazdanpanah G, Alam J, de Paiva CS, Pflugfelder S
Investigative ophthalmology & visual science 2023 Apr 3;64(4):8
Investigative ophthalmology & visual science 2023 Apr 3;64(4):8
Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.
Wu Y, Pi D, Zhou S, Yi Z, Dong Y, Wang W, Ye H, Chen Y, Zuo Q, Ouyang M
Acta biochimica et biophysica Sinica 2023 Apr 19;55(4):587-600
Acta biochimica et biophysica Sinica 2023 Apr 19;55(4):587-600
Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells.
Kang TH, Shin S, Park J, Lee BR, Lee SI
Toxins 2023 Apr 19;15(4)
Toxins 2023 Apr 19;15(4)
Puerarin protects against sepsis-associated encephalopathy by inhibiting NLRP3/Caspase-1/GSDMD pyroptosis pathway and reducing blood-brain barrier damage.
Zhou S, Li Y, Hong Y, Zhong Z, Zhao M
European journal of pharmacology 2023 Apr 15;945:175616
European journal of pharmacology 2023 Apr 15;945:175616
Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B.
Lam HYP, Liang TR, Peng SY
Nutrients 2023 Apr 15;15(8)
Nutrients 2023 Apr 15;15(8)
Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites.
Yu J, Liu T, Guo Q, Wang Z, Chen Y, Dong Y
Microbiology spectrum 2023 Apr 13;11(2):e0469822
Microbiology spectrum 2023 Apr 13;11(2):e0469822
3,4-benzopyrene aggravates myocardial ischemia-reperfusion injury-induced pyroptosis through inhibition of autophagy-dependent NLRP3 degradation.
Huang KY, Liu S, Yu YW, Wu BS, Lin ZH, Zhu CX, Song DY, Xue YJ, Ji KT
Ecotoxicology and environmental safety 2023 Apr 1;254:114701
Ecotoxicology and environmental safety 2023 Apr 1;254:114701
Oroxin A ameliorates the oleic acid-induced A549 cell injury through the suppression of pyroptosis and degradation of alveolar surfactant.
Huang J, Chen C, Xie J, Zhai K, Wei S, Cheng X, Zhang R
Anais da Academia Brasileira de Ciencias 2022;94(suppl 4):e20211400
Anais da Academia Brasileira de Ciencias 2022;94(suppl 4):e20211400
β-hydroxybutyrate impairs monocyte function via the ROS-NLR family pyrin domain-containing three inflammasome (NLRP3) pathway in ketotic cows.
Dong Z, Sun X, Tang Y, Luo S, Jia H, Xu Q, Jiang Q, Loor JJ, Xu W, Xu C
Frontiers in veterinary science 2022;9:925900
Frontiers in veterinary science 2022;9:925900
Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion.
Chen Z, Tang Z, Kong J, Chen L, Liu J, Li Y, Huang W, Li W, Wu J, Zhao W, Meng X, Fan H
Frontiers in nutrition 2022;9:914323
Frontiers in nutrition 2022;9:914323
Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.
Liu Y, Wei Y, Wu L, Lin X, Sun R, Chen H, Shen S, Deng G
Frontiers in nutrition 2022;9:839174
Frontiers in nutrition 2022;9:839174
Using Collagen Peptides From the Skin of Monkfish (Lophius litulon) to Ameliorate Kidney Damage in High-Fat Diet Fed Mice by Regulating the Nrf2 Pathway and NLRP3 Signaling.
Miao B, Zheng J, Zheng G, Tian X, Zhang W, Yuan F, Yang Z
Frontiers in nutrition 2022;9:798708
Frontiers in nutrition 2022;9:798708
Sinapic Acid Alleviates Acute Pancreatitis in Association with Attenuation of Inflammation, Pyroptosis, and the AMPK/NF-[Formula: see text]B Signaling Pathway.
Huang ZW, Tan P, Yi XK, Chen H, Sun B, Shi H, Mou ZQ, Cheng YL, Li TX, Li Q, Fu WG
The American journal of Chinese medicine 2022;50(8):2185-2197
The American journal of Chinese medicine 2022;50(8):2185-2197
Cadmium mediates pyroptosis of human dermal lymphatic endothelial cells in a NLRP3 inflammasome-dependent manner.
Xing H, Liu Q, Hou Y, Tian Z, Liu J
The Journal of toxicological sciences 2022;47(6):237-247
The Journal of toxicological sciences 2022;47(6):237-247
NLRP3 inflammasome inhibitor MCC950 can reduce the damage of pancreatic and intestinal barrier function in mice with acute pancreatitis.
Shen Y, Yang H, Wu D, Yang H, Hong D
Acta cirurgica brasileira 2022;37(7):e370706
Acta cirurgica brasileira 2022;37(7):e370706
Tanshinone IIA ameliorates myocardial ischemia/reperfusion injury in rats by regulation of NLRP3 inflammasome activation and Th17 cells differentiation.
Li D, Yang Z, Gao S, Zhang H, Fan G
Acta cirurgica brasileira 2022;37(7):e370701
Acta cirurgica brasileira 2022;37(7):e370701
HSPB8 Overexpression Ameliorates Cognitive Impairment in Diabetic Mice via Inhibiting NLRP3 Inflammation Activation.
Chang Y, Wu Y, Jiang X, Zhu J, Wang C, Ma R, Li G
Oxidative medicine and cellular longevity 2022;2022:9251835
Oxidative medicine and cellular longevity 2022;2022:9251835
Simvastatin Inhibits NLRP3 Inflammasome Activation and Ameliorates Lung Injury in Hyperoxia-Induced Bronchopulmonary Dysplasia via the KLF2-Mediated Mechanism.
Wang X, Huo R, Liang Z, Xu C, Chen T, Lin J, Li L, Lin W, Pan B, Fu X, Chen S
Oxidative medicine and cellular longevity 2022;2022:8336070
Oxidative medicine and cellular longevity 2022;2022:8336070
Tanshinone IIA Improves Acute Gouty Arthritis in Rats through Regulating Neutrophil Activation and the NLRP3 Inflammasome.
Xu L, Liu X, Zhang Y, Jia T, Li L, Du Y, Chen W, Zhang S
Disease markers 2022;2022:5851412
Disease markers 2022;2022:5851412
Progesterone Reduces ATP-Induced Pyroptosis of SH-SY5Y Cells.
Cui C, Wang X, Zhang S, Wu H, Li M, Dong L, Yan C, Li D
BioMed research international 2022;2022:4827444
BioMed research international 2022;2022:4827444
Luteolin Induced Hippocampal Neuronal Pyroptosis Inhibition by Regulation of miR-124-3p/TNF-α/TRAF6 Axis in Mice Affected by Breast-Cancer-Related Depression.
Zhu Q, Meng P, Han Y, Yang H, Yang Q, Liu Z, Wang Y, Long M
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2715325
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2715325
Polysaccharides from Polygonatum cyrtonema Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis.
Shen F, Xie P, Li C, Bian Z, Wang X, Peng D, Zhu G
Oxidative medicine and cellular longevity 2022;2022:2566917
Oxidative medicine and cellular longevity 2022;2022:2566917
Silencing of TLR4 Inhibits Atrial Fibrosis and Susceptibility to Atrial Fibrillation via Downregulation of NLRP3-TGF-β in Spontaneously Hypertensive Rats.
Ge C, Zhao Y, Liang Y, He Y
Disease markers 2022;2022:2466150
Disease markers 2022;2022:2466150
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Hong Q, Zhang Y, Lin W, Wang W, Yuan Y, Lin J, Xie Z, Li X, Meng Y
Journal of immunology research 2022;2022:2291877
Journal of immunology research 2022;2022:2291877
Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.
Bai L, Dai J, Xia Y, He K, Xue H, Guo Q, Tian D, Xiao L, Zhang X, Teng X, Wu Y, Jin S
Oxidative medicine and cellular longevity 2022;2022:1392896
Oxidative medicine and cellular longevity 2022;2022:1392896
Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury.
Qin X, Zhou Y, Jia C, Chao Z, Qin H, Liang J, Liu X, Liu Z, Sun T, Yuan Y, Zhang H
International journal of biological sciences 2022;18(4):1521-1538
International journal of biological sciences 2022;18(4):1521-1538
Nrf2 Inhibits the Progression of Parkinson's Disease by Upregulating AABR07032261.5 to Repress Pyroptosis.
Zhong Y, Cai X, Ding L, Liao J, Liu X, Huang Y, Chen X, Long L
Journal of inflammation research 2022;15:669-685
Journal of inflammation research 2022;15:669-685
Inhibition of Dectin-1 Alleviates Neuroinflammatory Injury by Attenuating NLRP3 Inflammasome-Mediated Pyroptosis After Intracerebral Hemorrhage in Mice: Preliminary Study Results.
Ding Z, Zhong Z, Wang J, Zhang R, Shao J, Li Y, Wu G, Tu H, Yuan W, Sun H, Wang Q
Journal of inflammation research 2022;15:5917-5933
Journal of inflammation research 2022;15:5917-5933
Comprehensive Analysis of Prognostic Value and Immune Infiltration of NLRC4 and CASP1 in Colorectal Cancer.
Peng L, Zhu N, Wang D, Zhou Y, Liu Y
International journal of general medicine 2022;15:5425-5440
International journal of general medicine 2022;15:5425-5440
Yishen Capsule Alleviated Symptoms of Diabetic Nephropathy via NOD-like Receptor Signaling Pathway.
Zhang Z, Hu Y, Liu W, Zhang X, Wang R, Li H, Sun D, Fang J
Diabetes, metabolic syndrome and obesity : targets and therapy 2022;15:2183-2195
Diabetes, metabolic syndrome and obesity : targets and therapy 2022;15:2183-2195
Trimethylamine N-oxide promotes demyelination in spontaneous hypertension rats through enhancing pyroptosis of oligodendrocytes.
Ji X, Tian L, Niu S, Yao S, Qu C
Frontiers in aging neuroscience 2022;14:963876
Frontiers in aging neuroscience 2022;14:963876
Trichodimerol inhibits inflammation through suppression of the nuclear transcription factor-kappaB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway.
Huo XY, Lei LR, Guo WX, Hu YJ, Kuang QX, Liu MD, Peng W, Dai YF, Wang D, Gu YC, Guo DL, Deng Y
Frontiers in microbiology 2022;13:999996
Frontiers in microbiology 2022;13:999996
Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral replication.
Deng H, Zhu S, Zhu L, Sun J, Ding Y, Li F, Jian Z, Zhao J, Deng L, Deng J, Deng Y, Guo H, Sun X, Lai SY, Tang H, Cui H, Ge LP, Xu Z
Frontiers in immunology 2022;13:955671
Frontiers in immunology 2022;13:955671
Taohong siwu decoction attenuates AIM2 and NLRC4 inflammasomes by ameliorates deoxyribonucleic acid damage after ischemic stroke.
Wang N, Chu F, Zhang L, Fei C, Yu C, Xue S, Wang Y, Fang L, Peng D, Duan X, Chen W
Frontiers in pharmacology 2022;13:954867
Frontiers in pharmacology 2022;13:954867
Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia.
Gao T, Xu J, Xiao Y, Li J, Hu W, Su X, Shen X, Yu W, Chen Z, Huang B, Li H, Wang X
Frontiers in pharmacology 2022;13:950699
Frontiers in pharmacology 2022;13:950699
Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome.
Hou Q, Kan S, Wang Z, Shi J, Zeng C, Yang D, Jiang S, Liu Z
Frontiers in pharmacology 2022;13:938391
Frontiers in pharmacology 2022;13:938391
Integrated pyroptosis measurement and metabolomics to elucidate the effect and mechanism of tangzhiqing on atherosclerosis.
Chen R, Chen T, Zhou Z, Song Z, Feng W, Yang X, Wang X, Li B, Ding X, Zhang H, Wang Y
Frontiers in physiology 2022;13:937737
Frontiers in physiology 2022;13:937737
NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.
Luo C, Peng Y, Zhou X, Fan J, Chen W, Zhang H, Wei A
Frontiers in endocrinology 2022;13:913296
Frontiers in endocrinology 2022;13:913296
Natural Compound Library Screening Identifies Oroxin A for the Treatment of Myocardial Ischemia/Reperfusion Injury.
Cheng X, Huang T, Wang C, Hao S, Shu L, Wang S, Cheng G, Zhang Q, Huang J, Chen C
Frontiers in pharmacology 2022;13:894899
Frontiers in pharmacology 2022;13:894899
Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation.
Biao Y, Chen J, Liu C, Wang R, Han X, Li L, Zhang Y
Frontiers in pharmacology 2022;13:877924
Frontiers in pharmacology 2022;13:877924
Neutrophil Extracellular Traps (NETs) Promote Non-Small Cell Lung Cancer Metastasis by Suppressing lncRNA MIR503HG to Activate the NF-κB/NLRP3 Inflammasome Pathway.
Wang Y, Liu F, Chen L, Fang C, Li S, Yuan S, Qian X, Yin Y, Yu B, Fu B, Zhang X, Li Y
Frontiers in immunology 2022;13:867516
Frontiers in immunology 2022;13:867516
Stem Cells From Human Exfoliated Deciduous Teeth Alleviate Liver Cirrhosis via Inhibition of Gasdermin D-Executed Hepatocyte Pyroptosis.
Chen P, Zhou YK, Han CS, Chen LJ, Wang YM, Zhuang ZM, Lin S, Zhou YH, Jiang JH, Yang RL
Frontiers in immunology 2022;13:860225
Frontiers in immunology 2022;13:860225
Dendrobium Nobile Lindl. Alkaloid Suppresses NLRP3-Mediated Pyroptosis to Alleviate LPS-Induced Neurotoxicity.
Li DD, Fan HX, Yang R, Li YY, Zhang F, Shi JS
Frontiers in pharmacology 2022;13:846541
Frontiers in pharmacology 2022;13:846541
Succinate/IL-1β Signaling Axis Promotes the Inflammatory Progression of Endothelial and Exacerbates Atherosclerosis.
Xu J, Zheng Y, Zhao Y, Zhang Y, Li H, Zhang A, Wang X, Wang W, Hou Y, Wang J
Frontiers in immunology 2022;13:817572
Frontiers in immunology 2022;13:817572
Methamphetamine Disturbs Gut Homeostasis and Reshapes Serum Metabolome, Inducing Neurotoxicity and Abnormal Behaviors in Mice.
Zhang KK, Chen LJ, Li JH, Liu JL, Wang LB, Xu LL, Yang JZ, Li XW, Xie XL, Wang Q
Frontiers in microbiology 2022;13:755189
Frontiers in microbiology 2022;13:755189
Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis.
Liao C, Wang D, Qin S, Zhang Y, Chen J, Xu R, Xu F, Zhang P
Frontiers in pharmacology 2022;13:677738
Frontiers in pharmacology 2022;13:677738
Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis.
Li W, Yang K, Li B, Wang Y, Liu J, Chen D, Diao Y
Frontiers in pharmacology 2022;13:1060104
Frontiers in pharmacology 2022;13:1060104
Modified Baihu decoction therapeutically remodels gut microbiota to inhibit acute gouty arthritis.
