Antibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [13]
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Validation data
Reference
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- Product number
- ABIN252521 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Caspase 1 (CASP1) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 14F468
- Vial size
- 0.1 mg
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles.
Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells.
Myeloid cell transmigration across the CNS vasculature triggers IL-1β-driven neuroinflammation during autoimmune encephalomyelitis in mice.
Exosome-mediated inflammasome signaling after central nervous system injury.
Gossypol induces pyroptosis in mouse macrophages via a non-canonical inflammasome pathway.
Mechanisms of inflammasome activation by Vibrio cholerae secreted toxins vary with strain biotype.
Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular.
Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis.
Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation.
Involvement of the inflammasome in abnormal semen quality of men with spinal cord injury.
Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis.
Effects of therapeutic hypothermia on inflammasome signaling after traumatic brain injury.
Caspase-1 level is higher in the scalp in androgenetic alopecia.
P2X4 receptors influence inflammasome activation after spinal cord injury.
Human trophoblast-derived exosomal fibronectin induces pro-inflammatory IL-1β production by macrophages.
The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome.
Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats.
Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain.
Inflammasome up-regulation and activation in dysferlin-deficient skeletal muscle.
Transcription regulation of caspase-1 by R393 of HIPPI and its molecular partner HIP-1.
TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells.
Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells.
Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.
Fleetwood AJ, Lee MKS, Singleton W, Achuthan A, Lee MC, O'Brien-Simpson NM, Cook AD, Murphy AJ, Dashper SG, Reynolds EC, Hamilton JA
Frontiers in cellular and infection microbiology 2017;7:351
Frontiers in cellular and infection microbiology 2017;7:351
Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells.
Fernandez MV, Miller E, Krammer F, Gopal R, Greenbaum BD, Bhardwaj N
Journal of leukocyte biology 2016 May;99(5):723-34
Journal of leukocyte biology 2016 May;99(5):723-34
Myeloid cell transmigration across the CNS vasculature triggers IL-1β-driven neuroinflammation during autoimmune encephalomyelitis in mice.
Lévesque SA, Paré A, Mailhot B, Bellver-Landete V, Kébir H, Lécuyer MA, Alvarez JI, Prat A, de Rivero Vaccari JP, Keane RW, Lacroix S
The Journal of experimental medicine 2016 May 30;213(6):929-49
The Journal of experimental medicine 2016 May 30;213(6):929-49
Exosome-mediated inflammasome signaling after central nervous system injury.
de Rivero Vaccari JP, Brand F 3rd, Adamczak S, Lee SW, Perez-Barcena J, Wang MY, Bullock MR, Dietrich WD, Keane RW
Journal of neurochemistry 2016 Jan;136 Suppl 1:39-48
Journal of neurochemistry 2016 Jan;136 Suppl 1:39-48
Gossypol induces pyroptosis in mouse macrophages via a non-canonical inflammasome pathway.
Lin QR, Li CG, Zha QB, Xu LH, Pan H, Zhao GX, Ouyang DY, He XH
Toxicology and applied pharmacology 2016 Feb 1;292:56-64
Toxicology and applied pharmacology 2016 Feb 1;292:56-64
Mechanisms of inflammasome activation by Vibrio cholerae secreted toxins vary with strain biotype.
Queen J, Agarwal S, Dolores JS, Stehlik C, Satchell KJ
Infection and immunity 2015 Jun;83(6):2496-506
Infection and immunity 2015 Jun;83(6):2496-506
Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular.
Melehani JH, James DB, DuMont AL, Torres VJ, Duncan JA
PLoS pathogens 2015 Jun;11(6):e1004970
PLoS pathogens 2015 Jun;11(6):e1004970
Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis.
Rimessi A, Bezzerri V, Patergnani S, Marchi S, Cabrini G, Pinton P
Nature communications 2015 Feb 4;6:6201
Nature communications 2015 Feb 4;6:6201
Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation.
Paciello I, Silipo A, Lembo-Fazio L, Curcurù L, Zumsteg A, Noël G, Ciancarella V, Sturiale L, Molinaro A, Bernardini ML
Proceedings of the National Academy of Sciences of the United States of America 2013 Nov 12;110(46):E4345-54
Proceedings of the National Academy of Sciences of the United States of America 2013 Nov 12;110(46):E4345-54
Involvement of the inflammasome in abnormal semen quality of men with spinal cord injury.
