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Protein structure
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Top validated antibodies |
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| Proteintech Group |  13763-1-AP |
110 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | 13763-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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| Boster Biological Technology | M02382 |
1 references | Monoclonal |
WB
ICC
IP
IHC
FC
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| Novus Biologicals | H00005209-M08 |
12 references | Monoclonal |
WB
EL
IP
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| antibodies-online | ABIN518808 |
3 references | Monoclonal |
WB
EL
IP
|
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