Wang X, Long H, Chen M, Zhou Z, Wu Q, Xu S, Li G, Lu Z
Frontiers in physiology 2022;13:1023453
Frontiers in physiology 2022;13:1023453
miR-513c-5p Suppression Aggravates Pyroptosis of Endothelial Cell in Deep Venous Thrombosis by Promoting Caspase-1.
Chu C, Wang B, Zhang Z, Liu W, Sun S, Liang G, Zhang X, An H, Wei R, Zhu X, Guo Q, Zhao L, Fu X, Xu K, Li X
Frontiers in cell and developmental biology 2022;10:838785
Frontiers in cell and developmental biology 2022;10:838785
Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis.
Jia S, Yang Y, Bai Y, Wei Y, Zhang H, Tian Y, Liu J, Bai L
Frontiers in cell and developmental biology 2022;10:797855
Frontiers in cell and developmental biology 2022;10:797855
Mechanism of nonylphenol induced gastric inflammation through NF-κB/NLRP3 signaling pathway.
Xu J, Li S, Yang X, Wang H, Ma L, Shen Y, Yu J
Toxicology 2022 Sep;479:153294
Toxicology 2022 Sep;479:153294
ROCK2 knockdown alleviates LPS-induced inflammatory injury and apoptosis of renal tubular epithelial cells via the NF-κB/NLRP3 signaling pathway.
Qian X, Yang L
Experimental and therapeutic medicine 2022 Sep;24(3):603
Experimental and therapeutic medicine 2022 Sep;24(3):603
Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway.
Li Q, Zuo Z, Pan Y, Zhang Q, Xu L, Jiang B
Cardiovascular toxicology 2022 Sep;22(9):842-857
Cardiovascular toxicology 2022 Sep;22(9):842-857
Activation of NLRP3 inflammasome contributes to the inflammatory response to allergic rhinitis via macrophage pyroptosis.
Zhou H, Zhang W, Qin D, Liu P, Fan W, Lv H, Tan L, Gao Z, Xu Y
International immunopharmacology 2022 Sep;110:109012
International immunopharmacology 2022 Sep;110:109012
Aqueous extract of Scrophularia ningpoensis improves insulin sensitivity through AMPK-mediated inhibition of the NLRP3 inflammasome.
Yan S, Lu W, Zhou J, Guo X, Li J, Cheng H, Zhu X, Zhao Y, Duan M, Yang H, Zhang Y, Wang Q, Chen L, Zheng T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154308
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154308
A20 inhibits periodontal bone resorption and NLRP3-mediated M1 macrophage polarization.
Hou L, Ye Y, Gou H, Tang H, Zhou Y, Xu X, Xu Y
Experimental cell research 2022 Sep 1;418(1):113264
Experimental cell research 2022 Sep 1;418(1):113264
Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells.
Li M, Zhong X, Xu WT
Cell cycle (Georgetown, Tex.) 2022 Oct;21(20):2179-2191
Cell cycle (Georgetown, Tex.) 2022 Oct;21(20):2179-2191
Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy.
Zheng CM, Lu KC, Chen YJ, Li CY, Lee YH, Chiu HW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113565
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113565
Salvianolic acid B ameliorates non-alcoholic fatty liver disease by inhibiting hepatic lipid accumulation and NLRP3 inflammasome in ob/ob mice.
Meng LC, Zheng JY, Qiu YH, Zheng L, Zheng JY, Liu YQ, Miao XL, Lu XY
International immunopharmacology 2022 Oct;111:109099
International immunopharmacology 2022 Oct;111:109099
GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma.
Liu M, Li H, Yang R, Ji D, Xia X
Journal of neuroinflammation 2022 Oct 26;19(1):262
Journal of neuroinflammation 2022 Oct 26;19(1):262
LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.
Wang X, Li Q, He S, Bai J, Ma C, Zhang L, Guan X, Yuan H, Li Y, Zhu X, Mei J, Gao F, Zhu D
Molecular medicine (Cambridge, Mass.) 2022 Oct 25;28(1):126
Molecular medicine (Cambridge, Mass.) 2022 Oct 25;28(1):126
M378 exhibits anti-inflammatory activities through NLRP3 signaling pathway.
Xu J, Lv Q, Pan S, Qiu H, Liao Y, Zhou M, Li W, Li C, Zhang P, Li Y, Xu G, Yu Q
European journal of pharmacology 2022 Oct 15;933:175261
European journal of pharmacology 2022 Oct 15;933:175261
MicroRNA-122a aggravates intestinal ischemia/reperfusion injury by promoting pyroptosis via targeting EGFR-NLRP3 signaling pathway.
Wang F, Gu L, Wang Y, Sun D, Zhao Y, Meng Q, Yin L, Xu L, Lu X, Peng J, Lin Y, Sun P
Life sciences 2022 Oct 15;307:120863
Life sciences 2022 Oct 15;307:120863
Aerobic exercise training alleviates renal injury in db/db mice through inhibiting Nox4-mediated NLRP3 inflammasome activation.
Zhou Z, Ying C, Zhou X, Shi Y, Xu J, Zhu Y, Wang M, Li Y, Li X, Xiang J
Experimental gerontology 2022 Oct 15;168:111934
Experimental gerontology 2022 Oct 15;168:111934
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Zhao AN, Yang Z, Wang DD, Shi B, Zhang H, Bai Y, Yan BW, Zhang Y, Wen JK, Wang XL, Qu CB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner.
Xia P, Marjan M, Liu Z, Zhou W, Zhang Q, Cheng C, Zhao M, Tao Y, Wang Z, Ye Z
Experimental neurology 2022 Nov;357:114197
Experimental neurology 2022 Nov;357:114197
Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats.
Xiao Q, Kang Z, Liu C, Tang B
Frontiers in bioscience (Landmark edition) 2022 Nov 3;27(11):300
Frontiers in bioscience (Landmark edition) 2022 Nov 3;27(11):300
Hypoxia-Induced HIF-1α Expression Promotes Neurogenic Bladder Fibrosis via EMT and Pyroptosis.
Li Q, Hong Y, Chen J, Zhou X, Tian X, Yu Y, Shen L, Long C, Cai M, Wu S, Wei G
Cells 2022 Nov 29;11(23)
Cells 2022 Nov 29;11(23)
Taraxasterol inhibits inflammation in osteoarthritis rat model by regulating miRNAs and NF-κB signaling pathway.
Xie Z, Wang B, Zheng C, Qu Y, Xu J, Wang B, Gao Y, Shen P
Acta biochimica Polonica 2022 Nov 26;69(4):811-818
Acta biochimica Polonica 2022 Nov 26;69(4):811-818
Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway.
Sun H, Sun Z, Xu X, Lv Z, Li J, Wu R, Fei Y, Tan G, Liu Z, Liu Y, Shi D
Antioxidants (Basel, Switzerland) 2022 Nov 23;11(12)
Antioxidants (Basel, Switzerland) 2022 Nov 23;11(12)
Schisandra chinensis (Turcz.) Baill. Protects against DSS-induced colitis in mice: Involvement of TLR4/NF-κB/NLRP3 inflammasome pathway and gut microbiota.
Bian Z, Qin Y, Li L, Su L, Fei C, Li Y, Hu M, Chen X, Zhang W, Mao C, Yuan X, Lu T, Ji D
Journal of ethnopharmacology 2022 Nov 15;298:115570
Journal of ethnopharmacology 2022 Nov 15;298:115570
Neutrophil Extracellular Traps Mediate Bovine Endometrial Epithelial Cell Pyroptosis in Dairy Cows with Endometritis.
Shen W, Ma X, Shao D, Wu X, Wang S, Zheng J, Lv Y, Ding X, Ma B, Yan Z
International journal of molecular sciences 2022 Nov 13;23(22)
International journal of molecular sciences 2022 Nov 13;23(22)
Adipose stem cells preincubated with theanine exert liver regeneration through increase of stem cell paracrine VEGF and suppression of ROS, pyroptosis as well as autophagy markers in liver damage induced by N-nitrosodiethylamine.
Chen TS, Lai YA, Lai YJ, Chien CT
Life sciences 2022 Nov 1;308:120969
Life sciences 2022 Nov 1;308:120969
The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy.
Zhao W, He C, Jiang J, Zhao Z, Yuan H, Wang F, Shen B
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):427-438
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):427-438
LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1.
Sun Y, Teng Y, Wang L, Zhang Z, Chen C, Wang Y, Zhang X, Xiang P, Song X, Lu J, Li N, Gao L, Liang X, Xia Y, Wu Z, Ma C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 May;9(16):e2103135
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 May;9(16):e2103135
Leonurine inhibits the TXNIP/NLRP3 and NF-κB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.
Yan K, Hu J, Hou T, Ci X, Peng L
Phytotherapy research : PTR 2022 May;36(5):2161-2172
Phytotherapy research : PTR 2022 May;36(5):2161-2172
LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes.
Gu J, Shi JZ, Wang YX, Liu L, Wang SB, Sun JT, Shan TK, Wang H, Wang QM, Wang LS
Journal of cellular and molecular medicine 2022 May;26(10):2895-2907
Journal of cellular and molecular medicine 2022 May;26(10):2895-2907
PM(2.5) induced lung injury through upregulating ROS-dependent NLRP3 Inflammasome-Mediated Pyroptosis.
Ren F, Xu J, Zhang J, Xu X, Huang L, Sun W, Li R, Li F
Immunobiology 2022 May;227(3):152207
Immunobiology 2022 May;227(3):152207
Ghrelin ameliorates diabetes-associated behavioral deficits and NLRP3 inflammasome activation via autophagic flux enhancement.
Han W, Cui C, Zhang H, Guo Y, Xie D, Zhang W, Wang C, Yang M, Jiang P
Pharmacological research 2022 May;179:106224
Pharmacological research 2022 May;179:106224
Cynarin suppresses gouty arthritis induced by monosodium urate crystals.
Wu C, Chen S, Liu Y, Kong B, Yan W, Jiang T, Tian H, Liu Z, Shi Q, Wang Y, Liang Q, Xi X, Xu H
Bioengineered 2022 May;13(5):11782-11793
Bioengineered 2022 May;13(5):11782-11793
CCDC50 suppresses NLRP3 inflammasome activity by mediating autophagic degradation of NLRP3.
Lin Y, Li Z, Wang Y, Tian T, Jia P, Ye Y, He M, Yang Z, Li C, Guo D, Hou P
EMBO reports 2022 May 4;23(5):e54453
EMBO reports 2022 May 4;23(5):e54453
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
Yang J, Li J, Guo H, Zhang Y, Guo Z, Liu Y, Huo T
International journal of molecular sciences 2022 May 19;23(10)
International journal of molecular sciences 2022 May 19;23(10)
Nrf2 and NF-κB/NLRP3 inflammasome pathways are involved in Prototheca bovis infections of mouse mammary gland tissue and mammary epithelial cells.
Zhao W, Deng Z, Barkema HW, Xu M, Gao J, Liu G, Lin Y, Kastelic JP, Han B
Free radical biology & medicine 2022 May 1;184:148-157
Free radical biology & medicine 2022 May 1;184:148-157
Nicotine promotes chronic obstructive pulmonary disease via inducing pyroptosis activation in bronchial epithelial cells.
Mo R, Zhang J, Chen Y, Ding Y
Molecular medicine reports 2022 Mar;25(3)
Molecular medicine reports 2022 Mar;25(3)
Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation.
Yan J, Ding D, Feng G, Yang Y, Zhou Y, Ma L, Guo H, Lu Z, Jin Q
Experimental and therapeutic medicine 2022 Mar;23(3):222
Experimental and therapeutic medicine 2022 Mar;23(3):222
Fibronectin type III domain-containing 5 improves aging-related cardiac dysfunction in mice.
Hu C, Zhang X, Hu M, Teng T, Yuan YP, Song P, Kong CY, Xu SC, Ma ZG, Tang QZ
Aging cell 2022 Mar;21(3):e13556
Aging cell 2022 Mar;21(3):e13556
Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.
Wang F, Liang Q, Ma Y, Sun M, Li T, Lin L, Sun Z, Duan J
Free radical biology & medicine 2022 Mar;182:171-181
Free radical biology & medicine 2022 Mar;182:171-181
Klotho alleviates NLRP3 inflammasome-mediated neuroinflammation in a temporal lobe epilepsy rat model by activating the Nrf2 signaling pathway.
Xiang T, Luo X, Ye L, Huang H, Wu Y
Epilepsy & behavior : E&B 2022 Mar;128:108509
Epilepsy & behavior : E&B 2022 Mar;128:108509
Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease.
Pang Q, Wang P, Pan Y, Dong X, Zhou T, Song X, Zhang A
Cell death & disease 2022 Mar 30;13(3):283
Cell death & disease 2022 Mar 30;13(3):283
Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.
Wang H, Lv D, Jiang S, Hou Q, Zhang L, Li S, Zhu X, Xu X, Wen J, Zeng C, Zhang M, Yang F, Chen Z, Zheng C, Li J, Zen K, Liu Z, Li L
Cell death & disease 2022 Mar 29;13(3):281
Cell death & disease 2022 Mar 29;13(3):281
Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome.
Song L, Yao S, Zheng D, Xuan Y, Li W
International urology and nephrology 2022 Jun;54(6):1355-1364
International urology and nephrology 2022 Jun;54(6):1355-1364
Effect of NLRP3 repression on NLRP3 inflammasome activation in human corneal epithelial cells with black carbon exposure.
Xiao K, Shang J, Liu Y, Chen Z, Wang L, Long Q
Cutaneous and ocular toxicology 2022 Jun;41(2):107-112
Cutaneous and ocular toxicology 2022 Jun;41(2):107-112
MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to inhibit NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K cell pyroptosis, and inflammatory bowel disease in mice.
Wu G, Zhang D, Yang L, Wu Q, Yuan L
Molecular immunology 2022 Jun;146:57-68
Molecular immunology 2022 Jun;146:57-68
α(1) -Adrenoceptors activate the NLRP3 inflammasome through downregulation of Kir2.1 in cardiac inflammation.
Chen L, Wang W, Peng X, Liu L, Zhang A, Li X, Ma K, Wang L
Experimental physiology 2022 Jun;107(6):589-600
Experimental physiology 2022 Jun;107(6):589-600
Blockage of transient receptor potential vanilloid 4 prevents postoperative atrial fibrillation by inhibiting NLRP3-inflammasome in sterile pericarditis mice.
Yang S, Zhao Z, Zhao N, Liao J, Lu Y, Zhang S, Lu K, Wu Y, Wu Q, Dong Q, Chen L, Du Y
Cell calcium 2022 Jun;104:102590
Cell calcium 2022 Jun;104:102590
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Kou L, Chi X, Sun Y, Han C, Wan F, Hu J, Yin S, Wu J, Li Y, Zhou Q, Zou W, Xiong N, Huang J, Xia Y, Wang T
Journal of neuroinflammation 2022 Jun 6;19(1):133
Journal of neuroinflammation 2022 Jun 6;19(1):133
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Han N, Wang Z, Luo H, Chi Y, Zhang T, Wang B, Li Y
Biochemical and biophysical research communications 2022 Jun 25;610:162-169
Biochemical and biophysical research communications 2022 Jun 25;610:162-169
Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice.
