20920-1-AP

antibody from Proteintech Group

Targeting: ITCH AIP4

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

20920-1-AP

Provider

Proteintech Group

Product name

ITCH antibody

Antibody type

Polyclonal

Description

ITCH antibody (Cat. #20920-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

ZG16 represses tumor progression and M2 polarization of tumor-associated macrophages in hepatocellular carcinoma by promoting ubiquitination and degradation of SNX9 via binding to ITCH.

Meng H, Wang Z, Wang L, Fang X, Li H, Ma W, Ding Y, Nan M, Meng Y, Li L, Li Y, Chen K, Zhang M
Hepatology international 2026 Mar 4;

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From Single-Cell Clusters to Causality: ITCH Engagement for CKD Uncovered by Integrative Analysis of MR and MAGMA.

Zhang X, Zhang D, Shang J, Zeng Z, Chai S, Lv X, Lv Z, Wang R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71469

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The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells.

Cui D, Qu R, Li T, Wang L, Chen X, Shao S, Liang X, Xu J, Sun Y, Xiong X, Zhao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(3):e12652

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A TRIM21-UCHL3-ITCH-SIPA1 axis promotes colorectal cancer growth and metastasis.

Lou S, Wang H, Mo G, Li H, Xie H, Huang Y, Li H, Ma K, Zhang X, Yan M, Zhang J, Pi Y, Han P
Cancer letters 2026 Feb 28;639:218221

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Dietary fiber-derived butyrate ameliorates pulmonary fibrosis by inhibiting YBX1 ubiquitination.

Li M, Pan T, Ma X, Hu X, Jiang J, Zhang Y, Zhang L, Pan X, Wang Y
The Journal of nutritional biochemistry 2026 Apr;150:110210

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PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer.

Liu F, Liu W, Tan Y, Shang Y, Ling S, Jiang X, Zhang Z, Sun S, Xie P
Oncogene 2025 Sep;44(33):2997-3013

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ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration.

Xiang Q, Lu Y, Wang H, Chen H, Chen P, Zhao X, Cortes Morales L, Yang Y, Yang J, Zhang T, Wang J
Science advances 2025 Oct 24;11(43):eado4330

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Inhibition of HIF-1α ameliorates pulmonary fibrosis by suppressing M2 macrophage polarization through PRMT1/STAT6 signals.

Liang J, Ran Y, Hu C, Zhou J, Ye L, Su W, Liu Z, Xi J
International immunopharmacology 2025 Jan 27;146:113931

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E3 ubiquitin ligase ITCH-mediated proteasomal degradation of WBP2 sensitizes breast cancer cells to chemotherapy through restraining AMOTL2/c-JUN axis.

Zhu M, Zhong W, Wong S, Luo X, Hong Z, Lin J, Wu J, Zhou Y, Qi Z, Chen S
Biochemical pharmacology 2025 Feb;232:116720

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µMap proximity labeling in living cells reveals stress granule disassembly mechanisms.

Pan CR, Knutson SD, Huth SW, MacMillan DWC
Nature chemical biology 2025 Apr;21(4):490-500

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Identification and validation of CDC20 and ITCH as ubiquitination related biomarker in idiopathic pulmonary fibrosis.

Sun S, Wang Y, Feng J
Hereditas 2025 Apr 1;162(1):50

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ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis.

He J, Yi J, Ji L, Dai L, Chen Y, Xue W
Molecular medicine (Cambridge, Mass.) 2024 May 23;30(1):69

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NUAK1 activates STAT5/GLI1/SOX2 signaling to enhance cancer cell expansion and drives chemoresistance in gastric cancer.

Cao L, Lin G, Fan D, Weng K, Chen Y, Wang J, Li P, Zheng C, Huang C, Xie J
Cell reports 2024 Jul 23;43(7):114446

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Mitochondria-targeted catalase induced cell malignant transformation by the downregulation of p53 protein stability via USP28/miR-200b/PP2A-Cα axis.

Wen C, Huang C, Liao X, Luo Z, Huang C
Archives of biochemistry and biophysics 2024 Aug;758:110047

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Downregulation of TEX11 promotes S-Phase progression and proliferation in colorectal cancer cells through the FOXO3a/COP1/c-Jun/p21 axis.

Zhang X, Hu F, Zhu B, Jiao X, Li Y, Wu S, Ren G, Li J, Xie Q, Pan Y, Li H, Zhao L
Oncogene 2022 Nov;41(47):5133-5145

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ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3.

Zhou L, Song Z, Hu J, Liu L, Hou Y, Zhang X, Yang X, Chen K
Theranostics 2021;11(2):841-860

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Coiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 Degradation.

Wang C, Li H, Wu L, Jiao X, Jin Z, Zhu Y, Fang Z, Zhang X, Huang H, Zhao L
Frontiers in oncology 2021;11:668743

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GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma.

Ge QY, Chen J, Li GX, Tan XL, Song J, Ning D, Mo J, Du PC, Liu QM, Liang HF, Ding ZY, Zhang XW, Zhang BX
Clinical and translational medicine 2021 Nov;11(11):e635

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The E3 ubiquitin ligase Itch deficiency promotes antigen-driven B-cell responses in mice.

Fang Y, He Y, Zhai B, Hou C, Xu R, Xing C, Wang X, Ma N, Han G, Wang R
European journal of immunology 2021 Jan;51(1):103-114

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Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology.

Zhang Y, Chen X, Wang Q, Du C, Lu W, Yuan H, Zhang Z, Li D, Ling X, Ren X, Zhao Y, Su Q, Xing Z, Qin Y, Yang X, Shen Y, Wu H, Qi Y
Journal of molecular medicine (Berlin, Germany) 2021 Dec;99(12):1797-1813

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JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling.

Ren Y, Chen D, Zhai Z, Chen J, Li A, Liang Y, Zhou J
Cell death discovery 2021 Apr 19;7(1):85

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ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.

Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X, Zhou J
Developmental cell 2020 May 4;53(3):287-299.e5

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Heat stress activates YAP/TAZ to induce the heat shock transcriptome.

Luo M, Meng Z, Moroishi T, Lin KC, Shen G, Mo F, Shao B, Wei X, Zhang P, Wei Y, Guan KL
Nature cell biology 2020 Dec;22(12):1447-1459

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Increased miR-214 expression suppresses cell migration and proliferation in Hirschsprung disease by interacting with PLAGL2.

Wu L, Yuan W, Chen J, Zhou Z, Shu Y, Ji J, Liu Z, Tang Q, Zhang X, Shu X
Pediatric research 2019 Oct;86(4):460-470

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Calhex(231) Alleviates High Glucose-Induced Myocardial Fibrosis via Inhibiting Itch-Ubiquitin Proteasome Pathway in Vitro.

Yuan H, Xu J, Xu X, Gao T, Wang Y, Fan Y, Hu J, Shao Y, Zhao B, Li H, Sun J, Xu C
Biological & pharmaceutical bulletin 2019 Aug 1;42(8):1337-1344