ITCH

gene product
AIP4
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
284 antibodies from 35 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
5 antibodies
antibodies-online
81 antibodies
Atlas Antibodies
2 antibodies
Acris Antibodies GmbH
7 antibodies
Abnova Corporation
5 antibodies
Biorbyt
23 antibodies
LifeSpan BioSciences, Inc.
48 antibodies
FabGennix
3 antibodies
Invitrogen Antibodies
5 antibodies
GeneTex
4 antibodies
Affinity Biosciences
3 antibodies
NovoPro Bioscience Inc.
6 antibodies
Antibodies.com
1 antibody
Bethyl Laboratories
1 antibody
Cell Signaling Technology, Inc
1 antibody
Aviva Systems Biology
5 antibodies
NSJ Bioreagents
2 antibodies
Everest Biotech
1 antibody
OriGene
7 antibodies
RabMAbs
4 antibodies
Abgent
2 antibodies
Arigo
1 antibody
Sino Biological Inc.
5 antibodies
ProSci
3 antibodies
St John's Laboratory
3 antibodies
Boster Biological Technology
2 antibodies
Creative Biolabs
9 antibodies
Abiocode, Inc.
1 antibody
MyBioSource
6 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Creative Diagnostics
4 antibodies
Sigma-Aldrich
4 antibodies
Rockland Immunochemicals, Inc.
1 antibody
United States Biological
26 antibodies
EMD Millipore
1 antibody