Jiang J, Ding S, Zhang G, Dong Y
Ecotoxicology and environmental safety 2022 Jun 15;238:113571
Ecotoxicology and environmental safety 2022 Jun 15;238:113571
MMP2 and MMP9 contribute to lung ischemia-reperfusion injury via promoting pyroptosis in mice.
Zhou P, Song NC, Zheng ZK, Li YQ, Li JS
BMC pulmonary medicine 2022 Jun 15;22(1):230
BMC pulmonary medicine 2022 Jun 15;22(1):230
Carbenoxolone Ameliorates Allergic Airway Inflammation through NF-κB/NLRP3 Pathway in Mice.
He F, Cheng Q, Li N, Shang Y
Biological & pharmaceutical bulletin 2022 Jun 1;45(6):743-750
Biological & pharmaceutical bulletin 2022 Jun 1;45(6):743-750
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats.
Zheng J, Liao Y, Xu Y, Mo Z
Clinical and experimental pharmacology & physiology 2022 Jul;49(7):719-730
Clinical and experimental pharmacology & physiology 2022 Jul;49(7):719-730
Liraglutide Ameliorates Cerebral Ischemia in Mice via Antipyroptotic Pathways.
Yang L, Cheng J, Shi G, Zhang C, Du Y, Chen L, Qiao H, Chen R, Zhang X
Neurochemical research 2022 Jul;47(7):1904-1916
Neurochemical research 2022 Jul;47(7):1904-1916
Human iPSC colon organoid function is improved by exposure to fecal fermentates.
Pearce SC, Weber GJ, Doherty LA, Soares JW
FASEB bioAdvances 2022 Jul;4(7):468-484
FASEB bioAdvances 2022 Jul;4(7):468-484
Neuroprotective effects of CysLTR antagonist on Streptococcus pneumoniae-induced meningitis in rats.
Yu S, Chen X, Li X, Yan J, Jiang Y
Experimental and therapeutic medicine 2022 Jul;24(1):443
Experimental and therapeutic medicine 2022 Jul;24(1):443
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.
Liu Y, Sun R, Lin X, Wu L, Chen H, Shen S, Li Y, Wei Y, Deng G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113078
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113078
Malassezia globosa Activates NLRP3 Inflammasome in Human Sebocytes.
Li W, Wang T, Huang WB, Li FG, Quan JH, Shi G, Zouboulis CC, Fan YM
The Journal of investigative dermatology 2022 Jul;142(7):2042-2046.e11
The Journal of investigative dermatology 2022 Jul;142(7):2042-2046.e11
MCC950 attenuates inflammation-mediated damage in canines with Staphylococcus pseudintermedius keratitis by inhibiting the NLRP3 inflammasome.
Guo L, Wang Z, Li J, Cui L, Dong J, Meng X, Zhu G, Li J, Wang H
International immunopharmacology 2022 Jul;108:108857
International immunopharmacology 2022 Jul;108:108857
Protein nanoparticle-induced osmotic pressure gradients modify pulmonary edema through hyperpermeability in acute respiratory distress syndrome.
Qian Z, Wang Q, Qiu Z, Li D, Zhang C, Xiong X, Zheng Z, Ruan Q, Guo Y, Guo J
Journal of nanobiotechnology 2022 Jul 6;20(1):314
Journal of nanobiotechnology 2022 Jul 6;20(1):314
Fudosteine attenuates acute lung injury in septic mice by inhibiting pyroptosis via the TXNIP/NLRP3/GSDMD pathway.
He G, Chen K, Wang H, Li X, Li W, Liu L, Chen J, Yang D, Hu J, Xu D, Wen F, Wang T
European journal of pharmacology 2022 Jul 5;926:175047
European journal of pharmacology 2022 Jul 5;926:175047
Akkermansia muciniphila Colonization Alleviating High Fructose and Restraint Stress-Induced Jejunal Mucosal Barrier Disruption.
Yu J, Liu T, Gao Z, Liu R, Wang Z, Chen Y, Cao J, Dong Y
Nutrients 2022 Jul 30;14(15)
Nutrients 2022 Jul 30;14(15)
CysLT(2)R Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils.
Zhou L, Zhang J, Han X, Fang J, Zhou S, Lu L, Shi Q, Ying H
Brain sciences 2022 Jul 24;12(8)
Brain sciences 2022 Jul 24;12(8)
Circ_0000181 regulates miR-667-5p/NLRC4 axis to promote pyroptosis progression in diabetic nephropathy.
Li Y, Yu W, Xiong H, Yuan F
Scientific reports 2022 Jul 14;12(1):11994
Scientific reports 2022 Jul 14;12(1):11994
Protocatechuic aldehyde prevents ischemic injury by attenuating brain microvascular endothelial cell pyroptosis via lncRNA Xist.
Guo Y, Yang JH, He Y, Zhou HF, Wang Y, Ding ZS, Jin B, Wan HT
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153849
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153849
H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion.
Zhang X, Li C, Chen D, He X, Zhao Y, Bao L, Wang Q, Zhou J, Xie Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Jan;71(1):141-155
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Jan;71(1):141-155
RBC-hitchhiking chitosan nanoparticles loading methylprednisolone for lung-targeting delivery.
Ding Y, Lv B, Zheng J, Lu C, Liu J, Lei Y, Yang M, Wang Y, Li Z, Yang Y, Gong W, Han J, Gao C
Journal of controlled release : official journal of the Controlled Release Society 2022 Jan;341:702-715
Journal of controlled release : official journal of the Controlled Release Society 2022 Jan;341:702-715
Hepatitis B virus X mediates podocyte pyroptosis by regulating the ROS/NLRP3 signaling pathway in hepatitis B virus-associated glomerulonephritis.
Yu Y, Dong H, Sun J, Li B, Chen Y, Feng M, Yang X, Jiang W
Iranian journal of basic medical sciences 2022 Jan;25(1):103-109
Iranian journal of basic medical sciences 2022 Jan;25(1):103-109
Suppression of the caspase-1/GSDMD-mediated pyroptotic signaling pathway through dexamethasone alleviates corneal alkali injuries.
Tan Y, Zhang M, Pan Y, Feng H, Xie L
Experimental eye research 2022 Jan;214:108858
Experimental eye research 2022 Jan;214:108858
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Lou J, Zhang H, Qi J, Xu Y, Wang X, Jiang J, Hu X, Ni L, Cai Y, Wang X, Gao W, Xiao J, Zhou K
British journal of pharmacology 2022 Jan;179(2):301-321
British journal of pharmacology 2022 Jan;179(2):301-321
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway.
Zhang K, Chai B, Ji H, Chen L, Ma Y, Zhu L, Xu J, Wu Y, Lan Y, Li H, Feng Z, Xiao J, Zhang H, Xu K
Laboratory investigation; a journal of technical methods and pathology 2022 Jan;102(1):90-101
Laboratory investigation; a journal of technical methods and pathology 2022 Jan;102(1):90-101
Skin damage induced by zinc oxide nanoparticles combined with UVB is mediated by activating cell pyroptosis via the NLRP3 inflammasome-autophagy-exosomal pathway.
Chen YY, Lee YH, Wang BJ, Chen RJ, Wang YJ
Particle and fibre toxicology 2022 Jan 5;19(1):2
Particle and fibre toxicology 2022 Jan 5;19(1):2
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Zhou GQ, Chen G, Yang J, Qin WY, Ping J
Journal of ethnopharmacology 2022 Jan 30;283:114707
Journal of ethnopharmacology 2022 Jan 30;283:114707
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Xu LT, Wang T, Fang KL, Zhao Y, Wang XN, Ren DM, Shen T
Journal of ethnopharmacology 2022 Jan 30;283:114694
Journal of ethnopharmacology 2022 Jan 30;283:114694
Ketogenic diet ameliorates lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1.
Zhou J, Lu Y, Jia Y, Lu J, Jiang Z, Chen K
Molecular medicine (Cambridge, Mass.) 2022 Jan 3;28(1):1
Molecular medicine (Cambridge, Mass.) 2022 Jan 3;28(1):1
IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.
Chen G, Xu Y, Fan R, Liu Y, Yao Y, Jiang H, Wu Q, Li L, Chen W, Chen X
Biochemical and biophysical research communications 2022 Jan 22;589:267-274
Biochemical and biophysical research communications 2022 Jan 22;589:267-274
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Li W, Huang BS, Xiong YY, Yang LJ, Wu LX
Cancer cell international 2022 Jan 18;22(1):32
Cancer cell international 2022 Jan 18;22(1):32
Staphylococcal Enterotoxin A Induces Intestinal Barrier Dysfunction and Activates NLRP3 Inflammasome via NF-κB/MAPK Signaling Pathways in Mice.
Liu C, Chi K, Yang M, Guo N
Toxins 2022 Jan 1;14(1)
Toxins 2022 Jan 1;14(1)
Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy.
Ying C, Zhou Z, Dai J, Wang M, Xiang J, Sun D, Zhou X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Feb;71(2):191-204
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Feb;71(2):191-204
The Role of NF-κB/NLRP3 Inflammasome Signaling Pathway in Attenuating Pyroptosis by Melatonin Upon Spinal Nerve Ligation Models.
Wang YH, Gao X, Tang YR, Yu Y, Sun MJ, Chen FQ, Li Y
Neurochemical research 2022 Feb;47(2):335-346
Neurochemical research 2022 Feb;47(2):335-346
Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.
Zhu M, Wang Y, Zhu L, Du S, Wang Z, Zhang Y, Guo Y, Tu Y, Song E
Inflammation 2022 Feb;45(1):414-427
Inflammation 2022 Feb;45(1):414-427
IL-38-mediated NLRP3/caspase-1 inhibition is a disease-modifying treatment for TMJ inflammation.
Luo P, Zhao T, He H
Annals of the New York Academy of Sciences 2022 Feb;1508(1):92-104
Annals of the New York Academy of Sciences 2022 Feb;1508(1):92-104
The roles of mitochondrial dynamics and NLRP3 inflammasomes in the pathogenesis of retinal light damage.
Rong R, Yang R, Li H, You M, Liang Z, Zeng Z, Zhou R, Xia X, Ji D
Annals of the New York Academy of Sciences 2022 Feb;1508(1):78-91
Annals of the New York Academy of Sciences 2022 Feb;1508(1):78-91
Enhancement of anti-inflammatory effect of cattle bile by fermentation and its inhibition of neuroinflammation on microglia by inhibiting NLRP3 inflammasome.
Pei Y, Cheng F, Li W, Yu Q, Ma C, Zou Y, Xu T, Liu S, Zhang S, Wang Q
Journal of bioscience and bioengineering 2022 Feb;133(2):146-154
Journal of bioscience and bioengineering 2022 Feb;133(2):146-154
Effect of nonylphenol on the colonic mucosa in rats and intervention with zinc-selenium green tea (Camellia sinensis).
Li S, Zheng M, Yang X, Zhang J, Xu J, Yu J
Toxicology research 2022 Feb;11(1):122-133
Toxicology research 2022 Feb;11(1):122-133
Vagus nerve stimulation alleviated cerebral ischemia and reperfusion injury in rats by inhibiting pyroptosis via α7 nicotinic acetylcholine receptor.
Tang H, Li J, Zhou Q, Li S, Xie C, Niu L, Ma J, Li C
Cell death discovery 2022 Feb 8;8(1):54
Cell death discovery 2022 Feb 8;8(1):54
Staphylococcus aureus mediates pyroptosis in bovine mammary epithelial cell via activation of NLRP3 inflammasome.
Wang X, Liu M, Geng N, Du Y, Li Z, Gao X, Han B, Liu J, Liu Y
Veterinary research 2022 Feb 5;53(1):10
Veterinary research 2022 Feb 5;53(1):10
Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.
Zhang L, Zhu XZ, Badamjav R, Zhang JZ, Kou JP, Yu BY, Li F
European journal of pharmacology 2022 Feb 15;917:174748
European journal of pharmacology 2022 Feb 15;917:174748
Downregulation of macrophage migration inhibitory factor attenuates NLRP3 inflammasome mediated pyroptosis in sepsis-induced AKI.
Li T, Sun H, Li Y, Su L, Jiang J, Liu Y, Jiang N, Huang R, Zhang J, Peng Z
Cell death discovery 2022 Feb 14;8(1):61
Cell death discovery 2022 Feb 14;8(1):61
Neuropeptide Y and receptors are associated with the pyroptosis of nucleus pulposus in aging and degenerative intervertebral discs of rats.
Li F, Xie W, Chen Z, Zhou Z, Wang Z, Xiao J, Li Z
Neuropeptides 2022 Dec;96:102284
Neuropeptides 2022 Dec;96:102284
Paeoniflorin alleviates inflammatory response in IBS-D mouse model via downregulation of the NLRP3 inflammasome pathway with involvement of miR-29a.
Ke W, Wang Y, Huang S, Liu S, Zhu H, Xie X, Yang H, Lu Q, Gan J, He G, Che F, Wan X, Tang H
Heliyon 2022 Dec;8(12):e12312
Heliyon 2022 Dec;8(12):e12312
Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis.
Hao YY, Cui WW, Gao HL, Wang MY, Liu Y, Li CR, Hou YL, Jia ZH
Pharmaceutical biology 2022 Dec;60(1):274-281
Pharmaceutical biology 2022 Dec;60(1):274-281
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
Tang Q, Liu W, Yang X, Tian Y, Chen J, Hu Y, Fu N
DNA and cell biology 2022 Dec;41(12):1038-1052
DNA and cell biology 2022 Dec;41(12):1038-1052
Epigallocatechin-3-gallate (EGCG) attenuates inflammatory responses and oxidative stress in lipopolysaccharide (LPS)-induced endometritis via silent information regulator transcript-1 (SIRT1)/nucleotide oligomerization domain (NOD)-like receptor pyrin domain-containing 3 (NLRP3) pathway.
Di M, Zhang Q, Wang J, Xiao X, Huang J, Ma Y, Yang H, Li M
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23203
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23203
Сyclooxygenase-2 Inhibitor Parecoxib Reduces LPS-Induced Activation of BV2 Microglia Cells.
Li X, Zhou JX, Qu YD, Kuang X
Bulletin of experimental biology and medicine 2022 Dec;174(2):210-215
Bulletin of experimental biology and medicine 2022 Dec;174(2):210-215
Identification of key proteins of cytopathic biotype bovine viral diarrhoea virus involved in activating NF-κB pathway in BVDV-induced inflammatory response.
Fan W, Wang Y, Jiang S, Li Y, Yao X, Wang M, Zhao J, Sun X, Jiang X, Zhong L, Han Y, Song H, Xu Y
Virulence 2022 Dec;13(1):1884-1899
Virulence 2022 Dec;13(1):1884-1899
GABA regulates IL-1β production in macrophages.
