Antibody data

Product number
AP0292 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#AP0292, RRID:AB_2797474
Product name
PKC IJ (phospho T538) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human PKC IJ around the phosphorylation site of Threonine 538.
Description
Members of the protein kinase C (PKC) family of serine/threonine kinases play a key role in regulating the differentiation and growth of diverse cell types. PKC theta is a member of the PKC family, and its predominant expression in hematopoietic cells suggests that it may play a role in signal transduction and growth regulatory pathways unique to these cells. PKC theta is a Ca(2+)-independent PKC isoform that is selectively expressed in T lymphocytes (and muscle), and it is thought to play an important role in T cell receptor-induced activation. Among several PKC isoenzymes expressed in T cells, PKC theta is unique in being rapidly recruited to the site of TCR clustering. It has been shown that PKC theta is essential for TCR-mediated T-cell activation, but it is dispensable during TCR-dependent thymocyte development.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PRKCQ protein structure - AP0292 shown in red.