abx200352

antibody from Abbexa

Targeting: ITGA4 CD49D

Flow cytometry (Recommended by provider)

Antibody Data

Product number

abx200352

Provider

Abbexa

Product name

CD49d Antibody (FITC)

Antibody type

Monoclonal

Description

The CD29 antigen, also known as the ß-1 subunit, is common to the VLA family of integrins. When acting as a matrix receptor, the CD49d antigen binds to CS-1, an alternatively spliced domain of fibronectin. When functioning as a cell receptor, the CD49d antigen binds to the vascular cell-adhesion molecule-1 (VCAM-1). The interaction between the CD49d antigen and VCAM-1 is known to play an important role in stabilizing the adhesion of lymphocytes to endothelial cells and in mediating B-lymphocyte precursor/bone marrow stromal cell adhesion. The CD49d antigen, when associated with the ß integrin, forms a lymphocyte homing receptor for Peyer's patch, binding tothe mucosal vascular addressin MAdCAM-1. The CD49d antigen is also involved in CD3-dependent CD4+ T-lymphocyte activation via its interaction with fibronectin.

Reactivity

Human

Host

Mouse

Conjugate

Green dye

Isotype

IgG

Vial size

100 tests

Storage

Aliquot and store in the dark at 2°C to 8°C. Avoid exposure to light.