TRIM68

This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a ""really interesting new gene"" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Description

Tripartite motif containing 68

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (4598672 - 4608231)

Ensembl ID

ENSG00000167333  (ver. 103.38)

Orthologs

Mouse Trim68: ENSMUSG00000073968

UniProt

Q6AZZ1

neXtProt

NX_Q6AZZ1

Human splice variants
Mouse splice variants

Protein structure