Antibody data
- Antibody Data
- Antigen structure
- References [110]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 13763-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13763-1-AP, RRID:AB_2162854
- Product name
- PFKFB3-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PFKFB3-Specific antibody (Cat. #13763-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Angiotensin-(1-7) Modulates the Warburg Effect to Alleviate Inflammation in LPS-Induced Macrophages and Septic Mice.
Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure.
Bergenin alleviates proliferative arterial diseases by modulating glucose metabolism in vascular smooth muscle cells.
Integrating network pharmacology and bioinformatics to explore and experimentally verify the regulatory effect of Buyang Huanwu decoction on glycolysis and angiogenesis after cerebral infarction.
Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.
PFKFB3 promotes endometriosis cell proliferation via enhancing the protein stability of β-catenin.
The genetic and dietary landscape of the muscle insulin signalling network.
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells.
Noncoding RNA-Mediated High Expression of PFKFB3 Correlates with Poor Prognosis and Tumor Immune Infiltration of Lung Adenocarcinoma.
A glycometabolic gene signature associating with immune infiltration and chemosensitivity and predicting the prognosis of patients with osteosarcoma.
Defective branched-chain amino acid catabolism in dorsal root ganglia contributes to mechanical pain.
Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer.
Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor 1 in proangiogenic glomerular endothelial cells under diabetic condition.
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis.
TMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties.
Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.
Garlic-derived exosomes carrying miR-396e shapes macrophage metabolic reprograming to mitigate the inflammatory response in obese adipose tissue.
Evaluation of Mitochondrial Function in Blood Samples Shows Distinct Patterns in Subjects with Thyroid Carcinoma from Those with Hyperplasia.
Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation.
Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction.
Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells.
Acetate controls endothelial-to-mesenchymal transition.
Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis.
Iso-seco-tanapartholide from Artemisia argyi inhibits the PFKFB3-mediated glycolytic pathway to attenuate airway inflammation in lipopolysaccharide-induced acute lung injury mice.
Increased expression of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for growth of mouse embryonic stem cells that are undergoing differentiation.
Enhancement of glycolysis-dependent DNA repair regulated by FOXO1 knockdown via PFKFB3 attenuates hyperglycemia-induced endothelial oxidative stress injury.
Small extracellular vesicles derived from human adipose-derived stem cells regulate energetic metabolism through the activation of YAP/TAZ pathway facilitating angiogenesis.
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma.
Andrographolide inhibits murine embryonic neuronal development through PFKFB3-mediated glycolytic pathway.
Prognosis-related molecular subtyping in head and neck squamous cell carcinoma patients based on glycolytic/cholesterogenic gene data.
Effects of propranolol on glucose metabolism in hemangioma-derived endothelial cells.
p38 MAPK and MKP-1 control the glycolytic program via the bifunctional glycolysis regulator PFKFB3 during sepsis.
Garlic-derived exosomes regulate PFKFB3 expression to relieve liver dysfunction in high-fat diet-fed mice via macrophage-hepatocyte crosstalk.
Cryptotanshinone attenuates LPS-induced acute lung injury by regulating metabolic reprogramming of macrophage.
Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation.
ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3.
Inhibition of PFKFB3 in HER2-positive gastric cancer improves sensitivity to trastuzumab by inducing tumour vessel normalisation.
AAV-mediated expression of PFKFB3 in myofibers, but not endothelial cells, improves ischemic muscle function in mice with critical limb ischemia.
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
Placenta-Targeted Nanoparticles Loaded with PFKFB3 Overexpression Plasmids Enhance Angiogenesis and Placental Function.
BRAF activation by metabolic stress promotes glycolysis sensitizing NRAS(Q61)-mutated melanomas to targeted therapy.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Berberine Modulates Macrophage Activation by Inducing Glycolysis.
Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response.
Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch.
Dendropanax trifidus Sap-Mediated Suppression of Obese Mouse Body Weight and the Metabolic Changes Related with Estrogen Receptor Alpha and AMPK-ACC Pathways in Muscle Cells.
Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.
Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells.
Hyperglycemia induces miR-26-5p down-regulation to overexpress PFKFB3 and accelerate epithelial-mesenchymal transition in gastric cancer.
MiR-652-5p elevated glycolysis level by targeting TIGAR in T-cell acute lymphoblastic leukemia.
Candida tropicalis induces NLRP3 inflammasome activation via glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling pathway in myeloid-derived suppressor cells to promote colorectal carcinogenesis.
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer.
IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis.
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression.
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle.
PFKFB3 regulates lipopolysaccharide-induced excessive inflammation and cellular dysfunction in HTR-8/Svneo cells: Implications for the role of PFKFB3 in preeclampsia.
MALAT1 sponges miR-26a and miR-26b to regulate endothelial cell angiogenesis via PFKFB3-driven glycolysis in early-onset preeclampsia.
PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair.
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Prkaa1 Metabolically Regulates Monocyte/Macrophage Recruitment and Viability in Diet-Induced Murine Metabolic Disorders.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Inhibition of eNOS by L-NAME resulting in rat hind limb developmental defects through PFKFB3 mediated angiogenetic pathway.
PFKFB2 regulates glycolysis and proliferation in pancreatic cancer cells.
Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential.
Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation.
Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy.
Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3.
Deoxyelephantopin suppresses hepatic stellate cells activation associated with inhibition of aerobic glycolysis via hedgehog pathway.
PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.
PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells.
Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1.
Monocarboxylate transporter 1 promotes classical microglial activation and pro-inflammatory effect via 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3.
Phostine 3.1a as a pharmacological compound with antiangiogenic properties against diseases with excess vascularization.
Andrographolide attenuates imbalance of gastric vascular homeostasis induced by ethanol through glycolysis pathway.
PFKFB3/HIF-1α feedback loop modulates sorafenib resistance in hepatocellular carcinoma cells.
Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival.
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
The Glycolytic Enzyme PFKFB3 Controls TNF-α-Induced Endothelial Proinflammatory Responses.
PFKFB3 promotes endotoxemia-induced myocardial dysfunction through inflammatory signaling and apoptotic induction.
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.
Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor.
Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth.
FGF-dependent metabolic control of vascular development.
USP9X regulates centrosome duplication and promotes breast carcinogenesis.
6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor β1-enhanced invasion of Panc1 cells in vitro.
PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes.
PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense.
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer.
p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway.
Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells.
Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in Mouse Intestinal Epithelial Cells.
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
PFKFB3 Control of Cancer Growth by Responding to Circadian Clock Outputs.
Metabolic control of the cell cycle.
The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages.
Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis.
miR-26b inhibits proliferation, migration, invasion and apoptosis induction via the downregulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 driven glycolysis in osteosarcoma cells.
Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3).
Endothelial PFKFB3 plays a critical role in angiogenesis.
6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27.
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism.
Role of PFKFB3-driven glycolysis in vessel sprouting.
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
Yu D, Huang W, Sheng M, Zhang S, Pan H, Ren F, Luo L, Zhou J, Huang D, Tang L
Journal of inflammation research 2024;17:469-485
Journal of inflammation research 2024;17:469-485
Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure.
Li XY, Yin X, Lu JJ, Li QR, Xing WQ, Han Q, Ji H, Li SZ, Yang HM, Guo JR, Wang ZQ, Xu B
Cells 2024 Mar 25;13(7)
Cells 2024 Mar 25;13(7)
Bergenin alleviates proliferative arterial diseases by modulating glucose metabolism in vascular smooth muscle cells.
Song Y, Deng M, Qiu Y, Cui Y, Zhang B, Xin J, Feng L, Mu X, Cui J, Li H, Sun Y, Yi W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155592
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155592
Integrating network pharmacology and bioinformatics to explore and experimentally verify the regulatory effect of Buyang Huanwu decoction on glycolysis and angiogenesis after cerebral infarction.
Tian F, Yi J, Liu Y, Chen B, Wang X, Ouyang Y, Liu J, Tang Y, Long H, Liu B
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117218
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117218
Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.
Liu XT, Huang Y, Liu D, Jiang YC, Zhao M, Chung LH, Han XD, Zhao Y, Chen J, Coleman P, Ting KK, Tran C, Su Y, Dennis CV, Bhatnagar A, Liu K, Don AS, Vadas MA, Gorrell MD, Zhang S, Murray M, Kavurma MM, McCaughan GW, Gamble JR, Qi Y
Journal of translational medicine 2024 Jan 10;22(1):43
Journal of translational medicine 2024 Jan 10;22(1):43
PFKFB3 promotes endometriosis cell proliferation via enhancing the protein stability of β-catenin.
Ling X, Liu L, Jiang A, Shi X, Liu L, Wang X, Lu C, Ren C, Yu Z
Molecular and cellular endocrinology 2024 Jan 1;579:112083
Molecular and cellular endocrinology 2024 Jan 1;579:112083
The genetic and dietary landscape of the muscle insulin signalling network.
van Gerwen J, Masson SWC, Cutler HB, Vegas AD, Potter M, Stöckli J, Madsen S, Nelson ME, Humphrey SJ, James DE
eLife 2024 Feb 8;12
eLife 2024 Feb 8;12
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells.
Zhuang W, Liu X, Liu G, Lv J, Qin H, Wang C, Xie L, Saimaier K, Han S, Shi C, Hua Q, Zhang R, Du C
International journal of biological sciences 2023;19(11):3576-3594
International journal of biological sciences 2023;19(11):3576-3594
Noncoding RNA-Mediated High Expression of PFKFB3 Correlates with Poor Prognosis and Tumor Immune Infiltration of Lung Adenocarcinoma.
Gu X, Li X, Zhang X, Tong L, Feng R, Liu L, Sun H, Zhang Q, Bian T, Zhang J, Gao L, Zhang C, Liu J, Liu Y
OncoTargets and therapy 2023;16:767-783
OncoTargets and therapy 2023;16:767-783
A glycometabolic gene signature associating with immune infiltration and chemosensitivity and predicting the prognosis of patients with osteosarcoma.
Wang F, Yang K, Pan R, Xiang Y, Xiong Z, Li P, Li K, Sun H
Frontiers in medicine 2023;10:1115759
Frontiers in medicine 2023;10:1115759
Defective branched-chain amino acid catabolism in dorsal root ganglia contributes to mechanical pain.
Xie H, Li J, Lian N, Xie M, Wu M, Tang K, Kang Y, Lu P, Li T
EMBO reports 2023 Nov 6;24(11):e56958
EMBO reports 2023 Nov 6;24(11):e56958
Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer.
