CASP1

gene product
ICE, IL1BC
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
More gene data

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
1011 antibodies from 42 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
366 antibodies
Boster Biological Technology
5 antibodies
GeneTex
15 antibodies
R&D Systems
2 antibodies
Enzo Life Sciences
4 antibodies
Novus Biologicals
31 antibodies
Arigo
3 antibodies
Abnova Corporation
18 antibodies
Biorbyt
71 antibodies
OriGene
25 antibodies
Invitrogen Antibodies
15 antibodies
Acris Antibodies GmbH
23 antibodies
LifeSpan BioSciences, Inc.
177 antibodies
Rockland Immunochemicals, Inc.
3 antibodies
Cell Signaling Technology, Inc
4 antibodies
Proteintech Group
1 antibody
Abgent
8 antibodies
Aviva Systems Biology
12 antibodies
St John's Laboratory
8 antibodies
ProSci
4 antibodies
Affinity Biosciences
5 antibodies
NovoPro Bioscience Inc.
1 antibody
NSJ Bioreagents
4 antibodies
Atlas Antibodies
1 antibody
Bioworld Technology, Inc
5 antibodies
Abbkine Scientific Co.Ltd.
7 antibodies
BioLegend
2 antibodies