Fu J, Han Z, Wu Z, Xia Y, Yang G, Yin Y, Ren W
Cell reports 2022 Dec 6;41(10):111770
Cell reports 2022 Dec 6;41(10):111770
Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function.
Fan R, Jiang H, Hu Y, Xu Y, Zhou Y, Chen G, Liu Y, Yao Y, Qin W, Chen W, Huang F, Chen X
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):112-120
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):112-120
Glucagon-like Peptide 1 Receptor Activation Inhibits Microglial Pyroptosis via Promoting Mitophagy to Alleviate Depression-like Behaviors in Diabetic Mice.
Yang F, Wang X, Qi J, Zhang K, Jiang Y, Feng B, Lv T, Yang L, Yang Q, Zhao M, Liu S, Ma X
Nutrients 2022 Dec 21;15(1)
Nutrients 2022 Dec 21;15(1)
NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits.
Li Z, Vidjro OE, Guo G, Du Y, Zhou Y, Xie Q, Li J, Gao K, Zhou L, Ma T
Journal of neuroinflammation 2022 Dec 20;19(1):308
Journal of neuroinflammation 2022 Dec 20;19(1):308
Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis.
Zhang Y, Xu T, Tian H, Wu J, Yu X, Zeng L, Liu F, Liu Q, Huang X
Cancers 2022 Dec 15;14(24)
Cancers 2022 Dec 15;14(24)
Inhibited transcription factor EB function induces reactive oxygen species overproduction to promote pyroptosis in cadmium-exposed renal tubular epithelial cells.
Dong PF, Li ZF, Lian CY, Wang ZY, Wang L
Chemico-biological interactions 2022 Dec 1;368:110249
Chemico-biological interactions 2022 Dec 1;368:110249
USP1 Inhibits NF-κB/NLRP3 Induced Pyroptosis through TRAF6 in Osteoblastic MC3T3-E1 Cells.
Sun D, Peng Y, Ge S, Fu Q
Journal of musculoskeletal & neuronal interactions 2022 Dec 1;22(4):536-545
Journal of musculoskeletal & neuronal interactions 2022 Dec 1;22(4):536-545
Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome.
Zheng X, Gong T, Tang C, Zhong Y, Shi L, Fang X, Chen D, Zhu Z
BMC anesthesiology 2022 Dec 1;22(1):371
BMC anesthesiology 2022 Dec 1;22(1):371
Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis.
Luo Y, Zhang Y, Han X, Yuan Y, Zhou Y, Gao Y, Yu H, Zhang J, Shi Y, Duan Y, Zhao X, Yan S, Hao H, Dai C, Zhao S, Shi J, Li W, Zhang S, Xu W, Fang N, Gong Y, Li Y
EBioMedicine 2022 Aug;82:104087
EBioMedicine 2022 Aug;82:104087
Mechanism of miR-126 in hypoxia-reoxygenation-induced cardiomyocyte pyroptosis by regulating HMGB1 and NLRP3 inflammasome.
Fei L, Zhang N, Zhang J
Immunopharmacology and immunotoxicology 2022 Aug;44(4):500-509
Immunopharmacology and immunotoxicology 2022 Aug;44(4):500-509
ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment.
Muhammad W, Zhu J, Zhai Z, Xie J, Zhou J, Feng X, Feng B, Pan Q, Li S, Venkatesan R, Li P, Cao H, Gao C
Acta biomaterialia 2022 Aug;148:258-270
Acta biomaterialia 2022 Aug;148:258-270
Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1(G93A) ALS mouse model.
Zhang H, Li H, Huang B, Wang S, Gao Y, Meng F, Chen Y, Zhou F, Guan Y, Wang X
BMC neuroscience 2022 Aug 9;23(1):50
BMC neuroscience 2022 Aug 9;23(1):50
N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways.
Huang L, Gong L, Huo X, Lei L, Zhang Q, Hu Y, Kuang Q, Gui Y, Dai Y, Gu Y, Deng Y, Wang D, Guo D
Acta biochimica et biophysica Sinica 2022 Aug 25;55(1):23-33
Acta biochimica et biophysica Sinica 2022 Aug 25;55(1):23-33
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
Yang G, Wang J, Wang S, Zhu Y
International journal of molecular sciences 2022 Aug 20;23(16)
International journal of molecular sciences 2022 Aug 20;23(16)
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.
Chen Y, Hao C, Chen W, Cheng W, Li P, Shen J, Tong T, Yan S, Huang S, He T, Huang Z, Meng X
Neuroscience letters 2022 Aug 10;785:136787
Neuroscience letters 2022 Aug 10;785:136787
Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.
Lam HYP, Cheng PC, Peng SY
International journal for parasitology 2022 Apr;52(5):275-284
International journal for parasitology 2022 Apr;52(5):275-284
Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo.
Liu Y, Shang L, Zhou J, Pan G, Zhou F, Yang S
Inflammation 2022 Apr;45(2):753-767
Inflammation 2022 Apr;45(2):753-767
Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation.
Xin X, Yang K, Liu H, Li Y
Apoptosis : an international journal on programmed cell death 2022 Apr;27(3-4):222-232
Apoptosis : an international journal on programmed cell death 2022 Apr;27(3-4):222-232
Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy.
Zou R, Nie C, Pan S, Wang B, Hong X, Xi S, Bai J, Yu M, Liu J, Yang W
Free radical biology & medicine 2022 Apr;183:35-50
Free radical biology & medicine 2022 Apr;183:35-50
Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice.
Song Z, Wang L, Cao Y, Liu Z, Zhang M, Zhang Z, Jiang S, Fan R, Hao T, Yang R, Wang B, Guan Z, Zhu L, Liu Z, Zhang S, Zhao L, Xu Z, Xu H, Dai G
International immunopharmacology 2022 Apr;105:108539
International immunopharmacology 2022 Apr;105:108539
EB1089 promotes the expression of vitamin D receptor in the intestinal epithelial cell line HT-29 and reduces lipopolysaccharide-induced inflammatory response.
Lu D, Yu M, Chen L, Ye J, Huang L, Zhu G, Lan B
Annals of translational medicine 2022 Apr;10(8):476
Annals of translational medicine 2022 Apr;10(8):476
Dihydromyricetin improves LPS-induced sickness and depressive-like behaviors in mice by inhibiting the TLR4/Akt/HIF1a/NLRP3 pathway.
Wei Y, Hu Y, Qi K, Li Y, Chen J, Wang R
Behavioural brain research 2022 Apr 9;423:113775
Behavioural brain research 2022 Apr 9;423:113775
ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation.
Li L, Cui YJ, Liu Y, Li HX, Su YD, Li SN, Wang LL, Zhao YW, Wang SX, Yan F, Dong B
Cell death discovery 2022 Apr 4;8(1):161
Cell death discovery 2022 Apr 4;8(1):161
Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK/NF-κB/NLRP3 pathway.
Wang Z, Li C, He X, Xu K, Xue Z, Wang T, Xu Z, Liu X
Food & function 2022 Apr 4;13(7):3946-3956
Food & function 2022 Apr 4;13(7):3946-3956
Baclofen attenuates cognitive deficits in post-cardiac arrest brain injury.
Sun Y, Cong T, Li L, Li J, Wu H, Chen X, Zhou Y, Xiao Z
Biochemical and biophysical research communications 2022 Apr 30;602:135-141
Biochemical and biophysical research communications 2022 Apr 30;602:135-141
Dietary Tryptophan Supplementation Improves Antioxidant Status and Alleviates Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Pyroptosis in the Intestine of Piglets after Lipopolysaccharide Challenge.
Liu G, Tao J, Lu J, Jia G, Zhao H, Chen X, Tian G, Cai J, Zhang R, Wang J
Antioxidants (Basel, Switzerland) 2022 Apr 28;11(5)
Antioxidants (Basel, Switzerland) 2022 Apr 28;11(5)
The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy.
Meihe L, Shan G, Minchao K, Xiaoling W, Peng A, Xili W, Jin Z, Huimin D
Frontiers in cell and developmental biology 2021;9:707959
Frontiers in cell and developmental biology 2021;9:707959
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Liu H, Zhang Y, Song W, Sun Y, Jiang Y
Frontiers in cell and developmental biology 2021;9:681790
Frontiers in cell and developmental biology 2021;9:681790
Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy.
Li C, Zhu Y, Wu Y, Fu M, Wu Y, Wu Y, Qiu Y, Zhang H, Ding M
Frontiers in medicine 2021;8:813047
Frontiers in medicine 2021;8:813047
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.
Yu YW, Que JQ, Liu S, Huang KY, Qian L, Weng YB, Rong FN, Wang L, Zhou YY, Xue YJ, Ji KT
Frontiers in cardiovascular medicine 2021;8:768214
Frontiers in cardiovascular medicine 2021;8:768214
CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation.
Wu J, Li J, Gaurav C, Muhammad U, Chen Y, Li X, Chen J, Wang Z
General psychiatry 2021;34(6):e100529
General psychiatry 2021;34(6):e100529
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Zhang Q, Zhao C, Zhang L, Sun K, Yu L, Wang X, Ren L, Zhang N, Chen C, Liu J, Wang H, Tian H
Oxidative medicine and cellular longevity 2021;2021:9921839
Oxidative medicine and cellular longevity 2021;2021:9921839
P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk.
Li Z, Huang Z, Zhang H, Lu J, Tian Y, Wei Y, Yang Y, Bai L
Oxidative medicine and cellular longevity 2021;2021:8868361
Oxidative medicine and cellular longevity 2021;2021:8868361
Effect and Mechanism of Mycobacterium tuberculosis Lipoprotein LpqH in NLRP3 Inflammasome Activation in Mouse Ana-1 Macrophage.
Liu L, Zhai K, Chen Y, Chen X, Wang G, Wu L
BioMed research international 2021;2021:8239135
BioMed research international 2021;2021:8239135
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Xu Y, Hu X, Li F, Zhang H, Lou J, Wang X, Wang H, Yin L, Ni W, Kong J, Wang X, Li Y, Zhou K, Xu H
Oxidative medicine and cellular longevity 2021;2021:8186877
Oxidative medicine and cellular longevity 2021;2021:8186877
Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation.
Zhu JJ, Yu BY, Huang XK, He MZ, Chen BW, Chen TT, Fang HY, Chen SQ, Fu XQ, Li PJ, Lin ZL, Zhu JH
Oxidative medicine and cellular longevity 2021;2021:6654954
Oxidative medicine and cellular longevity 2021;2021:6654954
Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation.
Ma W, Wang Z, Zhao Y, Wang Q, Zhang Y, Lei P, Lu W, Yan S, Zhou J, Li X, Yu W, Zhong Y, Chen L, Zheng T
Oxidative medicine and cellular longevity 2021;2021:6614574
Oxidative medicine and cellular longevity 2021;2021:6614574
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Zhu X, Hu X, Lou J, Li J, Xu Y, Yu G, Wu C, Ding J, Gao W, Xiao J, Zhou K, Jia C
Oxidative medicine and cellular longevity 2021;2021:6610603
Oxidative medicine and cellular longevity 2021;2021:6610603
Tongxinluo Exerts Inhibitory Effects on Pyroptosis and Amyloid-β Peptide Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Wang B, Lyu Z, Chan Y, Li Q, Zhang L, Liu K, Li Y, Yu Z
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5788602
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5788602
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Liao Z, Li S, Liu R, Feng X, Shi Y, Wang K, Li S, Zhang Y, Wu X, Yang C
Oxidative medicine and cellular longevity 2021;2021:5584447
Oxidative medicine and cellular longevity 2021;2021:5584447
Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NF-κB Signaling Pathway.
Li DF, Chang X, Zhao JL, Chen XM, Xu ZL, Zhang DG, Wu BH, Wang LS, Bai Y, Yao J
Oxidative medicine and cellular longevity 2021;2021:5570731
Oxidative medicine and cellular longevity 2021;2021:5570731
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
Bai Y, Feng Y, Jiang B, Yang Y, Pei Z, Yang Q, Cui Y
BioMed research international 2021;2021:5512518
BioMed research international 2021;2021:5512518
Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Lyu Z, Chan Y, Li Q, Zhang Q, Liu K, Xiang J, Li X, Cai D, Li Y, Wang B, Yu Z
Neural plasticity 2021;2021:4504363
Neural plasticity 2021;2021:4504363
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Zhang Y, Liu W, Zhong Y, Li Q, Wu M, Yang L, Liu X, Zou L
Oxidative medicine and cellular longevity 2021;2021:1806344
Oxidative medicine and cellular longevity 2021;2021:1806344
Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways.
Zhang H, Zhao J, Lu Q, Sun B, Liu X, Yang C, Li S, Li L, Yi S, Yang Z, Xu J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1718709
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1718709
Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.
Wu C, Chen H, Zhuang R, Zhang H, Wang Y, Hu X, Xu Y, Li J, Li Y, Wang X, Xu H, Ni W, Zhou K
International journal of biological sciences 2021;17(4):1138-1152
International journal of biological sciences 2021;17(4):1138-1152
SOCS2 Suppresses Inflammation and Apoptosis during NASH Progression through Limiting NF-κB Activation in Macrophages.
Li S, Han S, Jin K, Yu T, Chen H, Zhou X, Tan Z, Zhang G
International journal of biological sciences 2021;17(15):4165-4175
International journal of biological sciences 2021;17(15):4165-4175
Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer.
Yan H, Luo B, Wu X, Guan F, Yu X, Zhao L, Ke X, Wu J, Yuan J
International journal of biological sciences 2021;17(10):2606-2621
International journal of biological sciences 2021;17(10):2606-2621
GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.
Peng W, Wu Y, Zhang G, Zhu W, Chang M, Rouzi A, Jiang W, Tong L, Wang Q, Liu J, Song Y, Li H, Li K, Zhou J
International journal of chronic obstructive pulmonary disease 2021;16:2817-2832
International journal of chronic obstructive pulmonary disease 2021;16:2817-2832
Punicalin Ameliorates Cell Pyroptosis Induced by LPS/ATP Through Suppression of ROS/NLRP3 Pathway.
Shen R, Yin P, Yao H, Chen L, Chang X, Li H, Hou X
Journal of inflammation research 2021;14:711-718
Journal of inflammation research 2021;14:711-718
Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes.
Fan W, Chen S, Wu X, Zhu J, Li J
Journal of inflammation research 2021;14:3523-3536
Journal of inflammation research 2021;14:3523-3536
PARK2 attenuates house dust mite-induced inflammatory reaction, pyroptosis and barrier dysfunction in BEAS-2B cells by ubiquitinating NLRP3.
Ge X, Cai F, Shang Y, Chi F, Xiao H, Xu J, Fu Y, Bai C
American journal of translational research 2021;13(1):326-335
American journal of translational research 2021;13(1):326-335
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.
Que R, Zheng J, Chang Z, Zhang W, Li H, Xie Z, Huang Z, Wang HT, Xu J, Jin D, Yang W, Tan EK, Wang Q
Frontiers in immunology 2021;12:794770
Frontiers in immunology 2021;12:794770
Yi-Zhi-Fang-Dai Formula Exerts Neuroprotective Effects Against Pyroptosis and Blood-Brain Barrier-Glymphatic Dysfunctions to Prevent Amyloid-Beta Acute Accumulation After Cerebral Ischemia and Reperfusion in Rats.