Zhang L, Liang J, Qin H, Lv Y, Liu X, Li Z, Chao Z, Jia C, Qin X, Zhang H
Journal of experimental & clinical cancer research : CR 2023 Nov 10;42(1):296
Journal of experimental & clinical cancer research : CR 2023 Nov 10;42(1):296
Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor 1 in proangiogenic glomerular endothelial cells under diabetic condition.
Yu B, Shen K, Li T, Li J, Meng M, Liu W, Tang Q, Zhu T, Wang X, Leung SWS, Shi Y
American journal of physiology. Cell physiology 2023 Nov 1;325(5):C1354-C1368
American journal of physiology. Cell physiology 2023 Nov 1;325(5):C1354-C1368
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis.
Jiang A, Liu J, Wang Y, Zhang C
Free radical biology & medicine 2023 Nov 1;208:516-529
Free radical biology & medicine 2023 Nov 1;208:516-529
TMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties.
Cao M, Liu Z, You D, Pan Y, Zhang Q
Stem cell research & therapy 2023 May 4;14(1):119
Stem cell research & therapy 2023 May 4;14(1):119
Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.
Gou Y, Wang H, Wang T, Wang H, Wang B, Jiao N, Yu Y, Cao Y, Wang H, Zhang Z
Immunology 2023 Mar;168(3):389-402
Immunology 2023 Mar;168(3):389-402
Garlic-derived exosomes carrying miR-396e shapes macrophage metabolic reprograming to mitigate the inflammatory response in obese adipose tissue.
Bian Y, Li W, Jiang X, Yin F, Yin L, Zhang Y, Guo H, Liu J
The Journal of nutritional biochemistry 2023 Mar;113:109249
The Journal of nutritional biochemistry 2023 Mar;113:109249
Evaluation of Mitochondrial Function in Blood Samples Shows Distinct Patterns in Subjects with Thyroid Carcinoma from Those with Hyperplasia.
Bernal-Tirapo J, Bayo Jiménez MT, Yuste-García P, Cordova I, Peñas A, García-Borda FJ, Quintela C, Prieto I, Sánchez-Ramos C, Ferrero-Herrero E, Monsalve M
International journal of molecular sciences 2023 Mar 29;24(7)
International journal of molecular sciences 2023 Mar 29;24(7)
Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation.
Cheng X, Jia X, Wang C, Zhou S, Chen J, Chen L, Chen J
World journal of surgical oncology 2023 Mar 28;21(1):112
World journal of surgical oncology 2023 Mar 28;21(1):112
Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction.
Wang F, Yin X, Fan YM, Zhang X, Ma C, Jia K, Zhou W, Tang Z, Qi LW, Li J
Journal of molecular medicine (Berlin, Germany) 2023 Jun;101(6):743-756
Journal of molecular medicine (Berlin, Germany) 2023 Jun;101(6):743-756
Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells.
Jiang M, Zhang YX, Bu WJ, Li P, Chen JH, Cao M, Dong YC, Sun ZJ, Dong DL
British journal of pharmacology 2023 Jul;180(14):1862-1877
British journal of pharmacology 2023 Jul;180(14):1862-1877
Acetate controls endothelial-to-mesenchymal transition.
Zhu X, Wang Y, Soaita I, Lee HW, Bae H, Boutagy N, Bostwick A, Zhang RM, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder NW, Yu L, Arany Z, Simons M
Cell metabolism 2023 Jul 11;35(7):1163-1178.e10
Cell metabolism 2023 Jul 11;35(7):1163-1178.e10
Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis.
Zhang L, Li L, Li Y, Jiang H, Sun Z, Zang G, Qian Y, Shao C, Wang Z
Diabetes & vascular disease research 2023 Jan-Feb;20(1):14791641231159009
Diabetes & vascular disease research 2023 Jan-Feb;20(1):14791641231159009
Iso-seco-tanapartholide from Artemisia argyi inhibits the PFKFB3-mediated glycolytic pathway to attenuate airway inflammation in lipopolysaccharide-induced acute lung injury mice.
Kong M, Zhu D, Dong J, Kong L, Luo J
Journal of ethnopharmacology 2023 Jan 30;301:115781
Journal of ethnopharmacology 2023 Jan 30;301:115781
Increased expression of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for growth of mouse embryonic stem cells that are undergoing differentiation.
Guzel S, Gurpinar Y, Altunok TH, Yalcin A
Cytotechnology 2023 Feb;75(1):27-38
Cytotechnology 2023 Feb;75(1):27-38
Enhancement of glycolysis-dependent DNA repair regulated by FOXO1 knockdown via PFKFB3 attenuates hyperglycemia-induced endothelial oxidative stress injury.
Sun D, Chen S, Li S, Wang N, Zhang S, Xu L, Zhu S, Li H, Gu Q, Xu X, Wei F
Redox biology 2023 Feb;59:102589
Redox biology 2023 Feb;59:102589
Small extracellular vesicles derived from human adipose-derived stem cells regulate energetic metabolism through the activation of YAP/TAZ pathway facilitating angiogenesis.
Sun J, Lin Z, Liao Z, Wu Z, Li H, Wang H
Cell biology international 2023 Feb;47(2):451-466
Cell biology international 2023 Feb;47(2):451-466
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
Zhao Y, Wang Y, Wu Y, Tao C, Xu R, Chen Y, Qian L, Xu T, Lian X
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200
Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma.
Yang K, Qiu T, Zhou J, Gong X, Zhang X, Lan Y, Zhang Z, Ji Y
Journal of translational medicine 2023 Feb 6;21(1):85
Journal of translational medicine 2023 Feb 6;21(1):85
Andrographolide inhibits murine embryonic neuronal development through PFKFB3-mediated glycolytic pathway.