Zhang X, Ibrahim E, de Rivero Vaccari JP, Lotocki G, Aballa TC, Dietrich WD, Keane RW, Lynne CM, Brackett NL
Fertility and sterility 2013 Jan;99(1):118-24
Fertility and sterility 2013 Jan;99(1):118-24
Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis.
Taxman DJ, Swanson KV, Broglie PM, Wen H, Holley-Guthrie E, Huang MT, Callaway JB, Eitas TK, Duncan JA, Ting JP
The Journal of biological chemistry 2012 Sep 21;287(39):32791-9
The Journal of biological chemistry 2012 Sep 21;287(39):32791-9
Effects of therapeutic hypothermia on inflammasome signaling after traumatic brain injury.
Tomura S, de Rivero Vaccari JP, Keane RW, Bramlett HM, Dietrich WD
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012 Oct;32(10):1939-47
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012 Oct;32(10):1939-47
Caspase-1 level is higher in the scalp in androgenetic alopecia.
de Rivero Vaccari JP, Sawaya ME, Brand F 3rd, Nusbaum BP, Bauman AJ, Bramlett HM, Dietrich WD, Keane RW
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2012 Jul;38(7 Pt 1):1033-9
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2012 Jul;38(7 Pt 1):1033-9
P2X4 receptors influence inflammasome activation after spinal cord injury.
de Rivero Vaccari JP, Bastien D, Yurcisin G, Pineau I, Dietrich WD, De Koninck Y, Keane RW, Lacroix S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Feb 29;32(9):3058-66
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Feb 29;32(9):3058-66
Human trophoblast-derived exosomal fibronectin induces pro-inflammatory IL-1β production by macrophages.
Atay S, Gercel-Taylor C, Taylor DD
American journal of reproductive immunology (New York, N.Y. : 1989) 2011 Oct;66(4):259-69
American journal of reproductive immunology (New York, N.Y. : 1989) 2011 Oct;66(4):259-69
The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome.
Taxman DJ, Holley-Guthrie EA, Huang MT, Moore CB, Bergstralh DT, Allen IC, Lei Y, Gris D, Ting JP
The Journal of biological chemistry 2011 Jun 3;286(22):19605-16
The Journal of biological chemistry 2011 Jun 3;286(22):19605-16
Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats.
Mawhinney LJ, de Rivero Vaccari JP, Dale GA, Keane RW, Bramlett HM
BMC neuroscience 2011 Dec 1;12:123
BMC neuroscience 2011 Dec 1;12:123
Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain.
Nadeau S, Filali M, Zhang J, Kerr BJ, Rivest S, Soulet D, Iwakura Y, de Rivero Vaccari JP, Keane RW, Lacroix S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Aug 31;31(35):12533-42
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Aug 31;31(35):12533-42
Inflammasome up-regulation and activation in dysferlin-deficient skeletal muscle.
Rawat R, Cohen TV, Ampong B, Francia D, Henriques-Pons A, Hoffman EP, Nagaraju K
The American journal of pathology 2010 Jun;176(6):2891-900
The American journal of pathology 2010 Jun;176(6):2891-900
Transcription regulation of caspase-1 by R393 of HIPPI and its molecular partner HIP-1.
Banerjee M, Datta M, Majumder P, Mukhopadhyay D, Bhattacharyya NP
Nucleic acids research 2010 Jan;38(3):878-92
Nucleic acids research 2010 Jan;38(3):878-92
TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells.
Hurst J, Prinz N, Lorenz M, Bauer S, Chapman J, Lackner KJ, von Landenberg P
Immunobiology 2009;214(8):683-91
Immunobiology 2009;214(8):683-91
Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells.
Craven RR, Gao X, Allen IC, Gris D, Bubeck Wardenburg J, McElvania-Tekippe E, Ting JP, Duncan JA
PloS one 2009 Oct 14;4(10):e7446
PloS one 2009 Oct 14;4(10):e7446
Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.
Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP
Journal of immunology (Baltimore, Md. : 1950) 2009 May 15;182(10):6460-9
Journal of immunology (Baltimore, Md. : 1950) 2009 May 15;182(10):6460-9
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
Dostert C, Pétrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J
Science (New York, N.Y.) 2008 May 2;320(5876):674-7
Science (New York, N.Y.) 2008 May 2;320(5876):674-7
Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.
Dorfleutner A, Bryan NB, Talbott SJ, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C
Infection and immunity 2007 Mar;75(3):1484-92
Infection and immunity 2007 Mar;75(3):1484-92
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