Lyu Z, Li Q, Yu Z, Chan Y, Fu L, Li Y, Zhang C
Frontiers in pharmacology 2021;12:791059
Frontiers in pharmacology 2021;12:791059
Entinostat Improves Motor Function and Neuronal Damage Via Downregulating NLRP3 Inflammasome Activation After Spinal Cord Injury.
Dai C, Liu B, Peng B, Qu B, Lin J, Peng B, Li DM
Frontiers in pharmacology 2021;12:774539
Frontiers in pharmacology 2021;12:774539
An Integrative Pharmacology Based Analysis of Refined Liuweiwuling Against Liver Injury: A Novel Component Combination and Hepaprotective Mechanism.
Gao Y, Shi W, Yao H, Ai Y, Li R, Wang Z, Liu T, Dai W, Xiao X, Zhao J, Niu M, Bai Z
Frontiers in pharmacology 2021;12:747010
Frontiers in pharmacology 2021;12:747010
CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome-Pyroptosis Pathway.
Jiang X, Gu Y, Huang Y, Zhou Y, Pang N, Luo J, Tang Z, Zhang Z, Yang L
Frontiers in pharmacology 2021;12:724747
Frontiers in pharmacology 2021;12:724747
AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation.
Kong L, Zhang H, Lu C, Shi K, Huang H, Zheng Y, Wang Y, Wang D, Wang H, Huang W
Frontiers in pharmacology 2021;12:724514
Frontiers in pharmacology 2021;12:724514
Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.
Feng B, Zhao X, Zhao W, Jiang H, Ren Z, Chen Y, Yuan Y, Du Z
Frontiers in pharmacology 2021;12:719822
Frontiers in pharmacology 2021;12:719822
Oleanolic Acid Improves Obesity-Related Inflammation and Insulin Resistance by Regulating Macrophages Activation.
Li W, Zeng H, Xu M, Huang C, Tao L, Li J, Zhang T, Chen H, Xia J, Li C, Li X
Frontiers in pharmacology 2021;12:697483
Frontiers in pharmacology 2021;12:697483
Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation.
Li J, Dai X, Zhou L, Li X, Pan D
Frontiers in pharmacology 2021;12:691773
Frontiers in pharmacology 2021;12:691773
Inflammasome-Induced Osmotic Pressure and the Mechanical Mechanisms Underlying Astrocytic Swelling and Membrane Blebbing in Pyroptosis.
Zheng Z, Wang T, Chen J, Qiu H, Zhang C, Liu W, Qin S, Tian J, Guo J
Frontiers in immunology 2021;12:688674
Frontiers in immunology 2021;12:688674
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Liu X, Xu Y, Cheng S, Zhou X, Zhou F, He P, Hu F, Zhang L, Chen Y, Jia Y
Frontiers in pharmacology 2021;12:687394
Frontiers in pharmacology 2021;12:687394
LPS Mediates Bovine Endometrial Epithelial Cell Pyroptosis Directly Through Both NLRP3 Classical and Non-Classical Inflammasome Pathways.
Ma X, Li Y, Shen W, Oladejo AO, Yang J, Jiang W, Imam BH, Wu X, Ding X, Yang Y, Wang S, Yan Z
Frontiers in immunology 2021;12:676088
Frontiers in immunology 2021;12:676088
Subicular Caspase-1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy.
Xu C, Zhang S, Gong Y, Nao J, Shen Y, Tan B, Xu S, Cui S, Ruan Y, Wang S, Wang Y, Chen Z
Annals of neurology 2021 Sep;90(3):377-390
Annals of neurology 2021 Sep;90(3):377-390
Hypoxia-preconditioned mesenchymal stem cells attenuate microglial pyroptosis after intracerebral hemorrhage.
Liu J, He J, Huang Y, Ge L, Xiao H, Zeng L, Jiang Z, Lu M, Hu Z
Annals of translational medicine 2021 Sep;9(17):1362
Annals of translational medicine 2021 Sep;9(17):1362
Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Liao Z, Liu H, Ma L, Lei J, Tong B, Li G, Ke W, Wang K, Feng X, Hua W, Li S, Yang C
ACS nano 2021 Sep 28;15(9):14709-14724
ACS nano 2021 Sep 28;15(9):14709-14724
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.
Chen S, Li Y, Chu B, Yuan L, Liu N, Zhu Y, Wang J
Microorganisms 2021 Sep 17;9(9)
Microorganisms 2021 Sep 17;9(9)
H(2)S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.
Cui J, Xu G, Bian F
International journal of cardiology 2021 Sep 1;338:215-225
International journal of cardiology 2021 Sep 1;338:215-225
LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling.
Zhang Y, Guo S, Wang S, Li X, Hou D, Li H, Wang L, Xu Y, Ma B, Wang H, Jiang X
Ecotoxicology and environmental safety 2021 Sep 1;220:112376
Ecotoxicology and environmental safety 2021 Sep 1;220:112376
MerTK inhibits the activation of the NLRP3 inflammasome after subarachnoid hemorrhage by inducing autophagy.
Du Y, Lu Z, Yang D, Wang D, Jiang L, Shen Y, Du Q, Yu W
Brain research 2021 Sep 1;1766:147525
Brain research 2021 Sep 1;1766:147525
Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
Xu M, Ye Z, Zhao X, Guo H, Gong X, Huang R
Cellular signalling 2021 Oct;86:110084
Cellular signalling 2021 Oct;86:110084
Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis.
Hou CC, Ma HF, Ye JF, Luo D, Bao HF, Guan JL
Clinical rheumatology 2021 Oct;40(10):4143-4155
Clinical rheumatology 2021 Oct;40(10):4143-4155
Gardnerella vaginalis induces NLRP3 inflammasome-mediated pyroptosis in macrophages and THP-1 monocytes.
Xiang N, Yin T, Chen T
Experimental and therapeutic medicine 2021 Oct;22(4):1174
Experimental and therapeutic medicine 2021 Oct;22(4):1174
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury.
Chen Y, Gong K, Guo L, Zhang B, Chen S, Li Z, Quanhua X, Liu W, Wang Z
Cell death discovery 2021 Oct 12;7(1):290
Cell death discovery 2021 Oct 12;7(1):290
Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-κB pathway.
Wei YY, Fan YM, Ga Y, Zhang YN, Han JC, Hao ZH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov;92:153743
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov;92:153743
LncRNA HOTAIR Promotes Neuronal Damage Through Facilitating NLRP3 Mediated-Pyroptosis Activation in Parkinson's Disease via Regulation of miR-326/ELAVL1 Axis.
Zhang Q, Huang XM, Liao JX, Dong YK, Zhu JL, He CC, Huang J, Tang YW, Wu D, Tian JY
Cellular and molecular neurobiology 2021 Nov;41(8):1773-1786
Cellular and molecular neurobiology 2021 Nov;41(8):1773-1786
Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.
Zhai J, Gao H, Wang S, Zhang S, Qu X, Zhang Y, Tao L, Sun J, Song Y, Fu L
Journal of biochemical and molecular toxicology 2021 Nov;35(11):e22896
Journal of biochemical and molecular toxicology 2021 Nov;35(11):e22896
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Hao W, Hao C, Wu C, Xu Y, Wu S, Lu X, Yang J, Jin C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Inflammatory and immune-related factor Caspase 1 contributes to the development of oral lichen planus.
Zeng X, Luo X, Mao X, Wen D, Zhang H, Wang J
Archives of oral biology 2021 Nov;131:105244
Archives of oral biology 2021 Nov;131:105244
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Wang L, Wang X, Kong L, Wang S, Huang K, Wu J, Wang C, Sun H, Liu K, Meng Q
International immunopharmacology 2021 Nov;100:108159
International immunopharmacology 2021 Nov;100:108159
Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis.
Huang J, An Q, Ju BM, Zhang J, Fan P, He L, Wang L
International immunopharmacology 2021 Nov;100:108131
International immunopharmacology 2021 Nov;100:108131
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Ge S, Yang W, Chen H, Yuan Q, Liu S, Zhao Y, Zhang J
International journal of molecular sciences 2021 Nov 17;22(22)
International journal of molecular sciences 2021 Nov 17;22(22)
Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis.
Li Z, Huang Z, Zhang H, Lu J, Tian Y, Piao S, Lin Z, Bai L
Cell death discovery 2021 Nov 10;7(1):346
Cell death discovery 2021 Nov 10;7(1):346
Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
Zhuang J, Zhou X, Liu T, Zhang S, Yuan F, Zhang L, Yang Z, Chen Y
Die Pharmazie 2021 Nov 1;76(11):551-558
Die Pharmazie 2021 Nov 1;76(11):551-558
The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase-1 signaling pathway and oxidative stress in Wistar rats.
Wei J, Wang X, Liu Q, Zhou N, Zhu S, Li Z, Li X, Yao J, Zhang L
Environmental toxicology 2021 May;36(5):935-944
Environmental toxicology 2021 May;36(5):935-944
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Li J, Chen H, Lou J, Bao G, Wu C, Lou Z, Wang X, Ding J, Li Z, Xiao J, Xu H, Gao W, Zhou K
Journal of cellular physiology 2021 May;236(5):3641-3659
Journal of cellular physiology 2021 May;236(5):3641-3659
The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.
Yue XF, Shen CX, Wang JW, Dai LY, Fang Q, Long L, Zhi Y, Li XR, Wang YW, Shen GF, Liu ZJ, Shi CM, Li WB
Asian journal of andrology 2021 May-Jun;23(3):249-258
Asian journal of andrology 2021 May-Jun;23(3):249-258
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Jauhari A, Baranov SV, Suofu Y, Kim J, Singh T, Yablonska S, Li F, Wang X, Oberly P, Minnigh MB, Poloyac SM, Carlisle DL, Friedlander RM
The Journal of clinical investigation 2021 May 3;131(9)
The Journal of clinical investigation 2021 May 3;131(9)
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
Han M, Li S, Li L
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75
Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats.
Nie C, Ding X, A R, Zheng M, Li Z, Pan S, Yang W
Life sciences 2021 May 1;272:119248
Life sciences 2021 May 1;272:119248
NLRP3 inflammasome activation in alveolar epithelial cells promotes myofibroblast differentiation of lung-resident mesenchymal stem cells during pulmonary fibrogenesis.
Ji J, Hou J, Xia Y, Xiang Z, Han X
Biochimica et biophysica acta. Molecular basis of disease 2021 May 1;1867(5):166077
Biochimica et biophysica acta. Molecular basis of disease 2021 May 1;1867(5):166077
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Wei Z, Fei Y, Wang Q, Hou J, Cai X, Yang Y, Chen T, Xu Q, Wang Y, Li YG
Free radical biology & medicine 2021 May 1;167:243-257
Free radical biology & medicine 2021 May 1;167:243-257
Cordyceps acid alleviates lung cancer in nude mice.
Wang J, Chen H, Li W, Shan L
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
NLRP3 inflammasome-mediated endothelial cells pyroptosis is involved in decabromodiphenyl ethane-induced vascular endothelial injury.
Zheng D, Shi Z, Yang M, Liang B, Zhou X, Jing L, Sun Z
Chemosphere 2021 Mar;267:128867
Chemosphere 2021 Mar;267:128867
Airborne particulate matter (PM(2.5)) triggers ocular hypertension and glaucoma through pyroptosis.
Li L, Xing C, Zhou J, Niu L, Luo B, Song M, Niu J, Ruan Y, Sun X, Lei Y
Particle and fibre toxicology 2021 Mar 4;18(1):10
Particle and fibre toxicology 2021 Mar 4;18(1):10
Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1.
Zeng J, Tao J, Xia L, Zeng Z, Chen J, Wang Z, Meng J, Liu L
Biochemistry and cell biology = Biochimie et biologie cellulaire 2021 Jun;99(3):339-347
Biochemistry and cell biology = Biochimie et biologie cellulaire 2021 Jun;99(3):339-347
Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway.
Huang X, Shen H, Liu Y, Qiu S, Guo Y
International immunopharmacology 2021 Jun;95:107505
International immunopharmacology 2021 Jun;95:107505
Golgi phosphoprotein 3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome.
Zhu Z, Zhu Q, Cai D, Chen L, Xie W, Bai Y, Luo K
Oncology reports 2021 Jun;45(6)
Oncology reports 2021 Jun;45(6)
IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.
Wang J, Yuan X, Ding N
Experimental and therapeutic medicine 2021 Jun;21(6):593
Experimental and therapeutic medicine 2021 Jun;21(6):593
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Lam HYP, Liang TR, Peng SY
PLoS neglected tropical diseases 2021 Jun;15(6):e0009554
PLoS neglected tropical diseases 2021 Jun;15(6):e0009554
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
Li D, Liu M, Li Z, Zheng G, Chen A, Zhao L, Yang P, Wei L, Chen Y, Ruan XZ
Aging and disease 2021 Jun;12(3):747-763
Aging and disease 2021 Jun;12(3):747-763
Wogonin Alleviates Cisplatin-induced Cardiotoxicity in Mice Via Inhibiting Gasdermin D-mediated Pyroptosis.
Xu J, Zhang B, Chu Z, Jiang F, Han J
Journal of cardiovascular pharmacology 2021 Jun 16;78(4):597-603
Journal of cardiovascular pharmacology 2021 Jun 16;78(4):597-603
Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation.
Ge C, Cheng Y, Fan Y, He Y
Clinical science (London, England : 1979) 2021 Jun 11;135(11):1409-1426
Clinical science (London, England : 1979) 2021 Jun 11;135(11):1409-1426
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.
Li J, Qin X, Shi J, Wang X, Li T, Xu M, Chen X, Zhao Y, Han J, Piao Y, Zhang W, Qu P, Wang L, Xiang R, Shi Y
eLife 2021 Jun 11;10
eLife 2021 Jun 11;10
Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway.
Xu X, Huang X, Zhang L, Huang X, Qin Z, Hua F
BMC nephrology 2021 Jun 10;22(1):218
BMC nephrology 2021 Jun 10;22(1):218
MIF inhibitor ISO-1 alleviates severe acute pancreatitis-associated acute kidney injury by suppressing the NLRP3 inflammasome signaling pathway.
Liu Y, Liu Y, Wang Q, Song Y, Chen S, Cheng B, Zhang Y, Cui Z, Wu Z, Zhu C
International immunopharmacology 2021 Jul;96:107555
International immunopharmacology 2021 Jul;96:107555
Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes.
Liu X, Zhang M, Liu H, Zhu R, He H, Zhou Y, Zhang Y, Li C, Liang D, Zeng Q, Huang G
Experimental neurology 2021 Jul;341:113700
Experimental neurology 2021 Jul;341:113700
N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia-reperfusion rats via the TLR4/NF-κB/NLRP3 pathway.
