RRM1

This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Description

ribonucleotide reductase catalytic subunit M1

Protein family

Enzymes, FDA approved drug targets, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

11:p15.4 (4094707 - 4138932)

Ensembl ID

ENSG00000167325  (ver. 99.38)

Orthologs

Mouse Rrm1: ENSMUSG00000030978

UniProt

P23921

neXtProt

NX_P23921

Human splice variants
Mouse splice variants