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Itchy E3 ubiquitin protein ligaseAIP4
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Top validated antibodies |
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| Invitrogen Antibodies |  PA5-65539 |
1 references | Polyclonal |
WB
ICC
IP
OA
|
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| Proteintech Group | 20920-1-AP |
12 references | Polyclonal |
WB
EL
IP
IHC
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| NSJ Bioreagents | RQ5693 |
Polyclonal |
WB
EL
ICC
IHC
FC
|
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| Novus Biologicals | NB100-68142 |
1 references | Polyclonal |
WB
EL
ICC
FC
|
|
| Boster Biological Technology | A00195-1 |
Polyclonal |
WB
EL
ICC
IHC
FC
|
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