Shi L, Li H, Wang Z, Liu W, Wu X, Li J, Jin Z, Hu W, Guo Q, Zhang L, Wang Y, Liang B, Zhu S, Zhang H, Xu H, Yang L, Shi R, Wang Y
European journal of pharmacology 2023 Feb 5;940:175474
European journal of pharmacology 2023 Feb 5;940:175474
Prognosis-related molecular subtyping in head and neck squamous cell carcinoma patients based on glycolytic/cholesterogenic gene data.
Zhou Z, Tang J, Lu Y, Jia J, Luo T, Su K, Dai X, Zhang H, Liu O
Cancer cell international 2023 Feb 25;23(1):37
Cancer cell international 2023 Feb 25;23(1):37
Effects of propranolol on glucose metabolism in hemangioma-derived endothelial cells.
Yang K, Li X, Qiu T, Zhou J, Gong X, Lan Y, Ji Y
Biochemical pharmacology 2023 Dec;218:115922
Biochemical pharmacology 2023 Dec;218:115922
p38 MAPK and MKP-1 control the glycolytic program via the bifunctional glycolysis regulator PFKFB3 during sepsis.
Mager CE, Mormol JM, Shelton ED, Murphy PR, Bowman BA, Barley TJ, Wang X, Linn SC, Liu K, Nelin LD, Hafner M, Liu Y
The Journal of biological chemistry 2023 Apr;299(4):103043
The Journal of biological chemistry 2023 Apr;299(4):103043
Garlic-derived exosomes regulate PFKFB3 expression to relieve liver dysfunction in high-fat diet-fed mice via macrophage-hepatocyte crosstalk.
Liu J, Li W, Bian Y, Jiang X, Zhu F, Yin F, Yin L, Song X, Guo H, Liu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Apr;112:154679
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Apr;112:154679
Cryptotanshinone attenuates LPS-induced acute lung injury by regulating metabolic reprogramming of macrophage.
Ye Z, Wang P, Feng G, Wang Q, Liu C, Lu J, Chen J, Liu P
Frontiers in medicine 2022;9:1075465
Frontiers in medicine 2022;9:1075465
Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation.
Zhou Z, Plug LG, Patente TA, de Jonge-Muller ESM, Elmagd AA, van der Meulen-de Jong AE, Everts B, Barnhoorn MC, Hawinkels LJAC
Frontiers in immunology 2022;13:966067
Frontiers in immunology 2022;13:966067
ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3.
Hu M, Bao R, Lin M, Han XR, Ai YJ, Gao Y, Guan KL, Xiong Y, Yuan HX
Oncogene 2022 Sep;41(40):4547-4559
Oncogene 2022 Sep;41(40):4547-4559
Inhibition of PFKFB3 in HER2-positive gastric cancer improves sensitivity to trastuzumab by inducing tumour vessel normalisation.
Yao X, He Z, Qin C, Zhang P, Sui C, Deng X, Fang Y, Li G, Shi J
British journal of cancer 2022 Sep;127(5):811-823
British journal of cancer 2022 Sep;127(5):811-823
AAV-mediated expression of PFKFB3 in myofibers, but not endothelial cells, improves ischemic muscle function in mice with critical limb ischemia.
Salyers ZR, Coleman M, Le D, Ryan TE
American journal of physiology. Heart and circulatory physiology 2022 Sep 1;323(3):H424-H436
American journal of physiology. Heart and circulatory physiology 2022 Sep 1;323(3):H424-H436
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
Tang M, Xu H, Huang H, Kuang H, Wang C, Li Q, Zhang X, Ge Y, Song M, Zhang X, Wang Z, Ma C, Kang J, Zhang W, Wang Y, Zhang B, Zhang X, Chen Y, Cong M, Melino G, Wang X, Zhou F, Sun Q, Shi H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992
Placenta-Targeted Nanoparticles Loaded with PFKFB3 Overexpression Plasmids Enhance Angiogenesis and Placental Function.
Li Q, Liu X, Liu W, Zhang Y, Liu W, Wu M, Chen Z, Zhao Y, Zou L
Bioengineering (Basel, Switzerland) 2022 Nov 4;9(11)
Bioengineering (Basel, Switzerland) 2022 Nov 4;9(11)
BRAF activation by metabolic stress promotes glycolysis sensitizing NRAS(Q61)-mutated melanomas to targeted therapy.
McGrail K, Granado-Martínez P, Esteve-Puig R, García-Ortega S, Ding Y, Sánchez-Redondo S, Ferrer B, Hernandez-Losa J, Canals F, Manzano A, Navarro-Sabaté A, Bartrons R, Yanes O, Pérez-Alea M, Muñoz-Couselo E, Garcia-Patos V, Recio JA
Nature communications 2022 Nov 19;13(1):7113
Nature communications 2022 Nov 19;13(1):7113
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Berberine Modulates Macrophage Activation by Inducing Glycolysis.
Li M, Zhang H, Zhang Y, Fan J, Zhu J, Gu X, Li Z, Zhang C, Liu Z, Li Y, Zang M, Jin G, Li G, Mi Y
Journal of immunology (Baltimore, Md. : 1950) 2022 May 15;208(10):2309-2318
Journal of immunology (Baltimore, Md. : 1950) 2022 May 15;208(10):2309-2318
Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response.