Liu J, Zhang N, Zhang M, Yin H, Zhang X, Wang X, Wang X, Zhao Y
Experimental eye research 2021 Jul;208:108595
Experimental eye research 2021 Jul;208:108595
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.
Tang W, Yang Y, Yang L, Tang M, Chen Y, Li C
Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470
Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470
Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis.
Liu Y, Li YP, Xiao LM, Chen LK, Zheng SY, Zeng EM, Xu CH
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):837-850
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):837-850
hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis.
Cai X, Zhang ZY, Yuan JT, Ocansey DKW, Tu Q, Zhang X, Qian H, Xu WR, Qiu W, Mao F
Stem cell research & therapy 2021 Jul 22;12(1):416
Stem cell research & therapy 2021 Jul 22;12(1):416
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.
Malireddi RKS, Karki R, Sundaram B, Kancharana B, Lee S, Samir P, Kanneganti TD
ImmunoHorizons 2021 Jul 21;5(7):568-580
ImmunoHorizons 2021 Jul 21;5(7):568-580
Toll‑like receptor 4 activates the NLRP3 inflammasome pathway and periodontal inflammaging by inhibiting Bmi‑1 expression.
Qin ZY, Gu X, Chen YL, Liu JB, Hou CX, Lin SY, Hao NN, Liang Y, Chen W, Meng HY
International journal of molecular medicine 2021 Jan;47(1):137-150
International journal of molecular medicine 2021 Jan;47(1):137-150
Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway.
Xu S, Chen H, Ni H, Dai Q
Atherosclerosis 2021 Jan;317:1-9
Atherosclerosis 2021 Jan;317:1-9
Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342-3p targeting of CASP1 in diabetic retinopathy.
Yu X, Ma X, Lin W, Xu Q, Zhou H, Kuang H
Experimental eye research 2021 Jan;202:108300
Experimental eye research 2021 Jan;202:108300
Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice.
Yu Y, Chen D, Zhao Y, Zhu J, Dong X
International journal of immunopathology and pharmacology 2021 Jan-Dec;35:20587384211036819
International journal of immunopathology and pharmacology 2021 Jan-Dec;35:20587384211036819
Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice.
Shi Y, Zou Y, Xiong Y, Zhang S, Song M, An X, Liu C, Zhang W, Chen S
Gut microbes 2021 Jan-Dec;13(1):1946369
Gut microbes 2021 Jan-Dec;13(1):1946369
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Guo Z, Qiu C, Mecca C, Zhang Y, Bian J, Wang Y, Wu X, Wang T, Su W, Li X, Zhang W, Chen B, Xiang H
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth.
Fu F, Bao R, Yao S, Zhou C, Luo H, Zhang Z, Zhang H, Li Y, Yan S, Yu H, Du W, Yang Y, Jin H, Tong P, Sun ZT, Yue M, Chen D, Wu C, Ruan H
Scientific reports 2021 Jan 12;11(1):772
Scientific reports 2021 Jan 12;11(1):772
Protection of hUC-MSCs against neuronal complement C3a receptor-mediated NLRP3 activation in CUMS-induced mice.
Li J, Tian S, Wang H, Wang Y, Du C, Fang J, Wang X, Wang Y, Gong Z, Yan B, Wang M
Neuroscience letters 2021 Jan 10;741:135485
Neuroscience letters 2021 Jan 10;741:135485
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis.
Wang X, Liu K, Gong H, Li D, Chu W, Zhao D, Wang X, Xu D
Toxicology and applied pharmacology 2021 Jan 1;410:115363
Toxicology and applied pharmacology 2021 Jan 1;410:115363
Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression.
Li W, Ali T, He K, Liu Z, Shah FA, Ren Q, Liu Y, Jiang A, Li S
Brain, behavior, and immunity 2021 Feb;92:10-24
Brain, behavior, and immunity 2021 Feb;92:10-24
lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome.
Dai W, Wang M, Wang P, Wen J, Wang J, Cha S, Xiao X, He Y, Shu R, Bai D
International journal of molecular medicine 2021 Feb;47(2):607-620
International journal of molecular medicine 2021 Feb;47(2):607-620
Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.
Chen LJ, Zhi X, Zhang KK, Wang LB, Li JH, Liu JL, Xu LL, Yoshida JS, Xie XL, Wang Q
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111946
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111946
Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
Hu J, Qiao J, Yu Q, Liu B, Zhen J, Liu Y, Ma Q, Li Y, Wang Q, Wang C, Lv Z
Journal of translational medicine 2021 Feb 15;19(1):69
Journal of translational medicine 2021 Feb 15;19(1):69
Silenced microRNA-222 suppresses inflammatory response in gestational diabetes mellitus mice by promoting CXCR4.
Zhang H, Luan S, Xiao X, Lin L, Zhao X, Liu X
Life sciences 2021 Feb 1;266:118850
Life sciences 2021 Feb 1;266:118850
An In-vivo Study into the Effects of Schisandrin B in the Liver, Spleen, Kidney, and Brain of Acute Thioacetamide-intoxicated Mice.
Lam HYP, Hung MY, Liang TR, Peng SY
Iranian journal of pharmaceutical research : IJPR 2021 Fall;20(4):300-314
Iranian journal of pharmaceutical research : IJPR 2021 Fall;20(4):300-314
Huoxue Qianyang Qutan recipe attenuates cardiac fibrosis by inhibiting the NLRP3 inflammasome signalling pathway in obese hypertensive rats.
Lu B, Xie J, Fu D, Chen X, Zhao M, Gui M, Yao L, Zhou X, Li J
Pharmaceutical biology 2021 Dec;59(1):1045-1057
Pharmaceutical biology 2021 Dec;59(1):1045-1057
Dexmedetomidine inhibits endoplasmic reticulum stress to suppress pyroptosis of hypoxia/reoxygenation-induced intestinal epithelial cells via activating the SIRT1 expression.
Liu X, Leng Y, Lv X, Lv J, Zhang M, Shi Y
Journal of bioenergetics and biomembranes 2021 Dec;53(6):655-664
Journal of bioenergetics and biomembranes 2021 Dec;53(6):655-664
Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM(2.5).
Zhang X, Qi W, Shi Y, Li X, Yin J, Huo C, Zhang R, Zhao W, Ye J, Zhou L, Ye L
Toxicology 2021 Dec;464:152993
Toxicology 2021 Dec;464:152993
Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway.
Jiang W, Geng H, Lv X, Ma J, Liu F, Lin P, Yan C
Cardiovascular drugs and therapy 2021 Dec;35(6):1129-1145
Cardiovascular drugs and therapy 2021 Dec;35(6):1129-1145
MEHP induces pyroptosis and autophagy alternation by cathepsin B activation in INS-1 cells.
Jiang L, Qiu T, Yao X, Chen H, Yao K, Sun X, Yang G, Jiang L, Zhang C, Wang N, Zhang H, Liu X
Environmental science and pollution research international 2021 Dec;28(47):66628-66642
Environmental science and pollution research international 2021 Dec;28(47):66628-66642
DDX3X deficiency alleviates LPS-induced H9c2 cardiomyocytes pyroptosis by suppressing activation of NLRP3 inflammasome.
Feng D, Guo L, Liu J, Song Y, Ma X, Hu H, Liu J, Hao E
Experimental and therapeutic medicine 2021 Dec;22(6):1389
Experimental and therapeutic medicine 2021 Dec;22(6):1389
MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice.
Wu X, Zhang Y, Zhang Y, Xia L, Yang Y, Wang P, Xu Y, Ren Z, Liu H
Brain research bulletin 2021 Dec;177:31-38
Brain research bulletin 2021 Dec;177:31-38
ESR2 regulates PINK1-mediated mitophagy via transcriptional repression of microRNA-423 expression to promote asthma development.
Kong X, Chen R, Zhang L, Wu M, Wu J, Wei Y, Dai W, Jiang Y
Pharmacological research 2021 Dec;174:105956
Pharmacological research 2021 Dec;174:105956
Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke.
Li F, Xu D, Hou K, Gou X, Lv N, Fang W, Li Y
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2021 Dec;16(4):835-853
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2021 Dec;16(4):835-853
Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway.
Ruan Y, Ling J, Ye F, Cheng N, Wu F, Tang Z, Cheng X, Liu H
International immunopharmacology 2021 Dec;101(Pt B):108364
International immunopharmacology 2021 Dec;101(Pt B):108364
Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice.
Li A, Wu X, Yang J, Li J, Guo H, Zhang Y, Jiang H, Huo T
Journal of ethnopharmacology 2021 Dec 5;281:114584
Journal of ethnopharmacology 2021 Dec 5;281:114584
Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice.
Cao LL, Guan PP, Zhang SQ, Yang Y, Huang XS, Wang P
Journal of neuroinflammation 2021 Dec 3;18(1):281
Journal of neuroinflammation 2021 Dec 3;18(1):281
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.
Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, Liu L, Li M, Li W, Zou F
Journal of neuroinflammation 2021 Dec 20;18(1):295
Journal of neuroinflammation 2021 Dec 20;18(1):295
Prototheca spp. induce an inflammatory response via mtROS-mediated activation of NF-κB and NLRP3 inflammasome pathways in bovine mammary epithelial cell cultures.
Zhao W, He F, Barkema HW, Xu S, Gao J, Liu G, Deng Z, Shahid M, Shi Y, Kastelic JP, Han B
Veterinary research 2021 Dec 11;52(1):144
Veterinary research 2021 Dec 11;52(1):144
Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways.
Wang X, Chen S, Zhao L, Shi X
International immunopharmacology 2021 Aug;97:107506
International immunopharmacology 2021 Aug;97:107506
Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome‑mediated inflammation.
Feng H, Zhu X, Tang Y, Fu S, Kong B, Liu X
International journal of molecular medicine 2021 Aug;48(2)
International journal of molecular medicine 2021 Aug;48(2)
Resveratrol affects the expression of uric acid transporter by improving inflammation.
Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, Wang X, Song G
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Microtubule associated protein 4 (MAP4) phosphorylation reduces cardiac microvascular density through NLRP3-related pyroptosis.
Feng YH, Li LF, Zhang Q, Zhang JH, Huang Y, Lv YL, Jia JZ, Zhang D, Hu JY, Huang YS
Cell death discovery 2021 Aug 12;7(1):213
Cell death discovery 2021 Aug 12;7(1):213
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Zeng J, Tao J, Xi L, Wang Z, Liu L
International journal of molecular medicine 2021 Apr;47(4)
International journal of molecular medicine 2021 Apr;47(4)
Carthamin yellow improves cerebral ischemia‑reperfusion injury by attenuating inflammation and ferroptosis in rats.
Guo H, Zhu L, Tang P, Chen D, Li Y, Li J, Bao C
International journal of molecular medicine 2021 Apr;47(4)
International journal of molecular medicine 2021 Apr;47(4)
Therapeutic Effect of Endothelin-Converting Enzyme Inhibitor on Chronic Kidney Disease through the Inhibition of Endoplasmic Reticulum Stress and the NLRP3 Inflammasome.
Hsu YH, Zheng CM, Chou CL, Chen YJ, Lee YH, Lin YF, Chiu HW
Biomedicines 2021 Apr 7;9(4)
Biomedicines 2021 Apr 7;9(4)
Kupffer cell-targeting strategy for the protection of hepatic ischemia/reperfusion injury.
Dai Q, Jiang W, Liu H, Qing X, Wang G, Huang F, Yang Z, Wang C, Gu E, Zhao H, Zhang J, Liu X
Nanotechnology 2021 Apr 6;32(26)
Nanotechnology 2021 Apr 6;32(26)
Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.
Dai J, Chen Q, Huang W, Shi K, Zhang Y, Li T, Mou T, Huang Z, Wu Z
Acta biochimica et biophysica Sinica 2021 Apr 15;53(5):601-611
Acta biochimica et biophysica Sinica 2021 Apr 15;53(5):601-611
Absent in melanoma 2 suppresses gastric cancer cell proliferation and migration via inactivation of AKT signaling pathway.
Wang D, Zou J, Dai J, Cheng Z
Scientific reports 2021 Apr 15;11(1):8235
Scientific reports 2021 Apr 15;11(1):8235
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis.
Zheng T, Wang Q, Bian F, Zhao Y, Ma W, Zhang Y, Lu W, Lei P, Zhang L, Hao X, Chen L
Toxicology and applied pharmacology 2021 Apr 1;416:115468
Toxicology and applied pharmacology 2021 Apr 1;416:115468
Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats.
Hou J, Lei Z, Cui L, Hou Y, Yang L, An R, Wang Q, Li S, Zhang H, Zhang L
Ecotoxicology and environmental safety 2021 Apr 1;212:112012
Ecotoxicology and environmental safety 2021 Apr 1;212:112012
VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice.
Sun Z, Nyanzu M, Yang S, Zhu X, Wang K, Ru J, Yu E, Zhang H, Wang Z, Shen J, Zhuge Q, Huang L
Oxidative medicine and cellular longevity 2020;2020:7879629
Oxidative medicine and cellular longevity 2020;2020:7879629
Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R(-/-)) Mice via Its Anti-inflammatory and Antipyroptotic Effects.
Pei ZW, Guo Y, Zhu HL, Dong M, Zhang Q, Wang F
BioMed research international 2020;2020:4878704
BioMed research international 2020;2020:4878704
Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia.
He XM, Zhou YZ, Sheng S, Li JJ, Wang GQ, Zhang F
Oxidative medicine and cellular longevity 2020;2020:2963540
Oxidative medicine and cellular longevity 2020;2020:2963540
Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice.
Guo LP, Liu SX, Yang Q, Liu HY, Xu LL, Hao YH, Zhang XQ
BioMed research international 2020;2020:1594726
BioMed research international 2020;2020:1594726
Blocking the LncRNA MALAT1/miR-224-5p/NLRP3 Axis Inhibits the Hippocampal Inflammatory Response in T2DM With OSA.
Du P, Wang J, Han Y, Feng J
Frontiers in cellular neuroscience 2020;14:97
Frontiers in cellular neuroscience 2020;14:97
Maresin 1 Attenuates Radicular Pain Through the Inhibition of NLRP3 Inflammasome-Induced Pyroptosis via NF-κB Signaling.
Wang YH, Li Y, Wang JN, Zhao QX, Jin J, Wen S, Wang SC, Sun T
Frontiers in neuroscience 2020;14:831
Frontiers in neuroscience 2020;14:831
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Gao Z, Sui J, Fan R, Qu W, Dong X, Sun D
Drug design, development and therapy 2020;14:1971-1982
Drug design, development and therapy 2020;14:1971-1982
Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux.
Zeng Q, Zhou Y, Liang D, He H, Liu X, Zhu R, Zhang M, Luo X, Wang Y, Huang G
Frontiers in cellular neuroscience 2020;14:182
Frontiers in cellular neuroscience 2020;14:182
Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.
Wu X, Mao X, Huang Y, Zhu Q, Guan J, Wu L
International journal of clinical and experimental pathology 2020;13(6):1408-1414
International journal of clinical and experimental pathology 2020;13(6):1408-1414
Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease.
