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Protein structure
ITGA4
Integrin subunit alpha 4CD49D
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Top validated antibodies |
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| Invitrogen Antibodies |  14-0499-82 |
12 references | Monoclonal |
ICC
IHC
FC
OA
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| Proteintech Group | 19676-1-AP |
18 references | Polyclonal |
WB
EL
IHC
FC
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| antibodies-online | ABIN1106427 |
2 references | Monoclonal |
WB
EL
FC
|
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| GeneTex | GTX41951 |
1 references | Monoclonal |
IP
IHC
FC
FA
|
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| Novus Biologicals | NBP1-77333 |
2 references | Polyclonal |
WB
EL
ICC
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