Cobo I, Cheng A, Murillo-Saich J, Coras R, Torres A, Abe Y, Lana AJ, Schlachetzki J, Liu-Bryan R, Terkeltaub R, Sanchez-Lopez E, Glass CK, Guma M
Cell reports 2022 Mar 8;38(10):110489
Cell reports 2022 Mar 8;38(10):110489
Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch.
Tan J, Yang M, Wang H, Shen C, Wu M, Xu H, Wu Y, Li Y, Li X, Huang T, Deng S, Yang Z, Gao S, Li H, Zhou J, Chen H, Cao N, Cai W
Cell reports 2022 Mar 8;38(10):110468
Cell reports 2022 Mar 8;38(10):110468
Dendropanax trifidus Sap-Mediated Suppression of Obese Mouse Body Weight and the Metabolic Changes Related with Estrogen Receptor Alpha and AMPK-ACC Pathways in Muscle Cells.
Lee A, Koh E, Kim D, Lee N, Cho SM, Lee YJ, Cho IH, Yang HJ
Nutrients 2022 Mar 5;14(5)
Nutrients 2022 Mar 5;14(5)
Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.
Yang Z, Huang C, Wen X, Liu W, Huang X, Li Y, Zang J, Weng Z, Lu D, Tsang CK, Li K, Xu A
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Mar 2;30(3):1275-1287
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Mar 2;30(3):1275-1287
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.
Lu J, Fu S, Dai J, Hu J, Li S, Ji H, Wang Z, Yu J, Bao J, Xu B, Guo J, Yang H
Journal of Zhejiang University. Science. B 2022 Jun 15;23(6):461-480
Journal of Zhejiang University. Science. B 2022 Jun 15;23(6):461-480
Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells.
Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, Tan L, Song C, Qiu X, Liao Y, Yu S, Liu X, Lin SH, Ding C
Autophagy 2022 Jul;18(7):1503-1521
Autophagy 2022 Jul;18(7):1503-1521
Hyperglycemia induces miR-26-5p down-regulation to overexpress PFKFB3 and accelerate epithelial-mesenchymal transition in gastric cancer.
He X, Cheng X, Ding J, Xiong M, Chen B, Cao G
Bioengineered 2022 Feb;13(2):2902-2917
Bioengineered 2022 Feb;13(2):2902-2917
MiR-652-5p elevated glycolysis level by targeting TIGAR in T-cell acute lymphoblastic leukemia.
Liu S, Wang H, Guo W, Zhou X, Shu Y, Liu H, Yang L, Tang S, Su H, Liu Z, Zeng L, Zou L
Cell death & disease 2022 Feb 14;13(2):148
Cell death & disease 2022 Feb 14;13(2):148
Candida tropicalis induces NLRP3 inflammasome activation via glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling pathway in myeloid-derived suppressor cells to promote colorectal carcinogenesis.
Zhang Z, Chen Y, Yin Y, Chen Y, Chen Q, Bing Z, Zheng Y, Hou Y, Shen S, Chen Y, Wang T
International immunopharmacology 2022 Dec;113(Pt B):109430
International immunopharmacology 2022 Dec;113(Pt B):109430
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Wang L, Lin Y, Zhou X, Chen Y, Li X, Luo W, Zhou Y, Cai L
Cancer letters 2022 Apr 28;532:215586
Cancer letters 2022 Apr 28;532:215586
Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer.
Wang J, Huang Q, Hu X, Zhang S, Jiang Y, Yao G, Hu K, Xu X, Liang B, Wu Q, Ma Z, Wang Y, Wang C, Wu Z, Rong X, Liao W, Shi M
Cancer research 2022 Apr 15;82(8):1503-1517
Cancer research 2022 Apr 15;82(8):1503-1517
IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis.
Song C, Wang S, Fu Z, Chi K, Geng X, Liu C, Cai G, Chen X, Wu D, Hong Q
Cell death & disease 2022 Apr 13;13(4):340
Cell death & disease 2022 Apr 13;13(4):340
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Zhang Y, Liu W, Zhong Y, Li Q, Wu M, Yang L, Liu X, Zou L
Oxidative medicine and cellular longevity 2021;2021:1806344
Oxidative medicine and cellular longevity 2021;2021:1806344
PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression.
Sun Q, Yuan M, Wang H, Zhang X, Zhang R, Wang H, Chen X, Zhu M, Liu S, Wu J
Frontiers in oncology 2021;11:767116
Frontiers in oncology 2021;11:767116
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Jiang M, Li X, Zhang J, Lu Y, Shi Y, Zhu C, Liu Y, Qin B, Luo Z, Du Y, Luo L, Peng L, You J
ACS nano 2021 Sep 28;15(9):14522-14534
ACS nano 2021 Sep 28;15(9):14522-14534
Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle.
Christianto A, Baba T, Takahashi F, Inui K, Inoue M, Suyama M, Ono Y, Ohkawa Y, Morohashi KI
Communications biology 2021 Nov 4;4(1):1264
Communications biology 2021 Nov 4;4(1):1264
PFKFB3 regulates lipopolysaccharide-induced excessive inflammation and cellular dysfunction in HTR-8/Svneo cells: Implications for the role of PFKFB3 in preeclampsia.