Zhang J, Pei L, Zang D, Xue Y, Wang X, Chen Y, Li J, Yu J, Gao Q, Di W, Cui C, Su W, Wang X
Frontiers in aging neuroscience 2020;12:512097
Frontiers in aging neuroscience 2020;12:512097
Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway.
Luo W, Han Y, Meng P, Yang Q, Zhao H, Ling J, Wang Y
Cancer management and research 2020;12:13003-13014
Cancer management and research 2020;12:13003-13014
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
Li N, Zhao T, Cao Y, Zhang H, Peng L, Wang Y, Zhou X, Wang Q, Li J, Yan M, Dong X, Zhao H, Li P
Frontiers in pharmacology 2020;11:623489
Frontiers in pharmacology 2020;11:623489
Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome.
Wei C, Guo S, Liu W, Jin F, Wei B, Fan H, Su H, Liu J, Zhang N, Fang D, Li G, Shu S, Li X, He X, Zhang X, Duan C
Frontiers in pharmacology 2020;11:610734
Frontiers in pharmacology 2020;11:610734
Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury.
Jin H, Zhao Z, Lan Q, Zhou H, Mai Z, Wang Y, Ding X, Zhang W, Pi J, Evans CE, Liu X
Frontiers in pharmacology 2020;11:592238
Frontiers in pharmacology 2020;11:592238
Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats.
Jiang M, Wang W, Zhang J, Wang C, Bi Y, Li P, Yang S, Li J, Xu YT, Wang T
Frontiers in pharmacology 2020;11:546
Frontiers in pharmacology 2020;11:546
MiR-139 protects against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced nerve injury through targeting c-Jun to inhibit NLRP3 inflammasome activation.
Wang QS, Luo XY, Fu H, Luo Q, Wang MQ, Zou DY
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Sep;29(9):105037
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Sep;29(9):105037
Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity.
Li S, Shi M, Wan Y, Wang Y, Zhu M, Wang B, Zhan Y, Ran B, Wu C
Ecotoxicology and environmental safety 2020 Sep 15;201:110801
Ecotoxicology and environmental safety 2020 Sep 15;201:110801
Mesenchymal stem cells-derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis.
Zhang J, Zhang J, Zhang Y, Liu W, Ni W, Huang X, Yuan J, Zhao B, Xiao H, Xue F
Journal of cellular and molecular medicine 2020 Oct;24(20):11742-11754
Journal of cellular and molecular medicine 2020 Oct;24(20):11742-11754
Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Wu P, Chen J, Chen J, Tao J, Wu S, Xu G, Wang Z, Wei D, Yin W
Journal of cellular physiology 2020 Oct;235(10):6582-6591
Journal of cellular physiology 2020 Oct;235(10):6582-6591
The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.
Wang G, Zuo T, Li R
Drug development research 2020 Nov;81(7):859-866
Drug development research 2020 Nov;81(7):859-866
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
Xu Y, Fang H, Xu Q, Xu C, Yang L, Huang C
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3054-3065
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3054-3065
MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor.
Tao J, Xia LZ, Liang L, Chen Y, Wei D, Meng J, Wu S, Wang Z
Placenta 2020 Nov;101:176-184
Placenta 2020 Nov;101:176-184
A novel mechanism of protection against isoproterenol-induced cardiac inflammation via regulation of the SIRT1/NRF2 signaling pathway with a natural SIRT1 agonist.
Nie Q, Zhang J, He B, Wang F, Sun M, Wang C, Sun W, Guo J, Wen J, Liu P
European journal of pharmacology 2020 Nov 5;886:173398
European journal of pharmacology 2020 Nov 5;886:173398
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice.
Wang D, Weng Y, Zhang Y, Wang R, Wang T, Zhou J, Shen S, Wang H, Wang Y
The Science of the total environment 2020 Nov 25;745:141049
The Science of the total environment 2020 Nov 25;745:141049
Cyanidin-3-O-β-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SirT1/NF-κB signaling pathway.
Zhou Y, Wang S, Wan T, Huang Y, Pang N, Jiang X, Gu Y, Zhang Z, Luo J, Yang L
Free radical biology & medicine 2020 Nov 20;160:334-341
Free radical biology & medicine 2020 Nov 20;160:334-341
Polysaccharides from Armillariella tabescens mycelia ameliorate insulin resistance in type 2 diabetic mice.
Yang R, Li Y, Cai J, Ji J, Wang Y, Zhang W, Pan W, Chen Y
Food & function 2020 Nov 18;11(11):9675-9685
Food & function 2020 Nov 18;11(11):9675-9685
Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo.
Tan S, Gao J, Li Q, Guo T, Dong X, Bai X, Yang J, Hao S, He F
Scientific reports 2020 Nov 17;10(1):20013
Scientific reports 2020 Nov 17;10(1):20013
Antiviral mechanism of carvacrol on HSV-2 infectivity through inhibition of RIP3-mediated programmed cell necrosis pathway and ubiquitin-proteasome system in BSC-1 cells.
Wang L, Wang D, Wu X, Xu R, Li Y
BMC infectious diseases 2020 Nov 11;20(1):832
BMC infectious diseases 2020 Nov 11;20(1):832
Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway.
Jia Y, Cui R, Wang C, Feng Y, Li Z, Tong Y, Qu K, Liu C, Zhang J
Redox biology 2020 May;32:101534
Redox biology 2020 May;32:101534
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
Zhu Y, Zhu C, Yang H, Deng J, Fan D
Pharmacological research 2020 May;155:104746
Pharmacological research 2020 May;155:104746
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H
Cellular & molecular immunology 2020 Mar;17(3):283-299
Cellular & molecular immunology 2020 Mar;17(3):283-299
Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.
Luo X, Li Y, Yang P, Chen Y, Wei L, Yu T, Xia J, Ruan XZ, Zhao L, Chen Y
EBioMedicine 2020 Jun;56:102797
EBioMedicine 2020 Jun;56:102797
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.
Kai J, Yang X, Wang Z, Wang F, Jia Y, Wang S, Tan S, Chen A, Shao J, Zhang F, Zhang Z, Zheng S
Free radical biology & medicine 2020 Jun;153:89-102
Free radical biology & medicine 2020 Jun;153:89-102
Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway.
Yang K, Zhan L, Lu T, Zhou C, Chen X, Dong Y, Lv G, Chen S
Cytokine 2020 Jun;130:155058
Cytokine 2020 Jun;130:155058
Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages.
Zhang C, Zhao C, Chen X, Tao R, Wang S, Meng G, Liu X, Shao C, Su X
Cell death & disease 2020 Jun 18;11(6):470
Cell death & disease 2020 Jun 18;11(6):470
Dose-dependent structural and immunological changes in the placenta and fetal brain in response to systemic inflammation during pregnancy.
Chudnovets A, Lei J, Na Q, Dong J, Narasimhan H, Klein SL, Burd I
American journal of reproductive immunology (New York, N.Y. : 1989) 2020 Jul;84(1):e13248
American journal of reproductive immunology (New York, N.Y. : 1989) 2020 Jul;84(1):e13248
RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.
Liu N, Wang Y, Zeng L, Yin S, Hu Y, Li S, Fu Y, Zhang X, Xie C, Shu L, Li Y, Sun H, Yang M, Sun J, Yang X
Journal of agricultural and food chemistry 2020 Jul 8;68(27):7143-7151
Journal of agricultural and food chemistry 2020 Jul 8;68(27):7143-7151
Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
Lam HYP, Liang TR, Jiang SJ, Peng SY
Biomolecules 2020 Jul 5;10(7)
Biomolecules 2020 Jul 5;10(7)
NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury.
Chang Y, Zhu J, Wang D, Li H, He Y, Liu K, Wang X, Peng Y, Pan S, Huang K
Journal of neuroinflammation 2020 Jul 23;17(1):219
Journal of neuroinflammation 2020 Jul 23;17(1):219
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Xie C, Ge M, Jin J, Xu H, Mao L, Geng S, Wu J, Zhu J, Li X, Zhong C
Journal of hazardous materials 2020 Jul 15;394:122549
Journal of hazardous materials 2020 Jul 15;394:122549
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Pang H, Wang N, Chai J, Wang X, Zhang Y, Bi Z, Wu W, He G
European journal of medicinal chemistry 2020 Jul 1;197:112314
European journal of medicinal chemistry 2020 Jul 1;197:112314
α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome.
Wang X, Chi J, Huang D, Ding L, Zhao X, Jiang L, Yu Y, Gao F
Experimental and therapeutic medicine 2020 Feb;19(2):931-938
Experimental and therapeutic medicine 2020 Feb;19(2):931-938
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
Zhou Y, Fu X, Guan Y, Gong M, He K, Huang B
Biochemical pharmacology 2020 Feb;172:113752
Biochemical pharmacology 2020 Feb;172:113752
H(2)S alleviates renal injury and fibrosis in response to unilateral ureteral obstruction by regulating macrophage infiltration via inhibition of NLRP3 signaling.
Zhou Y, Zhu X, Wang X, Peng Y, Du J, Yin H, Yang H, Ni X, Zhang W
Experimental cell research 2020 Feb 1;387(1):111779
Experimental cell research 2020 Feb 1;387(1):111779
Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME.
Zheng X, Zhong T, Ma Y, Wan X, Qin A, Yao B, Zou H, Song Y, Yin D
Life sciences 2020 Feb 1;242:117186
Life sciences 2020 Feb 1;242:117186
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Lang L, Xu B, Yuan J, Li S, Lian S, Chen Y, Guo J, Yang H
International immunopharmacology 2020 Dec;89(Pt B):106908
International immunopharmacology 2020 Dec;89(Pt B):106908
Salvianolic acid B alleviates myocardial ischemic injury by promoting mitophagy and inhibiting activation of the NLRP3 inflammasome.
Hu Y, Wang X, Li Q, Pan Y, Xu L
Molecular medicine reports 2020 Dec;22(6):5199-5208
Molecular medicine reports 2020 Dec;22(6):5199-5208
Latcripin-7A, derivative of Lentinula edodes C(91-3), reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G(1) phase in breast cancer cells.
Din SRU, Zhong M, Nisar MA, Saleem MZ, Hussain A, Khinsar KH, Alam S, Ayub G, Kanwal S, Li X, Zhang W, Wang X, Ning A, Cao J, Huang M
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma.
Tang Q, Li W, Zheng X, Ren L, Liu J, Li S, Wang J, Du G
Signal transduction and targeted therapy 2020 Dec 2;5(1):279
Signal transduction and targeted therapy 2020 Dec 2;5(1):279
Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm.
Zhang X, Li F, Wang W, Ji L, Sun B, Xiao X, Wang X, Chen Y, Liu B, Ye W, Tian C, Wang H, Zheng Y
Biochemical and biophysical research communications 2020 Dec 17;533(4):1012-1020
Biochemical and biophysical research communications 2020 Dec 17;533(4):1012-1020
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.
Lam HYP, Chen TT, Chen CC, Yang TH, Cheng PC, Peng SY
Parasitology international 2020 Aug;77:102119
Parasitology international 2020 Aug;77:102119
A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.
Wang YH, Li Y, Wang JN, Zhao QX, Wen S, Wang SC, Sun T
Neurochemical research 2020 Aug;45(8):1860-1869
Neurochemical research 2020 Aug;45(8):1860-1869
FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis.
Zeng Z, Zheng Q, Chen J, Tan X, Li Q, Ding L, Zhang R, Lin X
Experimental cell research 2020 Aug 15;393(2):112108
Experimental cell research 2020 Aug 15;393(2):112108
Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway.
Chen JJ, Tao J, Zhang XL, Xia LZ, Zeng JF, Zhang H, Wei DH, Lv YC, Li GH, Wang Z
DNA and cell biology 2020 Apr;39(4):661-670
DNA and cell biology 2020 Apr;39(4):661-670
Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice.
Liu Q, Guo X, Huang Z, He Q, Zhu D, Zhang S, Peng Z, Che Y, Feng X
Behavioural brain research 2020 Apr 6;383:112539
Behavioural brain research 2020 Apr 6;383:112539
Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells.
Bai Z, Liu W, He D, Wang Y, Yi W, Luo C, Shen J, Hu Z
Aging 2020 Apr 22;12(8):7534-7548
Aging 2020 Apr 22;12(8):7534-7548
Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.
Yang K, Lu T, Zhan L, Zhou C, Zhang N, Lei S, Wang Y, Yang J, Yan M, Lv G, Chen S
International journal of biological macromolecules 2020 Apr 15;149:320-330
International journal of biological macromolecules 2020 Apr 15;149:320-330
Methylene Blue Attenuates Diabetic Retinopathy by Inhibiting NLRP3 Inflammasome Activation in STZ-Induced Diabetic Rats.
Hao J, Zhang H, Yu J, Chen X, Yang L
Ocular immunology and inflammation 2019;27(5):836-843
Ocular immunology and inflammation 2019;27(5):836-843
Purple Sweet Potato Color Attenuates Kidney Damage by Blocking VEGFR2/ROS/NLRP3 Signaling in High-Fat Diet-Treated Mice.
Zheng GH, Shan Q, Mu JJ, Wang YJ, Zhang ZF, Fan SH, Hu B, Li MQ, Xie J, Chen P, Wu DM, Lu J, Zheng YL
Oxidative medicine and cellular longevity 2019;2019:5189819
Oxidative medicine and cellular longevity 2019;2019:5189819
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Leng B, Zhang Y, Liu X, Zhang Z, Liu Y, Wang H, Lu M
Mediators of inflammation 2019;2019:1082497
Mediators of inflammation 2019;2019:1082497
Eplerenone Ameliorates Cell Pyroptosis in Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction.
Ma X, Chang Y, Xiong Y, Wang Z, Wang X, Xu Q
Nephron 2019;142(3):233-242
Nephron 2019;142(3):233-242
Porous Se@SiO(2) nanospheres attenuate ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) and inflammation by antioxidative stress.
Zheng Z, Deng G, Qi C, Xu Y, Liu X, Zhao Z, Zhang Z, Chu Y, Wu H, Liu J
International journal of nanomedicine 2019;14:215-229
International journal of nanomedicine 2019;14:215-229
Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats.
Zhuang K, Zuo YC, Sherchan P, Wang JK, Yan XX, Liu F
Frontiers in neuroscience 2019;13:1441
Frontiers in neuroscience 2019;13:1441
NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.
Liu SG, Wu XX, Hua T, Xin XY, Feng DL, Chi SQ, Wang XX, Wang HB
OncoTargets and therapy 2019;12:6927-6936
OncoTargets and therapy 2019;12:6927-6936
Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation.
Chen C, Wei YZ, He XM, Li DD, Wang GQ, Li JJ, Zhang F
Frontiers in immunology 2019;10:936
Frontiers in immunology 2019;10:936
TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease.
Wang Y, Zhu X, Yuan S, Wen S, Liu X, Wang C, Qu Z, Li J, Liu H, Sun L, Liu F
Frontiers in endocrinology 2019;10:603
Frontiers in endocrinology 2019;10:603
Weighted Gene Co-expression Network Analysis for RNA-Sequencing Data of the Varicose Veins Transcriptome.
