MAOA

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

Description

Monoamine oxidase A

Tissue specificity

Tissue enhanced (intestine)

Subcell location

Mitochondria, Cytosol

Predicted location

Membrane

Protein family

Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (43654907 - 43746824)

Ensembl ID

ENSG00000189221  (ver. 103.38)

Orthologs

Mouse Maoa: ENSMUSG00000025037

UniProt

P21397

neXtProt

NX_P21397

Human splice variants
Mouse splice variants

Protein structure