Zhang Y, Liu W, Wu M, Li Q, Liu Y, Yang L, Chen Y, Zhong Y, Liu X, Zou L
Placenta 2021 Mar;106:67-78
Placenta 2021 Mar;106:67-78
MALAT1 sponges miR-26a and miR-26b to regulate endothelial cell angiogenesis via PFKFB3-driven glycolysis in early-onset preeclampsia.
Li Q, Liu X, Liu W, Zhang Y, Wu M, Chen Z, Zhao Y, Zou L
Molecular therapy. Nucleic acids 2021 Mar 5;23:897-907
Molecular therapy. Nucleic acids 2021 Mar 5;23:897-907
PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair.
Ninou AH, Lehto J, Chioureas D, Stigsdotter H, Schelzig K, Åkerlund E, Gudoityte G, Joneborg U, Carlson J, Jonkers J, Seashore-Ludlow B, Gustafsson NMS
Cancers 2021 Jul 18;13(14)
Cancers 2021 Jul 18;13(14)
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH, Song MS
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9
Prkaa1 Metabolically Regulates Monocyte/Macrophage Recruitment and Viability in Diet-Induced Murine Metabolic Disorders.
Yang Q, Ma Q, Xu J, Liu Z, Zou J, Shen J, Zhou Y, Da Q, Mao X, Lu S, Fulton DJ, Weintraub NL, Bagi Z, Hong M, Huo Y
Frontiers in cell and developmental biology 2020;8:611354
Frontiers in cell and developmental biology 2020;8:611354
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446
American journal of translational research 2020;12(2):428-446
Inhibition of eNOS by L-NAME resulting in rat hind limb developmental defects through PFKFB3 mediated angiogenetic pathway.
Wu Z, Yao H, Xu H, Wang Y, Hu W, Lou G, Zhang L, Huang C, Jiang C, Zhou S, Shi Y, Chen X, Yang L, Xu Y, Wang Y
Scientific reports 2020 Oct 7;10(1):16754
Scientific reports 2020 Oct 7;10(1):16754
PFKFB2 regulates glycolysis and proliferation in pancreatic cancer cells.
Ozcan SC, Sarioglu A, Altunok TH, Akkoc A, Guzel S, Guler S, Imbert-Fernandez Y, Muchut RJ, Iglesias AA, Gurpinar Y, Clem AL, Chesney JA, Yalcin A
Molecular and cellular biochemistry 2020 Jul;470(1-2):115-129
Molecular and cellular biochemistry 2020 Jul;470(1-2):115-129
Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential.
Prieto I, Alarcón CR, García-Gómez R, Berdún R, Urgel T, Portero M, Pamplona R, Martínez-Ruiz A, Ruiz-Sanz JI, Ruiz-Larrea MB, Jove M, Cerdán S, Monsalve M
Redox biology 2020 Jan;29:101396
Redox biology 2020 Jan;29:101396
Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation.
Woods PS, Kimmig LM, Meliton AY, Sun KA, Tian Y, O'Leary EM, Gökalp GA, Hamanaka RB, Mutlu GM
American journal of respiratory cell and molecular biology 2020 Feb;62(2):243-255
American journal of respiratory cell and molecular biology 2020 Feb;62(2):243-255
Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
Wang J, Guan H, Liu H, Lei Z, Kang H, Guo Q, Dong Y, Liu H, Sun Y, Fang Z, Li F
Journal of cellular and molecular medicine 2020 Feb;24(3):2294-2307
Journal of cellular and molecular medicine 2020 Feb;24(3):2294-2307
TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy.
Zeng H, Qi X, Xu X, Wu Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Dec;69(12):1215-1234
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Dec;69(12):1215-1234
Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3.
Wang Z, Kong L, Tan S, Zhang Y, Song X, Wang T, Lin Q, Wu Z, Xiang P, Li C, Gao L, Liang X, Ma C
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 15;204(8):2232-2241
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 15;204(8):2232-2241
Deoxyelephantopin suppresses hepatic stellate cells activation associated with inhibition of aerobic glycolysis via hedgehog pathway.
Gao W, Sun J, Wang F, Lu Y, Wen C, Bian Q, Wu H
Biochemical and biophysical research communications 2019 Sep 3;516(4):1222-1228
Biochemical and biophysical research communications 2019 Sep 3;516(4):1222-1228
PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.
Kovacs L, Cao Y, Han W, Meadows L, Kovacs-Kasa A, Kondrikov D, Verin AD, Barman SA, Dong Z, Huo Y, Su Y
American journal of respiratory and critical care medicine 2019 Sep 1;200(5):617-627
American journal of respiratory and critical care medicine 2019 Sep 1;200(5):617-627
PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells.
Yan S, Zhou N, Zhang D, Zhang K, Zheng W, Bao Y, Yang W
International journal of molecular sciences 2019 Oct 30;20(21)
International journal of molecular sciences 2019 Oct 30;20(21)
Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1.
Almacellas E, Pelletier J, Manzano A, Gentilella A, Ambrosio S, Mauvezin C, Tauler A
iScience 2019 Oct 25;20:434-448
iScience 2019 Oct 25;20:434-448
Monocarboxylate transporter 1 promotes classical microglial activation and pro-inflammatory effect via 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3.
Kong L, Wang Z, Liang X, Wang Y, Gao L, Ma C
Journal of neuroinflammation 2019 Nov 28;16(1):240
Journal of neuroinflammation 2019 Nov 28;16(1):240
Phostine 3.1a as a pharmacological compound with antiangiogenic properties against diseases with excess vascularization.