Zhang J, Nie Q, Si C, Wang C, Chen Y, Sun W, Pan L, Guo J, Kong J, Cui Y, Wang F, Fan X, Ye Z, Wen J, Liu P
Frontiers in physiology 2019;10:278
Frontiers in physiology 2019;10:278
Sorghum Phenolics Inhibits Inflammasomes in Lipopolysaccharide (LPS)-Primed and Adenosine Triphosphate (ATP)-Activated Macrophages.
Dia VP, Bradwell J, Pangloli P
Plant foods for human nutrition (Dordrecht, Netherlands) 2019 Sep;74(3):307-315
Plant foods for human nutrition (Dordrecht, Netherlands) 2019 Sep;74(3):307-315
Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.
Deng G, Chen W, Wang P, Zhan T, Zheng W, Gu Z, Wang X, Ji X, Sun Y
International immunopharmacology 2019 Sep;74:105682
International immunopharmacology 2019 Sep;74:105682
Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway.
Tang YS, Zhao YH, Zhong Y, Li XZ, Pu JX, Luo YC, Zhou QL
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019 Sep;68(9):727-738
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019 Sep;68(9):727-738
Treatment with andrographolide sulfonate provides additional benefits to imipenem in a mouse model of Klebsiella pneumoniae pneumonia.
Zhang G, Jiang C, Xie N, Xu Y, Liu L, Liu N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109065
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109065
FNDC5 inhibits foam cell formation and monocyte adhesion in vascular smooth muscle cells via suppressing NFκB-mediated NLRP3 upregulation.
Zang YH, Chen D, Zhou B, Chen AD, Wang JJ, Gao XY, Chen Q, Li YH, Kang YM, Zhu GQ
Vascular pharmacology 2019 Oct;121:106579
Vascular pharmacology 2019 Oct;121:106579
Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways.
Wang Y, Lin Z, Zhang B, Jiang Z, Guo F, Yang T
International journal of molecular sciences 2019 Oct 4;20(19)
International journal of molecular sciences 2019 Oct 4;20(19)
Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation.
Jia C, Zhang J, Chen H, Zhuge Y, Chen H, Qian F, Zhou K, Niu C, Wang F, Qiu H, Wang Z, Xiao J, Rong X, Chu M
Cell death & disease 2019 Oct 14;10(10):778
Cell death & disease 2019 Oct 14;10(10):778
Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high-fat high cholesterol diet via regulating NF-κB and NLRP3 inflammasome pathway.
Huang Y, Wan T, Pang N, Zhou Y, Jiang X, Li B, Gu Y, Huang Y, Ye X, Lian H, Zhang Z, Yang L
Journal of cellular physiology 2019 Nov;234(11):21224-21234
Journal of cellular physiology 2019 Nov;234(11):21224-21234
Iguratimod (T-614) attenuates severe acute pancreatitis by inhibiting the NLRP3 inflammasome and NF-κB pathway.
Hou C, Zhu X, Shi C, Peng Y, Huang D, Li Q, Miao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109455
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109455
Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis.
Wang X, Bian Y, Zhang R, Liu X, Ni L, Ma B, Zeng R, Zhao Z, Song X, Liu C
Biochemical and biophysical research communications 2019 Nov 5;519(2):402-408
Biochemical and biophysical research communications 2019 Nov 5;519(2):402-408
Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli.
Qi H, Gao Y, Li Y, Wei J, Su X, Zhang C, Liu Y, Zhu H, Sui L, Xiong Y, Yang X, Xu Y, Zhang Y, Yang R
iScience 2019 Nov 22;21:474-489
iScience 2019 Nov 22;21:474-489
The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice.
Qu J, Yuan Z, Wang G, Wang X, Li K
International immunopharmacology 2019 May;70:147-155
International immunopharmacology 2019 May;70:147-155
OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway.
Zhaolin Z, Jiaojiao C, Peng W, Yami L, Tingting Z, Jun T, Shiyuan W, Jinyan X, Dangheng W, Zhisheng J, Zuo W
Journal of cellular physiology 2019 May;234(5):7475-7491
Journal of cellular physiology 2019 May;234(5):7475-7491
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh-Asahara N
Cells 2019 May 31;8(6)
Cells 2019 May 31;8(6)
TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice.
Wang Z, Zhou L, An D, Xu W, Wu C, Sha S, Li Y, Zhu Y, Chen A, Du Y, Chen L, Chen L
Cell death & disease 2019 May 16;10(6):386
Cell death & disease 2019 May 16;10(6):386
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA
Nature neuroscience 2019 Mar;22(3):401-412
Nature neuroscience 2019 Mar;22(3):401-412
STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3.
Li N, Zhou H, Wu H, Wu Q, Duan M, Deng W, Tang Q
Redox biology 2019 Jun;24:101215
Redox biology 2019 Jun;24:101215
Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3.
Peng J, Zhang P, Zheng H, Ren YQ, Yan H
Chinese journal of traumatology = Zhonghua chuang shang za zhi 2019 Jun;22(3):161-165
Chinese journal of traumatology = Zhonghua chuang shang za zhi 2019 Jun;22(3):161-165
NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.
Wang H, Zhong D, Chen H, Jin J, Liu Q, Li G
Life sciences 2019 Jun 15;227:101-113
Life sciences 2019 Jun 15;227:101-113
MicroRNA-135b alleviates MPP(+)-mediated Parkinson's disease in in vitro model through suppressing FoxO1-induced NLRP3 inflammasome and pyroptosis.
Zeng R, Luo DX, Li HP, Zhang QS, Lei SS, Chen JH
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2019 Jul;65:125-133
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2019 Jul;65:125-133
LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF-κB/NLRP3 inflammasome pathway.
Ma M, Pei Y, Wang X, Feng J, Zhang Y, Gao MQ
Cell proliferation 2019 Jan;52(1):e12525
Cell proliferation 2019 Jan;52(1):e12525
Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.
Zhang Q, Tao X, Xia S, Qu J, Song H, Liu J, Li H, Shang D
Oncology reports 2019 Jan;41(1):270-278
Oncology reports 2019 Jan;41(1):270-278
Granisetron protects polymicrobial sepsis-induced acute lung injury in mice.
Wang J, Gong S, Wang F, Niu M, Wei G, He Z, Gu T, Jiang Y, Liu A, Chen P
Biochemical and biophysical research communications 2019 Jan 22;508(4):1004-1010
Biochemical and biophysical research communications 2019 Jan 22;508(4):1004-1010
Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.
Du L, Shen K, Bai Y, Chao J, Hu G, Zhang Y, Yao H
Toxicology letters 2019 Feb;301:53-63
Toxicology letters 2019 Feb;301:53-63
LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.
Wang K, Xu T, Ruan H, Xiao H, Liu J, Song Z, Cao Q, Bao L, Liu D, Wang C, Cheng G, Liang H, Chen Z, Yang H, Chen K, Zhang X
Cell death & disease 2019 Feb 15;10(3):159
Cell death & disease 2019 Feb 15;10(3):159
Protective effects of acarbose against vascular endothelial dysfunction through inhibiting Nox4/NLRP3 inflammasome pathway in diabetic rats.
Li XX, Ling SK, Hu MY, Ma Y, Li Y, Huang PL
Free radical biology & medicine 2019 Dec;145:175-186
Free radical biology & medicine 2019 Dec;145:175-186
Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy.
Yu X, Hao M, Liu Y, Ma X, Lin W, Xu Q, Zhou H, Shao N, Kuang H
European journal of pharmacology 2019 Dec 1;864:172715
European journal of pharmacology 2019 Dec 1;864:172715
Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.
Lin Y, Wang S, Yang Z, Gao L, Zhou Z, Yu P, Wu B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Aug;116:108973
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Aug;116:108973
UFL1 modulates NLRP3 inflammasome activation and protects against pyroptosis in LPS-stimulated bovine mammary epithelial cells.
Li C, Wang X, Kuang M, Li L, Wang Y, Yang F, Wang G
Molecular immunology 2019 Aug;112:1-9
Molecular immunology 2019 Aug;112:1-9
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Liu H, Sun Y, Zhang Y, Yang G, Guo L, Zhao Y, Pei Z
Inflammation 2019 Apr;42(2):516-525
Inflammation 2019 Apr;42(2):516-525
Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.
Zhou F, Zhang Y, Chen J, Hu Y, Xu Y
Frontiers in endocrinology 2018;9:640
Frontiers in endocrinology 2018;9:640
Chronic Kidney Disease Increases Atrial Fibrillation Inducibility: Involvement of Inflammation, Atrial Fibrosis, and Connexins.
Qiu H, Ji C, Liu W, Wu Y, Lu Z, Lin Q, Xue Z, Liu X, Wu H, Jiang W, Zou C
Frontiers in physiology 2018;9:1726
Frontiers in physiology 2018;9:1726
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.
Wu Q, Zhu YH, Xu J, Liu X, Duan C, Wang MJ, Wang JF
Frontiers in microbiology 2018;9:1661
Frontiers in microbiology 2018;9:1661
Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice.
Zhong H, Liu M, Ji Y, Ma M, Chen K, Liang T, Liu C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):1885-1897
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):1885-1897
Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway.
Zheng T, Yang X, Li W, Wang Q, Chen L, Wu D, Bian F, Xing S, Jin S
Oxidative medicine and cellular longevity 2018;2018:8597897
Oxidative medicine and cellular longevity 2018;2018:8597897
Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome.
Du Y, Gu X, Meng H, Aa N, Liu S, Peng C, Ge Y, Yang Z
American journal of translational research 2018;10(12):4235-4246
American journal of translational research 2018;10(12):4235-4246
Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3 inflammasome activation.
Jiang Y, Yang W, Gui S
Immunobiology 2018 Oct;223(10):555-561
Immunobiology 2018 Oct;223(10):555-561
Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.
Bando H, Lee Y, Sakaguchi N, Pradipta A, Ma JS, Tanaka S, Cai Y, Liu J, Shen J, Nishikawa Y, Sasai M, Yamamoto M
mBio 2018 Oct 9;9(5)
mBio 2018 Oct 9;9(5)
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.
Wang S, Lin Y, Yuan X, Li F, Guo L, Wu B
Nature communications 2018 Oct 12;9(1):4246
Nature communications 2018 Oct 12;9(1):4246
Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells.
Song S, Qiu D, Luo F, Wei J, Wu M, Wu H, Du C, Du Y, Ren Y, Chen N, Duan H, Shi Y
Journal of molecular endocrinology 2018 Oct 1;61(3):101-113
Journal of molecular endocrinology 2018 Oct 1;61(3):101-113
Polybrominated Diphenyl Ethers Quinone Induced Parthanatos-like Cell Death through a Reactive Oxygen Species-Associated Poly(ADP-ribose) Polymerase 1 Signaling.
Dong W, Yang B, Wang Y, Yuan J, Fan Y, Song E, Song Y
Chemical research in toxicology 2018 Nov 19;31(11):1164-1171
Chemical research in toxicology 2018 Nov 19;31(11):1164-1171
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
He W, Ye S, Zeng C, Xue S, Hu X, Zhang X, Gao S, Xiong Y, He X, Vivalda S, Li L, Wang Y, Ye Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
[Effect of vimentin on activation of NLRP3 inflammasome in the brain of mice with EV71 infection].
Xiao HS, Xie Q, Zhong JY, Gerald Rukundo B, He XL, Qu YL, Cao H
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2018 Jun 20;38(6):704-710
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2018 Jun 20;38(6):704-710
Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.
Wu X, Zhang H, Qi W, Zhang Y, Li J, Li Z, Lin Y, Bai X, Liu X, Chen X, Yang H, Xu C, Zhang Y, Yang B
Cell death & disease 2018 Feb 7;9(2):171
Cell death & disease 2018 Feb 7;9(2):171
Salvianolate reduces atrial fibrillation through suppressing atrial interstitial fibrosis by inhibiting TGF-β1/Smad2/3 and TXNIP/NLRP3 inflammasome signaling pathways in post-MI rats.
Qiu H, Liu W, Lan T, Pan W, Chen X, Wu H, Xu D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Dec 1;51:255-265
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Dec 1;51:255-265
2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease.
Han M, Zhang T, Gu W, Yang X, Zhao R, Yu J
Experimental and therapeutic medicine 2018 Aug;16(2):1087-1094
Experimental and therapeutic medicine 2018 Aug;16(2):1087-1094
Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway.
Yin Y, Chen F, Wang W, Wang H, Zhang X
Molecular vision 2017;23:242-250
Molecular vision 2017;23:242-250
A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells.
Pang Y, Li C, Wang S, Ba W, Yu T, Pei G, Bi D, Liang H, Pan X, Zhu T, Gou M, Han Y, Li Q
Cell communication and signaling : CCS 2017 Oct 16;15(1):42
Cell communication and signaling : CCS 2017 Oct 16;15(1):42
The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease.
Chin LH, Hsu YJ, Hsu SC, Chen YH, Chang YL, Huang SM, Tsai CS, Lin CY
Oncotarget 2017 Dec 26;8(69):113303-113317
Oncotarget 2017 Dec 26;8(69):113303-113317
Pepsin-pancreatin hydrolysis reduced the ability of lunasin-enriched material to inhibit activation of the inflammasomes in THP-1 human macrophages.
Price SJ, Pangloli P, Dia VP
Food & function 2017 Dec 13;8(12):4449-4458
Food & function 2017 Dec 13;8(12):4449-4458
Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice.
Zhou F, Zhang Y, Chen J, Hu X, Xu Y
European journal of pharmacology 2016 Nov 15;791:735-740
European journal of pharmacology 2016 Nov 15;791:735-740
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
Ding C, Zhao Y, Shi X, Zhang N, Zu G, Li Z, Zhou J, Gao D, Lv L, Tian X, Yao J
Scientific reports 2016 Jun 27;6:28734
Scientific reports 2016 Jun 27;6:28734
Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice.
Fu X, Ju J, Lin Z, Xiao W, Li X, Zhuang B, Zhang T, Ma X, Li X, Ma C, Su W, Wang Y, Qin X, Liang S
Scientific reports 2016 Jul 22;6:30239
Scientific reports 2016 Jul 22;6:30239
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.
Wu Q, Liu MC, Yang J, Wang JF, Zhu YH
Applied and environmental microbiology 2016 Feb 15;82(4):1173-1182
Applied and environmental microbiology 2016 Feb 15;82(4):1173-1182
The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.
Wang X, Shaw DK, Hammond HL, Sutterwala FS, Rayamajhi M, Shirey KA, Perkins DJ, Bonventre JV, Velayutham TS, Evans SM, Rodino KG, VieBrock L, Scanlon KM, Carbonetti NH, Carlyon JA, Miao EA, McBride JW, Kotsyfakis M, Pedra JH
PLoS pathogens 2016 Aug;12(8):e1005803
PLoS pathogens 2016 Aug;12(8):e1005803
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Caspase 1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Caspase 1. This antibody recognizes human, mouse, rat antigen. The Caspase 1 antibody has been validated for the following applications: ELISA, WB analysis.