Bousseau S, Marchand M, Soleti R, Vergori L, Hilairet G, Recoquillon S, Le Mao M, Gueguen N, Khiati S, Clarion L, Bakalara N, Martinez MC, Germain S, Lenaers G, Andriantsitohaina R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):5864-5875
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):5864-5875
Andrographolide attenuates imbalance of gastric vascular homeostasis induced by ethanol through glycolysis pathway.
Yao H, Wu Z, Xu Y, Xu H, Lou G, Jiang Q, Fan W, Liu W, Zheng C, Gao Y, Wang Y
Scientific reports 2019 Mar 21;9(1):4968
Scientific reports 2019 Mar 21;9(1):4968
PFKFB3/HIF-1α feedback loop modulates sorafenib resistance in hepatocellular carcinoma cells.
Long Q, Zou X, Song Y, Duan Z, Liu L
Biochemical and biophysical research communications 2019 Jun 4;513(3):642-650
Biochemical and biophysical research communications 2019 Jun 4;513(3):642-650
Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival.
Lypova N, Telang S, Chesney J, Imbert-Fernandez Y
The Journal of biological chemistry 2019 Jul 5;294(27):10530-10543
The Journal of biological chemistry 2019 Jul 5;294(27):10530-10543
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
Li Q, Wang Y, Wu S, Zhou Z, Ding X, Shi R, Thorne RF, Zhang XD, Hu W, Wu M
Cell metabolism 2019 Jul 2;30(1):157-173.e7
Cell metabolism 2019 Jul 2;30(1):157-173.e7
The Glycolytic Enzyme PFKFB3 Controls TNF-α-Induced Endothelial Proinflammatory Responses.
Zhang R, Li R, Liu Y, Li L, Tang Y
Inflammation 2019 Feb;42(1):146-155
Inflammation 2019 Feb;42(1):146-155
PFKFB3 promotes endotoxemia-induced myocardial dysfunction through inflammatory signaling and apoptotic induction.
Tian W, Guo HS, Li CY, Cao W, Wang XY, Mo D, Hao XW, Feng YD, Sun Y, Lei F, Zhang HN, Zhao MG, Li XQ
Toxicology and applied pharmacology 2019 Apr 1;368:26-36
Toxicology and applied pharmacology 2019 Apr 1;368:26-36
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
Gustafsson NMS, Färnegårdh K, Bonagas N, Ninou AH, Groth P, Wiita E, Jönsson M, Hallberg K, Lehto J, Pennisi R, Martinsson J, Norström C, Hollers J, Schultz J, Andersson M, Markova N, Marttila P, Kim B, Norin M, Olin T, Helleday T
Nature communications 2018 Sep 24;9(1):3872
Nature communications 2018 Sep 24;9(1):3872
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.
Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, Xu X, Yang Q, Zeng X, Zhou Y, Gu X, Lu S, Fu Z, Fulton DJ, Weintraub NL, Caldwell RB, Zhang W, Wu C, Liu XL, Chen JF, Ahmad A, Kaddour-Djebbar I, Al-Shabrawey M, Li Q, Jiang X, Sun Y, Sodhi A, Smith L, Hong M, Huo Y
Nature communications 2017 Sep 19;8(1):584
Nature communications 2017 Sep 19;8(1):584
Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor.
Park Y, Woo SH, Seo SK, Kim H, Noh WC, Lee JK, Kwon BM, Min KN, Choe TB, Park IC
Oncology letters 2017 Oct;14(4):5027-5033
Oncology letters 2017 Oct;14(4):5027-5033
Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth.
Gibb AA, Epstein PN, Uchida S, Zheng Y, McNally LA, Obal D, Katragadda K, Trainor P, Conklin DJ, Brittian KR, Tseng MT, Wang J, Jones SP, Bhatnagar A, Hill BG
Circulation 2017 Nov 28;136(22):2144-2157
Circulation 2017 Nov 28;136(22):2144-2157
FGF-dependent metabolic control of vascular development.
Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M
Nature 2017 May 11;545(7653):224-228
Nature 2017 May 11;545(7653):224-228
USP9X regulates centrosome duplication and promotes breast carcinogenesis.
Li X, Song N, Liu L, Liu X, Ding X, Song X, Yang S, Shan L, Zhou X, Su D, Wang Y, Zhang Q, Cao C, Ma S, Yu N, Yang F, Wang Y, Yao Z, Shang Y, Shi L
Nature communications 2017 Mar 31;8:14866
Nature communications 2017 Mar 31;8:14866
6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor β1-enhanced invasion of Panc1 cells in vitro.
Yalcin A, Solakoglu TH, Ozcan SC, Guzel S, Peker S, Celikler S, Balaban BD, Sevinc E, Gurpinar Y, Chesney JA
Biochemical and biophysical research communications 2017 Mar 11;484(3):687-693
Biochemical and biophysical research communications 2017 Mar 11;484(3):687-693
PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes.
Hamanaka RB, Mutlu GM
The Journal of investigative dermatology 2017 Jun;137(6):1267-1276
The Journal of investigative dermatology 2017 Jun;137(6):1267-1276
PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense.
Jiang H, Shi H, Sun M, Wang Y, Meng Q, Guo P, Cao Y, Chen J, Gao X, Li E, Liu J
Journal of immunology (Baltimore, Md. : 1950) 2016 Oct 1;197(7):2880-90
Journal of immunology (Baltimore, Md. : 1950) 2016 Oct 1;197(7):2880-90
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer.
O'Neal J, Clem A, Reynolds L, Dougherty S, Imbert-Fernandez Y, Telang S, Chesney J, Clem BF
Breast cancer research and treatment 2016 Nov;160(1):29-40
Breast cancer research and treatment 2016 Nov;160(1):29-40
p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway.
Franklin DA, He Y, Leslie PL, Tikunov AP, Fenger N, Macdonald JM, Zhang Y
Scientific reports 2016 Nov 30;6:38067
Scientific reports 2016 Nov 30;6:38067
Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells.
Salabei JK, Lorkiewicz PK, Mehra P, Gibb AA, Haberzettl P, Hong KU, Wei X, Zhang X, Li Q, Wysoczynski M, Bolli R, Bhatnagar A, Hill BG
The Journal of biological chemistry 2016 Jun 24;291(26):13634-48
The Journal of biological chemistry 2016 Jun 24;291(26):13634-48
Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in Mouse Intestinal Epithelial Cells.
Botchlett R, Li H, Guo X, Qi T, Zhao J, Zheng J, Woo SL, Pei Y, Liu M, Hu X, Chen G, Guo T, Yang S, Li Q, Xiao X, Huo Y, Wu C
Scientific reports 2016 Jul 8;6:28963
Scientific reports 2016 Jul 8;6:28963
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
Reid MA, Lowman XH, Pan M, Tran TQ, Warmoes MO, Ishak Gabra MB, Yang Y, Locasale JW, Kong M
Genes & development 2016 Aug 15;30(16):1837-51
Genes & development 2016 Aug 15;30(16):1837-51
PFKFB3 Control of Cancer Growth by Responding to Circadian Clock Outputs.
Chen L, Zhao J, Tang Q, Li H, Zhang C, Yu R, Zhao Y, Huo Y, Wu C
Scientific reports 2016 Apr 15;6:24324
Scientific reports 2016 Apr 15;6:24324
Metabolic control of the cell cycle.
Kalucka J, Missiaen R, Georgiadou M, Schoors S, Lange C, De Bock K, Dewerchin M, Carmeliet P
Cell cycle (Georgetown, Tex.) 2015;14(21):3379-88
Cell cycle (Georgetown, Tex.) 2015;14(21):3379-88
The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages.
Tan Z, Xie N, Banerjee S, Cui H, Fu M, Thannickal VJ, Liu G
The Journal of biological chemistry 2015 Jan 2;290(1):46-55
The Journal of biological chemistry 2015 Jan 2;290(1):46-55
Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis.
Xie N, Tan Z, Banerjee S, Cui H, Ge J, Liu RM, Bernard K, Thannickal VJ, Liu G
American journal of respiratory and critical care medicine 2015 Dec 15;192(12):1462-74
American journal of respiratory and critical care medicine 2015 Dec 15;192(12):1462-74
miR-26b inhibits proliferation, migration, invasion and apoptosis induction via the downregulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 driven glycolysis in osteosarcoma cells.
Du JY, Wang LF, Wang Q, Yu LD
Oncology reports 2015 Apr;33(4):1890-8
Oncology reports 2015 Apr;33(4):1890-8
Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3).
Imbert-Fernandez Y, Clem BF, O'Neal J, Kerr DA, Spaulding R, Lanceta L, Clem AL, Telang S, Chesney J
The Journal of biological chemistry 2014 Mar 28;289(13):9440-8
The Journal of biological chemistry 2014 Mar 28;289(13):9440-8
Endothelial PFKFB3 plays a critical role in angiogenesis.
Xu Y, An X, Guo X, Habtetsion TG, Wang Y, Xu X, Kandala S, Li Q, Li H, Zhang C, Caldwell RB, Fulton DJ, Su Y, Hoda MN, Zhou G, Wu C, Huo Y
Arteriosclerosis, thrombosis, and vascular biology 2014 Jun;34(6):1231-9
Arteriosclerosis, thrombosis, and vascular biology 2014 Jun;34(6):1231-9
6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27.
Yalcin A, Clem BF, Imbert-Fernandez Y, Ozcan SC, Peker S, O'Neal J, Klarer AC, Clem AL, Telang S, Chesney J
Cell death & disease 2014 Jul 17;5(7):e1337
Cell death & disease 2014 Jul 17;5(7):e1337
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism.
Klarer AC, O'Neal J, Imbert-Fernandez Y, Clem A, Ellis SR, Clark J, Clem B, Chesney J, Telang S
Cancer & metabolism 2014 Jan 23;2(1):2
Cancer & metabolism 2014 Jan 23;2(1):2
Role of PFKFB3-driven glycolysis in vessel sprouting.
De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P
Cell 2013 Aug 1;154(3):651-63
Cell 2013 Aug 1;154(3):651-63
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
Telang S, Clem BF, Klarer AC, Clem AL, Trent JO, Bucala R, Chesney J
Journal of translational medicine 2012 May 16;10:95
Journal of translational medicine 2012 May 16;10:95
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse thymus tissue were subjected to SDS PAGE followed by western blot with 13763-1-AP(PFKFB3 antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PFKFB3-Specific antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PFKFB3-Specific. This antibody recognizes human,mouse,rat antigen. The PFKFB3-Specific antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 13763-1-AP(PFKFB3 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 13763-1-AP(PFKFB3 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue